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| 1 | Selective blockade of NF-kappa B by novel mutated I kappa B alpha suppresses CD3/CD28-induced activation of memory CD4(+) T cells in asthma显示文摘Background:Nuclear factor kappa B(NF-kappa B) overactivation plays a crucial role in T-helper 2 (Th2)-biased allergic airway inflammation by increased activation and decreased apoptosis of CD4(+) T cells. We have shown that targeted NF-kappa B suppression in dendritic cells by adenoviral gene transfer of a novel mutated inhibitor of NF-kappa B(I kappa B alpha) (AdI kappa B alpha M) contributes to T-cell tolerance, but the immunosuppressive action of AdI kappa B alpha M on memory(CD45RO(+)) CD4(+) T cells remains enigmatic. Methods:CD45RO(+) T cells from Dermatophagoides farinaei-sensitized asthmatic patients, untransfected or transfected with AdI kappa B alpha M or AdLacZ(beta-galactosidase) for 24 h, were stimulated with anti-CD3(1.0 mu g/ml) plus anti-CD28(0.5 mu g/ml) monoclonal antibody for an additional 24 h. I kappa B alpha M transgene expression and NF-kappa B activation were detected by polymerase chain reaction(PCR), reverse transcription-PCR(RT-PCR), Western blot analysis, and electrophoretic mobility shift assay. Phenotype and apoptosis were measured by flow cytometry, annexin V binding, and terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling analyses. Cytokine production and cell proliferation were determined using enzyme-linked immunosorbent assay andH-3 thymidine incorporation. Results:A unique 801-bp I kappa B alpha M cDNA and a dose-dependent increase in I kappa B alpha M transgene expression were observed in AdI kappa B alpha M-transfected CD45RO(+) T cells. Significantly, AdI kappa B alpha M inhibited CD3/CD28-mediated NF-kappa B activation in CD45RO(+) T cells, leading to evident apoptosis, reduction of eotaxin, RANTES, Th1 interferon (IFN)-gamma and interleukin (IL)-2, and Th2 (IL-4, IL-5, and IL-13 despite a slight decrease in IL-10) cytokines and secondary proliferative response. AdI kappa B alpha M also upregulated cytotoxic T lymphocyte-associated antigen 4(CTLA-4) and downregulated CD69 besides no change in CD28. Conclusion:I kappa B alpha M might be beneficial to augment memory CD4(+) T-cell tolerance through modulating B7-CD28/CTLA-4 co-stimulatory pathways and NF-kappa B-dependent cytokine profiles in allergic inflammatory diseases including asthma. | Zhou,L. F. Zhang,M. S. Hu,A. H. Zhu Z. Yin,K. S. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 40 |
| 2 | PHYSICAL MODELING FOR THE MECHANISMS OF BEAD FORMATION DEFECTS BASED ON THE STABILITY OF LIQUID METAL显示文摘Based on the theory of stability of the liquid metal under the action of surface tension,a physical mod- el is established for the mechanisms of the bead formation deferct’ humping’, which is generated during high - speed welding.A boundary function is introduced to correct the model,theoretical results got by the model correspond well with the experimental phenomena. A two - dimensional conducting model is adoopted in the simulation of the temperature field during high - speed welding.Finally, the factors acting upon the stability of liquid metal are analyzed. | S. Y. Yin L. Feng J. Z. Ding and S. J. Chan( 1) Beijing Polytechnic University, Beijing 100022, China 2) National Key Laboratory of Advanced Wdlding Production Technology, HIT, Harbin 150001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 28 |
| 3 | COMPUTERIZED SIMULATION AND EXPERIMENTAL RESEARCH ON SOFT-SWITCHING ARC WELDING INVERTER POWER SOURCE显示文摘Based on the existing component models in the Pspice software package, a combined model for Insulat- ed the Bipolar Transistor (IGBT) is established, in which a non - linear is introduced to represent the parasitic capacitance. Using this model, computerized simulation is conducted for the FB - ZVZCS - PWM soft - ewitching converter,the switching and energy-transferring characteristics of the components are analyzed.The simulation results are testified by experiments.It is proved that by abopting appropriate models,computerized simulation becomes an effective tool for investigation of arc welding inverter power source. | S. J. Chen S. Y. Yin L. Feng and L. Y. Li( 1) School of Materials Science and Engineering, Beijing Polytechnic University, Beijing 100022, China 2)National Key Laboratory of Advanced Welding Production Technology, HIT, Harbin 150001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 24 |
| 4 | Self-Assembly and Photocatalysis of Mesoporous TiO2 Nanocrystal Clusters显示文摘有大表面区域和提高的 photocatalytic 活动的锐钛矿 TiO2 的 Mesoporous nanocrystal 簇成功地被综合了。合成包含进亚微米簇,有硅石层的这些簇的涂层,移开器官的 ligands 并且改进簇的 crystallinity 的热处理,和暴露 mesoporous 催化剂的最后搬迁的硅石的恐水病的 TiO2 nanocrystals 自己组装。在硅石涂层的帮助下,簇不仅维持他们的小谷物尺寸而且在高温度在锻烧以后保留他们的 mesoporous 结构(与象 277 m2/g 一样高的赌注表面区域) 。蚀刻 SiO2 也导致在水里有高 dispersity 的簇。我们能识别最佳的锻烧温度生产拥有高 crystallinity 和大表面区域的 TiO2 nanocrystal 簇,因此由紫外光在照明下面在器官的分子的分解显示出优秀催化效率。与氮的方便的做在可见的光和自然日光把这些 nanocrystal 簇变换成活跃光催化剂。用 nanocrystals 形成明确的 mesoporous 簇的策略为与提高的活动和稳定性设计光催化剂答应一个万用、有用的方法。 | Qiao Zhang Ji-Bong Joo Zhenda Lu Michael Dahl Diana Q. L. Oliveira Miaomiao Ye Yadong Yin | 2011 | Nano Research2011，4，1： | 17 |
| 5 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 6 | Elevated Expressions of 15-Lipoxygenase and Lipoxin A(4) in Children with Acute Poststreptococcal Glomerulonephritis显示文摘 | Wu, S.H. Liao, P. Y. Yin, P. L. Zhang, Y. M. Dong, L. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 5 |
| 7 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
| 8 | A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction显示文摘 | Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 5 |
| 9 | The Level of Expression of Thioredoxin is Linked to Fundamental Properties and Applications of Wheat Seeds显示文摘有谷物(大麦和小麦) 和荚(Medicago truncatula ) 的工作作为种子的中央规章的蛋白质建立了 thioredoxin h (Trx h ) 。Trx h 由减少二硫化物(SS ) 扮演一些多样的种子蛋白质(存储蛋白质,酶,和酶禁止者) ,从而便于萌芽。早,在 vitro,蛋白质研究与有在内乳的 Trx h overexpressed 的大麦种子在显示出加速的萌芽和联系的酶(淀粉酶和 pullulanase ) 的早或提高的表示的实验被补充。当前的学习扩大转基因的工作到小麦。二条途径被跟随在内乳改变 Trx h 基因的表示:(1 ) 一个大麦蛋白倡导者和它指向顺序的蛋白质身体导致了 Trx h5 的 overexpression,并且(2 ) Trx h9 的 antisense 构造导致了那基因(Arabidopsis 指明) 的 cytosolic underexpression。Trx h9 的 Underexpression 导致了对在萌芽的 barleyretardation 为 overexpression Trx h5 观察并且推迟了或减少联系的酶的表示的那些相反的效果。类似的酶变化在开发种子被观察。有 underexpressed Trx 的小麦线看了发芽的推迟的 preharvest 没有减少,什么时候在最后的产量在温室或领域成长。有 overexpressed Trx h5 的小麦显示出与同量的变化在 vitro 工作更早:二硫化物蛋白质的增加的溶解度和麦胶蛋白质部分的更低的 allergenicity。结果是在谷物内乳的 Trx h 的水平决定基本性质以及种子的潜在的应用程序的进一步的证据。 | Yong-Chun Li Jiang-Ping Ren Myeong-Je Cho Su-Mei Zhou Yong-Bum Kim Hong-Xiang Guo Joshua H. Wong Hong-Bin Niu Hyun-Kyung Kim Susumu Morigasaki Peggy G. Lemaux Oscar L. Frick Jun Yin Bob B. Buchanan | 2009 | Molecular Plant2009，2，3： | 5 |
| 10 | Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs显示文摘背景临床的观察证明了复杂 fractionated atrial 电记录图(CFAE ) 在心脏的自治神经系统与 ganglionated 丛活动联系。这研究试图在 vagal 调整上调查 CFAE 脱离的影响到正厅和危险开发 atrial 纤维性颤动(AF ).Methods 十条成年杂种狗被包含。颈的 sympathovagal 箱子被分散,同情的效果被堵住。CFAE 是在 atrial 3-dimensional 图象上标注并且加 sympathovagal 箱子刺激在 S1S2 导致的 AF 期间切除了规划刺激的颜色。Atrial 有效倔强的时期(ERP ) 和 AF 的危险窗户(VW ) 在 4 个中庭地点在基线上并且在 vagal 刺激被测量。连续织物节从夺格并且控制标本收到了 hematoxylin 并且曙红染色因为显微镜的 examination.Results 大多数 CFAE 区域在正确上级是局部性的肺的象限,远侧的冠的湾穴(CSd ) 象限,和近似冠的湾穴(CSp ) 象限(21.74% ,独立) 。弄短的湾穴节奏周期长度(SCL ) 没在这些地点在脱离以后显著地减少,包括正确 atrial 附器,左 atrial 附器, CSd,和 CSp (P 0.05 ) 。显著地在 vagal 刺激期间弄短的 ERP 在脱离(P 0.01 ) 以后减少了;到 vagal 刺激的 VW 显著地在脱离(P 0.05 ) 以后减少了。在 ablation.Conclusions CFAE 以后改变的单个 ganglia 的建筑学在狗有一个自治基础。在 CFAE 脱离以后弄短到 vagal 刺激的减少的 SCL 和 ERP 证明那 CFAE 脱离稀释 vagal 调整到正厅,从而压制 AF 由提高的 vagal 调停了活动。CFAE 脱离能压制 AF 由提高的 vagal 调停了活动。 | ZHANG Shu-long DONG Ying-xue JIANG Peng GAO Lian-jun CHA Yong-mei Douglas L. Packer XIA Yun-long YIN Xiao-meng CHANG Dong YANG Yan-zong | 2010 | Chinese Medical Journal2010，，22： | 5 |
| 11 | Propofol enhances the field excitatory postsynaptic potentials in CA1 hippocampal slices of young and aged mice显示文摘 | Yin Yiqing William J Middleton Carlos M. Florez Peter L. Carlen Hossam EI-Beheiry | 2014 | Chinese Medical Journal2014，，1： | 3 |
| 12 | Simulation of a dendritic microstructure with the lattice Boltzmann and cellular automaton methods显示文摘 | H. Yin S.D. Felicelli L. Wang | 2011 | Acta Materialia2011，，8： | 2 |
| 13 | Genetic gains in grain yield, net photosynthesis and stomatal conductance achieved in Henan Province of China between 1981 and 2008显示文摘 | T.C. Zheng X.K. Zhang G.H. Yin L.N. Wang Y.L. Han L. Chen F. Huang J.W. Tang X.C. Xia Z.H. He | 2011 | Field Crops Research2011，，3： | 2 |
| 14 | Vascular Calcification: Pathobiology of a Multifaceted Disease显示文摘 | Linda L. Demer Yin Tintut | 2008 | Circulation2008，，22： | 2 |
| 15 | Functions of autophagy in normal and diseased liver显示文摘 | Mark J. Czaja Wen-Xing Ding Terrence M. Donohue Scott L. Friedman Jae-Sung Kim Masaaki Komatsu John J. Lemasters Antoinette Lemoine Jiandie D. Lin Jing-hsiung James Ou David H. Perlmutter Glenn Randall Ratna B. Ray Allan Tsung Xiao-Ming Yin | 2013 | Autophagy2013，，8： | 2 |
| 16 | MR elastography of the human abdominal aorta: A preliminary study显示文摘 | Lei Xu Jun Chen Kevin J. Glaser Meng Yin Phillip J. Rossman Richard L. Ehman | 2013 | J. Magn. Reson. Imaging2013，，： | 1 |
| 17 | Key Points in Design of the Sheet Space Structure System显示文摘 | H. L. Zhao C. Q. Zhao Y. H. She X. M. Guo L. F. Yin | 2009 | International Journal of Space Structures2009，，3： | 1 |
| 18 | <ce:link locator='fx1'/> Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells显示文摘 | Stuart A.C. McDonald Laura C. Greaves Lydia Gutierrez–Gonzalez Manuel Rodriguez–Justo Maesha Deheragoda Simon J. Leedham Robert W. Taylor Chung Yin Lee Sean L. Preston Matthew Lovell Toby Hunt George Elia Dahmane Oukrif Rebecca Harrison Marco R. Novelli I | 2008 | Gastroenterology2008，，2： | 1 |
| 19 | Vascular calcification and its relation to bone calcification: Possible underlying mechanisms显示文摘 | Nilam Mody Yin Tintut Kristen Radcliff Linda L. Demer | 2003 | Journal of Nuclear Cardiology2003，，2： | 1 |
| 20 | Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography显示文摘 | Meng Yin Jayant A. Talwalkar Kevin J. Glaser Armando Manduca Roger C. Grimm Phillip J. Rossman Jeff L. Fidler Richard L. Ehman | 2007 | Clinical Gastroenterology and Hepatology2007，，10： | 1 |
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