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| 1 | WITHDRAWN: A PageRank-Based WeChat User Impact Assessment Algorithm显示文摘The publisher regrets that a technical error occurred,which led to the duplicate publication.We apologize to the authors and the readers for this unfortunate error and any inconvenience this may have caused. | Qiong Wang Yuewen Luo Hongliang Guo Peng Guo Jinghao Wei Tie Lin | 2021 | Journal of New Media2021，3，3： | 0 |
| 2 | Efficient gene editing in a medaka(Oryzias latipes)cell line and embryos by SpCas9/tRNA-gRNA显示文摘Generation of mutants with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)is commonly carried out in fish species by co-injecting a mixture of Cas9 messenger RNA(mRNA)or protein and transcribed guide RNA(gRNA).However,the appropriate expression system to produce functional gRNAs in fish embryos and cells is rarely present.In this study,we employed a poly-transfer RNA(tRNA)-gRNA(PTG)system driven by cytomegalovirus(CMV)promoter to target the medaka(Oryzias latipes)endogenous gene tyrosinase(tyr)or paired box 6.1(pax6.1)and illustrated its function in a medaka cell line and embryos.The PTG system was combined with the CRISPR/Cas9 system under high levels of promoter to successfully induce gene editing in medaka.This is a valuable step forward in potential application of the CRISPR/Cas9 system in medaka and other teleosts. | Qihua PAN Junzhi LUO Yuewen JIANG Zhi WANG Ke LU Tiansheng CHEN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 0 |
| 3 | USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID显示文摘Activation-induced cytidine deaminase(AID)initiates class-switch recombination and somatic hypermutation(SHM)in antibody genes.Protein expression and activity are tightly controlled by various mechanisms.However,it remains unknown whether a signal from the extracellular environment directly affects the AID activity in the nucleus where it works.Here,we demonstrated that a deubiquitinase USP10,which specifically stabilizes nuclear AID protein,can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain.Interestingly,the signals from BCR and TLR1/2 synergistically promoted this phosphorylation.The deficiency of USP10 in B cells significantly decreased AID protein levels,subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)or human immunodeficiency virus type 1(HIV-1)nanoparticle vaccines.Collectively,we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity.Its manipulation could be used for the development of vaccines and adjuvants. | Yuewen Luo Xiantao Zhang Ran Chen Rong Li Yang Liu Junsong Zhang Qin liu Meijun Si Jun Liu Bolin Wu Xuemei Wang Shijian Wu Yiwen Zhang Xu Zhang Deyin Guo Xin He Ting Pan Hui Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 4 | Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles显示文摘To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the pandemic.Generally,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[2]. | Xiantao Zhang Yaochang Yuan Bolin Wu Xuemei Wang Yingtong Lin Yuewen Luo Rong Li Tao Chen Jieyi Deng Xu Zhang Fan Zou Xin He Hui Zhang | 2021 | Cellular & Molecular Immunology2021，18，8： | 0 |
| 5 | A PageRank-Based WeChat User Impact Assessment Algorithm显示文摘In recent years,the mobile Internet has developed rapidly,and the network social platform has emerged as the times require,and more people make friends,chat and share dynamics through the network social platform.The network social platform is the virtual embodiment of the social network,each user represents a node in the directed graph of the social network.As the most popular online social platform in China,WeChat has developed rapidly in recent years.Large user groups,powerful mobile payment capabilities,and massive amounts of data have brought great influence to it.At present,the research on WeChat network at home and abroad mainly focuses on communication and sociology,but the research from the angle of influence is scarce.Therefore,based on the basic principle of PageRank,this paper proposes an influence evaluation model WURank algorithm suitable for WeChat network users.This algorithm takes into account the shortcomings of the traditional PageRank algorithm,and objectively evaluates the real-time influence of WeChat users from the perspective of WeChat user behavior(including:sharing,commenting,mentioning,collecting,likes)and time factors. | Qiong Wang Yuewen Luo Hongliang Guo Peng Guo Jinghao Wei Tie Lin | 2021 | Journal of New Media2021，3，2： | 0 |
| 6 | Withdrawal notice to: A PageRank-Based WeChat User Impact Assessment Algorithm显示文摘The publisher regrets that a technical error occurred,which led to the duplicate publication.We apologize to the authors and the readers for this unfortunate error and any inconvenience this may have caused. | Qiong Wang Yuewen Luo Hongliang Guo Peng Guo Jinghao Wei Tie Lin | 2021 | Journal of New Media2021，3，4： | 0 |
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