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| 1 | Prediction of eukaryotic gene structures based on multilevel optimization显示文摘Computational gene structure prediction, which is valuable for finding new genes and understanding the composition of genomes, plays a very important role in various kinds of genome projects. For eukaryotic gene structures, however, the prediction accuracy of existing methods is still limited. This paper presents a method of pre-dicting eukaryotic gene structures based on multilevel opti-mization. The complicated problem of predicting gene structure in eukaryotic DNA sequence containing multiple genes can be decomposed into a series of sub-problems at several levels with decreasing complexity, including the gene level (single-exon gene, multi-exon gene), the element level (exon, intron, etc.), and the feature level (functional site sig-nals, codon usage preference, etc.). On the basis of this de-composition, a multilevel model for the prediction of complex gene structures is created by a multilevel optimization proc-ess, in which the models dealing with sub-problems at low complexity level are first optimized respectively, and then optimally combined together to form models for those sub-problems at higher complexity level. Based on the multi-level model, a dynamic programming algorithm is designed to search for optimal gene structures from DNA sequences, and a new program GeneKey (1.0) for the prediction of eu-karyotic gene structures is developed. Testing results with widely used datasets demonstrate that the prediction accura-cies of GeneKey (1.0) at the nucleotide level, exon level and gene level are all higher than that of the well known program GENSCAN. A web server of GeneKey(1.0) is available at http://gffzze1e99242f9d74955hxuq6onqnx0wu6vc0.ffgz.tsg.suse.edu.cn. | ZHOUYanhong YANGLei WANGHui LUFeng WANHonghui | 2004 | Chinese Science Bulletin2004，49，4： | 7 |
| 2 | Logging Geology Study of the Caverned Paleokarst Reservoir Distribution显示文摘In recent years, many carbonate rock oilfields such as Lunnan and Tahe have been found in the Tarim Basin, and the main reservoir space of the stable high yield wells in these oilfields consists mainly of the caverns formed by the paleo-karstification and the dissolution pores and fractures connected with them. Nevertheless, it is difficult to predict effectively the distribution of the cavern reservoir because of its extremely serious heterogeneity. In this paper, a case study of the Lunxi Oilfield in the north uplift of the Tarim Basin is conducted to introduce the logging geology method for predicting the distribution of the caverned paleokarst reservoir. By means of building up the logging recognition style of different caverns and differentiating and correlating the karst zones with logging curves, and through an analysis of the paleokarst topography background, the favorable karst zones and distribution areas of the high quality cavern reservoir have been located, which lays a new basis for further exploration in this area. | WuXinsong YangLei PanWenqing GuQiaoyuan | 2005 | Petroleum Science2005，2，2： | 5 |
| 3 | Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol显示文摘Vitamin E is one of the most widely used vitamins.In the classical commercial synthesis of vitamin E(a-tocopherol),the chemical synthesis of isophytol is the key technical barrier.Here,we establish a new process for isophytol synthesis from microbial fermented farnesene.To achieve an efficient pathway for farnesene production,Saccharomyces cerevisiae was selected as the host strain.First,b-farnesene synthase genes from different sources were screened,and through protein engineering and system metabolic engineering. | Ziling Ye Bin Shi Yanglei Huang Tian Ma Zilei Xiang Ben Hu Zhaolin Kuang Man Huang Xiaoying Lin Zhu Tian Zixin Deng Kun Shen Tiangang Liu | 2022 | The Innovation2022，3，3： | 2 |
| 4 | Comprehensive genomic analysis and expression profiling of cysteine-rich polycomb-like transcription factor gene family in tea tree显示文摘Cysteine-rich polycomb-like(CPP)is a small gene family in plants,which plays key role in plant development and stress response.Although CPP transcription factors have been characterized in several other plant species,a genome-wide characterization of the CPP gene family has been absent in Camellia sinensis.In this study,we totally identified 7,8,and 8 non-redundant CsCPP genes in three published genomes,including Camellia sinensis var.assamica cv.Yunkang-10(CSA-YK10),Camellia sinensis var.sinensis cv.Biyun(CSS-BY)and Camellia sinensis var.sinensis cv.Shuchazao(CSS-SCZ).CPP proteins from tea tree and other plant species were classified into three groups,which were further divided into four subgroups based on phylogenetic relationships.Most CPP genes in the same subgroup had similar gene structures and conserved motifs.The cis-acting elements analysis indicated that CPP genes might be involved in plant growth,development and stress responses.Analysis of gene expression using qRT-PCR experiments validated that CPP genes exhibited different expression patterns across the examined tissues.All the genes were expressed differentially in a range of tissues,indicating that CPPs were involved in a range of developmental and physiological processes.This study has obtained new insights into the evolution and function of the CPP gene family in the growth and development of tea plants,and also provide candidate genes for further functional characterization in tea tree. | Hong Nan Yanglei Lin Xinghua Wang Lizhi Gao | 2021 | Horticultural Plant Journal2021，7，5： | 2 |
| 5 | 显示文摘 | LIGui-Xian(李贵贤) YANGLei(杨磊) MAJian-Jun(马建军) etal | 2009 | 聚氨酯工业2009，24，1： | 1 |
| 6 | Ectomycorrhizal influence on particle size, surface struc- ture, mineral crystallinity, functional groups, and elemental composition of soil colloids from different soil origins 显示文摘 | Li Yanhong Wang Huimei Wang Wenjie YangLei Zu Yuan gang | 2013 | Sci- entific World Journal2013，，14： | 1 |
| 7 | Process of Research on tile Alumina Ce- ramics Metaltization显示文摘 | Yanglei | 2015 | IVEC2015，，： | 1 |
| 8 | 显示文摘 | YangLei(杨雷) SunPeng(孙鹏) QiDongming(戚栋明) ShenYifeng(沈一峰) | 2013 | 高分子学报2013，，3： | 1 |
| 9 | 显示文摘 | YangLei(杨磊) JieXiaohua(揭晓华) GuoLi(郭黎) | 2010 | 电子元件与材料2010，29，8： | 1 |
| 10 | 显示文摘 | GaoHanwen(高瀚文) HeJiyu(何吉宇) YangRongjie(杨荣杰) YangLei(杨磊) | 2010 | 高分子材料科学与工程2010，26，： | 1 |
| 11 | 显示文摘 | JiangHui(蒋慧) ZhouLizhan(周利展) LiuWenwne(刘文文) YangLei(杨雷) ShenYifeng(沈一峰) | 2014 | 纺织学报2014，35，： | 1 |
| 12 | DesignconsiderationsofaplanarundulatorappliedinaterahertzFELoscillator显示文摘 | QinBin TanPin YangLei etal | 2013 | NuclearInstrumentsandMethodsinPhysicsResearchSectionA2013，727，： | 1 |
| 13 | 显示文摘 | JUSi-Ting(鞠思婷) PULing-Yu(朴玲钰) YANGLei(杨磊) etal | | HuaxueJinzhan0，，： | 1 |
| 14 | 显示文摘 | LIXian-Xue(李先学) SHENGao-Yang(沈高扬) YANGLei(杨磊) etal | | ZhongguoXituXuebao0，，： | 1 |
| 15 | Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota显示文摘Colorectal cancer(CRC)is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2% dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily(1 × 10^(9) CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression(like Occludin, Claudin-1, and ZO-1)and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators(like GSH and SOD)and reducing the level of oxidative mediators(like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria(like SCFAs-producing bacteria, Akkermansia)and decreasing the abundance of harmful bacteria(like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress. | Tao Wang Panpan Wang Li Yin Xiuchao Wang Yuanyuan Shan Yanglei Yi Yuan Zhou Bianfang Liu Xin Wang Xin Lü | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 16 | Research progress of traditional Chinese medicine in ferroptosis-related diseases显示文摘Ferroptosis—the novel and typical form of apoptosis—is different from apoptosis and necrosis in the fields of anatomy,genetics,cellular metabolism,and molecular biology.Reportedly,ferroptosis-related diseases can be cured using Traditional Chinese Medicine(TCM)products.Current research shows that TCM products cause little to no adverse effects.Moreover,TCM products have significant advantages,in terms of having multiple targets and using multiple pathways.In our study,we mainly summarize the mechanism of ferroptosis and the use of TCM in the treatment of ferroptosis-related diseases to clarify the efficacy of TCM products in ferroptosis-related diseases.This study is expected to provide the evidence for researchers engaged in the development and use of TCM in the future. | Yanglei Jiang Shucen Zhao Yali Zhou Zhe Wei | 2022 | Medicine in Novel Technology and Devices2022，，4： | 0 |
| 17 | Effects of Heavy Ions on Kinetic Alfvén Waves显示文摘Kinetic Alfven Wave (KAW) is one of the low-frequency electromagnetic fluctuations that are identified extensively in space plasmas by in situ observations of satellites and has been an interesting topic for discussion widely in the fields of laboratory, space, and astrophysical plasmas because of its potential importance in plasma particle energization. Some satellite observations show that the number density ratio of the oxygen ions to the ambient plasma is 30% ~ 50%, sometimes, even as high as 80%. In this paper, effects of heavy ion species on KAWs are studied in a Iow-beta plasma. The results show that heavy ions not only considerably reduce the propagation speed of KAWs, but also remarkably influence the parallel component of perturbed electric field of KAWs (to the ambient magnetic field). The ratio of parallel to perpendicular components of perturbed field decreases (or increases) with the heavyion abundance for KAWs dominated by the electron inertial length (or by ion acoustic gyroradius). In particular, the resonant condition of KAWs with thermal electrons is modified by the heavy ion species. | YANGLei WUDe-Jin | 2005 | Communications in Theoretical Physics2005，43，2： | 0 |
| 18 | A phenomenological model for the dynamics of cell cycle in responding to X-rays显示文摘 | Zhang Sheng Ao Bin Ye Caiyong Yang Lei Zhou Guangming ZhangSheng AoBin YeCaiyong YangLei ZhouGuangming | 2015 | 中华放射医学与防护杂志2015，35，1： | 0 |
| 19 | Studies on the Separation of Cesium From Fission Products显示文摘^135Cs is a long-life fission product. When measuring its thermal cross section, we must separate radiochemical purity cesium from fission products. Except for decontaminating radio- nuclides, others which can be activated must be avoided to come into solution. So ion exchanger is used. Inorganic ion exchangers have received increased attention because of their high resistance to radiation and their very efficient separation of alkali metal ions. | QIANLi-juan ZHANGSheng-dong GUOJing-ru CUIAn-zhi YANGLei WUWang-suo | 2003 | Annual Report of China Institute of Atomic Energy2003，，1： | 0 |
| 20 | Research progress of traditional Chinese medicine in ferroptosis-related diseases Volume 16,December 2022,100203显示文摘Corrigendum:We corrected the reference sequence number of the third illustration and adjusted the reference sequence number of the rest of the article.Research progress of traditional Chinese medicine in ferroptosisrelated diseases.[66]Chen LH,Xiang Y.Research progress of ferroptosis in tumor immunotherapy.Cancer Prev Treat 2022;35:765-9. | Yanglei Jiang Shucen Zhao Yali Zhou Zhe Wei | 2023 | Medicine in Novel Technology and Devices2023，，1： | 0 |
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