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| 1 | Statistics-based Optimization of the Polarimetric Radar Hydrometeor Classification Algorithm and Its Application for a Squall Line in South China显示文摘A modified hydrometeor classification algorithm(HCA) is developed in this study for Chinese polarimetric radars. This algorithm is based on the U.S. operational HCA. Meanwhile, the methodology of statistics-based optimization is proposed including calibration checking, datasets selection, membership functions modification, computation thresholds modification,and effect verification. Zhuhai radar, the first operational polarimetric radar in South China, applies these procedures. The systematic bias of calibration is corrected, the reliability of radar measurements deteriorates when the signal-to-noise ratio is low, and correlation coefficient within the melting layer is usually lower than that of the U.S. WSR-88D radar. Through modification based on statistical analysis of polarimetric variables, the localized HCA especially for Zhuhai is obtained,and it performs well over a one-month test through comparison with sounding and surface observations. The algorithm is then utilized for analysis of a squall line process on 11 May 2014 and is found to provide reasonable details with respect to horizontal and vertical structures, and the HCA results—especially in the mixed rain–hail region—can reflect the life cycle of the squall line. In addition, the kinematic and microphysical processes of cloud evolution and the differences between radardetected hail and surface observations are also analyzed. The results of this study provide evidence for the improvement of this HCA developed specifically for China. | Chong WU Liping LIU Ming WEI Baozhu XI Minghui YU | 2018 | Advances in Atmospheric Sciences2018，35，3： | 32 |
| 2 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 3 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 4 | Operating condition influences on PCDD/Fs emissions from sinter pot tests with hot flue gas recycling显示文摘This study was designed to clarify the influence of operating conditions on the formation and emissions of polychlorinated-p-dibenzodioxins and dibenzofurans (PCDD/Fs) from a sintering process with hot flue gas recycling. A pilot scale sinter pot with simulated flue gas recycling was developed, and four key operational parameters, including temperature, oxygen content of the simulated waste flue gas, the coke rate of the sintering mixture, and the quicklime quality, were selected for exploring PCDD/Fs formation. The results showed that the temperature of the recycled flue gas had a major affect on PCDD/Fs formation, and a high temperature could significantly increase their formation during sintering. A clear linear correlation between the temperature of recycling flue gas and PCDD/Fs emission (r = 0.93) was found. PCDD/Fs could be reduced to a certain extent by decreasing the level of oxygen in the recycled flue gas, while sintering quality was unchanged. The coke rate had no significant influence on the formation of PCDD/Fs, but the quality of quicklime used in the sintering mixture could affect not only the amount of PCDD/Fs emissions but also the sintering productivity. Compared with a benchmark sinter pot test, PCDD/Fs emissions markedly decreased with improvements to quicklime quality. However, the reduction in PCDD/Fs emissions realized by using high-quality quicklime was limited by the temperature of the inlet gas. The highest reduction achieved was 51% compared with conventional quicklime when the temperature of the inlet gas was 150°C. | Yongmei Yu Minghui Zheng Xianwei Li Xiaolei He | 2012 | Journal of Environmental Sciences2012，24，5： | 11 |
| 5 | Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress显示文摘Background: Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants,has a variety of functions including anti-aging, anti-cancer and anti-inflammatory activities. In the current study, we investigated the beneficial effects of resveratrol on in vitro porcine oocyte maturation under heat stress(HS). The effect of resveratrol, melatonin and their combination on alleviating HS was compared according to the maturation rate of oocytes and the development competence of embryos after parthenogenetic activation(PA).Results: Supplementation with resveratrol(2.0 μmol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos' PA from oocytes that underwent HS by increasing their glutathione(GSH)level, reducing reactive oxygen species(ROS) and up-regulating the expression of Sirtuin 1(SIRT1). It was also found that melatonin(10^(-7)mol/L) and the combination of resveratrol(2.0 μmol/L) plus melatonin(10^(-7)mol/L) exhibited more potent effects than resveratrol alone regarding their protective activities on oocyte maturation under HS.Conclusions: This study compared the efficiencies of resveratrol, melatonin and their combination for protecting porcine oocytes from heat stress. The mechanisms are attributed to the fact that each treatment may have different ability to regulate the synthesis of steroid hormones and the expression of mature related genes. | Yu Li Jing Wang Zhenzhen Zhang Jinyun Yi Changjiu He Feng Wang Xiuzhi Tian Minghui Yang Yukun Song Pingli He Guoshi Liu | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 7 |
| 6 | Study on the relative radiometric correction of CBERS satellite CCD image显示文摘The main payload on CBERS-01/02 of China-Brazil Earth Resources Satellite (CBERS) is a push-broom CCD camera with moderate spatial and radiant resolution. Because at lab the data for calibration at satellite assembly stage were unable to be collected, and also because the onboard calibrator after launch was in a different state from imaging, the calibration of CCD image got a series of difficulties involved. In practice, two methods are used in the processing on the ground station: One is extracting calibration data by statistics from the image itself, and the other is the method of histogram match. It was proved that the latter can calibrate the image much better, because it can remove the effect of unstable response of the camera largely and also can overcome the nonlinearity of the camera basically by using Look-Up Table (LUT) calculated from histogram statistics of different temporal images. Considering the problems of CBERS-01, a lot of calibration tests were done before the launch of CBERS-02, in which a set of lab coefficients for relative calibration was formulated after the data collection by using integration-hemisphere in the stage of satellite assembly test. During the on-orbit test, it was found that the calibration result from such coefficients was not satisfying, especially there being response difference between 3 detector arrays, which was attributed to the unstable dark currents of the CCD camera. This paper comes up with a statistic method to remove such response difference. In this method the middle detector array was used as reference to find the response differences of adjacent similar features between these arrays and it was proved to have a broad adaptability. | GUO Jianning, YU Jin, ZENG Yong, XU Jianyan, PAN Zhiqiang & HOU Minghui China Center for Resource Satellite Data and Application, Beijing 100830, China | 2005 | Science China(Technological Sciences)2005，48，S2： | 6 |
| 7 | Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells显示文摘Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells(A10 cells). BAM15 relaxed phenylephrine(PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium. Pretreatment with BAM15 inhibited PEinduced constriction of rat mesenteric arteries with intact and denuded endothelium. BAM15, CCCP,and niclosamide had the comparable IC50 value of vasorelaxation in PE-induced constriction of rat mesenteric arteries. BAM15 was less cytotoxic in A10 cells compared with CCCP and niclosamide.BAM15 depolarized mitochondrial membrane potential, induced mitochondrial fission, increased mitochondrial ROS production, and increased mitochondrial oxygen consumption rate in A10 cells.BAM15 potently activated AMPK in A10 cells and the efficacy of BAM15 was stronger than that of CCCP, niclosamide, and AMPK positive activators metformin and AICAR. In conclusion, BAM15 activates AMPK in vascular smooth muscle cells with higher potency than that of CCCP, niclosamide and the known AMPK activators metformin and AICAR. The present work indicates that BAM15 is a potent AMPK activator. | Yu Tai Lanjun Li Xuan Peng Junxue Zhu Xihai Mao Nan Qin Minghui Ma Rong Huo Yunlong Bai Deli Dong | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 8 | Microvascular pathological features and changes in related injury factors in a rat acute blood stasis model显示文摘OBJECTIVE: To examine the microvascular pathological characteristics and changes in related injury factors in a rat model of acute blood stasis.METHODS: A total of 75 Sprague-Dawley rats were divided randomly and equally into a control group and four experimental groups assessed at different times after the induction of stasis(0, 1, 3 or 6 h after stasis)(n = 15). The acute blood stasis model was established through rat tail-vein injection of high-molecular-weight dextran. After Electrocardiograph(ECG) detection at predetermined times(0,1, 3 and 6 h after induction of stasis), the rats were sacrificed and blood and cardiac samples were harvested for analysis. Hematoxylin-eosin(HE) staining and transmission electron microscopy were used for histopathological detection; an enzyme linked immunosorbent assay(ELISA) was used to detect thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-Keto-PGF1α) concentrations; a real-time polymerase chain reaction(PCR) reaction system was used to detect intercellular adhesion molecule1(ICAM-1) and vascular cell adhesion molecule1(VCAM-1) m RNA expression; western blotting was used to detect vascular endothelial cadherin(VE-cadherin) protein expression.RESULTS: The ST segment in the ECG showed gradual elevation after induction of stasis and continued elevation at a high level at 3 and 6 h. The HE staining showed changes in myocardial cell necrosis and tissue dissociation after the induction of stasis, along with inflammatory infiltration. Results of transmission electron microscopy showed immediate changes in blood stasis and lumen occlusion in the microvasculature, along with endothelial cell swelling. After the induction of stasis, TXB2 concentrations gradually increased while 6-Keto-PGF1αconcentrations were immediately significantly reduced. The TXB2/6-Keto-PGF1αratio was maintained at a high level. ICAM-1 m RNA expression showed an unstable elevation while VCAM-1 m RNA expression was significantly reduced after the induction of stasis. Compared with the control group, VE-cadherin protein expression increased at 0 and 3 h after the induction of stasis, while no change occurred at 1 and 6 h.CONCLUSION: The pathological manifestations of acute blood stasis are microvascular blood retention, lumen stenosis and even occlusion. The condition is also called 'blood coagulation and weep' in Traditional Chinese Medicine. The blood stasis model resulted in the injury and necrosis of endothelial cells and cardiomyocytes, along with the presence of an imbalance of vasomotor factor levels, platelet activation, and increases in the expression of adhesion molecules and endothelial barrier dysfunction,which corresponds to 'blood failed to nourish' in Traditional Chinese Medicine. | Zhang Junxiu Feng Yu Li Shaodan, Liu Yi Zhang Yin Guo Yunxia Yang Minghui | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 5 |
| 9 | Study on the stability of non-cohesive river bank显示文摘Frequent bank collapse in nature highlights the need to study the mechanism of bank stability. This paper presents a theoretical analysis and a flume experimental study on the interaction of hydrodynamic conditions and non-cohesive banks of meandering and straight rivers. No bank collapse occurs if the bank angle is smaller than a critical value. The critical angle is a function of a dimensionless parameter K UD, which is directly proportional to the square of flow velocity near river bed and inversely proportional to the median diameter of bank material. Furthermore, the critical angle reduces with flow velocity and is higher in meandering rivers than in straight rivers. Formulas for estimating the threshold of bank stability are obtained by curve fitting method with experimental data. The results agree with the data measured in the middle and lower reaches of the Yangtze River. | Minghui YU Hongyan WEI Yanjie LIANG Chunyan HU | 2010 | International Journal of Sediment Research2010，25，4： | 4 |
| 10 | Highly-anisotropic optical and electrical properties in layered SnSe显示文摘因为他们极化依赖者或方向依赖者的唯一的联合,各向异性的材料具有可观的兴趣电、光、热电的性质。低对称二维(2D ) covalently 结合的原子层叠的货车 der Waals 形成的材料内在地是各向异性的。分层的 SnSe 展出格子对称的低度,与弄歪的 NaCl 结构和在里面飞机 anisotropy。这里,我们报导在里面飞机的系统的研究在分层的 SnSe 的各向异性的性质用散布的解决角度的拉曼,光吸收,和电的运输学习。光、电的描述是方向依赖者,并且成功地在分层的 SnSe 识别了水晶的取向。而且, SnSe 薄片厚度和刺激波长上的 Raman 紧张 anisotropy 的依赖被实验和理论计算调查。最后,电的运输研究证明很少层 SnSe 地效果晶体管(联邦货物税) 有在扶手椅和之字形方向之间的搬运人活动性(5.8 ) 的大各向异性的比率,它是高价值为 2D 报导了的一个记录各向异性的材料。分层的 SnSe 的高度各向异性的性质在新窗户中为各向异性的光学,电子学,和 optoelectronics.Open | Shengxue Yang Yuan Liu Minghui Wu Li-Dong Zhao Zhaoyang Lin Hung-chieh Cheng Yiliu Wang Chengbao Jiang Su-Huai Wei Li Huang Yu Huang Xiangfeng Duan | 2018 | Nano Research2018，11，1： | 4 |
| 11 | Hd1,Ghd7,and DTH8 synergistically determine the rice heading date and yield-related agronomic traits显示文摘Heading date determines the seasonal and regional adaptation of rice(Oryza sativa L.)varieties and is mainly controlled by photoperiod sensitivity(PS).The core heading date genes Hd1,Ghd7,DTH8,and PRR37 act synergistically in regulating the PS.In this study,we systematically analyze the heading date,PS,and agronomic traits of eight homozygous lines with various combinations of Hd1,Ghd7,and DTH8 alleles in the prr37 background under long-day(LD)and short-day(SD)conditions,respectively.We find that Hd1 alone promotes heading,regardless of the day length.However,under LDs,Hd1 suppresses flowering,in coordination with functional Ghd7 or with Ghd7 and DTH8.These loci cooperate to negatively regulate the Ehd1-Hd3 a/RFT1 pathway and delay heading.Under SDs,Hd1 competes with various heading suppressors to promote heading.Therefore,the dual function of Hd1 is vital for PS.The lines carrying Hd1 alone show reduced plant height with fewer primary and secondary branches in panicles.Lines carrying Ghd7 and DTH8(with hd1)show delayed heading and improve agronomic traits.Overall,our results reveal the regulation of rice PS flowering by the core heading date genes and their effects on agronomic traits,providing valuable information for the selection of rice varieties for adaptation to different light and temperature conditions. | Kangli Sun Minghui Huang Wubei Zong Dongdong Xiao Chen Lei Yanqiu Luo Yingang Song Shengting Li Yu Hao Wanni Luo Bingqun Xu Xiaotong Guo Guangliang Wei Letian Chen Yao-Guang Liu Jingxin Guo | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 12 | COORDINATING PRICING, ORDERING AND ADVERTISING FOR PERISHABLE PRODUCTS OVER AN INFINITE HORIZON显示文摘众多的实验研究证明那个做广告的努力能在两个现在和将来的时期刺激需求,并且在定价之间有一个相互作用,为决定做广告并且订。这些决定怎么并且什么与对方一起交往在定价上做广告并且订的效果是决定?理解这个相互作用,我们考虑在一个稳定的市场卖一个容易腐烂的产品并且动态地决定联合的订,定价和做广告的策略的一个书报摊贩类型公司。这个问题与做广告的 carryover 效果和价格敏感的需求作为一个无限的地平线书报摊贩问题被建模。我们描绘最佳的定价,做广告并且盘点策略和他们的比较静电干扰,并且考虑没有做广告的效果,这条政策怎么不同于传统的途径。我们证明最佳的有效做广告水平 monotonically 在以前的时期,和因此最佳的策略与有效做广告水平正在增加(做广告,定价,库存水平) 全球性长远来说收敛到稳定的状态。我们数字地证明最佳的政策能收获重要利润,它强调订的做广告开车和定价策略的重要性。 | Ye Lu Minghui Xu Yimin Yu | 2018 | Journal of Systems Science and Systems Engineering2018，27，1： | 3 |
| 13 | Using coupling slabs to tailor surface-acoustic-wave band structures in phononic crystals consisting of pillars attached to elastic substrates显示文摘The propagation of surface acoustic waves(SAWs) in two-dimensional phononic crystals(PnCs) with and without coupling-enhancement slabs was theoretically investigated using a three-dimensional finite element method.Different piezoelectric substrates,for example,lithium niobate(LiNbO_3),gallium nitride(GaN),and aluminium nitride(A1N),were taken into account.Compared to the PnCs without coupling-enhancement slabs,the coupling between each pillar and its nearest neighbor was largely enhanced in the presence of slabs.The bandwidth of the first directional band gap increased markedly compared with its initial value for the PnCs without a slab(within square symmetry).In addition,with increasing thicknesses of the slabs bonded between neighboring pillars,the first directional band-gap and second directional band gap of the PnCs tend to merge.Therefore,the structure with coupling-enhancement slabs can be used as an excellent electrical band elimination filter for most electro-SAW devices,offering a new strategy to realize chip-scale applications in electroacoustic signal processing,optoacoustic modulation,and even SAW microfluidic devices. | Heng Zhang SiYuan Yu FuKang Liu Zhen Wang MingHui Lu XiaoBo Hu YanFeng Chen XianGang Xu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 3 |
| 14 | Changes in nitric oxide,angiotensinⅡ,angiopoietin-like protein 4 mRNA,neuregulin 1 mRNA,and platelet endothelial cell adhesion molecule-1 in rats with acute blood stasis induced by high-molecular-weight dextran显示文摘OBJECTIVE: To investigate the influence of acute blood stasis on nitric oxide(NO), angiotensin Ⅱ(Ang Ⅱ), angiopoietin-like protein 4(ANGPTL4)m RNA, neuregulin 1(NRG-1) m RNA, and platelet endothelial cell adhesion molecule-1(PECAM-1) in rats with stasis induced by high-molecular-weight dextran(HMWD).METHODS: Seventy-five Sprague Dawley rats were divided randomly into five groups(n = 15 in each group): control group, immediate group, 1 h group,3 h group, and 6 h group. A model of acute blood stasis was established via injection of HMWD into the tail vein. After performing electrocardiogram at the predetermined times according to the grouping, we collected blood and cardiac samples for hematoxylin-eosin(HE) staining and histopathological examination via transmission electron microscopy. Enzyme-linked immunosorbent assay was used to detect plasma levels of NO, AngⅡ, and fibrinogen. Real-time polymerase chain reaction was used to detect the expression of ANGPTL4 m RNA and NRG-1 m RNA. Immunohistochemical methods were used to detect PECAM-1 protein expression.RESULTS: The rat model of blood stasis showed blood retention in the capillary lumens. The ST segment showed gradual elevation, and was still elevated at 3 and 6 h after induction of blood stasis.HE staining showed myocardial cell necrosis and dissolution after modeling, along with basement membrane rupture and mitochondrial structural damage. Transmission electron microscopy showed endothelial cell swelling and an increase in absorption vesicles immediately after modeling. Endothelial cell apoptosis was increased at 3 and 6 h after modeling. Cardiac muscle fibers were disordered and intercalated discs were blurred immediately after modeling. There were massive numbers of dissolved cardiac muscle fibers, ruptured basement membranes, and mitochondrial structural damage at 3 and 6 h after modeling. NO plasma concentration was significantly reduced immediately and 1 h after modeling, while it was increased at 3 and 6 h.AngⅡ plasma concentration was decreased immediately after modeling, but increased at 1, 3, and6 h. Fibrinogen plasma concentration was significantly increased at immediate, 1, 3, and 6 h after modeling. PECAM-1 protein expression was obviously increased immediately after modeling, at 1, 6 h was found mild augment. Expression of Ang PTL4 m RNA was increased at immediate, 1, 3, and 6 h after modeling, and was found further augment at 3,and 6 h. Expression of NRG-1 m RNA was increased at immediate, 1, 3, and 6 h after modeling, and the strongest expression was at 1 h.CONCLUSION: The pathological manifestation of acute blood stasis is characterized by microvascular blood retention. Prolonged blood stasis leads to worsening endothelial cell and cardiomyocyte damage, along with imbalances in the expression of vasomotor factors and increased vascular tone.The pathological damage caused by blood stasis also promotes the expression of cell protection factors. | Feng Yu Zhang Junxiu Li Shaodan Liu Yi Zhang Yin Guo Yunxia Yang Minghui | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 15 | Spatial pattern dynamics among co-dominant populations in early secondary forests in Southwest China显示文摘The canopy of subtropical natural forests usually consists of several co-dominant populations(CDPs),which play a crucial role in forest structure,formation of the forest environment,and ecological function.However,little attention has been given to changes in spatial patterns in CDPs during natural succession.Cyclobalanopsis glauca(Thunb.)Oerst.,Quercus variabilis Blume,and Pinus yunnanensis var.tenuifolia W.C.Cheng & Y.W.Law are canopy species that form CDPs in zonal forests along the Nanpan River in southwest China.We used the g(r) function and its bivariate distribution model,g_(12)(r),which is based on distances between pairs of points,to explore the dynamics of the three CDP species with respect to distribution patterns and spatial correlations in two secondary forests(one 30-year-old forest [30-YF] and one 57-year-old forest [57-YF]).The following key results were obtained:(1) there was a clumped pattern in the 30-YF,but the intensity of aggregation varied among populations and life stages.The distribution pattern gradually shifted to become random with longer succes sion time(i.e.,30-YF vs.57-YF),expansion of the observation scale(r=0-20 m),and at later life stages.(2) Aside from the mid-sized C.glauca trees and large P.yunnanensis trees,the trees repulsed each other at certain scales(r=0-2,5-6,11-12,14-16 m) in the 30-YF.Almost all of the life stages in the CDPs were independently correlated.This independent correlation was exacerbated by a longer succession time.(3) An increase in life stages and longer succession also promoted independent changes in intraspecific correlations.(4) Intraspecific correlations were stronger than interspecific correlations.Our results showed that reducing exclusive competition is essential to coexistence in CDPs.Inter-and intra-specific repulsion may occur at the same time,but intraspecific repulsion was the main driving force behind the random distributions and independent correlations. | Yuanfa Li Minghui Li Angang Ming Hongxiang Wang Sufang Yu Shaoming Ye | 2021 | Journal of Forestry Research2021，32，4： | 3 |
| 16 | The prognostic value of programmed cell death ligand 1expression in non-Hodgkin lymphoma:a meta-analysis显示文摘Objective: Although the prognostic value of programmed cell death-ligand 1(PD-L1) expression in non-Hodgkin lymphoma(NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis.Methods: The Pub Med, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. The hazard ratio(HR), 95% confidence interval(CI), and odds ratios(OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival(OS) and clinicopathological features. Review manager 5.3 and STATA 12.0 were used in this meta-analysis.Results: A total of 2,005 patients across nine studies were enrolled in our meta-analysis, and the pooled results showed that high PD-L1 expression was associated with a poor prognosis(HR=2.04, 95% CI: 1.18–3.54, P=0.01). In the subgroup analysis according to histology types, pooled results demonstrated that an increased PD-L1 expression was an unfavorable prognostic factor for diffuse large B-cell lymphoma(HR=1.92, 95% CI: 1.06–3.48, P=0.03) but not for natural killer/T-cell lymphoma(HR=2.41, 95%CI: 0.47–12.22, P=0.29). Pooled ORs indicated that PD-L1 expression was higher in NHL with international prognostic indices of≥3. However, PD-L1 expression had no correlation with gender, age, disease stage, lactate dehydrogenase level, B symptoms, and germinal center B-cell-like lymphoma.Conclusions: High PD-L1 expression was a poor prognostic biomarker in patients with NHL. Because of our limited sample size,high-quality studies with larger sample sizes are needed to validate our results. | Shu Zha Minghui Zhang Yu Zhang Hongxue Meng Yan Wang Yupeng Liu Jing Jing Lan Huang Mengqi Sun Yue Zhang Qingyuan Zhang | 2018 | Cancer Biology & Medicine2018，15，3： | 2 |
| 17 | Non-symmetrical levee breaching processes in a channel bend due to overtopping显示文摘A series of experiments were done to reveal the overtopping breaching process of non-cohesive and cohesive levees in a U-bend flume. The flood hydrograph and breaching geometry were measured and analyzed in detail. The results show that the levee breaching processes can be briefly divided into four stages: slope erosion, longitudinal headward gully-cutting, lateral erosion, and relative stabilization. For non-cohesive levees, non-symmetrical lateral development of the breach occurs throughout the four stages, and the final non-symmetrical coefficient is approximately 2.2-2.6. Larger flow discharge or higher water level can accelerate the breaching process, while coarser sands tend to accelerate the process initially but depress the process at the end. The fluvial erosion rate of a non-cohesive breach shows a power-function relation with the excess wall shear stress. For cohesive levees, a plateau forms in the breach partially blocking the flow in the first two stages. The breach flow is approximately perpendicular to the levee body, and, thus, the erosion rates of the two breach sides are almost the same.Non-symmetrical lateral development mainly occurs in the third stage when the deep gully forms. The final non-symmetrical coefficient is approximately 2.7-3.3. It is expected that these findings can provide a valuable experimental dataset and a theoretical basis for breach closure and flood alleviation. | Songbai Wu Minghui Yu Hongyan Wei Yanjie Liang Jing Zeng | 2018 | International Journal of Sediment Research2018，33，2： | 2 |
| 18 | Stability of superconducting Nd_(0.8)Sr_(0.2)NiO_(2) thin films显示文摘The discovery of superconducting states in the nickelate thin film with infinite-layer structure has paved a new way for studying unconventional superconductivity.So far,research in this field is still very limited due to difficulties in sample preparation.Here we report the successful preparation of the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)thin film(T_(c)=8.0-11.1 K)and study the stability of such films in the ambient environment,water,and under electrochemical conditions.Our work demonstrates that the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)is remarkably stable,which can last for at least 47-day continuous exposure to air at 20°C and 35%relative humidity.We also show that the superconductivity disappears after being immersed in de-ionized water at room temperature for 5 h.Surprisingly,it can also survive under ionic liquid gating conditions with an applied voltage of about 4 V,which is even more stable than conventional perovskite complex oxides. | Xiang Ding Shengchun Shen Huaqian Leng Minghui Xu Yan Zhao Junrui Zhao Xuelei Sui Xiaoqiang Wu Haiyan Xiao Xiaotao Zu Bing Huang Huiqian Luo Pu Yu Liang Qiao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，6： | 2 |
| 19 | Amphiphilic Pd@micro-organohydrogels with controlled wettability for enhancing gas-liquid-solid triphasic catalytic performance显示文摘The wettability of catalyst plays an important role in regulating catalytic performance in heterogenous catalysis because the microenvironment around the catalytic sites directly determines the mass transfer process of reactants.Inspired by gas trapped on the surface of subaquatic spiders,amphiphilic micro-organohydrogels with tunable surface wettabilities were developed by anchoring various alkane chains onto a poly(2-(dimethylamino)ethyl methacrylate)(p(DMAEMA))hydrophilic microgel network.Palladium nanoparticles(Pd NPs)were encapsulated in amphiphilic microgels(amphiphilic Pd@M)to catalyze hydrogenation reaction,achieving higher activities than pristine monohydrophilic Pd@M composite.The underwater oleophilicity and aerophilicity of Pd@M composites were quantified by oil/gas adhesion measurements and computational simulations.The higher amphiphilic catalytic activities are attributed to the formation of a gas-oil-solid reaction interface on the catalyst surfaces,allowing rapid transport of H2 and organic substrates through water to the Pd catalytic sites.Additionally,amphiphilic Pd@M composites also exhibit more superior catalytic performance in multi-substrates reaction. | Minghui Zhang Tianyi Zhao Cunming Yu Qian Liu Guangyan Wang Hui Yang Ming Yang Lei Jiang Mingjie Liu | 2022 | Nano Research2022，15，1： | 2 |
| 20 | Distributed Consensus for Blockchains in Internet-of-Things Networks显示文摘In recent years,due to the wide implementation of mobile agents,the Internet-of-Things(IoT) networks have been applied in several real-life scenarios,servicing applications in the areas of public safety,proximity-based services,and fog computing.Meanwhile,when more complex tasks are processed in IoT networks,demands on identity authentication,certifiable traceability,and privacy protection for services in IoT networks increase.Building a blockchain system in IoT networks can greatly satisfy such demands.However,the blockchain building in IoT brings about new challenges compared with that in the traditional full-blown Internet with reliable transmissions,especially in terms of achieving consensus on each block in complex wireless environments,which directly motivates our work.In this study,we fully considered the challenges of achieving a consensus in a blockchain system in IoT networks,including the negative impacts caused by contention and interference in wireless channel,and the lack of reliable transmissions and prior network organizations.By proposing a distributed consensus algorithm for blockchains on multi-hop IoT networks,we showed that it is possible to directly reach a consensus for blockchains in IoT networks,without relying on any additional network layers or protocols to provide reliable and ordered communications.In our theoretical analysis,we showed that our consensus algorithm is asymptotically optimal on time complexity and is energy saving.The extensive simulation results also validate our conclusions in the theoretical analysis. | Li Yang Yifei Zou Minghui Xu Yicheng Xu Dongxiao Yu Xiuzhen Cheng | 2022 | Tsinghua Science and Technology2022，27，5： | 2 |
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