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| 1 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 2 | Inflammasomes as therapeutic targets in human diseases显示文摘Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals.Inflammasome multiprotein complexes are composed of three parts:a sensor protein,an adaptor,and pro-caspase-1.Activation of the inflammasome leads to the activation of caspase-1,which cleaves pro-inflammatory cytokines such as IL-ip and IL-18,leading to pyroptosis.Effectors of the inflammasome not only provide protection against infectious pathogens,but also mediate control over sterile insults.Aberrant inflammasome signaling has been implicated in the development of cardiovascular and metabolic diseases,cancer,and neurodegenerative disorders.Here,we review the role of the inflammasome as a double-edged sword in various diseases,and the outcomes can be either good or bad depending on the disease,as well as the genetic background.We highlight inflammasome memory and the two-shot activation process.We also propose the M-and N-type inflammation model,and discuss how the inflammasome pathway may be targeted for the development of novel therapy. | Yangxin Li Hui Huang Bin Liu Yu Zhang Xiangbin Pan Xi-Yong Yu Zhenya Shen Yao-Hua Song | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 3 |
| 3 | Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rbl-mediated NLRP3 inflammasome pathway显示文摘Dear Editor,Lower-limb ischemia is a serious clinical condition affecting many patients world-wide and there is no effective therapy.Ischemia activates the NLRP3 inflammasome,which triggers tissue damage by releasing inflammatory cytokines including IL-1β and IL-18.1 However,the molecular mechanisms underlying activation of the NLRP3 inflammasome remain largely unknown. | Yanli Wang Wenping Xie Bin Liu Hui Huang Wei Luo Yu Zhang Xiangbin Pan Xi-Yong Yu Zhenya Shen Yangxin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 4 | Ni(OH)_2-Ni/C for hydrogen oxidation reaction in alkaline media显示文摘The development of the hydrogen electrode is vital for the application of alkaline polymer electrolyte fuel cells(APEFCs).In this study,a series of Ni(OH)_2 decorated Ni/C catalysts(Ni(OH)_2-Ni/C) were prepared by a three-step electrochemical treatment of Ni/C.The existence of Ni(OH)_2 was demonstrated by X-ray photoelectron spectroscopy(XPS),and the surface molar ratio of Ni(OH)_2/Ni of the samples was estimated via an electrochemical method.The HOR catalytic activity of the catalysts was evaluated by a rotation disk electrode(RDE) method,and a 'volcano plot' was established between the HOR exchange current(j0) and the surface molar ratio of Ni(OH)_2/Ni.On top of the 'volcano',the surface molar ratio of Ni(OH)_2/Ni is1.1:1,the j0 of which was 6.8 times of that of Ni/C.The stability of the samples toward HOR was evaluated to be good.Our study added a systematic experimental evidence to the HOR research,showing that the HOR catalytic activity of Ni can be deliberately controlled via decoration of Ni(OH)_2,which may help understanding the HOR mechanism on Ni. | Yangxin Pan Gaohe Hu Juntao Lu Li Xiao Lin Zhuang | 2019 | Journal of Energy Chemistry2019，28，2： | 2 |
| 5 | Hollow click-based porous organic polymers for heterogenization of [Ru(bpy)3]2+ through electrostatic interactions显示文摘为用在空基于按的多孔的器官的聚合物(H-CPPs ) 的非共有原子价相互作用的转变金属催化剂的 heterogenization 的一条灵巧的途径被介绍。催化地活跃的 cationic 种,[Ru (bpy )3]2+(bpy = 2,2-bipyridyl ) ,经由静电的相互作用在 H-CPPs 被使不能调动。内在的性质[Ru (bpy )3]2+ 很好被保留。当在可见光的照耀下面为 4-methoxyphenylboronic 酸的氧化 hydroxylation 使用了到 4-methoxyphenol 时,产生 Rucontaining 空聚合物展出了优秀催化活动,提高的稳定性,和好再循环能力。吸引人的催化表演主要从有效集体转移和 cationic Ru 建筑群的化学性质的维护导致了 H-CPPs。 | Liuyi Li Caiyan Cui Wenyue Su Yangxin Wang Ruihu Wang | 2016 | Nano Research2016，9，3： | 2 |
| 6 | Effective femtosecond laser shock peening on a Mg-3Gd alloy at low pulse energy 430 μJ of 1 kHz显示文摘In this paper,microstructure evolution and hardness of Mg-3 Gd alloy treated by femtosecond(fs)laser shock peening(LSP)with direct and confined ablation m odes were investigated in detail.Under a relatively low pulse energy of 430μJ with a repetition of 1 kHz,the surface hardness of sample has been enhanced by 70%effectively.Comp a r e d with ns-LSP with pulse fluence of 71.7J/cm2,fs-LSP with pulse fluence of 34.2 J/cm2 is superior in the hardness increment,both of which are in the same order of magnitude.A distinct grain refinement of surface layer has been discovered and results in the increase of hardness.Nonuse of absorption and confining layers and the employment of the industry commercial fs laser with high repetition can inspire big potential L S P application in special metal material.©2019 Published by Elsevier B.V.on behalf of Chongqing University. | Chenghao Lu Licheng Ge Bing Zhu Yangxin Li Xianfeng Chen Xiaoqin Zeng Yuping Chen | 2019 | Journal of Magnesium and Alloys2019，7，3： | 2 |
| 7 | The effect of basal dislocation on {11■1} twin boundary evolution in a Mg-Gd-Y-Zr alloy显示文摘This study aims to understand the features of{11■1}twin boundaries in a high strain rate compressed Mg-10 Gd-3Y-0.4Zr using electron backscatter diffraction(EBSD)and transmission electron microscopy(TEM).Based on the Schmid factor calculations,the basal dislocations are easily activated within the{11■1}twin and suppressed in the surrounding matrix.The consequent basal dislocation-twin interaction during deformation can lead to the misorentiation deviation of{11■1}twin boundaries,accompanying with the formation of a step at the twin boundary.Such a{11■1}twin boundary evolution mechanism provides a new vision of twinning behavior in Mg alloys. | Huan Zhang Yangxin Li Yuxuan Liu Qingchun Zhu Xixi Qi Gaoming Zhu Jinhui Wang Peipeng Jin Xiaoqin Zeng | 2021 | Journal of Materials Science & Technology2021，，22： | 2 |
| 8 | Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells显示文摘 | Yangxin Li XiYong Yu ShuGuang Lin XiaoHong Li Saidan Zhang Yao-Hua Song | 2007 | Biochemical and Biophysical Research Communications2007，，3： | 1 |
| 9 | Experimental Study of a Finned Tubes Impact Gas-Solid Separator for CFB Boilers显示文摘 | Kefa Cen Xiaodong Li Yangxin Li | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 10 | Vapor-liquid equilibrium properties for confined binary mixtures involving CO_2,CH_4,and N_2 from Gibbs ensemble Monte Carlo simulations显示文摘The effects of solid-fluid interactions on the vapor-liquid phase diagram,coexistence density,relative volatility and vaporization enthalpy have been investigated for confined binary systems of CO 2-CH 4,CO 2-N 2 and CH 4-N 2.The Gibbs ensemble Monte Carlo(GEMC) simulation results indicate that the confinement and the solid-fluid interaction have significant influences on the vapor-liquid equilibrium properties.The confinement and the strength of the solid-fluid interaction make the p-x i phase diagram move to higher pressure regions.They also make the two-phase region become narrower for each binary mixture.The strength of the solid-fluid interactions can cause increases in the coexistence liquid and vapor densities,and cause the decrease of the relative volatility and the vaporization enthalpy for the systems studied.As the pore width is decreased,the two-phase region of the binary mixture becomes narrower. | LI YingFeng YU YangXin ZHENG YuanXiang LI JiDing | 2012 | Science China Chemistry2012，55，9： | 1 |
| 11 | Ribosome biogenesis in disease:new players and therapeutic targets显示文摘The ribosome is a multi-unit complex that translates mRNA into protein.Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation,differentiation,apoptosis,development,and transformation.The mTORC1,Myc,and noncoding RNA signaling pathways are the primary mediators that work jointly with RNA polymerases and ribosome proteins to control ribosome biogenesis and protein synthesis.Activation of mTORC1 is required for normal fetal growth and development and tissue regeneration after birth.Myc is implicated in cancer development by enhancing RNA Pol II activity,leading to uncontrolled cancer cell growth.The deregulation of noncoding RNAs such as microRNAs,long noncoding RNAs,and circular RNAs is involved in developing blood,neurodegenerative diseases,and atherosclerosis.We review the similarities and differences between eukaryotic and bacterial ribosomes and the molecular mechanism of ribosome-targeting antibiotics and bacterial resistance.We also review the most recent findings of ribosome dysfunction in COVID-19 and other conditions and discuss the consequences of ribosome frameshifting,ribosome-stalling,and ribosome-collision.We summarize the role of ribosome biogenesis in the development of various diseases.Furthermore,we review the current clinical trials,prospective vaccines for COVID-19,and therapies targeting ribosome biogenesis in cancer,cardiovascular disease,aging,and neurodegenerative disease. | Lijuan Jiao Yuzhe Liu Xi-Yong Yu Xiangbin Pan Yu Zhang Junchu Tu Yao-Hua Song Yangxin Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 1 |
| 12 | Molecular simulation of MCM-41: Structural properties and adsorption of CO 2 , N 2 and flue gas显示文摘 | Yu Jing Li Wei Yundong Wang Yangxin Yu | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 13 | Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells 显示文摘 | Li Yangxin Yu Xiyong Lin Shuguang | 2007 | Biochem Biophys Res Commun2007，356，： | 1 |
| 14 | Jahn-Teller distortion assisted interstitial nitrogen engineering:Enhanced oxygen dehydrogenation activity of N-doped Mn_(x)Co_(3-x)O_(4) hierarchical micro-nano particles显示文摘Rational design of earth-abundant transition metal oxides catalysts is highly desirable for developing sustainable chemical processes.Herein,we demonstrate a prospective interstitial nitrogen engineering for fabricating oxygen vacancies(OVs)-rich nitrogen-doped-Mn_(x)Co_(3-x)O_(4)(N-Mn_(x)Co_(3-x)O_(4))oxide catalyst,in which the ratio of OVs concentration of N-Mn_(x)Co_(3-x)O_(4)to Mn species is as high as 1:1,according to the characterizations of X-ray absorption(XAS)and X-ray photoelectron(XPS)spectroscopies.The promising strategy of interstitial nitrogen engineering through lattice distortion caused by the Jahn-Teller effect can significantly increase the amount of interstitial nitrogen.The resulting catalyst enables an additive-free aerobic dehydrogenation coupling of aromatic amine to afford azo compounds with>99%yield and>99%selectivity at 60☆.We observed the superb catalytic activity is promoted by the enhanced oxygen mobility in OVs,which were created by the interstitial nitrogen in the catalyst matrix.The presence of interstitial nitrogen in transition metal oxides in this study shows how the manipulation of catalyst matrix can increase the OV sites to promote aerobic oxidation reaction. | Yangxin Jin Fengfeng Li Peixin Cui Yun Yang Qingping Ke Minh Ngoc Ha Wangcheng Zhan Fei Ruan Chao Wan Zhao Lei Van Noi Nguyen Wei Chen Jun Tang | 2021 | Nano Research2021，14，8： | 1 |
| 15 | Expression, Regula-tion, and Functionof IGF-1, IGF-IR, and IGF-1 Binding Proteins inBlood Vessels 显示文摘 | Patrice Delafontaine Yao-Hua Song Yangxin Li | 2004 | Arterioscler Thromb Vasc Biol2004，24，3： | 1 |
| 16 | The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor显示文摘 | Xi-Yong Yu Yong-Jian Geng Xiao-Hong Li Qiu-Xiong Lin Zhi-Xin Shan Shu-Guang Lin Yao-Hua Song Yangxin Li | 2009 | Molecular and Cellular Biochemistry (-)2009，，1： | 1 |
| 17 | Modification and application of the mean spherical approximation method 显示文摘 | Lu Jiufang Yu Yangxin Li Yigui | 1993 | Fluid Phase Equilibria1993，85，： | 1 |
| 18 | Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1显示文摘 | Xi-Yong Yu Yao-Hua Song Yong-Jian Geng Qiu-Xiong Lin Zhi-Xin Shan Shu-Guang Lin Yangxin Li | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 1 |
| 19 | High levels of glucose induce “metabolic memory” in cardiomyocyte via epigenetic histone H3 lysine 9 methylation显示文摘 | Xi-Yong Yu Yong-Jian Geng Jia-Liang Liang Saidan Zhang He-Ping Lei Shi-Long Zhong Qiu-Xiong Lin Zhi-Xin Shan Shu-Guang Lin Yangxin Li | 2012 | Molecular Biology Reports2012，，9： | 1 |
| 20 | A survey of the development of biomimetic intelligence and robotics显示文摘Biomimetics is the development of novel theories and technologies by emulating the models and systems of nature.The transfer of function from biological science into engineering promotes emerging research areas across many disparate disciplines.Recently,advances in biomimetic intelligence and robotics have gained great popularity.Biomimetic robotics are designed with biological characteristics and functions to be applied in different scenarios,such as humanoid robot in the home environment,quadruped robot in the field,and bird-like flying robot in the sky.Biomimetic intelligence aims to solve many complex problems by studying the principles of biological systems,resulting in a series of efficient algorithms,such as the genetic algorithm and neural network.Biomimetic intelligence further facilitates the performance of biomimetic robotics,making it possible to be deployed in more and more practical applications.This survey introduces the development of biomimetic intelligence and biomimetic robotics.We survey different biomimetic robots,biomimetic sensors and sensing technologies,and popular biomimetic intelligence algorithms.The conclusion is drawn by discussing current challenges and future research directions. | Jiankun Wang Weinan Chen Xiao Xiao Yangxin Xu Chenming Li Xiao Jia Max Q-H.Meng | 2021 | Biomimetic Intelligence & Robotics2021，1，1： | 1 |
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