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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 3 | Diversity among selected Vigna angularis (Azuki) accessions on the basis of RAPD and AFLP markers显示文摘 | Yee E Kidwell K K Sills G R | 1999 | Crop Science1999，39，： | 2 |
| 4 | Numerical solution of initial boundary value problems involving Maxwell's equations in isotropic media显示文摘 | Yee K S | 1996 | IEEE AP1996，14，5： | 2 |
| 5 | 显示文摘 | Gomes V G Yee K W K | 2002 | Separation and Purification Technology2002，28，： | 1 |
| 6 | Buckytubes and derivatives:their growth and implications for buckyball formation显示文摘 | DRAVID V P LIN X WANG X K YEE A KETTERSON J B CHANG R P H | 1993 | Science1993，259，： | 1 |
| 7 | Numerical solution of initial boundary value problems involving Maxwell's equations in isotropic media显示文摘 | Yee K S | 1966 | IEEE Transaction on Antennas and Propagation1966，14，5： | 1 |
| 8 | Conformal Finite-Difference time-domain (FDTD) with overlapping grids显示文摘 | K S Yee Jei Shuan Chen and Albert H Chang | 1992 | IEEE Transactions on Antennas and Propagation1992，40，9： | 1 |
| 9 | A numerical example of a two dimensional scattering problem using a subgrid显示文摘 | Kasher J C Yee K S | 1987 | Applied Computational Electromagnetic Society Journal and Newsletter1987，2，2： | 1 |
| 10 | Forward kinematics solution of stewartplatform using neural networks 显示文摘 | YEE C S LIM K B | 1997 | Neurocomputing1997，16，3： | 1 |
| 11 | Numerical solution of initial boundary value problem involving Maxell equations in isotropic media显示文摘 | YEE K S | 1966 | IEEE Trans Antennas Propagate1966，14，3： | 1 |
| 12 | Effects microcarrier pore characteristics on methanogenic fluidized bed performance显示文摘 | Yee C J Hsu Y Shieh W K | 1992 | Water Res1992，26，8： | 1 |
| 13 | Epidemiology of colorectal cancer in Asia 显示文摘 | Yee Y K Tan V P Chan P | 2009 | J Gastroenterol Hepatol2009，24，12： | 1 |
| 14 | Numerical solution of initial boundary value problems involving maxwell' s equation in isotropie media 显示文摘 | Yee K S | 1966 | IEEE Trans Antennas Propagation1966，14，3： | 1 |
| 15 | Numerical solution of initial boundary value problems involving Maxwell’s equations in isotropic media显示文摘 | YEE K S | | 0，，03： | 1 |
| 16 | An evaluation of color-spatial retrieval techniques for large image databases显示文摘 | Tan K L Ooi B C Yee C Y | | 0，，01： | 1 |
| 17 | IEEE Trans显示文摘 | | 1966 | Antenna Propagation1966，14，： | 1 |
| 18 | Forward kinematics solution of stewart platform using neural networks显示文摘 | Yee C S Lim K B | 1997 | Neurocomuting1997，16，3： | 1 |
| 19 | Numerical solution of initial boundary value problems involving Maxwell's equations in isotropic media显示文摘 | Yee K S | 1966 | IEEE Trans on Antennas and Propagation1966，14，3： | 1 |
| 20 | TANMEI/EMB2757 encodes a WD repeat protein required for embryo development in Arabidopsis显示文摘 | YAMAGISHI K NAGATA N YEE K M | | Plant Physiol0，139，1： | 1 |
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