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| 1 | Zoning of land reclamation in coal mining area and new progresses for the past 10 years显示文摘Coal mining disturbed land is the main sources of land reclamation in China.With the rapid increase of economy and coal production,more and more land has been disturbed by construction and coal mining;thus,land reclamation has become highlights in the past 10 years,and China is boosting land reclamation in mining areas.Disturbance characteristics vary from region to region,according to natural and geological conditions,coal mining area land reclamation was divided into 3 zones,which are eastern,western and southern.Reclamation strategies are focused on prime farmland protection in eastern and ecological restoration in western and southern zones,respectively.Several innovative reclamation technologies and theories for the past 10 years were introduced in this paper,including concurrent mining and reclamation,Yellow river sediments backfilling,self-reclamation,and topsoil alternatives in opencast mines.Besides,in the government regulation and legal system building respect,several important laws and regulations were issued and implemented in the past 5 years,promoting land reclamation management and supervision greatly.Land reclamation is and will still be one of the most important parts of coal industry in the future,and more efforts and funds are expected to get involved. | Wu Xiao Zhenqi Hu Yanhua Fu | 2014 | International Journal of Coal Science & Technology2014，1，2： | 28 |
| 2 | miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation显示文摘microRNA-210(miR-210)has generally been reported to be associated with cell survival under hypoxia.However,there are few data regarding the role of miR-210 in the survival of mesenchymal stem cells(MSCs)under oxidative stress conditions.Thus,we sought to investigate whether miR-210 over-expression could protect MSCs against oxidative stress injury and what the primary mechanisms involved are.The results showed that over-expression of miR-210 significantly reduced the apoptosis of MSCs under oxidative stress,accompanied by obvious increases in cell viability and superoxide dismutase activity and remarkable decreases in malonaldehyde content and reactive oxygen species production,resulting in a noticeable reduction of apoptotic indices when compared with the control.Moreover,the above beneficial effects of miR-210 could be significantly reduced by c-Met pathway repression.Collectively,these results showed that miR-210 over-expression improved MSC survival under oxidative stress through antioxidation and c-Met pathway activation,indicating the potential development of a novel approach to enhance the efficacy of MSC-based therapy for injured myocardium. | XU JianFeng HUANG ZheYong LIN Li FU MingQiang GAO YanHua SHEN YunLi ZOU YunZeng SUN AiJun QIAN JuYing GE JunBo | 2014 | Science China(Life Sciences)2014，57，10： | 10 |
| 3 | A novel miR167a-OsARF6-OsAUX3 module regulates grain length and weight in rice显示文摘Grain size is one of the most important factors that control rice yield,as it is associated with grain weight(GW).To date,dozens of rice genes that regulate grain size have been isolated;however,the regulatory mechanism underlying GW control is not fully understood.Here,the quantitative trait locus qGL5 for grain length(GL)and GW was identified in recombinant inbred lines of 9311 and Nipponbare(NPB)and fine mapped to a candidate gene,OsAUX3.Sequence variations between 9311 and NPB in the OsAUX3 promoter and loss of function of OsAUX3 led to higher GL and GW.RNA sequencing,gene expression quantification,dual-luciferase reporter assays,chromatin immunoprecipitation-quantitative PCR,and yeast one-hybrid assays demonstrated that OsARF6 is an upstream transcription factor regulating the expression of OsAUX3.OsARF6 binds directly to the auxin response elements of the OsAUX3 promoter,covering a single-nucleotide polymorphism site between 9311 and NPB/Dongjin/Hwayoung,and thereby controls GL by altering longitudinal expansion and auxin distribution/content in glume cells.Furthermore,we showed that miR167a positively regulate GL and GW by directing OsARF6 mRNA silencing.Taken together,our study reveals that a novel miR167a-OsARF6-OsAUX3 module regulates GL and GW in rice,providing a potential target for the improvement of rice yield. | Jiyue Qiao Hongzhen Jiang Yuqing Lin Lianguang Shang Mei Wang Dongming Li Xiangdong Fu Markus Geisler Yanhua Qi Zhenyu Gao Qian Qian | 2021 | Molecular Plant2021，14，10： | 8 |
| 4 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 5 | Traffic Prediction in 3G Mobile Networks Based on Multifractal Exploration显示文摘Traffic prediction plays an integral role in telecommunication network planning and network optimization. In this paper, we investigate the traffic forecasting for data services in 3G mobile networks. Although the Box-Jenkins model has been proven to be appropriate for voice traffic (since the arrival of calls follows a Poisson distribution), it has been demonstrated that the Internet traffic exhibits statistical self-similarity and has to be modeled using the Fractional AutoRegressive Integrated Moving Average (FARIMA) process. However, a few studies have concluded that the FARIMA process may fail in modeling the Internet traffic. To this end, we conducted experiments on the modeling of benchmark Internet traffic and found that the FARIMA process fails because of the significant multifractal characteristic inherent in the traffic series. Thereafter, we investigate the traffic series of data services in a 3G mobile network from a province in China. Rich multifractal spectra are found in this series. Based on this observation, an integrated method combining the AutoRegressive Moving Average (ARMA) and FARIMA processes is applied. The obtained experimental results verify the effectiveness of the integrated prediction method. | Yanhua Yu Meina Song Yu Fu Junde Song | 2013 | Tsinghua Science and Technology2013，18，4： | 6 |
| 6 | Optimization model research on efficacy in treatment of chronic urticaria by Chinese and Western Medicine based on a genetic algorithm显示文摘OBJECTIVE: To investigate the potential rules and knowledge of Traditional Chinese Medicine (TCM) and Western Medicine (WM) treatment on chronic urticaria (CU) based on data-mining methods. METHODS: Sixty patients with chronic urticaria, treated with TCM and WM, were selected. Gray correlation analyses were adopted to determine therapeutic efficacy. Association algorithms were utilized to ascertain the correlation between the disease course and treatment results. A genetic algorithm was applied to discover the optimization model in theTCM andWM treatment on CU. RESULTS: The total symptom scores after 4 weeks and 8 weeks of treatment in the TCM spleen-strengthening group correlated highly with the pretreatment total symptom score. The duration of treatment showed the greatest impact on the total symptom score. A quartic equation was established (y=-1.6403×10-6x4+0.00025576x3+0.0012819 x2-1.024x+79.5879, and x=106.9518, y=83.0036) using the genetic algorithm. CONCLUSION: TCM treatment had a better effect in the later stage, whereas WM was better in the early stage. The duration of disease course had an impact on the effects of treatment. If the average total symptom score before treatment was ≤ 83.0036, TCM or WM treatment could achieve better efficacy. | Macheng Yan Fuyuan Ye Yuquan Zhang Xi Cai Yanhua Fu Xuming Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 4 |
| 7 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://gffzz3ff3e9d9e9f64aa3hfvu5q9qxo5v66po0.ffgz.tsg.suse.edu.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 8 | Analysis of the effect of repeated-pulse transcranial magnetic stimulation at the Guangming point on electroencephalograms显示文摘Here, we administered repeated-pulse transcranial magnetic stimulation to healthy people at the left Guangming(GB37) and a mock point, and calculated the sample entropy of electroencephalogram signals using nonlinear dynamics. Additionally, we compared electroencephalogram sample entropy of signals in response to visual stimulation before, during, and after repeated-pulse transcranial magnetic stimulation at the Guangming. Results showed that electroencephalogram sample entropy at left(F3) and right(FP2) frontal electrodes were significantly different depending on where the magnetic stimulation was administered. Additionally, compared with the mock point, electroencephalogram sample entropy was higher after stimulating the Guangming point. When visual stimulation at Guangming was given before repeated-pulse transcranial magnetic stimulation, significant differences in sample entropy were found at five electrodes(C3, Cz, C4, P3, T8) in parietal cortex, the central gyrus, and the right temporal region compared with when it was given after repeated-pulse transcranial magnetic stimulation, indicating that repeated-pulse transcranial magnetic stimulation at Guangming can affect visual function. Analysis of electroencephalogram revealed that when visual stimulation preceded repeated pulse transcranial magnetic stimulation, sample entropy values were higher at the C3, C4, and P3 electrodes and lower at the Cz and T8 electrodes than visual stimulation followed preceded repeated pulse transcranial magnetic stimulation. The findings indicate that repeated-pulse transcranial magnetic stimulation at the Guangming evokes different patterns of electroencephalogram signals than repeated-pulse transcranial magnetic stimulation at other nearby points on the body surface, and that repeated-pulse transcranial magnetic stimulation at the Guangming is associated with changes in the complexity of visually evoked electroencephalogram signals in parietal regions, central gyrus, and temporal regions. | Xin Zhang Lingdi Fu Yuehua Geng Xiang Zhai Yanhua Liu | 2014 | Neural Regeneration Research2014，9，5： | 3 |
| 9 | Floralozone protects endothelial function in atherosclerosis by ameliorating NHE1显示文摘Endothelial dysfunction is the pathological basis of atherosclerosis.Incomplete understanding of endothelial dysfunction etiology has impeded drug development for this devastating disease despite the currently available therapies.Floralozone,an aroma flavor,specifically exists in rabbit ear grass.Recently,floralozone has been demonstrated to inhibit atherosclerosis,but the underlying mechanisms are undefined.The present study was undertaken to explore whether floralozone pharmacologically targets endothelial dysfunction and therefore exerts therapeutic effects on atherosclerosis.The Na+/H+exchanger 1(NHE1),a channel protein,plays a vital role in atherosclerosis.Whether NHE1 is involved in the therapeutic effects of floralozone on endothelial dysfunction has yet to be further answered.By performing oil red staining and hematoxylin–eosin staining,vascular functional study,and oxidative stress monitoring,we found that floralozone not only reduced the size of carotid atherosclerotic plaque but also prevented endothelial dysfunction in atherosclerotic rats.NHE1 expression was upregulated in the inner membrane of carotid arteries and H2O2-induced primary rat aortic endothelial cells.Inspiringly,floralozone prevented the upregulation of NHE1 in vivo and in vitro.Notably,the administration of NHE1 activator LiCl significantly weakened the protective effect of floralozone on endothelial dysfunction in vivo and in vitro.Our study demonstrated that floralozone exerted its protective effect on endothelial dysfunction in atherosclerosis by ameliorating NHE1.NHE1 maybe a drug target for the treatment of atherosclerosis,and floralozone may be an effective drug to meet the urgent needs of atherosclerosis patients by dampening NHE1. | Ning Huang Yue Qiu Yanhua Liu Tianheng Liu Xianjun Xue Ping Song Jian Xu Yutian Fu Ruili Sun Yaling Yin Peng Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 10 | Naringenin nanocrystals for improving antirheumatoid arthritis activity显示文摘Naringenin(NAR)is recognized for its anti-inflammatory activity.However,the clinical application of NAR is limited by low bioavailability,which is attributed to its poor aqueous solubility.In this study,we aimed to improve the therapeutic efficacy of NAR by formulating it into nanocrystals(NCs)via wet milling.The obtained NARNCs exhibited superior dissolution behaviors,increased cellular uptake,and enhanced transcellular diffusion relative to those of bulk NAR.Oral administration of NARNCs also significantly improved bioavailability in rats.In addition,the NARNCs effectively improved rheumatoid arthritis treatment in collagen-induced arthritic rats by reducing inflammatory cell infiltration and synovial damage.These results indicate that NARNCs provides a promising strategy for rheumatoid arthritis treatment. | Guangshuai Zhang Guangyuan Sun Haishan Guan Mo Li Yanhua Liu Baocheng Tian Zhonggui He Qiang Fu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 11 | Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia显示文摘 | Lantu Gou Mingde Fu Yanhua Xu Ying Tian Bingyu Yan Luchuan Yang | 2005 | American Heart Journal2005，，5： | 1 |
| 12 | Relationship between plasma lipid concentrations and HDL subclasses显示文摘 | Yuye Yang Bingyu Yan Mingde Fu Yanhua Xu Ying Tian | 2004 | Clinica Chimica Acta2004，，1： | 1 |
| 13 | Molecular dynamics and mesoscopic dynamics simulations for prediction of miscibility in polypropylene/polyamide-11 blends显示文摘 | Yizheng Fu Liqiong Liao Yanhua Lan Luxia Yang Linyu Mei Yaqing Liu Shuangqi Hu | 2011 | Journal of Molecular Structure2011，，： | 1 |
| 14 | Alterations of HDL subclasses in hyperlipidemia显示文摘 | Yanhua Xu Mingde Fu | 2003 | Clinica Chimica Acta2003，，1： | 1 |
| 15 | Relationship between apolipoproteins and the alteration of HDL subclasses in hyperlipidemic subjects显示文摘 | Lianqun Jia Xinwei Wu Mingde Fu Yanhua Xu Ying Tian Haoming Tian Li Tian | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 16 | Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia显示文摘 | Lianqun Jia Mingde Fu Ying Tian Yanhua Xu Lantu Gou Haoming Tian Li Tian | 2006 | International Journal of Cardiology2006，，3： | 1 |
| 17 | Expression and distribution of cell adhesion-related proteins in bovine parthenogenetic embryos: The effects of oocyte vitrification显示文摘 | Yan Zeng Xiangwei Fu Guangbin Zhou Mingxing Yue Yanhua Zhou Shien Zhu | 2013 | Theriogenology2013，，1： | 1 |
| 18 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 19 | Isolation and characterization of Akabane virus Ib substrain and its pathogenesis in sulking mice显示文摘Dear Editor,Akabane disease is an arthropod-borne viral disease caused by the Akabane virus(AKAV)that can affect cattle,sheep,and goats.Inapparent infections in adults can lead months later to abortions,stillbirths,congenital defects,and death in newborns(Kurogi et al.,1976).Wild ruminants can also be affected,but abnormalities of the offspring in these species have not been reported.One report suggests that this virus can also cause clinical signs in pigs(Yanase et al.,2018). | Xiaohui Zan Shirong Wang Tianqi Zhang Ying Li Chunge Zhang Cun Fu Jialei Wang Youzhi Wu Yanhua Ma Zhifei Li Yan Wang Hao Wang Yuhai Bi Wei Wang | 2023 | Virologica Sinica2023，38，6： | 0 |
| 20 | An efficient method for the sanitary vitrification of bovine oocytes in straws显示文摘Background:At present,vitrification has been widely applied to humans,mice and farm animals.To improve the efficiency of vitrification in straw,bovine oocytes were used to test a new two-step vitrification method in this study.Results:When in vitro matured oocytes were exposed to 20%ethylene glycol(EG20) for 5 min and 40%ethylene glycol(EG40) for 30 s,followed by treatment with 30%glycerol(Gly30),Gly40 or Gly50,a volume expansion was observed in Gly30 and Gly40 but not Gly50.This indicates that the intracellular osmotic pressure after a 30 s differs between EG40 and ranged between Gly40(approximately 5.6 mol/L) and Gly50(approximately 7.0 mol/L).Since oocytes are in EG40 just for only a short period of time(30 s) and at a lower temperature(4℃),we hypothesize that the main function of this step in to induce dehydration.Based on these results,we omitted the EG40 step,before oocytes were pretreated in EG20 for 5 min,exposed to pre-cooled(4℃) Gly50,for 30 s,and then dipped into liquid nitrogen.After warming,81.1%of the oocytes survived,and the surviving oocytes developed into cleavage stage embryos(63.5%) or blastocysts(20.0%) after parthenogenetic activation.Conclusions:These results demonstrate that in a two-step vitrification procedure,the permeability effect in the second step is not necessary.It is possible that the second step is only required to provide adequate osmotic pressure to condense the intracellular concentration of CPAs to a level required for successful vitrification. | Yanhua Zhou Xiangwei Fu Guangbin Zhou Baoyu Jia Yi Fang Yunpeng Hou Shien Zhu | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 0 |
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