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| 1 | A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres显示文摘The object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time(37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temperatures with magnetic stirring to further accelerate the release. Second, the most similar profile at elevated temperatures with the real time release was chosen with the help of the n value in the fitted Korsmeyer-Peppas Function. Third,the Weibull function and conversion ratio were used to deduce the function of real time release according to the chosen profile at elevated temperatures. The key point in this study was to provide a quick and precise method to predict the real time release for long acting progesterone PLGA microspheres. So the elevated temperatures coupled with magnetic stirring were used to accelerate the release further, and when there have many similar release profiles with the real time release at elevated temperatures, releasing time at elevated temperatures and the R2 of the final deduced function will be used to help choosing the most similar release profile with the real time release. Four different types of progesterone PLGA microspheres were used to verify the method, and all the deduced function correlated well with the real time releases, for R2 = 0.9912, 0.9781, 0.9918 and 0.9972, respectively. | Mingzhu Ye Hongliang Duan Lixia Yao Yicheng Fang Xiaoyu Zhang Ling Dong Feifei Yang Xinggang Yang Weisan Pan | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 3 |
| 2 | Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways显示文摘The immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage,thus acting as a fortress of the body.However,excessive responses cause detrimental effects,such as inflammation and autoimmune diseases.To balance the immune responses and maintain immune homeostasis,there are immune checkpoints to terminate overwhelmed immune responses.Pathogens and tumor cells can also exploit immune checkpoint pathways to suppress immune responses,thus escaping immune surveillance.As a consequence,therapeutic antibodies that target immune checkpoints have made great breakthroughs,in particular for cancer treatment.While the overall efficacy of immune checkpoint blockade(ICB)is unsatisfactory since only a small group of patients benefted from ICB treatment.Hence,there is a strong need to search for other targets that improve the efficacy of ICB.Ubiquitination is a highly conserved process which participates in numerous biological activities,including innate and adaptive immunity.A growing body of evidence emphasizes the importance of ubiquitination and its reverse process,deubiquitination,on the regulation of immune responses,providing the rational of simultaneous targeting of immune checkpoints and ubiquitination/deubiquitination pathways to enhance the therapeutic efficacy.Our review will summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity,and discuss therapeutic significance of targeting ubiquitination/deubiquitination pathways in the future of immunotherapy. | Jiaxin Liu Yicheng Cheng Ming Zheng Bingxiao Yuan Zimu Wang Xinying Li Jie Yin Mingxiang Ye Yong Song | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 3 | Crack evolution of soft–hard composite layered rock-like specimens with two fissures under uniaxial compression显示文摘Acoustic emission and digital image correlation were used to study the spatiotemporal evolution characteristics of crack extension of soft and hard composite laminated rock masses(SHCLRM)containing double fissures under uniaxial compression.The effects of different rock combination methods and prefabricated fissures with different orientations on mechanical properties and crack coalescence patterns were analyzed.The characteristics of the acoustic emission source location distribution,and frequency changes of the crack evolution process were also investigated.The test results show that the damage mode of SHCLRM is related to the combination mode of rock layers and the orientation of fractures.Hard layers predominantly produce tensile cracks;soft layers produce shear cracks.The first crack always sprouts at the tip or middle of prefabricated fractures in hard layers.The acoustic emission signal of SHCLRM with double fractures has clear stage characteristics,and the state of crack development can be inferred from this signal to provide early warning for rock fracture instability.This study can provide a reference for the assessment of the fracture development status between adjacent roadways in SHCLRM in underground mines,as well as in roadway layout and support. | Dong ZHOU Yicheng YE Nanyan HU Weiqi WANG Xianhua WANG | 2021 | Frontiers of Structural and Civil Engineering2021，15，6： | 2 |
| 4 | RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis显示文摘Acetylcholinesterase (疼痛) 表示可以在各种各样的房间类型在 apoptosis 期间被导致。这里,我们使用了疼痛的 C 终端屏蔽人的胎儿的大脑图书馆并且发现它在组织微导管的中心(RanBPM ) 与跑绑定蛋白质交往了。这个相互作用被 coimmunoprecipitation 分析进一步证实。在 HEK293T 房间, RanBPM 和疼痛不同类地在 cisplatin 未经治疗的细胞质的摘录并且在对待 cisplatin 的细胞质或原子的摘录被表示。我们用词法方法执行的以前的研究在 apoptosis 期间从细胞质显示出那疼痛 translocates 到原子核。一起拿,这些结果建议 RanBPM 是在 apoptosis 期间是从进原子核的细胞质的 translocated 的交往疼痛的蛋白质,类似于在疼痛的情况下观察的 translocation。 | Xiaowen Gong Weiyuan Ye Haibo Zhou Xiaohui Ren Zhigang Li Weiyin Zhou Jun Wu Yicheng Gong Qi Ouyang Xiaolin Zhao Xuejun Zhang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，11： | 2 |
| 5 | The first discovery of eclogite and Palaeoproterozoic granitoids in the Beishan area,northwestern Gansu Province,China显示文摘The eclogite, discovered in Liuyuan, occurs as lenticular enclave within granitic gneiss. It has typical features of eclogite in petrology and mineralogy. The eclogite provides an important wirdow to reconstruct the tectonic border of the Tarim block. The granitoids, located in Baihu area, yield U-Pb zircon ages of 1 660—2 000 Ma (Palaeoproterozoic), which irrplies an early Precambrian basement in the area. | Hualin Mei Haifeng Yu Quan Li Songnian Lu Huimin Li Yicheng Zuo Guochao Zuo Dejin Ye Jincheng Liu | 1999 | Chinese Science Bulletin1999，44，4： | 1 |
| 6 | A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research显示文摘 | Yuanbo Feng Yi Xie Huaijun Wang Feng Chen Yuxiang Ye Lixin Jin Guy Marchal Yicheng Ni | 2009 | The International Journal of Cardiovascular Imaging2009，，3： | 1 |
| 7 | Simulation on mine water-in- rush characteristics of cross roadway based on CFX 显示文摘 | Wang Qin Ye Yicheng Jiang Ying | 2011 | Procedia Engineering2011，26，： | 1 |
| 8 | A particle Swarm optmization approach based on Monte Carlo simulation for solving the complex network reliability problem显示文摘 | YE Weichang LIN Yicheng YU Yingchung | 2010 | IEEE Transactions on Reliability2010，59，1： | 1 |
| 9 | A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research显示文摘 | Yuanbo Feng Yi Xie Huaijun Wang Feng Chen Yuxiang Ye Lixin Jin Guy Marchal Yicheng Ni | 2009 | The International Journal of Cardiovascular Imaging2009，，3： | 1 |
| 10 | Experimental Study on the Heavy Metal Pollution in the Soil Irrigated by Reclaimed Water from Sewage Treatment Plant显示文摘Reclaimed water irrigation is one of the potential ways of solving the shortage of water resources,and the pollution risk on migration behavior of heavy metals in the soil which are irrigated by reclaimed water and the related soil surface is still short of research. Through the experimental study of different kinds of water irrigation methods on vegetable,it can be concluded that compared with sewage irrigation and tap water irrigation,reclaimed water irrigation does not pollute the soil,and it greatly saves the cost of water resources,and even provides a large number of growth elements for vegetables. The results show that after leaching by reclaimed water for 60 days,Cr,Cd,As,Hg,Pb,Ni,Zn and Cu from reclaimed water are enriched in soil to a certain degree,but with the leaching time extending,concentrations of the heavy metal remain stable. The variation of heavy metal content in soil irrigated by reclaimed water is small in vertical depth,basically showing a horizontal trend. According to Soil Environmental Quality Standards( GB15618- 1995),soil irrigated by reclaimed water does not exceed the standard,better than soil quality standard of planting vegetables. | Xing YAN Gang LUO Jian CAO Jiawen XU Shuang WANG Weihai YE Yicheng LIANG | 2015 | Asian Agricultural Research2015，7，6： | 0 |
| 11 | Amorphous silicon from low-temperature reduction of silica in the molten salts and its lithium-storage performance显示文摘Amorphous silicon(a-Si) is one of the most promising anode-materials for the lithium-ion battery owing to its large capacity and superior fracture resistance.However,a-Si is usually fabricated with the sophisticated chemical vapor deposition or pulse laser deposition in a limited scale.In this work,we have succes s fully pre pared a-Si spheres(~200 nm) by reducing the TiO2-coated silica spheres with Al powders in the molten salts at 300℃.The coated TiO2 layer acts as a protective layer for structural maintenance during the reduction and a precursor for doping.The doped Ti element may suppress the crystal growth of Si to facilitate the formation of a-Si.The observation with in-situ transmission electron microscopy(TEM) further reveals that lithiation kinetics of the synthesized a-Si is controlled by the interfacial reaction.The Li^(+) diffusivity in a-Si determined from the observation is in the order of 10^(-14) cm^(2)/s.The anode of a-Si spheres together with crystalline Si nanoparticles exhibits excellent electrochemical performance,delivering a reversible capacity of 1604 mAh/g at 4 A/g and a capacity retention of 78,3%after 500 cycles.The low temperature reduction process reported in this study provides a low-cost method to fabricate a-Si nanostructures as high-capacity durable anode materials. | Xi Huang Xuyun Guo Yicheng Ding Run Wei Shengnan Mao Ye Zhu Zhihao Bao | 2021 | Chinese Chemical Letters2021，32，2： | 0 |
| 12 | Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment显示文摘Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical applications.However,motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging.Herein,swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia amplification.By decomposing urea into carbon dioxide and ammonia,the designed proteomotors are endowed with self-propulsive capability,which leads to improved internalization and enhanced penetration in vitro.As a glutamine synthetase inhibitor,the loaded L-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells,resulting in local ammonia amplification.After intravesical instillation,the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse effects.We envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment. | Hao Tian Juanfeng Ou Yong Wang Jia Sun Junbin Gao Yicheng Ye Ruotian Zhang Bin Chen Fei Wang Weichang Huang Huaan Li Lu Liu Chuxiao Shao Zhili Xu Fei Peng Yingfeng Tu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 13 | A Deep Generative Model with Multiscale Features Enabled Industrial Internet of Things for Intelligent Fault Diagnosis of Bearings显示文摘Effective condition monitoring and fault diagnosis of bearings can not only maximize the life of rolling bearings and prevent unexpected shutdowns caused by equipment failures but also eliminate unnecessary costs and waste caused by excessive maintenance.However,the existing deep-learning-based bearing fault diagnosis models have the following defects.First of all,these models have a large demand for fault data.Second,the previous models only consider that single-scale features are generally less effective in diagnosing bearing faults.Therefore,we designed a bearing fault data collection platform based on the Industrial Internet of Things,which is used to collect bearing status data from sensors in real time and feed it back into the diagnostic model.On the basis of this platform,we propose a bearing fault diagnosis model based on deep generative models with multiscale features(DGMMFs)to solve the above problems.The DGMMF model is a multiclassification model,which can directly output the abnormal type of the bearing.Specifically,the DGMMF model uses 4 different variational autoencoder models to augment the bearing data and integrates features of different scales.Compared with single-scale features,these multiscale features contain more information and can perform better.Finally,we conducted a large number of related experiments on the real bearing fault datasets and verified the effectiveness of the DGMMF model using multiple evaluation metrics.The DGMMF model has achieved the highest value under all metrics,among which the value of precision is 0.926,the value of recall is 0.924,the value of accuracy is 0.926,and the value of F1 score is 0.925. | He-xuan Hu Yicheng Cai Qiang Hu Ye Zhang | 2023 | Research2023，，3： | 0 |
| 14 | Interface bond degradation and damage characteristics of full-length grouted rock bolt in tunnels with high temperature显示文摘Full-length grouted bolts play a crucial role in geotechnical engineering thanks to their excellent stability.However,few studies have been concerned with the degrading performance of grouted rock bolts caused by extensive and continuous heat conduction from surrounding rocks in high-geothermal tunnels buried more than 100 m(temperature from 28C to 100C).To investigate the damage mechanism,we examined the time-varying behaviors of grouted rock bolts in both constant and variable temperature curing environments and their damage due to the coupling effects of high temperature and humidity through mechanical and micro-feature tests,including uniaxial compression test,pull-out test,computed tomography(CT)scans,X-ray diffraction(XRD)test,thermogravimetric analysis(TGA),etc.,and further analyzed the relationship between grout properties and anchorage capability.In order to facilitate a rapid assessment and control of the anchorage performance of anchors in different conditions,results of the interface bond degradation tests were correlated to environment parameters based on the damage model of interfacial bond stress proposed.Accordingly,a thermal hazard classification criterion for anchorage design in high-geothermal tunnels was suggested.Based on the reported results,although high temperature accelerated the early-stage hydration reaction of grouting materials,it affected the distribution and quantity of hydration products by inhibiting hydration degree,thus causing mechanical damage to the anchorage system.There was a significant positive correlation between the strength of the grouting material and the anchoring force.Influenced by the changes in grout properties,three failure patterns of rock bolts typically existed.Applying a hot-wet curing regime results in less reduction in anchorage force compared to the hot-dry curing conditions.The findings of this study would contribute to the design and investigations of grouted rock bolts in high-geothermal tunnels. | Yunpeng Hu Mingming Zheng Wenkai Feng Jianjun Tong Yicheng Wang Qiling Wang Kan Liu Longzhen Ye | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，10： | 0 |
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