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| 1 | Simultaneous acquisition of multi-nuclei enhanced NMR/MRI by solution-state dynamic nuclear polarization显示文摘Dynamic nuclear polarization(DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance(NMR) of various molecules.Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarization of all kinds of nuclei in the system.The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy(MRS) and image(MRI).Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority.We have observed very large simultaneous DNP enhancements for different nuclei,such as ~1H and ^(23)Na,~1H and ^(31)P,^(19)F and ^(31)P,especially for the first time to report sodium ion enhancement in liquid.We have also obtained the simultaneous images of ^(19)H and ^(31)P,^(19)F and ^(31)P at low field by solution-state DNP for the first time. | Yugui He Zhen Zhang Jiwen Feng Chongyang Huang Fang Chen Chaoyang Liu Maili Liu | 2016 | Science China Chemistry2016，59，7： | 2 |
| 2 | Inhibitory effect of lanosterol on cataractous lens of cynomolgus monkeys using a subconjunctival drug release system Keke显示文摘Background:To evaluate the effect of lanosterol on cataractous lens of cynomolgus monkeys using a subconjunctival drug release system.Methods:Nine elder cynomolgus monkeys were used,consisting of three monkeys without cataract as controls,three monkeys with naturally occurring cortical cataract,and three monkeys with nuclear cataract as intervention groups.Nanoparticulated thermogel with lanosterol and fluorescein was administered by subconjunctival injection in the monkeys with cataract.Fluorescence changes of injected thermogel and cataract progression were observed.Lanosterol concentration in aqueous humor,solubility changes in lens proteins,and oxidative stress levels were analyzed in the lenses of the control and intervention groups.Results:Injected thermogel showed decreased fluorescence during follow up.Lanosterol concentration in aqueous humor increased in the first 2 weeks and then gradually decreased,which was in accordance with the changes in cortical lens clarity.However,lenses with nuclear opacification showed little change.In the cortical region of lenses with cortical cataract,solubility ofα-crystallin was significantly increased after administration of lanosterol,as well as the reduction of oxidative stress.Conclusions:We demonstrated the effect of lanosterol on cataract progression based on in vivo models of primates.Lanosterol showed a short-term and reliable reversal effect on reducing cataract severity in cortical cataract in the early stages,possibly due to the increase in the solubility of lens proteins and changes in the oxidative stress status.Lanosterol administration using subconjunctival drug release system could be a promising nonsurgical approach for future clinical studies of cataract prevention and treatment. | Zhang Wenwen He Yu Du Yugui Zhou Xiaokang Wu Jie Zhu Xiangjia Zhu Kang Zhang Yi Lu | 2022 | Precision Clinical Medicine2022，5，3： | 0 |
| 3 | Insulin Receptor in Diabetes Mellitus显示文摘Changes in insulin receptor (IR) of red blood cells in 47 patients with noninsulin dependent diabetes mellitus (NIDDM) were compared with those of 28 normal controls, with respect to the clinical significance of the measurement of insulin receptors and the mechanism of NIDDM. The levels of high and low affinity IR in the 47 patients with NIDDM were lower than those of normal controls and were prominent in untreated newly diagnosed NIDDM patients. Hyperinsulinemia was not found in these patients, indicating that the low IR activity is a primary defect, not caused by the down regulation mechanism. In patients with insulin dependent diabetes mellitus (IDDM) the level of high and low affinity IR were higher than those of the normal controls, but decreased markedly after insulin therapy, indicating that the up regulation is attributable to the high IR levels, other than the primary IR defect. | He Ronghua (何戎华) Cui Yugui (崔毓桂) Zhu Xuesu (朱学素) Huang Fengyun (黄凤云) Zhu An (朱\ 安) Chen Jiawei (陈家伟) Department of Endocrinology, the First Affiliated Hospital, Nanjing Medical University, Nanjing\ 210029, P.R.China | 1999 | The Journal of Biomedical Research1999，23，2： | 0 |
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