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| 1 | Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats显示文摘AIM: To investigate the effect of Platycodon grandi- florum extract (PGE) on lipid metabolism and FABP mRNA expression in subcutaneous adipose tissue of high fat diet-induced obese rats. METHODS: PGE was treated to investigate the inhibitory effect on the pre-adipocyte 3T3-L1 differentiation and pancreatic lipase activity. Male Sprague-Dawley rats with an average weight of 439.03 ± 7.61 g were divided into four groups: the control groups that fed an experimental diet alone (C and H group) and PGE treatment groups that administered PGE along with a control diet or HFD at a concentration of 150 mg/kg body weight (C + PGE and H + PGE group, respectively) for 7 wk. Plasma total cholesterol (TC) and triglycerol (TG) concentrations were measured from the tail vein of rats. Adipocyte cell area was measured from subcutaneous adipose tissue and the fatty acid binding protein (FABP) mRNA expression was analyzed by northern blot analysis. RESULTS: PGE treatment inhibited 3T3-L1 pre-adipocyte differentiation and fat accumulation, and also decreased pancreatic lipase activity. In this experiment, PGE signifi cantly reduced plasma TC and TG concentrations as well as body weight and subcutaneous adipose tissue weight. PGE also significantly decreased the size of subcutaneous adipocytes. Furthermore, it significantly repressed the up-regulation of FABP mRNA expression induced by a high-fat feeding in subcutaneous adipose tissue. CONCLUSION: PGE has a plasma lipid lowering-effect and anti-obesity effect in obese rats fed a high fat diet.From these results, we can suggest the possibility that PGE can be used as a food ingredient or drug component to therapeutically control obesity. | Yoon Shin Park Yoosik Yoon Hong Seok Ahn | 2007 | World Journal of Gastroenterology2007，13，25： | 3 |
| 2 | Tanshinone II A i- solated from Salvia miltiorrhiza Bunge induced apoptosis in HI0 human premyelo- cytic leuke min cell line 显示文摘 | Yoosik Yoon Ye on -ok Kim Won - Kyung Teon | 1999 | J of Ethopharmacolog1999，68，13： | 1 |
| 3 | Sex-specific effects of social networks on the prevalence, awareness, and control of hypertension among older Korean adults显示文摘BackgroundHypertension 是在更老的成年人之中的普通长期的疾病,并且与医药复杂并发症和死亡被联系。试图在更旧的 adults.MethodsThe 朝鲜语聚会生活,健康,和老化工程(KSHAP ) 之中在高血压的流行,了解,和控制上检验社会网络特征的效果的这研究会见了 814 ≥从在 2011 年 12 月和 2012 年 3 月之间的一个农村镇区的 60 岁的居民和他们的配偶(反应率:95%) 。我们从 595 个参加者评估了数据。Multivariate 逻辑回归模型被用来在观察强壮的性特定的网络在高血压的流行,了解,和控制上完成的 hypertension.ResultsWe 上估计网络特征的效果。在老妇人之中,网络密度与高血压了解被联系[机会比率(或) :2.63, 95% 信心间隔(CI ) :1.03-5.37 ] 并且控制(或:1.72;95% CI:0.94-3.13 ) 。在老人之中,大网络与高血压的更低的流行被联系(或:0.75;95% CI:0.58-0.96 ) 。比作老妇人,有粗糙的网络的老人展出了更好的高血压了解(或:0.37;95% CI:0.14-0.95 ) 并且控制(或:0.42;95% CI:0.19-0.91 ) 。网络尺寸为高血压控制与密度交往了(P = 0.051 ) ,与与被联系的控制高血压大并且功课 networks.ConclusionsA 大网络为高血压与更低的风险被联系,并且一个粗糙的网络在老人之中与高血压了解和控制被联系。有稠密的网络的老妇人是最可能的展出高血压了解和控制。 | Jiwon Baek Nam Wook Hur Hyeon Chang Kim Yoosik Youm | 2016 | Journal of Geriatric Cardiology2016，13，7： | 1 |
| 4 | WNT/β-catenin pathway is modulated in asthma patients and LPS-stimulated RAW264.7 macrophage cell line显示文摘 | Haeyong Lee Sungmin Bae Byoung Whui Choi Yoosik Yoon | 2012 | Immunopharmacology and Immunotoxicology2012，，： | 1 |
| 5 | Tanshinone Ⅱ A isolated from Salvia miltionrrhiza Bunge induced apoptosis in HL 60 human premyelocytic leuke rain cell line显示文摘 | Ye on-ok Kim Won-Kyung Teon | 1999 | J of Ethopharmacolog1999，68，13： | 1 |
| 6 | Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway显示文摘 | Haeyong Lee Sungmin Bae Kijeong Kim Wonyong Kim Sang-In Chung Young Yang Yoosik Yoon | 2010 | Life Sciences2010，，7： | 1 |
| 7 | Tanshinone Ⅱ A isolated from salvia miltionrrbiza Bange induced apoptosis in HL 60 human premyelocytic leuke rain cell line显示文摘 | Yoosik Yoon Ye on - ok kim Won - kyung Teon | 1999 | J of Ethopharmacolog1999，68，3： | 1 |
| 8 | Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects显示文摘 | Yoosik Yoon Byung Lae Park Min Ho Cha Kil Soo Kim Hyun Sub Cheong Yoo Hyun Choi Hyoung Doo Shin | 2007 | Biochemical and Biophysical Research Communications2007，，3： | 1 |
| 9 | Tanshinone ⅡA isolated from Salvia miltiorrhiza Bunge induced apoptosis in HL60human premyelocytic leuke min cell line显示文摘 | Yoosik Yoon Yeon - ok Kim Won - Kyung Teon | 1999 | J of Ethopharmacology1999，68，13： | 1 |
| 10 | Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects显示文摘 | Yoosik Yoon Byung Lae Park Min Ho Cha Kil Soo Kim Hyun Sub Cheong Yoo Hyun Choi Hyoung Doo Shin | 2007 | Biochemical and Biophysical Research Communications2007，，3： | 1 |
| 11 | Racial/Ethnic Group Differences in the Prevalence of Sexually Transmitted Diseases in the United States: A Network Explanation显示文摘 | EDWARD O. LAUMANN YOOSIK YOUM | 1999 | Sexually Transmitted Diseases1999，，5： | 1 |
| 12 | Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE,induces apoptosis in human leukemia cell lines through theactivation of caspase-3 显示文摘 | Hyun JS Sun MC Yoosik Y | 1999 | Exp Mol Med1999，31，4： | 1 |
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