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| 1 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 2 | Effects of simulated atmospheric nitrogen deposition on inorganic nitrogen content and acidification in a cold-temperate coniferous forest soil显示文摘 | Wenlong Gao Shulan Cheng Huajun Fang Yan Chen Guirui Yu Mei Zhou Peilei Zhang Minjie Xu | 2013 | Acta Ecologica Sinica2013，，： | 1 |
| 3 | Responses of CO2 efflux from an alpine meadow soil on the Qinghai Tibetan Plateau to multi-form and low-level N addition显示文摘 | Huajun Fang Shulan Cheng Guirui Yu Jiaojiao Zheng Peilei Zhang Minjie Xu Yingnian Li Xueming Yang | 2012 | Plant and Soil (-)2012，，1： | 1 |
| 4 | Investigation on some Schiff bases as HCl corrosioninhibitors for copper显示文摘 | Shulan Li Shenhao Chen Shengbin Lei Houyi Ma Rui Yu Dexin Liu | 1999 | Corrosion Science1999，，7： | 1 |
| 5 | Human gingiva-derived mesenchymal stromal cells contribute to periodontal regeneration in beagle dogs显示文摘 | Yu Xinbo Ge Shaohua Chen Shulan | 2013 | Cells Tissues Organs2013，198，6： | 1 |
| 6 | A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells显示文摘 | Maxim A. Vodyanik Junying Yu Xin Zhang Shulan Tian Ron Stewart James A. Thomson Igor I. Slukvin | 2010 | Cell Stem Cell2010，，： | 1 |
| 7 | Low-cost FPGA implementation of 2D digital pre-distorter for concurrent dual-band power amplifier显示文摘This paper proposes a low-cost hardware architecture based on concurrent dual-band digital pre-distorter(DPD). The architecture is implemented on field programmable gate array(FPGA) to compensate for the nonlinearity of the concurrent dual-band power amplifier(PA). This implementation introduces a novel model complexity reduction technique into system, namely, time-division multiplexing for out-of-band lookup tables(LUTs) sharing. Performances are evaluated with an experimental test setup using a wideband class-F PA. The dual-band signal center frequency separated by 80 MHz. Lower and upper center frequency are located at 2.61 GHz and 2.69 GHz, respectively. This novel DPD implementation maintains excellent performance, but uses hardware resources reduced by 29.17% compared with conventional approaches. The results show that the adjacent channel power ratio(ACPR) is less than- 59 d Bc and normalized mean square error(NMSE) is around- 62 d B for lower sideband(LSB) and- 63 d B for upper sideband(USB). | Zeng Guang Yu Cuiping Li Shulan Liu Yuan'an | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，1： | 0 |
| 8 | Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China显示文摘In this study, differentially expressed genes in peripheral blood from patients with Kashin-Beck disease and Keshan disease were compared to further investigate the etiology and pathogenesis of both diseases, which occur in a common endemic area of China. Twenty Kashin-Beck disease patients and 12 healthy controls, and 16 Keshan disease patients and 16 healthy controls, were grouped into four pairs. Patients and controls were selected from common endemic areas for the two diseases. Total RNA was isolated from peripheral blood mononuclear cells from all patients and controls, and gene expression profiles analyzed by oligonucleotide microarrays. Sixteen genes differentially expressed in both Kashin-Beck disease and Keshan disease (versus controls) were identified, and comprised nine genes showing synchronous and seven asynchronous expression. The Comparative Toxicogenomics Database shows that expression and biological function of these genes can be affected by multiple environmental factors, including mycotoxin and selenium content, potential environmental risk factors for the two diseases. Thus, these shared differentially expressed genes may contribute to the distinct organ lesions, caused by common environmental risk factors of Kashin-Beck disease and Keshan disease. | WANG Xi WANG Shuang HE ShuLan ZHANG Feng TAN WuHong LEI YanXia YU HanJie LI Zheng NING YuJie XIANG YouZhang GUO Xiong | 2013 | Science China(Life Sciences)2013，56，9： | 0 |
| 9 | Bibliometric evaluation of the status of Picea research and research hotspots:comparison of China to other countries显示文摘Picea Mill.species are important components of boreal and subalpine forests.They have a wide geographical range in the Northern Hemisphere,extending from the Eurasian continent to North America.In this study,publications on Picea species from 2002 to 2016 were identified via the Web of Science(WoS)and the China National Knowledge Infrastructure(CNKI)databases,and subjected to relationship network visualization using CiteSpace software.This study represents the first such analysis of Picea and provides a reference for bibliometrics in forest tree species research.The results show that the total number of publications on Picea archived in WoS was20,958 and that the number of papers published annually has increased over time,peaking at 1725 in 2013.The studies were mainly conducted in North America,Europe and Asia;among them,Canada published the most papers and showed the strongest betweenness centrality(0.11).Among research institutions,the Swedish University of Agricultural Sciences in Uppsala had the highest publication record.The research contributions of the Chinese Academy of Sciences,the Chinese Academy of Forestry,and Beijing Forestry University have improved rapidly in recent years,greatly enhancing the international impact of Chinese research in this field.The research contents were grouped into five categories:forest ecosystems,pest resistance,extraction and functional analyses of active ingredients from various plant organs,nursery and afforestation techniques,and timber quality research.In China,the number of papers from the CNKI database was4532,increasing at an even pace.The research topics on Picea included forest ecosystems,seedling and afforestation techniques,basic studies on individual species and populations,and pests and diseases.Within and outside China,hotspots in Picea research included the relationships between Picea and environmental factors,and the genomic sequences of Picea. | Guozhen Duan Yu'e Bai Dongmei Ye Tao Lin Peng Peng Min Liu Shulan Bai | 2020 | Journal of Forestry Research2020，31，4： | 0 |
| 10 | Research perspective and prospective of additive manufacturing of biodegradable magnesium-based materials显示文摘Biodegradable metals such as magnesium(Mg)and its alloys have attracted extensive attention in biomedical research due to their excellent mechanical properties and biodegradability.However,traditional casting,extrusion,and commercial processing have limitations in manufacturing components with a complex shape/structure,and these processes may produce defects such as cavities and gas pores which can degrade the properties and usefulness of the products.Compared to conventional techniques,additive manufacturing(AM)can be used to precisely control the geometry of workpieces made of different Mg-based materials with multiple geometric scales and produce desirable medical products for orthopedics,dentistry,and other fields.However,a detailed and thorough understanding of the raw materials,manufacturing processes,properties,and applications is required to foster the production of commercial Mg-based biomedical components by AM.This review summarizes recent advances and important issues pertaining to AM of Mg-based biomedical products and discusses future development and application trends. | Qingyun Fu Wenqi Liang Jiaxin Huang Weihong Jin Baisong Guo Ping Li Shulan Xu Paul K.Chu Zhentao Yu | 2023 | Journal of Magnesium and Alloys2023，11，5： | 0 |
| 11 | A Brief Analysis on The Influencing Factors of Net Content Loss of Household Liquid Detergents显示文摘Through tracking the net content of household liquid detergent under different experimental conditions,it was found that the storage temperature,the storage humidity,the packing material,the thickness of the packing material and the inner-packing detergent all had some effects on the net content,and there is a certain relationship between the mass loss and time in a certain storage period.It was found that the higher the temperature and the lower the humidity,the greater the mass loss of the household liquid detergent;and The barrier property of the PE bottle is better than that of the PET bottle.In the case of the same material,the thinner the material is,the greater the mass loss will be;Different liquid household detergents have different mass loss under the same storage temperature and humidity conditions,and due to different composition and proportion of the contents,the mass loss of liquid household detergents was different too. | Liang Runcheng Cai Yan Yu Shulan | 2022 | China Detergent & Cosmetics2022，7，4： | 0 |
| 12 | Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase显示文摘 | Huimei Wang Shulan Han Lianyan Wang Tingyuan Yang Guifeng Zhang Lian Yu Yue Zhao | 2018 | Particuology2018，16，2： | 0 |
| 13 | The Significance of Cytoskeleton System in Tumor Cell Infiltration显示文摘Cytoskeleton system is mainly composed of three kinds of fibrils:microtubules,microfilaments and intermediate filaments.They are a complex network of protein filaments in the cytoplasm of eukaryotic cells.They not only act as scaffolds in cells,but also play an important role in maintaining the movement of cells,participating in the material transport and signal transmission in cells.It is found that the whole cytoskeleton system is closely related to tumor invasion and growth.Therefore,this article reviews the overview of the cytoskeleton system and its significance for tumor cell invasion and growth. | Han Yu Likun Liu Shulan Hao | 2021 | Journal of Advances in Medicine Science2021，4，2： | 0 |
| 14 | Boosting the photo-induced charge transfer in melon by lengthening the melon chains through a facile regrowth approach显示文摘Melon-derived carbon nitride photocatalysts are a kind of star layered materials applied in solar energy conversion.With in-planeπorbitals of the heptazine subunits and their overlap along the melon chains being the most distinctive feature,the condition of melon chains is of great importance for the atomic and energy band structures of carbon nitride photocatalysts as well as their photo-activities.In principle,fragmentized melon chains in practical carbon nitride would lead to unfavorable structure disorder both in longitudinal and vertical directions,thus inhibiting the efficient transfer for photo-induced electrons and holes,respectively.Here,with a facile regrowth approach,that is to treat carbon nitride under the atmosphere containing C/N species,the melon chains in carbon nitride were experimentally lengthened,which was reflected by the regularly fraction variation of different nitrogen species derived from X-ray photoelectron spectroscopy(XPS)analysis.The prolonged melon chains led to dramatically improved in-plane structure order and boosted transfer of photo-induced electrons and holes,which were confirmed by the spontaneous photo-deposition of oxidants and reductants.The combination of this regrowth approach with homogenously distributed nitrogen vacancies resulted in much enhanced visible-light-responsive photoactivities.Besides,control experiments using nitrogen-vacancy-free carbon nitride and different C/N-contained precursors showed the compatibility as well as the critical factors for the lengthening effects of the regrowth approach.We hope that the facile but efficient regrowth approach could be widely adopted in melon-derived carbon nitride photocatalysts used for various applications. | Tongtong Li Shulan Wang Li Li Xiaohua Yu Huaze Zhu Ningdong Feng Ju Rong Yongqiang Yang Gang Liu | 2023 | Nano Research2023，16，2： | 0 |
| 15 | Oxygen-deficient MoO_(x)/Ni_(3)S_(2) heterostructure grown on nickel foam as efficient and durable self-supported electrocatalysts for hydrogen evolution reaction显示文摘High-performance and ultra-durable electrocatalysts are vital for hydrogen evolution reaction(HER)during water splitting.Herein,by one-pot solvothermal method,MoO_(x)/Ni_(3)S_(2) spheres comprising Ni_(3)S_(2) nanoparticles inside and oxygen-deficient amorphous MoO_(x) outside in situ grow on Ni foam(NF),to assembly the heterostructure composites of MoO_(x)/Ni_(3)S_(2)/NF.By adjusting volume ratio of the solvents of ethanol to water,the optimized MoO_(x)/Ni_(3)S_(2)/NF-11 exhibits the best HER performance,requiring an extremely low overpotential of 76 mV to achieve the current density of 10 mA∙cm‒2(η_(10)=76 mV)and an ultra-small Tafel slope of 46 mV∙dec^(-1) in 0.5 mol∙L^(-1) H_(2)SO_(4).More importantly,the catalyst shows prominent high catalytic stability for HER(>100 h).The acid-resistant MoO_(x) wraps the inside Ni_(3)S_(2)/NF to ensure the high stability of the catalyst under acidic conditions.Density functional theory calculations confirm that the existing oxygen vacancy and MoO_(x)/Ni_(3)S_(2) heterostructure are both beneficial to the reduced Gibbs free energy of hydrogen adsorption(|∆G_(H*)|)over Mo sites,which act as main active sites.The heterostructure effectively decreases the formation energy of O vacancy,leading to surface reconstruction of the catalyst,further improving HER performance.The MoO_(x)/Ni_(3)S_(2)/NF is promising to serve as a highly effective and durable electrocatalyst toward HER. | Zihuan Yu Haiqing Yan Chaonan Wang Zheng Wang Huiqin Yao Rong Liu Cheng Li Shulan Ma | 2023 | Frontiers of Chemical Science and Engineering2023，17，4： | 0 |
| 16 | CENP-K and CENP-H may form coiled-coils in the kinetochores显示文摘Kinetochores are large proteinaceous structure on the surface of chromosomes’ primary constriction during mitosis. They link chromosomes to spindle microtubules and also regulate the spindle assem- bly checkpoint, which is crucial for correct chromosome segregation in all eukaryotes. The better known core networks of kinetochores include the KMN network (K, KNL1; M, Mis12 complex; N, Ndc80 complex)and CCAN (constitutive centromere-associated network). However, the detailed molecular mechanism of the kinetochore protein network remains unclear. This study demonstrates that CENP-H and CENP-K form quite stable subcomplex by TAP (tandem affinity purification) with HEK 293 cells which express TAP-CENP-K, with the ratio of purified CENP-H and CENP-K being close to 1︰1 even with high salt. Bioinformatic analysis suggests that CENP-H and CENP-K are enriched with coiled-coil regions. This implies that CENP-H and CENP-K form heterodimeric coiled-coils. Furthermore, the func- tional regions which form the complex are respectively located on their N- and C-terminals, but the association between the C-terminals is more complex. It is possible that this is the first identified het- erodimeric coiled-coils within the inner kinetochore, which is directly involved in the attachment be- tween kinetochores and the spindle microtubules. | QIU ShuLan, WANG JiaNing, YU Chuang & HE DaCheng The Key Laboratory for Cell Proliferation and Regulation Biology of the Ministry of Education, Beijing Normal University, Universities’ Confederated Institute of Proteomics, Beijing 100875, China | 2009 | Science China(Life Sciences)2009，52，4： | 0 |
| 17 | Synergistic effect of V and Fe in Ni/Fe/V ternary layered double hydroxides for efficient and durable oxygen evolution reaction显示文摘High-performance and stable electrocatalysts are vital for the oxygen evolution reaction(OER).Herein,via a one-pot hydrothermal method,Ni/Fe/V ternary layered double hydroxides(NiFeV-LDH)derived from Ni foam are fabricated to work as highly active and durable electrocatalysts for OER.By changing the feeding ratio of Fe and V salts,the prepared ternary hydroxides were optimized.At an Fe:V ratio of 0.5:0.5,NiFeV-LDH exhibits outstanding OER activity superior to that of the binary hydroxides,requiring overpotentials of 269 and 274 mV at 50 mA·cm^(−2)in the linear sweep voltammetry and sampled current voltammetry measurements,respectively.Importantly,NiFeV-LDH shows extraordinary long-term stability(≥75 h)at an extremely high current density of 200 mA·cm^(−2).In contrast,the binary hydroxides present quick decay at 200 mA·cm^(−2)or even reduced current densities(150 and 100 mA·cm^(−2)).The outstanding OER performance of NiFeV-LDH benefits from the synergistic effect of V and Fe while doping the third metal into bimetallic hydroxide layers:(a)Fe plays a crucial role as the active site;(b)electron-withdrawing V stabilizes the high valence state of Fe,thus accelerating the OER process;(c)V further offers great stabilization for the formed intermediate of FeOOH,thus achieving superior durability. | Lihong Chen Ruxin Deng Shaoshi Guo Zihuan Yu Huiqin Yao Zhenglong Wu Keren Shi Huifeng Li Shulan Ma | 2023 | Frontiers of Chemical Science and Engineering2023，17，1： | 0 |
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