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| 1 | Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development. | Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 2 | Achieving effective broadband microwave absorption with Fe_(3)O_(4)@C supraparticles显示文摘The X band(8 GHz-12 GHz)is the electromagnetic wave band emitted by most electronic instruments in our life,which will cause electromagnetic pollution harm to human health.Due to the coexistence of magnetic loss and dielectric loss,the modified Fe_(3)O_(4)-carbon-based nanomaterial exhibit strong electromagnetic(EM)wave absorptive capacity.However,there is a problem that the effective absorption bandwidth(EAB,the frequency bandwidth of reflection loss is less than-10 dB)of the X band is narrow.Increasing the EAB value of Fe_(3)O_(4)-carbon-based materials is of great significance for reducing electromagnetic pollution.Here,an emulsion-based self-assembly technique and ligand carbonization treatment have been used to construct the Fe_(3)O_(4)@C supraparticles for the evaluation of EM performance.The Fe_(3)O_(4)@C supraparticles exhibit excellent EM absorption properties,which can achieve full coverage of X band from 6.52 GHz to 12.9 GHz at a sample thickness of 3 mm.Besides,the optimum EAB value of Fe_(3)O_(4)@C supraparticles is up to 8.55 GHz from 9 to 18 GHz at a sample thickness of 2.5 mm.The Fe_(3)O_(4)@C supraparticles with superlattice structure will have potential development prospects in the application of broadband absorption. | Li Su Jiaxin Ma Fangzhou Zhang Yuchi Fan Wei Luo Lianjun Wang Wan Jiang Jianping Yang | 2021 | Journal of Materiomics2021，7，1： | 2 |
| 3 | Phytate-Coordination Triggered Enrichment of Surface NiOOH Species on Nickel Foam for Efficient Urea Electrooxidation显示文摘Nickel(Ni)-based materials are promising electrocatalysts for the urea electrooxidation reaction, as the in situ formed NiOOH species on their surface during operation are catalytically active sites. In this work, phytate-coordinated Ni foam(PA-NF)is shown to deliver a high catalytic performance, with a potential as low as 1.38 V at 10m A/cm2, a Tafel slope as low as 64.1 mV/dec, and superior catalytic stability. Characterizations revealed that such a high performance was ascribed to the kinetic acceleration of surface reconstruction and the enriched NiOOH active species on the PA-NF surface owing to PA-coordination induced upshift of d-band center of Ni sites.Overall, a novel and simple strategy is provided for designing the efficient as well as universal Ni-based catalyst for the electrooxidation of urea, which can also be extended to other transition-metal-based systems. | Jiayuan Li Yuefei Li Qingyu Xue Yuchi Gao Yuanyuan Ma | 2022 | Chinese Journal of Structural Chemistry2022，41，7： | 1 |
| 4 | Enhanced photodetector performance of black phosphorus by interfacing with chiral perovskite显示文摘Heterogeneous stackings of two-dimensional(2D)semiconductors and halide perovskites have attracted much attention owing to their respective superior optoelectronic properties.Black phosphorus(BP),as a unique 2D member with narrow bandgap,high mobility,and strong anisotropy,has never been combined with 2D layered perovskites.Herein,we construct a new BP-based van der Waals heterostructure combing with 2D chiral hybrid perovskite(i.e.,(MBA)_(2)PbI_(4))for promoting the performance and enriching the functionalities of BP.A series of BP characteristics,including carrier mobility,photoresponsivity,and polarization sensitivity,are synergistically enhanced when interfacing with(MBA)_(2)PbI_(4).For instance,the photodetector responsivity and photogain of BP in heterostructures are boosted by almost one order of magnitude with respect to BP alone,which is more obvious under excitation above the bandgap of perovskite.This is because the interfacing perovskite provides an inflow of numerous photogenerated carriers to BP,to reinforce the charge carrier transfer,separation,and transport processes.Additionally,the ability of both linearly and circularly polarized photodetection can be integrated into the BP/(MBA)_(2)PbI_(4)heterostructure.Our work sheds new insight on the heterostructure assembly for promising optoelectronic applications within 2D materials and perovskite families. | Yang Cao Congzhou Li Jie Deng Tong Tong Yuchi Qian Guixiang Zhan Xu Zhang Kaiyue HeHuifang Ma Junran Zhang Jing Zhou Lin Wang | 2022 | Nano Research2022，15，8： | 0 |
| 5 | Commissioning experiment of the high-contrast SILEX-Ⅱ multi-petawatt laser facility显示文摘The results of a commissioning experiment on the SILEX-Ⅱlaser facility(formerly known as CAEP-PW)are reported.SILEX-Ⅱis a complete optical parametric chirped-pulse amplification laser facility.The peak power reached about 1 PWin a 30 fs pulse duration during the experiment.The laser contrast was better than 1010 at 20 ps ahead of the main pulse.In the basic laser foil target interaction,a set of experimental data were collected,including spatially resolved x-ray emission,the image of the coherent transition radiation,the harmonic spectra in the direction of reflection,the energy spectra and beam profile of accelerated protons,hot-electron spectra,and transmitted laser energy fraction and spatial distribution.The experimental results show that the laser intensity reached 531020 W/cm^(2) within a 5.8μm focus(FWHM).Significant laser transmission did not occur when the thickness of theCHfoil was equal to or greater than 50 nm.The maximum energy of the accelerated protons in the target normal direction was roughly unchanged when the target thickness varied between 50 nm and 15μm.The maximum proton energy via the target normal sheath field acceleration mechanism was about 21 MeV.We expect the on-target laser intensity to reach 10^(22) W/cm^(2) in the near future,after optimization of the laser focus and upgrade of the laser power to 3 PW. | Wei Hong Shukai He Jian Teng Zhigang Deng Zhimeng Zhang Feng Lu Bo Zhang Bin Zhu Zenghai Dai Bo Cui Yuchi Wu Dongxiao Liu Wei Qi Jinlong Jiao Faqiang Zhang Zuhua Yang Feng Zhang Bi Bi Xiaoming Zeng Kainan Zhou Yanlei Zuo Xiaojun Huang Na Xie Yi Guo Jingqin Su Dan Han Ying Mao Leifeng Cao Weimin Zhou Yuqiu Gu Feng Jing Baohan Zhang Hongbo Cai Minqing He Wudi Zheng Shaoping Zhu Wenjun Ma Dahui Wang Yinren Shou Xueqing Yan Bin Qiao Yi Zhang Congling Zhong Xiaohui Yuan and Wenqing Wei | 2021 | Matter and Radiation at Extremes2021，6，6： | 0 |
| 6 | Integrating thin wall into block:A new scanning strategy for laser powder bed fusion of dense tungsten显示文摘Due to a combination of outstanding properties including high melting point,high density,low thermal expansion coefficient,low saturated vapor pressure and excellent thermal conductivity,tungsten(W)parts have been widely used as electrodes,heating elements,anti-scatter grids for Computed Tomography(CT)equipment,rocket nozzles and divertor materials for nuclear fusion[1]. | Zhengang Xiong Ji Zou Zhaoyang Deng Jinhan Chen Wei Liu Yuchi Fan Minshi Wang Xiaoqing Zhao Chunfeng Yu Dongdong Dong Wenyou Ma Weimin Wang Zhengyi Fu | 2022 | Journal of Materials Science & Technology2022，，25： | 0 |
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