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| 1 | GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons显示文摘我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。 | LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU | 2009 | 神经损伤与功能重建2009，4，4： | 25 |
| 2 | ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages显示文摘到巨噬细胞的不同类型的区别决定他们的不同功能。联系肿瘤的巨噬细胞(TAM ) 由于他们的 proangiogenic 和类似于那些的免疫者镇压的功能支持 tumorigenesis 或者激活(M2 ) 巨噬细胞。我们报导那反应的氧种类(ROS ) 生产为巨噬细胞区别和 superoxide 的那抑制是批评的(O 2−) 生产明确地堵住 M2 巨噬细胞的区别。我们发现当单核白血球被触发区分时, O 2− 为 biphasic 英皇家空军之阶级最低之兵激活被产生并且被需要,它为巨噬细胞区别是批评的。我们证明由 butylated hydroxyanisole (BHA ) 和另外的 ROS 禁止者的那 ROS 消除堵住巨噬细胞区别。然而,当房间被极化到时,巨噬细胞区别上的 ROS 消除的禁止的效果被克服古典主义地激活(M1 ) ,然而并非 M2,巨噬细胞。更重要地, ROS 禁止者 BHA 的连续管理高效地堵住了 TAM 的出现并且显著地在老鼠癌症模型压制了 tumorigenesis。由堵住 ROS 指向 TAM 能是为癌症治疗的一个潜在地有效的方法。 | Yan Zhang Swati Choksi Kun Chen Yelena Pobezinskaya Ilona Linnoila Zheng-Gang Liu | 2013 | Cell Research2013，23，7： | 12 |
| 3 | Women's willingness to be tested for human immunodeficiency virus during pregnancy: A review显示文摘Mother-to-child-transmission of human immunodeficiency virus(HIV) is a primary cause of pediatric infections with HIV. Many of these infections involve women who were not tested early enough in pregnancy, or who didnot receive prevention services. HIV testing of pregnant women is considered to be one of the key strategies for preventing mother-to-child-transmission of HIV, but HIV testing rates among pregnant women in various countries remain suboptimal. Understanding the factors relating to women's willingness to be tested for HIV during pregnancy is critical for developing strategies to increase HIV testing rates among pregnant women. Extensive research points to various factors relating to women's willingness to be tested for HIV during pregnancy, and various recommendations aimed at improving testing rates among pregnant women have been suggested based on the research. In light of the goals set by the United Nations to reduce the rate of infants infected with HIV, it is necessary to summarize what is currently known regarding factors related to women's willingness to be tested for HIV during pregnancy. The purpose of this review is therefore to examine factors related to women's willingness to be tested for HIV during pregnancy, and to summarize recommendations for practice and further research. | Merav Ben-Natan Yelena Hazanov | 2015 | World Journal of Virology2015，4，3： | 4 |
| 4 | Genetics in Keratoconus: where are we?显示文摘Keratoconus(KC)is a non-inflammatory thinning and protrusion of the cornea in which the cornea assumes a conical shape.Complex etiology of this condition at present remains an enigma.Although environmental factors have been involved in KC pathogenesis,strong underlining genetic susceptibility has been proven.The lack of consistent findings among early genetic studies suggested a heterogeneity and complex nature of the genetic contribution to the development of KC.Recently,genome-wide linkage studies(GWLS)and genome-wide association studies(GWAS)were undertaken.Next-generation sequencing(NGS)-based genomic screens are also currently being carried out.Application of these recently developed comprehensive genetic tools led to a much greater success and increased reproducibility of genetic findings in KC.Involvement of the LOX gene identified through GWLS has been confirmed in multiple cohorts of KC patients around the world.KC susceptibility region located at the 2q21.3 chromosomal region near the RAB3GAP1 gene identified through GWAS was independently replicated.Rare variants in the ZNF469 gene(mutated in corneal dystrophy Brittle Cornea Syndrome)and in the TGFBI gene(mutated in multiple corneal epithelial–stromal TGFBI dystrophies)have been repeatedly identified in familial and sporadic KC patients of different ethnicities.Additional comprehensive strategies using quantitative endophenotypes have been successfully employed to bring further understanding to the genetics of KC.Additional genetic determinants including the COL5A1 gene have been identified in the GWAS of KC-related trait central corneal thickness.These recent discoveries confirmed the importance of the endophenotype approach for studying complex genetic diseases such as KC and showed that different connective tissue disorders may have the same genetic determinants. | Yelena Bykhovskaya Benjamin Margines Yaron S.Rabinowitz | 2016 | Eye and Vision2016，3，1： | 2 |
| 5 | Anti - viral activity, of red microalgal polysaccharides against retrovims显示文摘 | Marina M Talyshinsky Yelena Y Souprun Mahmoud M Huleihel | 2002 | Caner Cell Int2002，2，： | 1 |
| 6 | Mutation in TRMU Related to Transfer RNA Modification Modulates the Phenotypic Expression of the Deafness-Associated Mitochondrial 12S Ribosomal RNA Mutations显示文摘 | Min-Xin Guan Qingfeng Yan Xiaoming Li Yelena Bykhovskaya Jaime Gallo-Teran Petr Hajek Noriko Umeda Hui Zhao Gema Garrido Emebet Mengesha Tsutomu Suzuki Ignacio del Castillo Jennifer Lynne Peters Ronghua Li Yaping Qian Xinjian Wang Ester Ballana Mordechai | 2006 | The American Journal of Human Genetics2006，，2： | 1 |
| 7 | Footprint handover rerouting protocol for low Earth orbit satellite networks显示文摘 | Hüseyin Uzunalio?lu Ian F. Akyildiz Yelena Yesha Wei Yen | 1999 | Wireless Networks1999，，5： | 1 |
| 8 | Pesticides and PCBs in sediments and fish from the Salton Sea California,USA显示文摘 | Yelena Sapozhnikova Ola Bawardi Daniel Schlenk | 2004 | Chemosphere2004，55，79： | 1 |
| 9 | Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy显示文摘 | David Yarnitsky Michal Granot Hadas Nahman-Averbuch Mogher Khamaisi Yelena Granovsky | 2012 | Pain2012，，6： | 1 |
| 10 | S1152 Early Infliximab Infusion in Hospitalized Severe UC Patients: One Year Outcome显示文摘 | Mukund Venu Amar S. Naik Ashwin N. Ananthakrishnan Yelena Zadvornova Susan Skaros Kathryn Johnson Lilani P. Perera David G. Binion Mazen Issa | 2009 | Gastroenterology2009，，5： | 1 |
| 11 | Impact of Autonomic Dysfunction on Inflammatory Bowel Disease显示文摘 | Ashwin N. Ananthakrishnan Mazen Issa Alexandru Barboi Safwan Jaradeh Yelena Zadvornova Sue Skaros Kathryn Johnson Mary F. Otterson David G. Binion | 2010 | Journal of Clinical Gastroenterology2010，，： | 1 |
| 12 | The use of RO to remove emerging micropollutants following CAS/UF or MBR treatment of municipal wastewater显示文摘 | Eyal Sahar Inbal David Yelena Gelman Haim Chikurel Avi Aharoni Rami Messalem Asher Brenner | 2010 | Desalination2010，，1： | 1 |
| 13 | Intravenous immunoglobulin-associated acute renal failure: Case series and literature review 显示文摘 | Yelena M Itkin Pharm D Toby C | 2005 | Pharmacotherapy2005，25，6： | 1 |
| 14 | Combination of Ozonation and the Fenton Processes for Landfill Leachate Treatment: Evaluation of Treatment Efficiency显示文摘 | Anna Goi Yelena Veressinina Marina Trapido | 2009 | Ozone: Science & Engineering2009，，1： | 1 |
| 15 | QTL analysis for capsaicinoid content in Capsicum显示文摘 | Arnon Ben-Chaim Yelena Borovsky Matthew Falise Michael Mazourek Byoung-Cheorl Kang Ilan Paran Molly Jahn | 2006 | Theoretical and Applied Genetics2006，，8： | 1 |
| 16 | Oral antidiabetic medication adherence and glycemic control in managed care显示文摘 | Yelena R Jacquelyn S Craig P eta1 | 2008 | Am J Manage Care2008，14，2： | 1 |
| 17 | Dose-Dependent Effect of Statins on the Incidence of Acute Kidney Injury After Cardiac Surgery显示文摘 | Salima Mithani Michael Kuskowski Yelena Slinin Areef Ishani Edward McFalls Selcuk Adabag | 2011 | The Annals of Thoracic Surgery2011，，2： | 1 |
| 18 | Concentrationdependent inhibition of Escherichia coli 0157:H7 and heterocyclic amines in heated ground beef patties by apple and olive extracts,onion powder and clove bud oil显示文摘 | LILIANA R HAVENS C M YELENA F | 2013 | Meat Science2013，94，4： | 1 |
| 19 | Regeneration of Pancreatic β cell from Intra-Islet Precursor Cells in an Experimental Model of Diabetes显示文摘 | Yelena Guz Irem Nasir Gladys teitelman | | Endocrinology0，142，11： | 1 |
| 20 | The effect of CD28/B7 blockade of alloreactive T and B cells after liver cell transplantation 显示文摘 | Bhoompally Reddy Sanjeev Gupta Yelena Chuzhin | 2001 | Transplantation2001，71，： | 1 |
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