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| 1 | miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro显示文摘Metastasis is a multistep process involving modification of morphology to suit migration, reduction of tumor cell adhesion to the extracellular matrix, increase of cell mobility, tumor cell resistance to anoikis, and other steps. MicroRNAs are well-suited to regulate tumor metastasis due to their capacity to repress numerous target genes in a coordinated manner, thereby enabling their intervention at multiple steps of the invasion-metastasis cascade. In this study, we identified a microRNA exemplifying these attributes, miR-124, whose expression was reduced in aggressive MDA-MB-231 and SK-3rd breast cancer cells. Down-regulation of miR-124 expression in highly aggressive breast cancer cells contributed in part to DNA hypermethylation around the promoters of the three genes encoding miR-124. Ectopic expression of miR-124 in MDA-MB-231 cells suppressed metastasis-related traits including formation of spindle-like morphology, migratory capacity, adhesion to fibronectin, and anoikis. These findings indicate that miR-124 suppresses multiple steps of metastasis by diverse mechanisms in breast cancer cells and suggest a potential application of miR-124 in breast cancer treatment. | Xiao-Bin Lv Yu Jiao Yanwei Qing Haiyan Hu Xiuying Cui Tianxin Lin Erwei Song Fengyan Yu | 2011 | Chinese Journal of Cancer2011，30，12： | 6 |
| 2 | TCP7 functions redundantly with several Class Ⅰ TCPs and regulates endoreplication in Arabidopsis显示文摘TCP(TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR) proteins, a family of plantspecific transcription factors, play important roles in many developmental processes. However, genetic and functional redundancy among class I TCP limits the analysis of their biological roles. Here, we identified a dominantnegative mutant of Arabidopsis thaliana TCP7 named leaf curling-upward(lcu), which exhibits smaller leaf cells and shorter hypocotyls than the wild type, due to defective endoreplication. A septuple loss-of-function mutant of TCP7, TCP8, TCP14, TCP15, TCP21, TCP22, and TCP23 displayed similar developmental defects to those of lcu.Genome-wide RNA-sequencing showed that lcu and the septuple mutant share many misexpressed genes.Intriguingly, TCP7 directly targets the CYCLIN D1;1 (CYCD1;1) locus and activates its transcription. We determined that the C-terminus of TCP7 accounts for its transcriptional activation activity. Furthermore, the mutant protein LCU exhibited reduced transcriptional activation activity due to the introduction of an EAR-like repressive domain at its C-terminus. Together, these observations indicate that TCP7 plays important roles during leaf and hypocotyl development, redundantly, with at least six class I TCPs, and regulates the expression of CYCD1;1 to affect endoreplication in Arabidopsis. | Guofang Zhang Hongtao Zhao Chunguang Zhang Xiaoyun Li Yuanyuan Lyu Dongmei Qi Yanwei Cui Lin Hu Zhenjie Wang Zheng Liang Sujuan Cui | 2019 | Journal of Integrative Plant Biology2019，61，11： | 5 |
| 3 | Literature Review on Wireless Sensing Wi-Fi Signal-Based Recognition of Human Activities显示文摘With the rapid development and wide deployment of wireless technology, Wi-Fi signals have no longer been confined to the Internet as a communication medium. Wi-Fi signals will be modulated again by human actions when propagating indoors, carrying rich human body state information. Therefore, a novel wireless sensing technology is gradually emerging that can realize gesture recognition, human daily activity detection, identification,indoor localization and human body tracking, vital signs detection, imaging, and emotional recognition by extracting effective feature information about human actions from Wi-Fi signals. Researchers mainly use channel state information or frequency modulated carrier wave in their current implementation schemes of wireless sensing technology, called 'Walls have eyes', and these schemes cover radio-frequency technology, signal processing technology, and machine learning. These available wireless sensing systems can be used in many applications such as smart home, medical health care, search-and-rescue, security, and with the high precision and passively device-free through-wall detection function. This paper elaborates the research actuality and summarizes each system structure and the basic principles of various wireless sensing applications in detail. Meanwhile, two popular implementation schemes are analyzed. In addition, the future diversely application prospects of wireless sensing systems are presented. | Chao Wang Siwen Chen Yanwei Yang Feng Hu Fugang Liu Jie Wu | 2018 | Tsinghua Science and Technology2018，23，2： | 5 |
| 4 | Violent offences of methamphetamine users and dilemmas of forensic psychiatric assessment显示文摘Methamphetamine(MA),an extremely addictive synthetic stimulant,has quickly spread to become the most frequently used illicit drug in China.People with a history of chronic and heavy MA use have a high possibility of exhibiting schizophrenia-like psychotic symptoms,mainly delusions of reference,auditory hallucinations and cognitive deficits.These emerging findings suggest MA use increases aggression and violence and that there is a correlation between MA use and violence.However,it is unclear how to assess the capacity of criminal responsibility in“MA-induced”psychosis and how to set clear boundaries between schizophrenia and MA-induced psychosis when only limited and inconsistent evidence is available.Furthermore,a final persuasive differential diagnostic method based on improved understanding of schizophrenia and MA-induced psychotic disorders has yet to be developed.This paper will evaluate the epidemiology,social harm,and forensic psychiatric assessment of MA users,propose a future direction for the differential diagnosis between MA-induced psychotic disorders and schizophrenia,and put forward some practical solutions to assess the capacity of criminal responsibility of defendants with drug-induced psychotic disorder. | Yi Liu Bo Hao Yanwei Shi Li Xue Xiaoguang Wang Yefei Chen Hu Zhao | 2017 | Forensic Sciences Research2017，2，1： | 3 |
| 5 | Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive amine oxidase gene expression and activity in apolipoprotein E knockout mice显示文摘Semicarbazide 敏感的胺 oxidase (SSAO ) 催化主要的芳香、脂肪族的胺的氧化 deamination。增加的 SSAO 活动在动脉粥样硬化和糖尿病 mellitus 被发现了。我们假设肝 X 受体(LXR ) 的 anti-atherogenic 效果可能与 SSAO 基因表示和它的活动的抑制有关。在这研究,我们在 apolipoprotein E 大美人在 SSAO 基因表示和它的活动上调查了 LXRagonist T0901317 的效果(apoE /) 老鼠。男 apoE / 老鼠(8 个星期旧) 随机被划分成四个组:基础控制组;车辆组;预防组;并且处理组。SSAO 基因表示被即时量的聚合酶链反应分析,它的活动是坚定的。superoxide dismutase 的活动和在主动脉和肝的 malondialdehyde 的内容也是坚定的。在对待 T0901317 的鼠标, SSAO 基因表示显著地在主动脉,肝,小肠,和大脑被减少。在浆液并且在这些纸巾的 SSAO 活动也被禁止。在预防组和处理组的主动脉和肝的 superoxide dismutase 的数量与车辆组相比是显著地更高的(P < 0.05 ) 。在这二个组的纸巾的 Malondialdehyde 与车辆组相比是显著地更低的(P < 0.05 ) 。我们的结果证明 T0901317 在 atherogenic apoE / 老鼠禁止 SSAO 基因表示和它的活动。LXR 收缩筋 T0901317 的 atheroprotective 效果与 SSAO 基因表示和它的活动的抑制有关。 | Xiaoyan Dai Xiang Ou Xinrui Hao Dongli Cao Yaling Tang Yanwei Hu Xiaoxu Li Chaoke Tang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 6 | Insulin sensitivity,βcell function,and adverse pregnancy outcomes in women with gestational diabetes显示文摘Background: The potential impact of β cell function and insulin sensitivity on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains uncertain. We aimed to investigate the association between β cell dysfunction, insulin resistance, and the composite adverse pregnancy outcomes.Methods: This observational study included 482 women diagnosed with GDM during pregnancy. Quantitative metrics on β cell function and insulin sensitivity during pregnancy were calculated using traditional equations. The association of β cell dysfunction and insulin resistance with the risk of the composite adverse pregnancy outcomes was investigated using multivariable-adjusted logistic regression models.Results: Multivariable-adjusted odds ratios (ORs) of adverse pregnancy outcomes across quartiles of homeostatic model assessment for insulin resistance (HOMA-IR) were 1.00, 0.95, 1.34, and 2.25, respectively (P for trend = 0.011). When HOMA-IR was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 1.34 (95% confidence interval 1.16-1.56) for each 1-unit increase in HOMA-IR. Multivariable-adjusted ORs of adverse pregnancy outcomes across quartiles of homeostatic model assessment for β cell function (HOMA-β) were 1.00, 0.51, 0.60, and 0.53, respectively (P for trend = 0.068). When HOMA-β was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 0.57 (95% CI 0.24-0.90) for each 1-unit increase in HOMA-β. However, other quantitative metrics were not associated with the composite adverse pregnancy outcomes.Conclusions: We demonstrated a significant association of β cell function and insulin sensitivity with the risk of adverse pregnancy outcomes. We have provided additional evidence on the early identification of adverse pregnancy outcomes besides the glycemic values. | Yun Shen Yanwei Zheng Yingying Su Susu Jiang Xiaojing Ma Jiangshan Hu Changbin Li Yajuan Huang Yincheng Teng Yuqian Bao Minfang Tao Jian Zhou | 2022 | Chinese Medical Journal2022，135，21： | 2 |
| 7 | Conserved and differentiated functions of CIK receptor kinases in modulating stem cell signaling in Arabidopsis显示文摘The shoot apical meristem(SAM)and root apical meristem(RAM)act as pools of stem cells that give rise to aboveground and underground tissues and organs in higher plants,respectively.The CLAVATA3(CLV3)-WUSCHEL(WUS)negative-feedback loop acts as a core pathway controlling SAM homeostasis,while CLV3/EMBRYO SURROUNDING REGION(ESR)40(CLE40)and WUSCHEL-RELATED HOMEOBOX5(WOX5),homologs of CLV3 and WUS,direct columella stem cell fate.Moreover,CLV3 INSENSITIVE KINASES(CIKs)have been shown to be essential for maintaining SAM homeostasis,whereas whether they regulate the distal root meristem remains to be elucidated.Here,we report that CIKs are indispensable for transducing the CLE40 signal to maintain homeostasis of the distal root meristem.We found that the cik mutant roots displayed disrupted quiescent center and delayed columella stem cell(CSC)differentiation.Biochemical assays demonstrated that CIKs interact with ARABIDOPSIS CRINKLY4(ACR4)in a ligand-independent manner and can be phosphorylated by ACR4 in vitro.In addition,the phosphorylation of CIKs can be rapidly induced by CLE40,which partially depends on ACR4.Although CIKs act as conserved and redundant regulators in the SAM and RAM,our results demonstrated that they exhibit differentiated functions in these meristems. | Yafen Zhu Chong Hu Yanwei Cui Li Zeng Sunjingnan Li Mingsong Zhu Fanhui Meng Shuting Huang Li Long Jing Yi Jia Li Xiaoping Gou | 2021 | Molecular Plant2021，14，7： | 2 |
| 8 | Hypoxia-Inducible Factor-1α C1772T Polymorphism and Cancer Risk: A Meta-Analysis Including 18,334 Subjects显示文摘 | Yanwei Ye Min Wang Shuang Hu Yingqiang Shi Xiefu Zhang Ye Zhou Chunlin Zhao Guojun Wang Jianguo Wen Hong Zong | 2014 | Cancer Investigation2014，，4： | 1 |
| 9 | Equivalent efficacy assessment of QL1101 and bevacizumab in nonsquamous non-small cell lung cancer patients:A two-year follow-up data update显示文摘Objective: Anti-vascular endothelial growth factor(VEGF) monoclonal antibodies are an effective means of treating non-small cell lung cancer(NSCLC). Here, we aim to update the equivalent efficacy assessment between QL1101 and bevacizumab based on two-year follow-up data.Methods: In total, 535 eligible NSCLC patients were enrolled in this randomized controlled trial. Patients were randomly assigned 1:1 to the QL1101 group and the bevacizumab group. The full end time of this study was defined as 24 months after the last enrolled patient was randomized. The primary endpoint was the objective response rate(ORR);equivalence was confirmed if the two-sided 90% confidence interval(90% CI) of the relative risk was within the range of 0.75-1.33. The secondary endpoints were progression-free survival(PFS) and overall survival(OS).Results: The two-year updated data showed similar ORR(QL1101 vs. bevacizumab: 53.1% vs. 54.3%;relative risk=0.977;90% CI: 0.838-1.144), PFS(235 d vs. 254 d, log-rank P=0.311), and OS(577 d vs. 641 d, log-rank P=0.099) results between the QL1101 group and the bevacizumab group. The mean shrinkage ratio of targeted lesions was also similar between the QL1101 group and the bevacizumab group(22.5% vs. 23.5%). For patients who received QL1101 maintenance therapy, similar results were shown between the QL1101 group(n=157) and the bevacizumab group(n=148)(PFS: 253 d vs. 272 d, log-rank P=0.387;OS: 673 d vs. 790 d, log-rank P=0.101;mean tumor shrinkage rate: 26.6% vs. 27.5%).Conclusions: This study reported that QL1101 had similar efficacy in treating nonsquamous NSCLC in terms of ORR, PFS and OS based on two-year updated data, providing a basis for the clinical application of QL1101. | Jun Lu Tianqing Chu Hongyu Liu Minjuan Hu Yuqing Lou Yanwei Zhang Zhiqiang Gao Wei Zhang Xueyan Zhang Huimin Wang Hua Zhong Baohui Han | 2022 | Chinese Journal of Cancer Research2022，34，1： | 1 |
| 10 | 帕博利珠单抗单药或联合化疗对PD-L1≥50%晚期NSCLC疗效的回顾性分析显示文摘目的该研究旨在评估及比较帕博利珠单抗联合含铂化疗(pembrolizumab plus platinum-based chemotherapy,PC)或帕博利珠单抗单药治疗(pembrolizumab monotherapy, PM)对程序性死亡配体1(programmed death ligand 1, PD-L1)肿瘤比例评分(tumor proportion score, TPS)≥50%的晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)患者的疗效。方法回顾性分析比较PM和PC作为一线治疗时,对PD-L1-TPS≥50%且无表皮生长因子受体(epidermal growth factor receptor,EGFR)和间变性淋巴瘤激酶(anaplastic lymphoma kinase, ALK)突变NSCLC患者的疗效。结果研究纳入115例PC和91例PM治疗患者。至2020年12月30日,中位随访时间为17.13个月。PC和PM组中位无进展生存期(progression-free survival, PFS)分别为12.37个月和9.60个月(HR:0.44, P<0.001)。中位总生存期(overall survival, OS)分别为未能评估(not evaluable, NE)和28.91个月(HR:0.40, P=0.005)。亚组分析发现,除脑转移患者外,PC对大多数患者的PFS均有显著改善。PC和PM组的1年OS率分别为89.3%和76.1%;客观缓解率分别为61.7和46.9%(P=0.004)。结论标准含铂化疗基础上联合帕博利珠单抗似乎是初治、PD-L1≥50%、无EGFR或ALK突变的晚期NSCLC患者治疗的更优方案,需前瞻性研究验证该结论。 | Ya CHEN Yanan WANG Zhengyu YANG Minjuan HU Yanwei ZHANG Fangfei QIAN Wei ZHANG Bo ZHANG Baohui HAN 王李强(翻译校对) | 2022 | 中国肺癌杂志2022，25，2： | 1 |
| 11 | COI and ITS2 sequences delimit species, reveal cryptic taxa and host specificity of figassociated Sycophila (Hymenoptera, Eurytonidae) 显示文摘 | Li Yanwei Zhou Xin Feng Gui Hu Haoyuan Niu Liming Hebert Paul D N Huang Dawei | 2010 | Molecular Ecology Resources2010，10，1： | 1 |
| 12 | Optimal reconfiguration of constellation using adaptive innovation driven multiobjective evolutionary algorithm显示文摘Constellation reconfiguration is a critical issue to recover from the satellite failure,maintain the regular operation,and enhance the overall performance.The constellation reconfiguration problem faces the difficulties of high dimensionality of design variables and extremely large decision space due to the great and continuously growing constellation size.To solve such real-world problems that can be hardly solved by traditional algorithms,the evolutionary operators should be promoted with available domain knowledge to guide the algorithm to explore the promising regions of the trade space.An adaptive innovationdriven multi-objective evolutionary algorithm(MOEA-AI)employing automated innovation(AI)and adaptive operator selection(AOS)is proposed to extract and apply domain knowledge.The available knowledge is extracted from the final or intermediate solution sets and integrated into an operator by the automated innovation mechanism.To prevent the overuse of knowledgedependent operators,AOS provides top-level management between the knowledge-dependent operators and conventional evolutionary operators.It evaluates and selects operators according to their actual performance,which helps to identify useful operators from the candidate set.The efficacy of the MOEAAI framework is demonstrated by the simulation of emergency missions.It was verified that the proposed algorithm can discover a non-dominant solution set with better quality,more homogeneous distribution,and better adaptation to practical situations. | HU Jiaxin YANG Leping HUANG Huan ZHU Yanwei | 2021 | Journal of Systems Engineering and Electronics2021，32，6： | 1 |
| 13 | Research of cloud manufacturing and resource encapsulation technology 显示文摘 | HU Chunyang WANG Yanwei ZHU Panfeng | 2011 | Applied Mechanics and Materials Information Technolo- gy for Manufacturing Systems II2011，5860，： | 1 |
| 14 | Re- search of cloud manufacturing and resource encapsulation technology显示文摘 | LI Chunquan HU Chunyang WANG Yanwei | 2011 | Applied Mechanics and Materials2011，5860，： | 1 |
| 15 | Commercial MPT64-based tests for rapid identification of Mycobacterium tuberculosis complex: A meta-analysis显示文摘 | Xiaomao Yin Lei Zheng Li Lin Yarong Hu Fen Zheng Yanwei Hu Qian Wang | 2013 | Journal of Infection2013，，： | 1 |
| 16 | Low Li ion diffusion barrier on low-crystalline FeOOH nanosheets and high performance of energy storage显示文摘To obtain symmetric supercapacitors(SCs)with high energy density,it is critical to fabricate an electrode with wide potential window and excellent capacitive performance.Herein,by using the strong double hydrolysis reaction between anions and cations,the FeOOH nanosheets on the surface of activated carbon cloth(FeOOH@AC)are prepared through a simple hydrothermal process.The FeOOH@AC electrode exhibits maximum capacitance of 4,090 mF·cm^−2 at wider potential window-1–0 V and 3,250 mF·cm^−2 at 0–1 V versus SCE in 2 M LiNO3 electrolyte.With two pieces of FeOOH@AC electrodes the obtained symmetric SC can operate at the voltage window of 2 V.This FeOOH symmetric SC shows high energy density of 13.261 mWh·cm^−3 at a power density of 14.824 mW·cm^−3 and maintains 4.175 mWh·cm^−3 at a maximum power density of 118.564 mW·cm^−3,as well as excellent charge storage capacity and cyclic stability.Li ion adsorption and diffusion mechanism on the(200)facets of FeOOH are explained by the density functional theory(DFT)calculations.The simple synthesis process and excellent capacitance performance of the FeOOH@AC composite make it a very promising candidate for high performance symmetric SC electrodes. | Jien Li Shuang Luo Congcong Wang Qian Tang Yanwei Wang Xiangyu Han Hao Ran Jing Wan Xiao Gu Xue Wang Chenguo Hu | 2020 | Nano Research2020，13，3： | 1 |
| 17 | Study on a harvester navigation and yield analysis system显示文摘 | Yuan Yanwei Zhang Xiaochao Hu Xiaoan | 2007 | New Zealand Journal of Agricultural Research2007，50，12： | 1 |
| 18 | Kinetic study on hydrolysis and oxidation of formamidine disulfide in acidic solutions显示文摘Hydrolysis and oxidation of formamidine disulfide in acidic medium were investigated using high-performance liquid chromatography(HPLC) and mass spectrometry(MS) at 25 °C.By controlling the slow reaction rate and choosing appropriate mobile phase,HPLC provides the unique advantages over other methods(UV-Vis,chemical separation) in species tracking and kinetic study.In addition to thiourea and formamidine sulfinic acid,two unreported products were also detected in the hydrolysis reaction.Mass spectrometry measurement indicates these two products to be formamidine sulfenic acid and thiocyanogen with mass weights of 92.28 and 116.36,respectively.In the oxidation of formamidine disulfide by hydrogen peroxide,besides thiourea,formamidine sulfenic acid,formamidine sulfinic acid,thiocyanogen and urea,formamidine sulfonic acid and sulfate could be detected.The oxidation reaction was found to be first order in both formamidine disulfide and hydrogen peroxide.The rate constants of hydrolysis and oxidation reactions were determined in the pH range of 1.5-3.0.It was found both rate constants are increased with the increasing of pH.Experimental curves of different species can be effectively simulated via a mechanism scheme for formamidine disulfide oxidation,including hydrolysis equilibrium of formamidine disulfide and irreversible hydrolysis of formamidine sulfenic acid. | HU Ying FENG JiaMin LI YanWei SUN YanYan XU Li ZHAO YueMin GAO QingYu | 2012 | Science China Chemistry2012，55，2： | 0 |
| 19 | Biquadratic tensors,biquadratic decompositions,and norms of biquadratic tensors显示文摘Biquadratic tensors play a central role in many areas of science.Examples include elastic tensor and Eshelby tensor in solid mechanics,and Riemannian curvature tensor in relativity theory.The singular values and spectral norm of a general third order tensor are the square roots of the M-eigenvalues and spectral norm of a biquadratic tensor,respectively.The tensor product operation is closed for biquadratic tensors.All of these motivate us to study biquadratic tensors,biquadratic decomposition,and norms of biquadratic tensors.We show that the spectral norm and nuclear norm for a biquadratic tensor may be computed by using its biquadratic structure.Then,either the number of variables is reduced,or the feasible region can be reduced.We show constructively that for a biquadratic tensor,a biquadratic rank-one decomposition always exists,and show that the biquadratic rank of a biquadratic tensor is preserved under an independent biquadratic Tucker decomposition.We present a lower bound and an upper bound of the nuclear norm of a biquadratic tensor.Finally,we define invertible biquadratic tensors,and present a lower bound for the product of the nuclear norms of an invertible biquadratic tensor and its inverse,and a lower bound for the product of the nuclear norm of an invertible biquadratic tensor,and the spectral norm of its inverse. | Liqun QI Shenglong HU Xinzhen ZHANG Yanwei XU | 2021 | Frontiers of Mathematics in China2021，16，1： | 0 |
| 20 | Synthesis of size-controlled hollow Fe3O4 nanospheres and their growth mechanism显示文摘Size-controlled hollow Fe3O4 nanospheres were synthesized via a one-pot hydrothermal method as a function of reaction time and sodium citrate,polyacrylamide,and urea content.Multiple characterization techniques such as scanning and transmission electron microscopy and Raman spectroscopy were employed to investigate the crystal structure and morphology of the obtained nanospheres.The Fe3O4 nanosphere formation mechanism was elucidated from analyzing the characterization data.High levels of sodium citrate and longer reaction times were observed to increase the diameter of the nanospheres until hollow structures formed.Furthermore,polyacrylamide and urea promoted the formation of hollow structures.The hollow-structured Fe3O4 nanospheres exhibited high magnetization saturation values in the range of 48.8-58.7 emu/g.The facile synthesis method described herein,to generate size-controlled Fe3O4 nanospheres with tailored properties,demonstrates potential across a wide range of fields from drug-delivery and stealth devices,to environmental and energy applications. | Lei Shi Yurong He Yanwei Hu Xinzhi Wang Baocheng Jiang Yimin Huang | 2020 | Particuology2020，18，2： | 0 |
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