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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Diversity among selected Vigna angularis (Azuki) accessions on the basis of RAPD and AFLP markers显示文摘 | Yee E Kidwell K K Sills G R | 1999 | Crop Science1999，39，： | 2 |
| 4 | Simultaneous optimization models for heat integration ( Ⅰ ):Area and energy targeting and modeling of multistream exchangers显示文摘 | Yee T F Grossmann I E Kravaanja Z | 1990 | Computers and Chemical Engineering1990，14，10： | 1 |
| 5 | Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells显示文摘 | Park S E Choi H J Yee S B | 2004 | Int J Oncol2004，25，1： | 1 |
| 6 | Effects of finite length in solid - rotor induction machines显示文摘 | Yee H Sc B E B | 1971 | PROC lEE1971，118，8： | 1 |
| 7 | Evaluation of the performance of error correcting codes on a Gilbert channel显示文摘 | Yee J R Weldon E J | 1995 | IEEE Trans Communications1995，43，8： | 1 |
| 8 | Expression of cell cycle regulators p57KIP2, cyclin D1, and cyclin E in epithelial ovarian tumors and survival 显示文摘 | Rosenberg E Zeleniuch- Jacquotte A Yee H | 2001 | Human Pathology2001，32，8： | 1 |
| 9 | Sim- ulatneous optimization models for heat integration -Ⅰ:area and energy targeting and modeling of multi-stream exchangers 显示文摘 | YEE T F GROSSMAN I E KRAVANJA Z | 1990 | Comput Chem Eng1990，14，10： | 1 |
| 10 | Neoadjuvant chemotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer显示文摘 | Newman E Marcus SG Potmesil M Sewak S Yee H Sorich J | 2002 | J Gastrointest Surg2002，6，22： | 1 |
| 11 | Simulatneous opti- mization models for heat integration - Ⅱ:heat exchanger network synthesis 显示文摘 | YEE T F GROSSMANN I E | 1990 | Comput Chem Eng1990，14，10： | 1 |
| 12 | High serum oestradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen-thawed embryo transfer cycles显示文摘 | YU-NG E H YEUNG W S YEE LAN LAU E | 2000 | Hum Reprod2000，15，2： | 1 |
| 13 | Bayesian inference for source determination with applications to a complex urban environment 显示文摘 | Keats A Yee E Lien F S | 2007 | Atrnospheric Environment2007，41，： | 1 |
| 14 | Computer simulation of nonlinear coupling of high-power microwaves with slots显示文摘 | Sieger G E Yee J H Mayhall D J | 1989 | IEEE Transactions on Plasma Science1989，17，4： | 1 |
| 15 | Evaluation of the Performance of Error Correcting Codes on a Gilbert Channel 显示文摘 | Yee J R Weldon E J | 1995 | IEEE Trans Communications1995，43，8： | 1 |
| 16 | A rapid decline in serum estradiol concentrations around the mid - luteal phase had no adverse effect on outcome in 763 assisted reproduction cycles 显示文摘 | Hung Yu Ng E Shu Biu Yeung W Yee Lan Lau E | 2000 | Hum Reprod2000，15，9： | 1 |
| 17 | A monoclonal antibody to β1 integrin(CD29)stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelialcells and matrix components显示文摘 | Kovach NL Carlos TM Yee E | 1992 | J Cell Biol1992，116，： | 1 |
| 18 | Large-eddy simulation of turbulent heat convection in a spanwise rotating channel flow显示文摘 | Xun Q Q Wang B C Yee E | 2011 | International Journal of Heat and Mass Transfer2011，54，1： | 1 |
| 19 | Podocyte detachment in type 2 diabetic nephropathy 显示文摘 | Weil E J Lemley K V Yee B | 2011 | Am J Nephrol2011，33，1： | 1 |
| 20 | Effects of finite length in solid-rotor induction machines显示文摘 | Yee H Sc B E B | 1971 | PROC IEE1971，118，8： | 1 |
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