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| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | The effects of acquired paternal obesity on the next generation显示文摘 | Neil A Youngson Emma Whitelaw | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 3 | Hydraulic and sedimentary characteristics of habitat utilized by Atlantic salmon for spawning in the Girnock Burn,Scotland显示文摘 | MOIR H J SOULSBY C YOUNGSON A | 1998 | Fisheries Management and Ecology1998，5，3： | 1 |
| 4 | Cure kinetics and mechanical properties of the blend system of epoxy/diaminodiphenyl sulfone and amine terminated polyetherimide-carboxyl terminated poly(butadiene-co-acrylonitrile) block copolymer显示文摘 | Donghyon Kim Jung-ok Beak Youngson Choe Wonho Kim | 2005 | Korean Journal of Chemical Engineering2005，，5： | 1 |
| 5 | A study of the incidence of overe-ruption and occlusal interferences in unopposed posterior teeth显示文摘 | Craddock HL Youngson CC | 2004 | Br Dent J2004，196，6： | 1 |
| 6 | Laparoscopic management of a large ovarian cyst in the neonate显示文摘 | Mahomed A Jibril A Youngson G | 1998 | Surg Endosc1998，12，10： | 1 |
| 7 | An in vitro study of corco- nal rnicroleakage around bonded amalgam coreonal - radicular cores in endodontically treated teeth 显示文摘 | Summitt JB Burgess JO Youngson CC | 2002 | Quinssence lnt2002，，： | 1 |
| 8 | Imidazoline receptors and agmatine in blood vessels:a novel system inhibiting vascular smooth muscle proliferation显示文摘 | Regunathan S Youngson C Raasch W | 1996 | J Pharmacol Exp Ther1996，276，3： | 1 |
| 9 | Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1,Dnmt3L,SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo显示文摘 | Roberts AR Blewitt ME Youngson NA | | 0，，： | 1 |
| 10 | Sex reversal in Salmonid culture显示文摘 | JOHNSTONE R SIMPSON T H YOUNGSON A F | 1978 | Aquculture1978，13，： | 1 |
| 11 | The potential role of breast conservation surgery and adjuvant breast radiation for adenoid cystic carcinoma of the breast 显示文摘 | MILLAR B A KERBA M YOUNGSON B | 2004 | Breast Cancer Res Treat2004，87，3： | 1 |
| 12 | The use of confocal microscopy to assess surface roughness of two milled CAD-CAM ceramics following two polishing techniques显示文摘 | Al-Shammery HAO Bubb NL Youngson CC | 2006 | Dent Mater2006，21，： | 1 |
| 13 | Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens显示文摘 | Sadi AM Wang DY Youngson BJ | | 0，，253： | 1 |
| 14 | Asymmetric regu- lation of imprinting on the maternal and paternal chromo- somes at the Dlkl-C, tl2 imprinted cluster on mouse chromo- some 12显示文摘 | Lin SP Youngson N Takada S | 2003 | Nat Genet2003，35，1： | 1 |
| 15 | A study of the incidence of overeruption and occlusal interferences in unopposed posterior teeth显示文摘 | Craddock HL Youngson CC | 2004 | Br Dent J2004，196，34： | 1 |
| 16 | Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12显示文摘 | Lin SP Youngson N Takada S | 2003 | Nat Genet2003，35，1： | 1 |
| 17 | The potential role of breast conservation surgery and adjuvant breast radiation for adenoid cyctic carcinoma of the breast 显示文摘 | Millar BA Kerba M Youngson B | 2004 | Breast Cancer Res Treat2004，87，3： | 1 |
| 18 | Comparative sequence analysis of the imprinted Dlkl-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region显示文摘 | Paulsen M Takada S Youngson N A | 2001 | Genome Res2001，11，12： | 1 |
| 19 | A study of the incidence of overeruption and occlusal interferences in unopposed posterior teeth 显示文摘 | Craddock H L Youngson C C | 2004 | Br Dent J2004，196，6： | 1 |
| 20 | Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12显示文摘 | LIN S P YOUNGSON?N TAKADA S | 2003 | Nat Genet2003，35，1： | 1 |
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