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| 1 | Fabrication and Characterization of Ca-Mg-P Containing Coating on Pure Magnesium显示文摘A biodegradable Ca-P coating mainly consisting of β-tricalcium phosphate(β-TCP) was fabricated on pure magnesium via the chemical deposition in a simulated Hank s solution.The method significantly accelerated the coating formation on magnesium.Moreover,the morphology,phase/chemical composition,the coating formation mechanism as well as degradation behavior in phosphate buffered saline(PBS) solution were investigated.Scanning electron microscopy(SEM) images showed that the coating had three layers and X-ray diffraction(XRD) patterns showed that the coating mainly contained Ca3(PO4)2 and(Ca,Mg)3(PO4)2.Electrochemical test showed that the corrosion current density(Icorr) of the coated Mg was decreased by about one order of magnitude as compared to that of pure magnesium.The immersion test indicated that the coating could obviously reduce the degradation rate. | Yanjin Lu Lili Tan Honglia. ng Xiang Bingchun Zhang Ke Yang Yangde Li | 2012 | Journal of Materials Science & Technology2012，28，7： | 3 |
| 2 | SStudy on corrosion resistance of pure magnesium with CaSiO_3 contained coating in NaCl solution显示文摘A composite coating was fabricated on pure magnesium by hydrothermal treatment in order to reduce its degradation in body environment.The coating was characterized by scanning electron microscopy(SEM) and X-ray diffraction(XRD).The XRD pattern showed that the main composition of the coating was a mixture of CaSiO3,MgSiO3 and Mg(OH)2.Electrochemical test showed that the corrosion current density(icorr) of the coated magnesium was decreased by about two orders of magnitude compared with that of the bare magnesium,and the EIS measurement also showed that the corrosion resistant performance of the coated magnesium was significantly enhanced.Meanwhile,weight loss test showed that the weight loss of the coated magnesium was lower than that of the bare magnesium.Hence,the present study indicated that the composite coating could greatly slow down the degradation of pure magnesium. | Yanjin LU Lili TAN Hongliang XIANG Bingchun ZHANG Ke YANG | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，4： | 2 |
| 3 | ADAPTIVE RIGID-PLASTIC MESHLESS GALERKIN METHOD AND ITS APPLICATION IN ANALYSIS OF EXTRUSION PROCESSES显示文摘Under the hypothesis of the rigid-plastic material,specific efforts are placed on the deve-lopments of the key simulation techniques of the meshless Galerkin method because of the complexity of the deformation process as well as the generality and atomization of the simulation procedures for non-steady state large deformation plastic processes,therefore,an adaptive rigid meshless Galerkin method is developed. The influence domain control method is used in the least square approximation by dynamic evaluation of the magnitude of the influence domain and the effective control of the amount and the positions of the points in the least square approximation in order to improve approxi-mation precision. The amount of the Gauss integration points in the discrete domain is maintained in a considerable magnitude in order to ensure the integration precision in the discrete domain. The length of the frictional boundary of the plastic deformation process may be getting longer when its deforma-tion is getting severe. Thus,the densities of the boundary points of some places get lower. The adap-tive boundary points setting method is employed to improve the approximation precision of the boundary points and enhance the constraint of the boundary condition by adaptive control of boun-dary point density. Some typical extrusion processes are analyzed,detail simulation results such as the deformation field,velocity field,effective strain field,effective strain rate field,the volume loss curve and load-stroke curve are obtained. The effectiveness of the method developed is demonstrated and the precision of the meshless simulation is proved by overall comparison with the results obtained by using the commercial software deform. | WU Xin ZHAO Guoqun WANG Weidong GUAN Yanjin LU Ping | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 1 |
| 4 | Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering显示文摘Lanthanum(La)has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic disorders.However,controlling its distribution and keeping the release of La^(3+)ions sustained and steady in the body is still a big challenge.In this study,we prepared La-OCP powders via co-precipitation method,and further prepared La-OCP/PLA porous scaffolds by 3 D printing.La^(3+)was successfully introduced into the OCP crystal structure and substituted Ca^(2+)at the Ca-5 and Ca-8 sites.In particular,some La^(3+)ions were deposited on the crystal surface in the form of nanoparticles.Both octacalcium phosphate(OCP,Ca_(8)H_(2)(PO_(4))_6·5 H_(2)O)crystals and nanoparticles played as the carriers for La^(3+)ions.The La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La^(3+).The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere,grow and proliferation.At a certain La^(3+)concentration,the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes,thus promoting the osteogenic differentiation of BMSCs.Moreover,the extracts regulated the immune responses.The experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in vivo.These findings suggest that 3 D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering. | Zeya Xu Bin Lin Chaoqian Zhao Yanjin Lu Tingting Huang Yan Chen Jungang Li Rongcan Wu Wenge Liu Jinxin Lin | 2022 | Journal of Materials Science & Technology2022，，23： | 1 |
| 5 | Micro Hierarchical Structure and Mechanical Property of Sparrow Hawk (Accipiter nisus) Feather Shaf显示文摘In this study,the real 3D model of the feather shaft that is composed of medulla and cortex is characterized by X-ray computer tomography,and the structural features are quantitatively analyzed.Compression and tensile tests are conducted to evaluate the mechanical performance of the feather shaft and cortex at different regions.The analysis of the 3D model shows that the medulla accounts for∼70%of the shaft volume and exhibits a closed-cell foam-like structure,with a porosity of 59%.The cells in the medulla show dodecahedron and decahedron morphology and have an equivalent diameter of∼30μm.In axial compression,the presence of medulla enhances the shaft stability.Especially,the combined effect of the medulla and cortex increases the buckling strength of the middle and distal shaft by 77%and 141%,respectively,compared to the calculated value of the shaft using linear mixed rule.The tensile properties of the cortex along the shaft axis are anisotropic because of the different fiber structures.As the fiber orientation gradually becomes uniform in the axial direction,the Young’s modulus and tensile strength of the cortex on the dorsal gradually increase from calamus to the distal shaft,and the fracture mode changes from tortuous fracture to V-shaped fracture.The cortex on the lateral shows the opposite trend,that is the distal shaft becomes weaker due to fiber tangles. | Yichen Lu Zongning Chen Enyu Guo Xiangqing Kong Huijun Kang Yanjin Xu Rengeng Li Guohua Fan Tongmin Wang | 2021 | Computer Modeling in Engineering & Sciences2021，，5： | 0 |
| 6 | Tuning osteoporotic macrophage responses to favour regeneration by Cu-bearing titanium alloy in Porphyromonas gingivalis lipopolysaccharide-induced microenvironments显示文摘Guided bone regeneration in inflammatory microenvironments of osteoporotic patients with large alve-olar bone defects remains a great challenge.Macrophages are necessary for alveolar bone regeneration via their polarization and paracrine actions.Our previous studies showed that Cu-bearing Ti6AI4V alloys are capable of regulating macrophage responses.When considering the complexity of oral microenvir-onments,the influences of Cu-bearing Ti6AI4V alloys on osteoporotic macrophages in infectious microenvironments are worthy of further investigations.In this study,we fabricated Ti6AI4V-Cu alloy by selective laser melting technology and used Porphyromonas gingivalis lipopolysaccharide(P.g-LPS)to imitate oral pathogenic bacterial infections.Then,we evaluated the impacts of T6AI4V-Cu on osteoporotic macrophages in infectious microenvironments.Our results indicated that Ti6AI4V-Cu not only inhibited the P.g-LPS-induced M1 polarization and pro-inflammatory cytokine production of osteoporotic macrophages but also shifted polarization towards the pro-regenerative M2 phenotype and remarkably promoted antinflammatory cytokine release.In addition,T6AI4V-Cu effectively promoted the actity of COMMD1 to potentially repress NF-κB-mediated transcription.It is concluded that the Cubearing Ti6AI4V alloy results in ameliorated osteoporotic macrophage responses to create a favourable microenvironment under infectious conditions,which holds promise to develop a GBR-barrier membrane for alveolar bone regeneration of osteoporosis patients. | Xiongcheng Xu Yanjin Lu Ling Zhou Mengjiao He Jin Zhuo Quan Zhong Kai Luo Jinxin Lin | 2021 | Regenerative Biomaterials2021，8，1： | 0 |
| 7 | Tuning the Corrosion Resistance,Antibacterial Activity,and Cytocompatibility by Constructing Grooves on the Surface of Ti6Al4V3Cu Alloy显示文摘Ti6Al4V3Cu alloy is a promising biomaterial for combating implant-related infection.However,the antibacterial property of Ti6Al4V3Cu is expected to be enhanced due to the low content of Cu element in titanium.To address this issue,the antibacterial property of Ti6Al4V3Cu was tailored by the grooves with different groove widths(30μm,60μm,and 90μm)that were constructed on the surface of the Ti6Al4V3Cu by selective laser melting.The effect of grooves on corrosion resistance,antibacterial property,and cytocompatibility was investigated.The electrochemical tests showed that the corrosion resistance decreased with increasing groove width.The antibacterial tests indicated that the groove with a width of 30μm and 90μm groups showed better antibacterial activity against S.aureus(>90%)compared with the groove with a width of 60μm.The in vitro study suggested that all samples with different grooves were found to exhibit good cytocompatibility with osteoblast cells.It is considered that creating grooves on Ti6Al4V3Cu by selective laser melting is a promising strategy to enhance the antibacterial activity without sacrificing cytocompatibility. | Minghui Zhou Hui Sun Yanming Gan Cheng Ji Yan Chen Yanjin Lu Jinxin Lin Qiang Wang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，12： | 0 |
| 8 | Doping Gd^(3+)Ion in PDA-PHBV Coating on Ti6Al4V Alloy for Enhancing Corrosion Resistance and Proliferation of Human Gingival Fibroblasts and Human Umbilical Vein Endothelial Cells显示文摘In this study,we fabricated poly(3-hydroxybutyrate-3-hydroxyvalerate)(PHBV)coatings doped with Gd^(3+)(1,5,and 10×10^(−4) mol/L)on Ti6Al4V alloy for the first time to promote soft tissue sealing around dental implants.The corrosion resistance of Gd^(3+)-modified PHBV-coated Ti6Al4V was studied by electrochemical and immersion tests,respectively,whereas CCK-8 and RT-PCR evaluated the biocompatibility to human gingival fibroblasts(HGFs)and human umbilical vein endothelial cells(HUVECs).It was found that the Gd^(3+)-modified PHBV coating could enhance the corrosion resistance of Ti6Al4V.In vitro cell tests showed that PHBV coatings with and without Gd^(3+) addition could promote adhesion and proliferation of HGFs and HUVECs,showing a Gd^(3+) content-dependent manner.Moreover,it was found that the PDA-PHBV@1Gd showed the best proliferation to HGFs by up-regulating gene expressions of VINCULIN,ITGB1,and ITGA3,whereas the best response to HUVECs with the highest gene expression of eNOS and HIF-1αgenes was found in the PDA-PHBV@5Gd-coated group. | Sijie Qin Xiongcheng Xu Yanjin Lu Liu Li Tingting Huang Jinxin Lin | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，5： | 0 |
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