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| 1 | Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System显示文摘 | Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen | 2017 | Molecular Plant2017，10，9： | 28 |
| 2 | Gastrodin inhibits neuroinflammation in rotenone-induced Parkinson's disease model rats显示文摘The present study showed that the latency of rats moving on a vertical grid was significantly prolonged,and the number of rats sliding down from the declined plane was increased remarkably,in rotenone-induced Parkinson's disease model rats compared with control rats.The moving latency recovered to normal levels,but the number of slides was significantly increased at 28 days after model establishment.The slope test is a meaningful approach to evaluate the symptoms of Parkinson's disease model rats treated with rotenone.In addition,loss of substantia nigral dopaminergic neurons in model rats was observed at 1 day after the model was established,and continued gradually at 14 and 28 days.The expression of tyrosine hydroxylase-positive cells was significantly increased in gastrodin-treated rats at 14 days.Significant numbers of activated microglia cells were observed in model rats at 14 and 28 days;treatment of rats with Madopar at 28 days suppressed microglial activation.Treatment of rats with gastrodin or Madopar at 28 days significantly reduced interleukin-1β expression.The loss of substantia nigral dopaminergic neurons paralleled the microglial activation in Parkinson's disease model rats treated with rotenone.The inflammatory factors tumor necrosis factor-α and interleukin-1β are involved in the substantia nigral damage.Gastrodin could protect dopaminergic neurons via inhibition of interleukin-1β expression and neuroinflammation in the substantia nigra. | Chun Li Xin Chen Nan Zhang Yangwen Song Yang Mu | 2012 | Neural Regeneration Research2012，7，5： | 15 |
| 3 | Integrated simulation of the dualistic water cycle and its associated processes in the Haihe River Basin显示文摘Water resource shortages, water environmental deterioration, and water ecological degradation are becoming increasingly prominent in the Haihe River Basin under the effects of global climate change and intense human activity. Finding ways to solve these problems reasonably is an urgent task in basin water resources management. The water cycle describes the formation and transformation of every water drop, while it interacts with associated water ecology and water environment processes. Therefore, to fundamentally solve the above problems, the three processes must be combined and the evolutionary trends of the ecology and water environment driven by the water cycle must be determined. To comprehensively diagnose and solve the problems of water resources, ecology and water environment in the basin, an integrated simulation platform of the dualistic water cycle and its associated processes in the Haihe River Basin was established by fully analyzing the 'natural-social' dualistic characteristics of the evolution of the basin water cycle in this study. Accordingly, it is a supporting tool to evaluate the future trends of water resources, ecology and the water environment by setting scenarios based on the predictions of a climate mode and water control conditions. The results show that with climate change, the water consumption, groundwater overexploitation, and the amount of water flowing to the sea could develop soundly and satisfy the requirements of national economic growth in the future planning year 2030 through the implementation of water consumption control management and the South-North Water Diversion Project. Meanwhile, associated water environmental deterioration can be alleviated, and a growing trend for production capacities of the natural ecosystem and agro-ecosystem is seen. The above results provide a foundation for implementing basin water resources regulation and the most strict water resources management. | WANG Hao JIA YangWen YANG GuiYu ZHOU ZuHao QIU YaQin NIU CunWen PENG Hui | 2013 | Chinese Science Bulletin2013，58，27： | 10 |
| 4 | Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease显示文摘Extensive iron deposition has been observed in the midbrain substantia nigra(SN) of Parkinson's disease(PD) patients,but the mechanisms of iron deposition in the SN remain poorly understood.The present study investigated the relationship between dopaminergic neuronal damage,iron content changes,and divalent metal transporter 1(DMT1) in the midbrain SN of PD rats to explore the relationship between time of iron deposition and DMT1 expression.Frozen midbrain SN sections from model rats were stained with Perls' iron.Results showed massive loss of tyrosine hydroxylase(TH)-positive cells in the SN and increased DMT1 expression in model group rats.No obvious iron deposition was observed in the SN during early stages after damage,but significant iron deposition was detected at 8 weeks post-injury.Results demonstrate that the loss of TH-positive cells in the SN appeared simultaneously with increased DMT1 expression.Extensive iron deposition occurred at 8 weeks post injury,which could be regarded as an early time window of iron deposition. | Yangwen Song Xin Chen Chun Li Nan Zhang | 2010 | Neural Regeneration Research2010，5，22： | 8 |
| 5 | Parallel relationship between microglial activation and substantia nigra damage in a rotenone-induced Parkinson's disease rat model显示文摘BACKGROUND:Inflammatory injury induced by microglial activation plays an important role in the occurrence and development of Parkinson's disease (PD). However, few studies have examined the relationship between microglia and substantia nigra damage or dopaminergic neuron loss in animals with rotenone-induced PD. OBJECTIVE: To explore the relationship between activated microglia and loss of the substantia nigra, and the changes in concentration and dose of rotenone in the brain of rats with rotenone-induced PD. DESIGN, TIME AND SETTING: The neuropathological experiment was performed at the School of Traditional Chinese Medicine, Capital Medical University, China, from July 2007 to July 2008. MATERIALS: Rotenone was purchased from Sigma, USA. METHODS: The Parkinson's model was induced by injection of a rotenone oily-emulsion (2 mg/kg daily) subcutaneously into the back of 58 male adult Wistar rats for 3-6 weeks. Another three rats served as normal controls. MAIN OUTCOME MEASURES: Neurobehavioral changes were observed and recorded following rotenone treatment. Tyrosine hydroxylase and complement receptor OX42 were separately analyzed by immunohistochemical staining within 4 weeks following stopping rotenone treatment. Rotenone content was measured using high performance liquid chromatography in the cerebellum of rats that scored 2, 4-6. RESULTS: Rotenone induced a loss of dopaminergic neurons in the substantia nigra as well as microglial activation, with increased behavior scores. Dopaminergic loss was still ongoing even when rotenone was stopped. Dopaminergic neuronal degeneration in the substantia nigra was ini- tially 6%, but was 85% at 2 weeks after scoring, and degeneration depended on activated microglia. Rotenone was detected in the cerebellum at concentrations between 78.9 μg/L and 309.6 μg/L. CONCLUSION: Nigrostriatal dopaminergic degeneration paralleled the microglial activation. Rotenone absorbed into the brain in its original form initiated pathological injury in the substantia nigra of PD rats. | Xin Chen Nan Zhang Chun Li Yangwen Song Siyuan Yu | 2010 | Neural Regeneration Research2010，5，4： | 7 |
| 6 | Necessity and feasibility for an ET-based modern water resources management strategy: A case study of soil water resources in the Yellow River Basin显示文摘The necessity and feasibility of an ET-based modern water resources management was analyzed to improve assessment of critical water resources scarcity in the region/basin. This analysis was based on the whole water cycle process and its analysis object is evapotranspiration (ET), a main consumption component in the water resources dynamic transformation process. A case study was undertaken by selecting soil water resources in the Yellow River Basin and employing the WEP-L distributed hydrological model with physics mechanisms. This paper discusses the amount and consumption efficiency of soil-water resources according to completely simulated results of water cycle elements throughout the basin. Results indicate that it is important for the ET-based modern water resources management strategy to alleviate water resources scarcity because it may not only avoid unused water wasting but also improve water use efficiency. Therefore, an ET-based modern water resources management scheme is a good complement to the traditional water resources demand management system. | WANG Hao YANG GuiYu JIA YangWen QIN DaYong GAN Hong WANG JianHua HAN ChunMiao | 2009 | Science China(Technological Sciences)2009，52，10： | 6 |
| 7 | Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus显示文摘The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal growth.Previously,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in rice.In this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to PHR2.RLI1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced genes.More importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate response.Therefore,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient. | Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen Qian Xiahe Huang Yongqiang Liu Xiujie Liu Yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu | 2021 | Molecular Plant2021，14，3： | 4 |
| 8 | Laparoscopic splenectomy in portal hypertension: a single-surgeon 13-year experience显示文摘 | Yuedong Wang Xiaoli Zhan Yangwen Zhu Zhijie Xie Jinhui Zhu Zaiyuan Ye | 2010 | Surgical Endoscopy2010，，5： | 4 |
| 9 | Alternation in Lipid Composition of Wheat Leaves Induced by Phosphate Deficiency Is Related to Both Lipid Biosynthesis and Phosphatidylglycerol Degradation显示文摘In this study, the causes of the changes in lipid composition induced by different phosphatenutrient levels were investigated. Wheat plants were grown in phosphate-deficient and phosphate-suffcient conditions, respectively, and lipid compositions in the leaves of 9-day-old and 16-day-old plants wereanalyzed. We found that phosphate deficiency induced a dramatic change at the lipid levels in photosyntheticmembranes of wheat leaves and the extent of changes in lipid composition depended on the leaf ages.Phosphate deficiency induced a gradual decrease in PG and MGDG and a concomitant increase in DGDGand SQDG from the first leaf to the second and the third leaf on 16-day-old plants. In addition, as comparedto leaves grown under phosphate sufficient solution, PG content in the first leaf of 16-day-old plants wassignificantly lower than that of 9-day-old leaf with 2.5 mol% versus 5.5 mol% when these plants were grownunder phosphate deficient condition. From these results, it is suggested that the alternation in lipidcomposition in wheat leaves induced by phosphate deficiency is related to both lipid biosynthesis and PGdegradation. PG decrease in younger leaves is mainly due to insufficient phosphate supply for PG biosynthesis,while PG degradation mainly resulted in the PG decrease in older leaves. | YANGWen FENGFu-Ying HOUHai-Tong JIANGGui-Zhen XUYi-Nong KUANGTing-Yun | 2004 | Acta Botanica Sinica2004，46，2： | 3 |
| 10 | A cryptic inhibitor of cytokinin phosphorelay controls rice grain size显示文摘Plant hormone cytokinin signals through histidine-aspartic acid(H-D)phosphorelay to regulate plant growth and development.While it is well known that the phosphorelay involves histidine kinases,histidine phosphotransfer proteins(HPs),and response regulators(RRs),how this process is regulated by external components remains unknown.Here we demonstrate that protein phosphatase with kelch-like domains(PPKL1),known as a signaling component of steroid hormone brassinosteroid,is actually a cryptic inhibitor of cytokinin phosphorelay in rice(Oryza sativa).Mutation at a specific amino acid D364 of PPKL1 activates cytokinin response and thus enlarges grain size in a semi-dominant mutant named s48.Overexpression of PPKL1 containing D364,either with the deletion of the phosphatase domain or not,rescues the s48 mutant phenotype.PPKL1 interacts with OsAHP2,one of authentic HPs,and D364 resides in a region resembling the receiver domain of RRs.Accordingly,PPKL1 can utilize D364 to suppress OsAHP2-to-RR phosphorelay,whereas mutation of D364 abolishes the effect.This function of PPKL1 is independent of the phosphatase domain that is required for brassinosteroid signaling.Importantly,editing of the D364-residential region produces a diversity of semi-dominant mutations associated with variously increased grain sizes.Further screening of the edited plants enables the identification of two genotypes that confer significantly improved grain yield.Collectively,our study uncovers a noncanonical cytokinin signaling suppressor and provides a robust tool for seed rational design. | Dapu Liu He Zhao Yunhua Xiao Guoxia Zhang Shouyun Cao Wenchao Yin Yangwen Qian Yanhai Yin Jinsong Zhang Shouyi Chen Chengcai Chu Hongning Tong | 2022 | Molecular Plant2022，15，2： | 3 |
| 11 | Study on consumption efficiency of soil water resources in the Yellow River Basin based on regional ET structure显示文摘Based on the regional water resources character, the concept of soil water resources is first redefined, and then associated with their transfer relationship in the hydrological cycle, Evapotranspiration (ET)-based consumption structure and consumption efficiency of soil water resources are analyzed. According to ET 's function in productivity, the consumption efficiency of soil water resources is di- vided into three classes: high efficient consumption from vegetation transpiration, low efficient con- sumption from soil evaporation among plants with high vegetation coverage and inefficient consump- tion from soil evaporation among plants with low vegetation coverage and bare soil evaporation. The high efficient and low efficient consumption were further classified as productive consumption. The ineffi- cient consumption is considered non-productive consumption because it is significant in the whole hydrological cycle process. Finally, according to these categories, and employing a WEP-L dis- tributed hydrological model, this paper analyzes the consumption efficiency of soil water resources in the Yel- low River Basin. The results show that there are 2078.89×108 m3 soil water resources in the whole basin. From the viewpoint of consumption structure, the soil water resources are comprised of 381.89×108 m3 transpiration consumption from vegetation and 1697.09×108 m3 evaporation consumption from soil among plants and bare soil. From the viewpoint of consumption efficiency, soil water re- sources are composed of 920.11×108 m3 efficient consumption and 1158.86×108 m3 of inefficient con- sumption. High efficient consumption accounts for 41.5 percent of the total efficient consumption of the whole basin, low efficient for 58.5 percent. Furthermore, consumption efficiency varies by region. Compared with ET from different land use conditions, the whole basin appears to follow the trend of having the greatest proportion of consumption as inefficient consumption, followed by low efficient consumption, and then the least proportion as high efficient consumption. The amount of inefficient consumption in some regions with vegetation is less than in other regions without vegetation. The amount of inefficient consumption in grasslands is much greater than in forestlands. However, the proportion of low efficient consumption is the greatest in crop fields. The amount of high efficient con- sumption in grasslands and forelands is similar to the corresponding low efficient consumption. However, the low efficient consumption in grasslands is larger than in the forelands. Therefore, when adjusting the utilization efficiency of soil water resources, vegetation coverage and plant structure should be modulated in terms of the principle of decreasing inefficient consumption, improving low efficiency ET and increasing high efficiency ET according to area character. | WANG Hao YANG GuiYu JIA YangWen QIN DaYong | 2008 | Science China Earth Sciences2008，51，3： | 3 |
| 12 | Laparoscopic splenectomy and azygoportal disconnection with intraoperative splenic blood salvage显示文摘 | Yuedong Wang Yun Ji Yangwen Zhu Zhijie Xie Xiaoli Zhan | 2012 | Surgical Endoscopy2012，，8： | 2 |
| 13 | Integrated modeling and assessment of water resources and water environment in the Yellow River Basin 显示文摘 | Yangwen Jia Cunwen Niu Hao Wang | 2007 | Journal of Hydro-Environment Research2007，，1： | 1 |
| 14 | The role of the TLR4 signaling pathway in cognitive deficits followingsurgery in aged rats显示文摘 | Yi Wang Huijuan He Dan Li Wenjing Zhu Kaiming Duan Yuan Le Yan Liao Yangwen Ou | 2013 | Molecular Medicine Reports2013，，： | 1 |
| 15 | Inflammation:a bridge between postoperative cognitive dysfunction and Alzheimer's disease显示文摘 | Zhonghua Hu Yangwen Ou Kaiming Duan | 2010 | Med Hypotheses2010，74，4： | 1 |
| 16 | Laparoscopic splenec- tomy and azygoportal disconnection with intraoperative splenic blood salvage显示文摘 | Yuedong Wang Yun Ji Yangwen Zhu | 2012 | Surg Endosc2012，26，8： | 1 |
| 17 | Inflammation: A bridge between postoperative cognitive dysfunction and Alzheimer’s disease显示文摘 | Zhonghua Hu Yangwen Ou Kaiming Duan Xianzhen Jiang | 2009 | Medical Hypotheses2009，，4： | 1 |
| 18 | An experimental study on dynamic processes of ephemeral gully erosion in loess landscapes显示文摘 | Gong Jiaguo Jia Yangwen Zhou Zuhao | 2011 | Geomorphology2011，125，1： | 1 |
| 19 | Structural characteristics and implication on tectonic evolution of the Daerbute strike-slip fault in West Junggar area, NW China显示文摘 | Kongyou WU Yangwen PEI Tianran LI Xulong WANG Yin LIU Bo LIU Chao MA | 2018 | Frontiers of Earth Science2018，12，3： | 1 |
| 20 | An activated form of NB-ARC protein RLS1 functions with cysteine-rich receptor-like protein RMC to trigger cell death in rice显示文摘A key event that follows pathogen recognition by a resistance(R)protein containing an NB-ARC(nucleotide-binding adaptor shared by Apaf-1,R proteins,and Ced-4)domain is hypersensitive response(HR)-type cell death accompanied by accumulation of reactive oxygen species and nitric oxide.However,the integral mechanisms that underlie this process remain relatively opaque.Here,we show that a gain-offunction mutation in the NB-ARC protein RLS1(Rapid Leaf Senescence 1)triggers high-light-dependent HR-like cell death in rice.The RLS1-mediated defense response is largely independent of salicylic acid accumulation,NPR1(Nonexpressor of Pathogenesis-Related Gene 1)activity,and RAR1(Required for Mla12 Resistance 1)function.A screen for suppressors of RLS1 activation identified RMC(Root Meander Curling)as essential for the RLS1-activated defense response.RMC encodes a cysteine-rich receptor-like secreted protein(CRRSP)and functions as an RLS1-binding partner.Intriguingly,their co-expression resulted in a change in the pattern of subcellular localization and was sufficient to trigger cell death accompanied by a decrease in the activity of the antioxidant enzyme APX1.Collectively,our findings reveal an NBARC-CRRSP signaling module that modulates oxidative state,the cell death process,and associated immunity responses in rice. | Yiqin Wang Zhenfeng Teng Hua Li Wei Wang Fan Xu Kai Sun Jinfang Chu Yangwen Qian Gary JLoake Chengcai Chu Jiuyou Tang | 2023 | Plant Communications2023，4，2： | 1 |
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