| 1 | Comparison of Compositions and Structural Characterizations of Synthetic Nano-hydroxyapatite and Mineral Phase from Porcine Femoral Bone显示文摘In the paper, nano-hydroxyapatite was synthesized by hydrothermal treatment. The crystal morphology and compositions of the synthetic HA were investigated using TEM, IR, XRD and XPS techniques and were compared with those of porcine femoral bone apatite. The results showed that the synthetic HA is nanometer rod crystal similar to the bone apatite, and the average crystal sizes calculated by Scherrer equation for the four samples (HA dried at 80℃, unburned bone apatite, HA calcined at 750℃ and bone apatite calcined at 750℃) are 20.6, 21.7, 22.5 and 27.6nm, respectively. Moreover, the essential compositions for the synthetic HA and bone apatite are almost the same. | 张利 LI Yubao WANG Xuejiang Peng Xuelin Zuo Yi Han Jimei | 2004 | High Technology Letters2004，10，4： | 4 |
| 2 | Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy显示文摘Although multifarious tumor-targeting modifications of nanoparticulate systems have been attempted in joint efforts by our predecessors,it remains challenging for nanomedicine to traverse physiological barriers involving blood vessels,tissues,and cell barriers to thereafter demonstrate excellent antitumor effects.To further overcome these inherent obstacles,we designed and prepared mycoplasma membrane(MM)-fused liposomes(LPs)with the goal of employing circulating neutrophils with the advantage of inflammatory cytokine-guided autonomous tumor localization to transport nanoparticles.We also utilized in vivo neutrophil activation induced by the liposomal form of the immune activator resiquimod(LPsR848).Fused LPs preparations retained mycoplasma pathogen characteristics and achieved rapid recognition and endocytosis by activated neutrophils stimulated by LPs-R848.The enhanced neutrophil infiltration in homing of the inflammatory tumor microenvironment allowed more nanoparticles to be delivered into solid tumors.Facilitated by the formation of neutrophil extracellular traps(NETs),podophyllotoxin(POD)-loaded MM-fused LPs(MM-LPs-POD)were concomitantly released from neutrophils and subsequently engulfed by tumor cells during inflammation.MM-LPs-POD displayed superior suppression efficacy of tumor growth and lung metastasis in a 4T1 breast tumor model.Overall,such a strategy of pathogen-mimicking nanoparticles hijacking neutrophils in situ combined with enhanced neutrophil infiltration indeed elevates the potential of chemotherapeutics for tumor targeting therapy. | Xiaobei Cheng Pei Yu Xiang Zhou Jiale Zhu Yubao Han Chao Zhang Lingyi Kong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
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