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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats显示文摘Emerging evidence indicates that CXCL12/CXCR4 signaling is involved in chronic pain. However, few studies have systemically assessed its role in direct nerve injury-induced neuropathic pain and the underlying mechanism. Here, we determined that spared nerve injury(SNI)increased the expression of CXCL12 and its cognate receptor CXCR4 in lumbar 5 dorsal root ganglia(DRG)neurons and satellite glial cells. SNI also induced longlasting upregulation of CXCL12 and CXCR4 in the ipsilateral L4–5 spinal cord dorsal horn, characterized by CXCL12 expression in neurons and microglia, and CXCR4 expression in neurons and astrocytes. Moreover, SNIinduced a sustained increase in TNF-a expression in the DRG and spinal cord. Intraperitoneal injection(i.p.) of the TNF-a synthesis inhibitor thalidomide reduced the SNI-induced mechanical hypersensitivity and inhibited the expression of CXCL12 in the DRG and spinal cord.Intrathecal injection(i.t.) of the CXCR4 antagonist AMD3100, both 30 min before and 7 days after SNI,reduced the behavioral signs of allodynia. Rats given an i.t.or i.p. bolus of AMD3100 on day 8 of SNI exhibited attenuated abnormal pain behaviors. The neuropathic pain established following SNI was also impaired by i.t. administration of a CXCL12-neutralizing antibody. Moreover,repetitive i.t. AMD3100 administration prevented the activation of ERK in the spinal cord. The mechanical hypersensitivity induced in na?¨ve rats by i.t. CXCL12 was alleviated by pretreatment with the MEK inhibitor PD98059. Collectively, our results revealed that TNF-a might mediate the upregulation of CXCL12 in the DRG and spinal cord following SNI, and that CXCL12/CXCR4 signaling via ERK activation contributes to the development and maintenance of neuropathic pain. | Liying Bai Xinru Wang Zhisong Li Cunlong Kong Yonghui Zhao Jun-Liang Qian Quancheng Kan Wei Zhang Ji-Tian Xu | 2016 | Neuroscience Bulletin2016，32，1： | 20 |
| 3 | A study of the contribution of mass elevation effect to the altitudinal distribution of timberline in the Northern Hemisphere显示文摘作为生态的转变地区,高山的树带界线长在许多地里吸引了科学家的注意,特别在最近的年里。许多单一、二盐基的恰当的模型被开发了探索在树带界线举起和纬度或温度之间的关系。然而,这些模型通常在地区性的规模上并且不能被用于另外的区域;在另一方面,半球规模并且大陆人规模模型通常基于大约 100 树带界线数据并且在精确是必然低的。现在的文章收集树带界线的 516 个数据地点,并且作为依赖变量作为独立变量和树带界线举起拿纬度,陆性率和集体举起效果(MEE ) 开发一个第三的线性回归模型。陆性率用 WorldClim 和山库举起释放的气象学的数据被计算(作为集体举起效果的一个代理) 根据 SRTM 90 米的分辨率举起数据被提取。结果证明线性模型的决心(R2 ) 的系数象 0.904 一样高,并且到树带界线举起的纬度,陆性率和 MEE 的贡献率是 45.02%(p=0.000 ) , 6.04%(p=0.000 ) 并且 48.94%(p=0.000 ) 分别地。这意味着 MEE 简单地是在大陆人和半球的规模上贡献树带界线的举起分发的主要因素。到树带界线高度的 MEE 的贡献率在不同区域不同,例如, 50.49%(p=0.000 ) 在北美洲, 48.73%(p=0.000 ) 在东方欧亚大陆,并且 43.6%(p=0.000 ) 在里面西方的欧亚大陆,而是它通常很高。 | ZHAO Fang ZHANG Baiping PANG Yu YAO Yonghui | 2014 | Journal of Geographical Sciences2014，24，2： | 10 |
| 4 | Hollow TiO2-x porous microspheres composed of wellcrystalline nanocrystals for high-performance lithiumion batteries显示文摘 | Chun Wang Faxing Wang Yujuan Zhao Yuhui Li Qin Yue Yupu Liu Yong Liu Ahmed A. Elzatahry Abdullah Al-Enizi Yuping Wu Yonghui Deng Dongyuan Zhao | 2016 | Nano Research2016，9，1： | 8 |
| 5 | Analysis of factors affecting the prognosis of transcatheter arterial chemoembolization for hepatitis B-related hepatocellular carcinoma显示文摘Objectives:The purpose of this study was to investigate the prognostic factors for transcatheter arterial chemoembolization(TACE)for hepatitis B-related hepatocellular carcinoma(HCC).Materials and methods:The variables that may affect overall survival(OS),such as age,gender,AFP,Child Pugh classification,body mass index,HBV-DNA,Hbe Ag,tumor number,tumor diameter,BCLC stage,embolization method,ablation therapy,and targeted therapy,were analyzed by single factor and many factor COX regression.In addition,predictive factors of OS were stratified and a Kaplan-Meier survival curve was drawn.Results:Among the 136 patients,the median follow-up time was 14.5 months(range:2–72 months).HCC patients with the tumor diameter<3 cm had the highest survival rate,followed by patients with a tumor diameter of 3–5 cm;the survival rate of patients with the tumor diameter(greater than 5 cm)was the lowest.Among the BCLC stages,stage A patients had the highest survival rate,followed by stage B and stage C patients,which had the lowest survival rate.The survival rate of Child Pugh grade A patients was higher than those with Child Pugh grade B.Compared with patients who did not undergo ablation treatment,the survival rate of patients with combined ablation treatment was relatively high.The survival rate of patients receiving drug-eluting beads transarterial chemoembolization(DEB-TACE)treatment was higher than those receiving conventional transarterial chemoembolization(c TACE)treatment.Additionally,repeated TACE treatment improved the OS rate of patients.These six factors were related to patient prognosis and the differences were statistically significant(P<0.05).Conclusions:Tumor diameter,BCLC stage,TACE repetition,and TACE combined with ablation were independent prognostic factors of OS. | Jiangping Cun Yonghui Xu Weidong Li Xingxiang Zhao | 2021 | Journal of Interventional Medicine2021，4，2： | 7 |
| 6 | Magnetic yolk-shell structured anatase-based microspheres loaded with Au nanoparticles for heterogeneous catalysis显示文摘磁性的蛋黄壳组织了基于锐钛矿的 microspheres 在磁铁矿粒子上通过连续、灵巧的大音阶的第五音胶化涂层被制作,由退火列在后面处理。在与金 nanoparticles 装载之上,获得的功能的磁性的 microspheres 在向苯乙烯氧化物与非凡的高变换(89.5%) 和选择(90.8%) 催化苯乙烯的 epoxidation 作为异构的催化剂显示出优异性能。这些迷人的材料的构造过程为创造另外的功能的 nanocomposites 展示许多含意,这被相信。 | Chun Wang Junchen Chen Xinran Zhou Wei Li Yong Liu Qin Yue Zhaoteng Xue Yuhui Li Ahmed A. Elzatahry Yonghui Deng Dongyuan Zhao | 2015 | Nano Research2015，8，1： | 7 |
| 7 | Thermal Transfer During the Activation Process in LiSi/FeS2 Thermal Batteries显示文摘 | KANG Bo ZHANG Wenli LIN Haibo XING Yonghui ZHAO Jinfeng WANG Yan | 2016 | Chemical Research in Chinese Universities2016，32，4： | 6 |
| 8 | Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin显示文摘Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions. | Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 9 | Active flutter suppression of a multiple-actuated-wing wind tunnel model显示文摘In this study, a multi-input/multi-output(MIMO) time-delay feedback controller is designed to actively suppress the flutter instability of a multiple-actuated-wing(MAW) wind tunnel model in the low subsonic flow regime. The unsteady aerodynamic forces of the MAW model are computed based on the doublet-lattice method(DLM). As the first attempt, the conventional linear quadratic-Gaussian(LQG) controller is designed to actively suppress the flutter of the MAW model. However, because of the time delay in the control loop, the wind tunnel tests illustrate that the LQG-controlled MAW model has no guaranteed stability margins. To compensate the time delay, hence, a time-delay filter, approximated via the first-order Pade approximation, is added to the LQG controller. Based on the time-delay feedback controller, a new digital control system is constructed by using a fixed-point and embedded digital signal processor(DSP) of high performance. Then, a number of wind tunnel tests are implemented based on the digital control system.The experimental results show that the present time-delay feedback controller can expand the flutter boundary of the MAW model and suppress the flutter instability of the open-loop aeroelastic system effectively. | Qian Wenmin Huang Rui Hu Haiyan Zhao Yonghui | 2014 | Chinese Journal of Aeronautics2014，27，6： | 5 |
| 10 | Ordered porous metal oxide semiconductors for gas sensing显示文摘Among various gas sensing materials, metal oxide semiconductors have shown great potential as resistive type sensors. The ordered porous structural metal oxide semiconductors with well-defined meso-or macro-pores chemically synthesized via soft-templating method and nanocasting strategy have high porosity, highly interconnected pore channels and high surface area with enormous active sites for interacting with gaseous molecules. These features enable them good performance in gas sensing,including high sensitivity, fast response and recovery, good selectivity. This review gives a comprehensive summary about the porous metal oxides with focus on the synthesis methods, structure related properties, as well as the modification strategies for gas sensing improved performances. | Xinran Zhou Xiaowei Cheng Yongheng Zhu Ahmed A. Elzatahry Abdulaziz Alghamdi Yonghui Deng Dongyuan Zhao | 2018 | Chinese Chemical Letters2018，29，3： | 5 |
| 11 | STABILITY OF DISCRETE-TIME COHEN-GROSSBERG BAM NEURAL NETWORKS WITH DELAYS显示文摘In this paper, we study the existence and stability of an equilibrium of discrete-time Cohen-Grossberg BAM Neural Networks with delays. We obtain several sufficient conditions ensuring the existence and stability of an equilibrium of such systems, using discrete Halanay-type inequality and vector Lyapunov methods. In addition, we show that the proposed sufficient condition is independent of the delay parameter. An example is given to demonstrate the effectiveness of the results obtained. | Zhao Yong (School of Science, Beijing University of Aeronautics and Astronautics, Beijing 100191) Xia Yonghui (College of Math. and Computer Science, Fuzhou University, Fuzhou 350002) | 2008 | Annals of Differential Equations2008，24，4： | 3 |
| 12 | Shifting from homogeneous to heterogeneous surfaces in estimating terrestrial evapotranspiration: Review and perspectives显示文摘Terrestrial evapotranspiration(ET)is a crucial link between Earth’s water cycle and the surface energy budget.Accurate measurement and estimation remain a major challenge in geophysical,biological,and environmental studies.Pioneering work,represented by Dalton and Penman,and the development of theories and experiments on turbulent exchange in the atmospheric boundary layer(ABL),laid the foundation for mainstream methodologies in ET estimation.Since the 1990s,eddy covariance(EC)systems and satellite remote sensing have been widely applied from cold to tropical and from arid to humid regions.They cover water surfaces,wetlands,forests,croplands,grasslands,barelands,and urban areas,offering an exceptional number of reports on diverse ET processes.Surface nocturnal ET,hysteresis between ET and environmental forces,turbulence intermittency,island effects on heterogeneous surfaces,and phase transition between underlying surfaces are examples of reported new phenomena,posing theoretical and practical challenges to mainstream ET methodologies.Additionally,based on non-conventional theories,new methods have emerged,such as maximum entropy production and nonparametric approaches.Furthermore,high-frequency on-site observation and aerospace remote sensing technology in combination form multi-scale observations across plant stomata,leaves,plants,canopies,landscapes,and basins.This promotes an insightful understanding of diverse ET processes and synthesizes the common mechanisms of the processes between and across spatial and temporal scales.All the recent achievements in conception,model,and technology serve as the basis for breaking through the known difficulties in ET estimation.We expect that they will provide a rigorous,reliable scientific basis and experimental support to address theoretical arguments of global significance,such as the water-heat-carbon cycle,and solve practical needs of national importance,including agricultural irrigation and food security,precise management of water resources and eco-environmental protection,and regulation of the urban thermal environment and climate change adaptation. | Yuanbo LIU Guoyu QIU Hongsheng ZHANG Yonghui YANG Yinsheng ZHANG Quan WANG Wenzhi ZHAO Li JIA Xibin JI Yujiu XIONG Chunhua YAN Ning MA Shumin HAN Yifan CUI | 2022 | Science China Earth Sciences2022，65，2： | 2 |
| 13 | Low temperature surface oxygen activation in crystalline MnO_(2) triggered by lattice confined Pd single atoms显示文摘Tuning the coordination environment is the research axis of single atom catalysts (SACs). SACs are commonly stabilized by various defects from support. Here, we report a lattice confined Pd SAC using MnO_(2) as support. Compared with the Pd clusters anchored on the surface, the lattice confined Pd single atoms allows spontaneous exaction of surrounding lattice oxygen at room temperature when employed in CO oxidation. The MnO_(2) supported Pd SAC exhibited a high turnover frequency of 0.203 s^(−1) at low reaction temperature, which is higher than that of recently reported Pd SACs. Theoretical calculations also confirmed the confined monatomic Pd activate lattice oxygen with an ultralow energy barrier. Our results illustrate that the unique coordination environment of single atom provided by lattice confinement is promising to boost the activity of SACs. | Xuemei Liao Yonghui Zhao Changwen Liu Xiaopeng Li Yu Sund Kenichi Kato Miho Yamauchi Zheng Jiang | 2021 | Journal of Energy Chemistry2021，30，11： | 2 |
| 14 | Effects of demineralization on phenols distribution and formation during coal pyrolysis显示文摘 | Yonghui Bai Lunjing Yan Guanlong Li Ruifang Zhao Fan Li | 2014 | Fuel2014，，： | 2 |
| 15 | Boundedness of commutators on Herz-Morrey spaces显示文摘 | Zhao Xiangqing Jiang Yinsheng Cao Yonghui | 2006 | Journal of Lanzhou University2006，42，5： | 1 |
| 16 | Parameterized aeroelastic modeling and flutter analysis for a folding wing显示文摘 | Zhao Yonghui Hu Haiyan | | 0，，02： | 1 |
| 17 | DELAY DIFFERENTIAL EQUATIONS UNDER NONLINEAR IMPULSIVE CONTROL AND APPLICATIONS TO NEURAL NETWORK MODELS显示文摘在这份报纸,延期的一个班有非线性的冲动的控制的微分方程被讨论。基于 nonsmooth 分析,稳定性的标准为有非线性的推动的微分方程在某些条件下面控制的延期被获得。这些标准能被用于一些神经网络模型。在纸的结束,二个例子被提供说明建议结果的可行性和有效性。 | Yong ZHAO Qishao LU Zhaosheng FENG Yonghui XIA | 2012 | Journal of Systems Science & Complexity2012，25，4： | 1 |
| 18 | An approximate analytical propagation formula for Gaussian beams through a cateye optical lens under large incidence angle condition显示文摘 | Zhao Yanzhong Sun Huayan Zheng Yonghui | 2011 | Chin Phys Lett2011，28，07： | 1 |
| 19 | Opioid δ1 and δ2 receptor agonist attenuate myocardial injury via mPTP in rats with acute hemorrhagic shock显示文摘 | Xiaoli Zeng Xiaoling Zhao Yonghui Yang | | 0，，02： | 1 |
| 20 | Study on the Formation of Phenols during Coal Flash Pyrolysis using Pyrolysis-GC/MS 显示文摘 | Kong Jiao Zhao Ruifang Bai Yonghui | 2014 | Fuei Processing Technology2014，127，11： | 1 |
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