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| 1 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 2 | Nonexistence of positive singular solutions for a class of semilinear elliptic systems显示文摘 | | 1996 | Electronic journal of differential equations1996，，8： | 1 |
| 3 | Prevalence of thyroid cancer in muhinodular goiter versus single nodule: a systematic review and meta-analysis显示文摘 | Brito JP Yarur A J Prokop LJ | 2013 | Thyroid2013，23，： | 1 |
| 4 | Prevalence of thyroid cancer in multinodular goiter versus single nodule: a systematic review and meta-analysis显示文摘 | Brito JP Yarur A J Prokop LJ | 2003 | Thyroid2003，23，4： | 1 |
| 5 | Tu1147 Serum Adalimumab Levels and Antibodies Correlate With Endoscopic Intestinal Inflammation and Inflammatory Markers in Patients With Inflammatory Bowel Disease显示文摘 | Andres J. Yarur Amar R. Deshpande Daniel A. Sussman Scott Hauenstein Steven Lockton Jamie S. Barkin Sharat Singh Maria T. Abreu | 2013 | Gastroenterology2013，，5： | 1 |
| 6 | Prevalence of thyroid cancer in muhinodular goiter versus single nodule: a systematic review and meta-analysis 显示文摘 | Brito JP Yarur A J Prokop LJ | 2013 | Thyroid2013，23，4： | 1 |
| 7 | Prevalence of thyroid cancer in multinodular goiter versus single nodule:a systematic review and meta-analysis显示文摘 | Brito JP Yarur AJ Prokop LJ | 2013 | Thyroid2013，23，4： | 1 |
| 8 | Prevalence of thyroid cancer in multinodular goiter versus single nodule:a systematic review and meta-analysis显示文摘 | Brito JP Yarur AJ Prokop LJ | 2013 | Thyroid2013，23，4： | 1 |
| 9 | Nonexistence of positive singular solutions for a class of semilinear elliptic systems显示文摘 | Yarur C S | 1996 | Electronic Journal of Differential Equations1996，，8： | 1 |
| 10 | Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease显示文摘BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory disease.Unfortunately,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional surgeries.With advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential limitations.Firstly,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after surgery.This strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off therapy.Consequently,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting of manuscript and final approval of manuscript;Melmed GY,Yarur AJ,Fleshner P,Kallman C and Devkota S were involved in study concept and design,data interpretation,drafting of manuscript and final approval of manuscript;Vasiliauskas EA,Bonthala N,Syal G,Ziring D and Targan SR were involved in data interpretation,drafting of manuscript and final approval of manuscript;Rabizadeh S was involved in study concept and design,drafting of manuscript and final approval of manuscript;McGovern DPB was involved in concept and design,statistical analysis,drafting of manuscript and final approval of manuscript. | Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern | 2024 | World Journal of Gastrointestinal Surgery2024，16，3： | 0 |
| 11 | 威利剧院显示文摘正达拉斯演艺中心主席兼首席执行官Bill Lively说,'达拉斯演艺中心的创建是我们城市文化产业投资的一部分。演艺中心和表演公园会一道成为激动人心的全天候度假场所,这将会给达拉斯和整个地区带来活力。这个新的演艺中心将会让达拉斯及本地区的后代享受到来自于全世界的最好的音乐、戏剧、歌剧和舞蹈。'在传统的剧场中,与演出相关的附属空间的激增影响到了观演厅自身的空间。 | Haviland Argo Steve Chen Dan Choi Robert Donnelly Selva Gurdogan Jonathan Handel Stine Hansen Oke Hauser Andrew Heid Nahyun Hwang Ashley Klein Trine Kobbelvedt Natalia Ibanez Lario Soren Sigurd Larsen Mads Kristensen Filip Rem Beatriz Ramo Gro Sarauw Max Schwitalla Rooshad Shroff Gregers Tang Thomsen Lisa Tiedje Angelica Trevino Kristine Wander Monika Wittig Dolly Yarur 方朔 | 2012 | 建筑技艺2012，，4： | 0 |
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