|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma显示文摘AIM: To explore the expression pattern of E2F5 in primary hepatocellular carcinomas (HCCs) and elucidate the roles of E2F5 in hepatocarcinogenesis. METHODS: E2F5 expression was analyzed in 120 primary HCCs and 29 normal liver tissues by immunohistochemistry analysis. E2F5-small interfering RNA was transfected into HepG2, an E2F5-overexpressed HCC cell line. After E2F5 knockdown, cell growth capacity and migrating potential were examined. RESULTS: E2F5 was significantly overexpressed in primary HCCs compared with normal liver tissues (P = 0.008). The E2F5-silenced cells showed significantly reduced proliferation (P = 0.004). On the colony formation and soft agar assays, the number of colonies was significantly reduced in E2F5-silenced cells (P = 0.004 and P = 0.009, respectively). E2F5 knockdown resulted in the accumulation of G0/G1 phase cells and a reduction of S phase cells. The number of migrating/invading cells was also reduced after E2F5 knockdown (P = 0.021). CONCLUSION: To our knowledge, this is the first evidence that E2F5 is commonly overexpressed in primary HCC and that E2F5 knockdown significantly repressed the growth of HCC cells. | Yuzhu Jiang Seon-Hee Yim Hai-Dong Xu Seung-Hyun Jung So Young Yang Hae-Jin Hu Chan-Kwon Jung Yeun-Jun Chung | 2011 | World Journal of Gastroenterology2011，17，4： | 10 |
| 2 | Epigenetic inactivation of the MIR34B/C in multiple myeloma显示文摘 | Wong KY Yim RL So CC | 2011 | Blood2011，118，： | 1 |
| 3 | Coordinate control of growth and cytokeratin 13 expression by retinoic acid显示文摘 | Kim SY Berger D Yim SO | 1996 | Mol-Carcinog1996，16，1： | 1 |
| 4 | Epigenetic inactivationof the MIR34B/C in multiple myeloma显示文摘 | WONG K Y YIM R L SO C C | 2011 | Blood2011，118，22： | 1 |
| 5 | Epigenetic inactivation of theMIR34B/C in multiple myeloma显示文摘 | Wong KY Yim RL So CC | 2011 | Blood2011，118，22： | 1 |
| 6 | Epigenetic inactivation of the MIR34B/C in multiple myeloma显示文摘 | Wong KY Yim RL So CC | 2011 | Blood2011，118，22： | 1 |
| 7 | Glutamine protects mice from acute graft-versus-host disease (aGVHD)显示文摘 | Eun-Kee Song Jun-Mo Yim Joo-Yun Yim Min-Young Song Hye-Won Rho Sung Kyun Yim Yeon-Hee Han So Yeon Jeon Hee Sun Kim Ho-Young Yhim Na-Ri Lee Jae-Yong Kwak Myung-Hee Sohn Ho Sung Park Kyu Yun Jang Chang-Yeol Yim | 2013 | Biochemical and Biophysical Research Communications2013，，1： | 1 |
| 8 | Free radicals generated during the glycation reaction of amino acids by ethylglyoxal: A model study of protein-erosslinked free radicals 显示文摘 | HS Yim SO Kang YC Hah | 1995 | The Journal of Biological Chemistry1995，270，28： | 1 |
| 9 | Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea显示文摘Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in Korea.We compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate(GFR).We extracted data of patients who took statin for the first time.We analyzed whether or not different statins affect the changes in GFR at 3 months after baseline and 4 years after.We included 3678 patients and analyzed the changes in GFR.The GFR decreased by 3.2%±0.4%on average 4 years after the first statin prescription,indicating statistically significant deterioration(from 83.5±0.4 mL/min/1.73 m2 to 79.9±0.4 mL/min/1.73 m2,P<0.001).When comparing the GFR among different statins,significant differences were observed between atorvastatin and fluvastatin(−5.3%±0.7%vs.1.2%±2.2%,P<0.05)and between atorvastatin and simvastatin(−5.3%±0.7%vs.−0.7%±0.8%,P<0.05).In pitavastatin(odds ratio[OR]=0.64,95%confidence interval[CI]=0.46-0.87,P<0.005)and simvastatin(OR=0.69,95%CI=0.53-0.91,P<0.008),the GFR rate that decreased by<60 mL/min/1.73 m2 was significantly lower than that of atorvastatin.Regarding long-term statin intake,GFR changed with the type of statin.This work is the first in Korea to compare each statin in terms of changes in the GFR after the statin prescription. | Seo Yeon Baik Hyunah Kim So Jung Yang Tong Min Kim Seung-Hwan Lee Jae Hyoung Cho Hyunyong Lee Hyeon Woo Yim Kun-Ho Yoon Hun-Sung Kim | 2019 | Frontiers of Medicine2019，13，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员