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| 1 | Deep seismic reflection profile across the juncture zone between the Tarim Basin and the West Kunlun Mountains显示文摘Fine structures of the crust and upper mantle of the basin-and-range juncture on the northwestern margin of the Qinghai-Tibetan Plateau are first delineated by the deep seismic reflection profile across the juncture zone between the Tarim Basin and the West Kunlun Mountains. Evidence is found for the northward subduction of the northwest marginal lithosphere of the Qinghai-Tibetan Plateau and its collision with Tarim lithosphere beneath the West Kunlun Mountains. The lithosphere image of the face-to-face subduction and collision determines the coupling relationship between the Tarim Basin and the West Kunlun Mountains at the lithosphere scale and reflects the process of continent- continent collision. | GAO Rui HUANG Dongding LU Deyuan QIAN Guihua LI Yingkang KUANG Chaoyang Li Qiusheng LI Pengwu Feng Rujin Guan Ye | 2000 | Chinese Science Bulletin2000，45，24： | 30 |
| 2 | The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice显示文摘动脉粥样硬化(作为) 疾病被多重因素导致,包括基因、环境的元素。现在的学习的目的是在致病上调查高胆固醇,高蛋氨酸食谱,和 apolipoprotein E 缺乏(ApoE/) 的全面效果作为。ApoE/ 老鼠用高胆固醇和蛋氨酸饮食被喂 15 个星期导致 hyperlipidemia 和 hyperhomocysteinemia。genomic DNA (gDNA ) 和 B1 的 methylation 层次在大动脉的纸巾的重复元素被两 methylation 依赖的限制分析测量并且嵌套 methylation 特定的聚合酶链反应(PCR ) 。Methylation 顺序偏爱模式是由有限制 endonuclease 消化的 DNA 接受甲基的能力的 assayed。DNA methyltransferase-1 的 mRNA 表示, 3 (DNMT1, 3 ) 被即时 PCR 检测。S-adenosylmethionine (SAM ) 和 S-adenosylhomocysteine (SAH ) 的集中被高效的液体层析决定。结果显示出 gDNA 和 B1 的 hypomethylation 重复元素。DNMT1 的 mRNA 表示被减少。SAM, SAH,和 SAM/SAH 比率的层次被增加。动脉粥样硬化患者损害区域强烈与风险因素相关。DNA demethylation 的分发被喜欢而不是 non-CpG 岛,它可以在 DNA 正直和 genomic 不稳定性上建议 hypomethylation 的主要影响。总的来说,我们的数据不含糊地证明高胆固醇,高蛋氨酸食谱,和 ApoE/ 的全面角色不与一个单个风险因素的角色一致地一致。DNA methylation 模式在这是相当复杂的并且取决于基因背景和许多深奥风险因素。 | Yideng Jiang Huiping Zhang Tao Sun Ju Wang Weiwei Sun Huihui Gong Binbin Yang Yingkang Shi Jun Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 16 |
| 3 | Formation mechanism of in-situ volcanic reservoirs in eastern China:A case study from Xushen gasfield in Songliao Basin显示文摘A large number of in-situ volcanic reservoirs have been discovered from the Meso-Cenozoic rift basin group in eastern China.Based on drilling results in combination with geological and geophysical analysis,a case study from the Early Cretaceous Xujiaweizi fault-depression shows that the formation mechanism of in-situ volcanic reservoirs is characterized by'fault-controlled body,body-controlled facies,facies-controlled reservoir,and reservoir-controlled accumulation'.In other words,deep faults control the volcanic eruption type,volcanic body,and gas reservoir distribution;the volcanic body determines the spatial distribution of volcanic facies and volcanic gas reservoir size;the volcanic facies control reservoir physical properties and effective thickness of gas formation;the volcanic reservoir properties control gas reservoir type and gas productivity.The result is useful to guiding the discovery of in-situ volcanic gas reservoirs in faulted basins in both theory and practice. | FENG ZiHui YIN ChangHai LIU JiaJun ZHU YingKang LU JiaMin LI JiangHai | 2014 | Science China Earth Sciences2014，57，12： | 12 |
| 4 | A deep seismic sounding profile across the Tianshan Mountains显示文摘The deep seismic sounding profile across the Tianshan Mountains revealed a two-layer crustal structure in the Tianshan region, namely the lower and upper crusts. Lateral variations of layer velocity and thickness are evidently shown. Low-velocity layers spread discontinuously at the bottom of the upper crust. The Mono depth is 47 km in the Kuytun area and 50 km in the Xayar area. In the Tianshan Mountains, the Moho becomes deeper with the maximum depth of 62 km around the boundary between the southern and northern Tianshan Mountains. The average velocity ranges from 6.1 to 6.3 km/s in the crust and 8.15 km/s at the top of the upper mantle. Two groups of reliable reflective seismic phases of the Moho (Pm1 and Pm2) are recognized on the shot record section of the Kuytun area. A staked and offset region, 20-30 km long, is displayed within a shot-geophone distance of 190-210 km in Pm1 and Pm2. Calculation shows that the Moho is offset by 10 km in the northern Tianshan region, 62 km deep in the south while | LU Deyuan LI Qiusheng GAO Rui LI Yingkang LI Dexing LIU Wen ZHANG Zhiying | 2000 | Chinese Science Bulletin2000，45，22： | 9 |
| 5 | Geophysical evidence for thrusting of crustal materials from orogenic belts over both sides of the Yangtze Block and its geological significance显示文摘Based on deep geophysical detections, we have reconstructed the crustal structure from the eastern margin of the Tibetan Plateau to the Jiangnan-Xuefeng orogenic belt. The results suggest that the Yangtze Block was overthrusted by crustal materials in its NW direction from the eastern Tibetan Plateau but in its SE direction from the Jiangnan orogen. These overthrusting effects control the crustal structure from the western Sichuan to the western area of the Jiangnan orogen-Xuefeng orogenic belt. The eastward extruded materials from the eastern Tibetan Plateau were blocked by the rigid basement in the Sichuan Basin, where upper-middle crust was overthrusted whereas the lower crust was underthrusted beneath the Sichuan Basin. The underthrusted unit was absorbed by crustal folding, shortening and thickening in the Yangtze Block, forming the Xiongpo and Longquan Mountains tectonic belts and resulting in the NW-directed thrusting of the Pujiang-Chengdu-Deyang fault, and the western hillsiden fault in the Longquan Mountain. These results provide resolution to the controversy where the eastward extrusion material from the Qinghai-Tibet Plateau had gone. Overall, that Yangtze Block was subjected to thrusting of the crustal materials from the orogenic belts over its both sides. This finding has implications for the study of the intracontinental orogenic mechanism in South China, the reconstruction of tectonic evolutionary history and the kinematics processes during the lateral extrusion of the Tibet Plateau. | Yingkang LI Jianwei GAO Jian HAN Yu'e YANG | 2019 | Science China Earth Sciences2019，62，5： | 5 |
| 6 | Characterization and immunogenicity of bone marrow-derived mesenchymal stem cells under osteoporotic conditions显示文摘Mesenchymal stem cells(MSCs)are characterized by their multilineage potential and low immunogenicity.However,the properties of MSCs under pathological conditions are unclear.The current study investigated the differentiation potential and immunological characteristics of bone marrow-derived MSCs from ovariectomized-osteoporotic rats(OP-BMSCs).Although the expression of cell morphology-and stemness-related surface markers was similar between OP-BMSCs and BMSCs from healthy rats(H-BMSCs),the proliferation rate was significantly decreased compared with that of H-BMSCs.Regarding multilineage potential,osteogenesis and chondrogenesis abilities of OP-BMSCs decreased,but the adipogenesis ability was significantly enhanced compared with that of H-BMSCs.As expected,decreased osteogenesis following osteogenic induction resulted in reduced expression ofβ-catenin,osteocalcin,and runt-related transcription factor 2 in OP-BMSCs.Remarkably,the expression of the co-stimulatory proteins CD40 and CD80 was significantly higher,whereas the expression of the negative costimulatory molecule programmed cell death ligand 1 was significantly lower in the OP-BMSCs than that in H-BMSCs.Consequently,H-BMSCs inhibited the proliferation and secretion of inflammatory cytokines from anti-CD3 antibody-activated T cells,whereas OP-BMSCs did not.These results indicate that decreased osteogenesis and increased immunogenicity of OPBMSCs contribute to bone loss in osteoporosis. | Yingkang Huang Yin Yin Yanzheng Gu Qiaoli Gu Huilin Yang Zhengyu Zhou Qin Shi | 2020 | Science China(Life Sciences)2020，63，3： | 4 |
| 7 | cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full- length gene显示文摘Background This investigation was undertaken to obtain differentially expressed genes related to human glioma using cDNA microarray and the characterization of one novel full-length gene. Methods Total RNA was extracted from human glioma tissues and normal brain tissues, and mRNA was used to make probes. After hybridization and washing, the results were scanned using a computer system. The gene named 681F05 clone was an expressed gene to human glioma through four-time hybridization and scanning. Subsequently northern blot analysis was performed by northern blot, 5’RACE and bioinformatics. Results Fifteen differentially expressed genes to human glioma were obtained through four-time hybridization and scanning. Northern blot analysis confirmed that 681F05 clone was low-expressed in human brain tissues and over-expressed in human glioma tissues. The analysis of BLASTn and BLASTx showed that 681F05 clone is two cDNA clones encoding two novel proteins that are highly identified to the cyclophilin isoform 10 of C. Elgans, respectively. Sequence analysis revealed the two cDNA clones are two different splicing variants of a novel cycophilin-like gene (PPIL3a and PPIL3b).Conclusions cDNA microarray technology can be successfully used to identify differentially expressed genes. The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma. | QIZhen-yu HUIGuo-zhen LIYao ZHOUZong-xiang GUShao-hua YINGKang XIEYi | 2005 | Chinese Medical Journal2005，，10： | 3 |
| 8 | Upper crustal structure under Jingtai–Hezuo profile in Northeastern Tibet from topography-dependent eikonal traveltime tomography显示文摘The Northeastern Tibetan plateau records Caledonian Qilian orogeny and Cenozoic reactivation by continental collision between the Indian and Asian plates. In order to provide the constraint on the Qilian orogenic mechanism and the expansion of the plateau,wide-angle seismic data was acquired along a 430 km-long profile between Jingtai and Hezuo. There is strong height variation along the profile,which is dealt by topography flattening scheme in our crustal velocity structure reconstruction. We herein present the upper crustal P-wave velocity structure model resulting from the interpretation of first arrival dataset from topography-dependent eikonal traveltime tomography. With topography flattening scheme to process real topography along the profile,the evenness of ray coverage times of the image area(upper crust)is improved,which provides upper crustal velocity model comparable to the classic traveltime tomography(with model expansion scheme to process irregular surface). The upper crustal velocity model shows zoning character which matcheswith the tectonic division of the Qaidam-Kunlun-West Qinling belt,the Central and Northern Qilian,and the Alax blocks along the profile. The resultant upper crustal P-wave velocity model is expected to provide important base for linkage between the mapped surface geology and deep structure or geodynamics in Northeastern Tibet. | Ting Ma Zhongjie Zhang Peng Wang Yingkang Li | 2014 | Earthquake Science2014，27，2： | 2 |
| 9 | Distribution of the Toxin following Medial Rectus Muscular Injection of Botulinum Toxin Gel in Rabbits显示文摘Purpose: To determine the distribution of the toxin among individual muscles after intramuscular injection of botulinum toxin gel.Methods: One eye of 7 New Zealand white rabbits was randomized into group A, and the contralateral eye was into group B. Eyes in group A received medial rectus intramuscular injection of 2.5 IU of 125I-BTX-A gel in 0.1 ml, and those in group B received equivalent amount of 125I-BTX-A solution by medial rectus intramuscular injection. Four rectus muscles and the levator palpebrae superioris were harvested and the radioactivity of muscles was measured 16 hours after the injection.Results: In group A, the radioactivity of per gram medial rectus was significantly higher than that of other muscles (P < 0.01), and there was no statistically significant difference in the radioactivity of per gram muscles among other muscles (P > 0.05). In group B, the radioactivity of per gram medial rectus and levator palpebrae superioris was significantly higher than that of other muscles respectively(P < 0.05), and the difference in the radioactivity of per gram muscles between medial rectus and levator palpebrae superioris was not statistically significant (P > 0.05). The radioactivity of per gram medial rectus in group A was higher than that in group B (t=3.731 ,P=0.01), and there was no significant difference in the radioactivity of per gram muscles among other homonymous muscles (P > 0.05).Conclusion: The toxin dispersed principally in the injected muscle and the local concentration of the toxin was much high following intramuscular injection of botulinum toxin gel. | JingchangChen GuanghuanMai XinpingYu HuanyuanYu HepingWu XiaomingLin DarningDeng YingKang | 2005 | Eye Science2005，21，1： | 2 |
| 10 | Crustal structure of seismic velocity in southern tibet and east-westward escape of the crustal material显示文摘 | Zhongjie Zhang Jiwen Teng Yingkang Li S. Klemperer Liqiang Yang | 2004 | Science in China Series D: Earth Sciences2004，，6： | 1 |
| 11 | Key technologies of precision demolition blasting of ultra-long urban viaduct in complicated surroundings显示文摘The key technologies of precision blasting were put forward based on the characteristics of urban viaduct blasting demolition in complicated surroundings.Initial bending instability mechanics model of reinforcing steel bar frame of blasting fragmented pier and sequenced collapsed dynamic model were established for quantitative blasting design.Technologies of water pressure blasting were applied in multi-cell box girder fragmentation.The detonating network of non-electric duplication crossover was adopted for the safety and reliability of ultra-long delay.The rationality of blasting scheme and parameters were validated by physical model test.Harmful effects were forecasted and controlled by integrated protective technologies.Specialization,cooperation,precision,execution(SCPE) project management method was put forward for precision management.The key technologies of precision demolition blasting can provide reference for similar projects. | Xie Xianqi Jia Yongsheng Yao Yingkang Sun Jinshan Wu Xinxia Liu Changbang | 2014 | Engineering Sciences2014，12，6： | 1 |
| 12 | Status and progress of China SKA Regional Centre prototype显示文摘The Square Kilometre Array(SKA)project consists of delivering two largest radio telescope arrays being built by the SKA Observatory(SKAO),which is an intergovernmental organization bringing together nations from around the world with China being one of the major member countries.The computing resources needed to process,distribute,curate and use the vast amount of data that will be generated by the SKA telescopes are too large for the SKAO to manage on its own.To address this challenge,the SKAO is working with the international community to create a shared,distributed data,computing and networking capability called the SKA Regional Centre Alliance.In this model,the SKAO will be supported by a global network of SKA Regional Centres(SRCs)distributed around the world in its member countries to build an end-to-end science data system that will provide astronomers with high-quality science products.SRCs undertake deep processing,scientific analysis,and long-term storage of the SKA data,as well as user support.China has been actively participating in and promoting the construction of SRCs.This paper introduces the international cooperation and ongoing prototyping of the global SRC network,the basis for the construction of the China SRC and describes in detail the progress of the China SRC prototype.The paper also presents examples of scientific applications of SKA precursor and pathfinder telescopes performed using resources from the China SRC prototype.Finally,the future prospects of the China SRC are presented. | Tao An Xiaocong Wu Baoqiang Lao Shaoguang Guo Zhijun Xu Weijia Lv Yingkang Zhang Zhongli Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，12： | 1 |
| 13 | On efficiency of optimization in fuzzy c-means显示文摘 | Yingkang Hu Richard J Hathaway | 2002 | Neural Parallel&Scientific Computations June 20022002，10，2： | 1 |
| 14 | 3D motion and geometric information system of single-antenna radar based on incomplete 1D range data显示文摘A 3D motion and geometric information system of single-antenna radar is proposed,which can be supported by spotlight synthetic aperture radar(SAR) system and inverse SAR(ISAR) system involving relative 3D motion of the rigid target.In this system,applying the geometry invariance of the rigid target,the unknown 3D shape and motion of the radar target can be reconstructed from the 1D range data of some scatterers extracted from the high-resolution range image.Compared with the current 1D-to-3D algorithm,in the proposed algorithm,the requirement of the 1D range data is expanded to incomplete formation involving large angular motion of the target and hence,the quantity of the scatterers and the abundance of 3D motion are enriched.Furthermore,with the three selected affine coordinates fixed,the multi-solution problem of the reconstruction is solved and the technique of nonlinear optimization can be successfully utilized in the system.Two simulations are implemented which verify the higher robustness of the system and the better performance of the 3D reconstruction for the radar target with unknown relative motion. | Yingkang Zhang Yang Xiao Shaohai Hu | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 1 |
| 15 | Reservoir-forming conditions and key exploration & development techniques for Xushen gas field in Northeast China显示文摘Exploration and development of volcanic gas reservoirs is a world-class problem,and less experience can be learned at home and abroad.Through study of reservoir-forming conditions of Xushen gas field,four sets of hydrocarbon source rocks,mainly mudstone and coal seam of Shahezi Formation,are identified in this gas field;its cap rocks are mudstone in Member 2 of Denglouku Formation,and Member 1 and Member 2 of Quantou Formation.By simulating reservoir-forming history,four filling periods of the Xushen gas field are determined,and the most favorable exploration targets are crater areas with structural highs,large thickness and good physical properties.On the basis of diagenetic mechanism study,the criteria of sequence series,lithology identification and reservoir types of gas reservoirs have been established;the volcanic rock bodies have been carefully depicted and the distribution laws of effective reservoirs of gas pools have been figured out.Based on evaluating reservoir-permeability characteristics of reservoirs,the gas well productivity characteristics(mainly type II,III and IV wells)have been identified,and the optimum design technology for volcanic gas reservoir development has been developed.The gas reservoirs in all blocks of Xushen gas field are classified into three types:singlebody gas reservoir model,disconnected multi-body gas reservoir model and interconnected multi-body gas reservoir model.Stimulation technologies,including multi-layer fracturing of vertical well,staged fracturing of open-hole horizontal well and volume fracturing,have been developed.According to gas well production performance,pressure change,well-controlled reserves and spatial distribution of volcanic bodies,combined with numerical simulation and prediction of gas reservoirs,the evaluation method of residual potential of volcanic gas reservoirs has been formed.Key technologies for effective exploration and development of complex volcanic gas reservoirs have been established and perfected,and bring good development effect.The research results can provide guidance and reference for exploration and development of similar gas reservoirs. | Fenglan Wang Yongzhuo Wang Xuemin Zhou Changhai Yin Ping Shu Baojun Cao Yingkang Zhu | 2019 | Petroleum Research2019，4，2： | 1 |
| 16 | Local residents' perceptions of the impact of 2010 EXPO显示文摘 | Yang Jie Zeng Xuehui Gu Yingkang | 2010 | Journal of Convention & Event Tourism2010，11，3： | 1 |
| 17 | Recent advances in the utilization of copper sulfide compounds for electrochemical CO2 reduction显示文摘Converting carbon dioxide(CO2)into value-added chemicals by CO2 reduction has been considered as a potential way to solve the current energy crisis and environmental problem.Among the methods of CO2 reduction,the electrochemical method has been widely used due to its mild reaction condition and high reaction efficiency.In the electrochemical reduction system,the CO2 electrocatalyst is the most important part.Although many CO2 electrocatalysts have been developed,efficient catalysts with high activity,selectivity and stability are still lacking.Copper sulfide compound,as a low-toxicity and emerging material,has broad prospects in the field of CO2 reduction due to its unique structural and electrochemical properties.Much progress has been achieved with copper sulfide nanocrystalline and the field is rapidly developing.This paper summarizes the preparation,recent progress in development,and factors affecting the electrocatalytic CO2 reduction performance with copper sulfide compound as a catalyst.Prospects for future development are also outlined,with the aim of using copper sulfide compound as a highly active and stable electrocatalyst for CO2 reduction. | Yingkang Chen Kejun Chen Junwei Fu Akira Yamaguchi Hongmei Li Hao Pan Junhua Hu Masahiro Miyauchi Min Liu | 2020 | Nano Materials Science2020，2，3： | 1 |
| 18 | Experimental Study on the Prevention of Anterior Segment Ischemia by Preservation of Anterior Ciliary Vessels显示文摘Purpose: To observe the effect of preserving anterior ciliary vessels (ACVs) on anteriorsegments of rabbit eyes undergoing tenotomy of extraocular muscles.Methods: Thirty-two adult New Zealand white rabbits were divided into four groups.Same procedures were done in both eyes in each group except that left eyes underwentpreservation of ACVs. In the first group medial and lateral recti, in the second group,superior and inferior recti, in the third group, medial, lateral and superior or inferior rectiand in the fourth group, all four recti, underwent tenotomy. Slit-lamp examination,intraocular pressure (IOP) measurement, total protein and lactic acid quantification inaqueous humor were done in all eyes pre- and post-operatively. By four weeks afteroperation, the eyes were enucleated for histological examination and electron microscopy.All data were analyzed using SPSS version 10.Results: In the left eyes of both group 1 and group 2, no inflammatory response wasobserved. In the left eyes of group 3 and 4, we observed mild inflammatory response withslit-lamp examination, which disappeared in one wk. However, we did not findsignificant changes in IOP, total protein and lactic acid of aqueous humor, histology andelectron microscopic examination in these groups. In the right eyes in group 2, 3 and 4,we observed moderate to severe inflammatory changes, a few even developed anteriorsegment ischemia, appeared as decreased IOP, increased total protein and lactic acid inaqueous humor, along with pathological and electron-microscopic changes.Conclusion: Simultaneous tenotomy of three or four recti or two vertical recti on one eyemay decrease anterior segment blood flow even lead to ischemia. ACVs preservation mayprotect the blood circulation in anterior segment. Our study suggests that ACVspreservation in strabismus surgeries especially those involving multi-recti tenotomies mayprevent potential anterior segment ischemia. | YannaLi GuanghuanMai ZhijianWang XinpingYu HuanyunYu] YanGuo XiaomingLin DamingDeng YingKang | 2003 | Eye Science2003，19，1： | 1 |
| 19 | Density-Weighted Fuzzy c-Means Clustering显示文摘 | Hathaway R J Hu Yingkang | 2009 | IEEE Transactions on Fuzzy Systems2009，17，1： | 1 |
| 20 | Preliminary Study on Deep Geology of Dabie Orogenic Belt显示文摘 | Dong Shuwen (Nanjing Institute of Geology and Mineral Resources CAGS Nanjing 210016 China)Wu Xuanzhi (Institute of Mineral Deposits CAGS Beijing 100037 China)Gao Rui Lu Deyuan (Institute of Geology CAGS Beijing 100037 China)Li Yingkang (562 Co | 1996 | Continental Dynamics1996，，02： | 1 |
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