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| 1 | Synthesis of 2, 6-(substituded)pyridine Derivatives Using Amide and Imine Groups显示文摘A new wo-armed?acyclic diamide Ia 2, 6-bis(1-ethanecarbozamido-2-amino)pyridine, and a new series of aromatic aldehyde schiff bases containing pyridine ring and amide bridge, IIa-f, were prepared. The compounds were characterized by elemental analysis, IR, 1HNMR and MS. The bioactivity half inhibitory concentration C1/2 is given. | Mei Ying LI, Pei Zhi HU*, Wan Ren ZHU, Kuo Xi XU College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072 | 2003 | Chinese Chemical Letters2003，14，6： | 9 |
| 2 | 北京地区单双频地基GPS大气水汽遥测试验与研究显示文摘该文对北京地区单双频地基GPS大气水汽监测网布网依据、单频与双频地基GPS测量数据解算技术应用、GAMIT和Bernese地基GPS数据分析处理软件应用、远程遥控GPS数据采集与通讯系统、资料分析与数值同化应用等方面的工作进展进行简要介绍,重点讨论了单双频地基GPS大气水汽资料的解算技术及其应用效果。结果表明:在北京天气敏感区通过单双频地基GPS接收机合理组网布局,可构建并利用高分辨率电离层延迟订正技术将单频接收机的大气水汽监测精度提高到实用水平,为强降水天气预报提供有价值的产品。 | 谢璞 张朝林 王迎春 楚艳丽 张京江 王京丽 李矩 Ying Hwa Kuo John Braun | 2006 | 应用气象学报2006，17，B08： | 9 |
| 3 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 4 | Genetic testing and PGD for unexplained recurrent fetal malformations with MAGEL2 gene mutation显示文摘Birth defects are caused by multiple factors,such as chromosome abnormality,environmental factors,and maternal factors.In this study,we focused on exploring the genetic causes of a non-consanguineous couple who suffered from four times of unsuccessful pregnancy due to unexplained recurrent fetal malformations with similar symptoms and normal chromosome copy number variations.Using trio-whole exome sequencing(trio-WES) for this couple and one of the affected fetuses,we found a mutation,c.1996 delC on the maternal imprinted gene MAGEL2 that was carried by the affected fetus and husband,leading to Schaaf-Yang syndrome.To screen this mutation,we further performed preimplantation genetic diagnosis(PGD) strategy followed by a gene pedigree validation and pathogenicity analysis.After the transfer of a PGD-screened embryo,a normal newborn without previous abnormal symptoms was born(February 15,2019).We present the first data that identified a pathogenic gene(MAGEL2 c.1996 delC) in a fetus with Schaaf-Yang syndrome in the EAS(East Asian) database and overcame this genetic defect by using processed PGD for this couple based on the WES results. | Wei Guo Yanli Nie Zhiqiang Yan Xiaohui Zhu Yuqian Wang Shuo Guan Ying Kuo Wenxin Zhang Xu Zhi Yuan Wei Liying Yan Jie Qiao | 2019 | Science China(Life Sciences)2019，62，7： | 4 |
| 5 | Identifying normal embryos from reciprocal translocation carriers by whole chromosome haplotyping显示文摘Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe | Zhiqiang Yan Yuqian Wang Yanli Nie Xu Zhi Xiaohui Zhu Meng Qin Shuo Guan Yixin Ren Ying Kuo Di Chang Wei Chen Peng Yuan Liying Yan Jie Qiao | 2018 | Journal of Genetics and Genomics2018，45，9： | 4 |
| 6 | Early Helicobacter pylori Eradication Decreases Risk of Gastric Cancer in Patients With Peptic Ulcer Disease显示文摘 | Chun–Ying Wu Ken N. Kuo Ming–Shiang Wu Yi–Ju Chen Chang–Bi Wang Jaw–Town Lin | 2009 | Gastroenterology2009，，5： | 4 |
| 7 | CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study显示文摘Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P < 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. | CHEN Li SUN Ke Xin JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 4 |
| 8 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 9 | Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a T aiwanese population显示文摘 | Wen‐Hung Hsu Sophie SW Wang Hsiang‐Yao Shih Meng‐Chieh Wu Yi‐Yu Chen Fu‐Chen Kuo Hui‐Ying Yang Shun‐Li Chiu Koung‐Shing Chu Kuang‐I Cheng Deng‐Chyang Wu I‐Cheng Lu | 2013 | Journal of Digestive Diseases2013，，3： | 3 |
| 10 | The Synthesis of 7-[1-Aza-2-(dimethylamino)vinyl]-4-methylhydroquinolin-2-ones and their Isomerism in Different Solvents显示文摘The reaction of 7-amino-4-methyl-2(1H)-quinolone 1 and its 6-methyl derivative 2 with Vilsmeier reagent (DMF and POCl3) afforded 7-[1-aza-2-(dimethylamino)vinyl]-4-methyl- hydro- quinolin-2-one 3 and 7-[1-aza-2-(dimethylamino)vinyl]-4,6-dimethylhydroquinolin- 2-one 4, respec-tively. 1H-NMR analysis in different solvents indicated that isomerism occurred due to hindered rotation around the (CH3)2N-C:N σ-bond. The rotational energy barrier of 3 was calculated. | Qian ZHANG,1 Ying CHEN,1 Yun Hong ZHENG,1 Wan Yun SHENG,1 Peng XIA1* Yi XIA,2 Zheng Yu YANG,2 Kuo Hsiung LEE2 1Department of Organic Chemistry, The School of Pharmacy, Shanghai Medical University, 138 Yi Xue Yuan Road, Shanghai 200032 2Natural Products | 2001 | Chinese Chemical Letters2001，12，1： | 3 |
| 11 | A novel pathogenic mutation in FBN2 associated with congenital contractural arachnodactyly for preimplantation genetic diagnosis显示文摘Congenital contractural arachnodactyly(CCA,OMIM:121050),also known as Beals syndrome,belongs to a group of rare autosomal dominant(AD)diseases of connective tissue(Maslen et al.,1997).People with CCA share many distinguishing features,such as arachnodactyly,camp tod actyly,multiple joint contractures(especially finger,elbow,and knee joints),crumpled ears,scoliosis,pectus deformities,and muscular hypoplasia(Jurko et al.,2013).It exhibits no specific geographic or ethnic predilection(Frederic et al.,2009). | Jiaxin Li Yuqian Wang Xiaohui Zhu Yanli Nie Ying Kuo Shuo Guan Jin Huang Ying Lian Yangyu Zhao Rong Li Yuan Wei Jie Qiao Liying Yan | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 12 | Quantum dot vertical-cavity surface-emitting lasers covering the ‘green gap’显示文摘Semiconductor vertical-cavity surface-emitting lasers(VCSELs)with wavelengths from 491.8 to 565.7 nm,covering most of the‘green gap’,are demonstrated.For these lasers,the same quantum dot(QD)active region was used,whereas the wavelength was controlled by adjusting the cavity length,which is difficult for edge-emitting lasers.Compared with reports in the literature for green VCSELs,our lasers have set a few world records for the lowest threshold,longest wavelength and continuous-wave(CW)lasing at room temperature.The nanoscale QDs contribute dominantly to the low threshold.The emitting wavelength depends on the electron–photon interaction or the coupling between the active layer and the optical field,which is modulated by the cavity length.The green VCSELs exhibit a low-thermal resistance of 915 kW^(−1),which benefits the CW lasing.Such VCSELs are important for small-size,low power consumption full-color displays and projectors. | Yang Mei Guo-En Weng Bao-Ping Zhang Jian-Ping Liu Werner Hofmann Lei-Ying Ying Jiang-Yong Zhang Zeng-Cheng Li Hui Yang Hao-Chung Kuo | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 13 | Fourier modified non-equigap GM ( 1,1 ) 显示文摘 | Kuo Ching Ying Ching Tong Liao | 2000 | The Journal of Grey System2000，12，2： | 1 |
| 14 | Induction of Apoptosis in Plasma Cells by B Lymphocyte-Induced Maturation Prorein-1 Knockdown 显示文摘 | Lin FR Kuo HK Ying HY | 2007 | Cancer Research2007，67，11： | 1 |
| 15 | 3G telecommunication operators' challenges and roles: A perspective of mobile commerce value chain 显示文摘 | KUO YING - FENG YU CHING - WEN | 2006 | Technovation2006，26，： | 1 |
| 16 | Temporal characteristics of inhalable mercury and arsenic aerosols in the urban atmosphere in southern Taiwan 显示文摘 | Tsai Ying I Kuo Su-ching Lin Yi-hsuan | 2003 | Atmospheric Environment2003，37，： | 1 |
| 17 | Temporal characteristics of inhalable mercury and arsenic aerosols in the urban atmosphere in southern Taiwan显示文摘 | Ying I Tsai Su-Ching Kuo Yi-Hsuan Lin | 2003 | Atmospheric Environment2003，，24： | 1 |
| 18 | Preparation and sorption activity of chitosan/cellulose blend beads显示文摘 | Yawo - Kuo Twu Hsin - I Huang Szu - Ying Chang | 2003 | Carbohydrate Polymer2003，54，： | 1 |
| 19 | A Tropical Cyclone Bogus Data Assimilation Scheme in the MM5 3D-Var System and Numerical Experiments with Typhoon Rusa (2002) Near Landfall显示文摘 | XIAO Qingnong KUO Ying-Hwa ZhANG Ying | 2006 | Journal of the Meteorological Society of Japan2006，84，4： | 1 |
| 20 | Rela- tionships between critical thinking ability and nursing com- petence in clinical nurses显示文摘 | Mei Jen Chang Ying - Ju Chang Shih - Hsien Kuo | 2011 | Journal of Clinical Nursing2011，20，： | 1 |
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