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| 1 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 2 | Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions显示文摘AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in rats.METHODS A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within 48hpostburn.RESULTS The gastric acid production in theacute shock period was markedly inhibited aftersevere burn injury.At the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(P<0.01),and reached the lowest point,0.63mL/L±0.20mL/L,10.81mmol/L±2.58mmol/L and 2.23mmol/h±0.73mmol/hrespectively,at the 12th h postburn.Althoughrestored to some degree 24 h after thermalinjury,the variables above were stillstatistically lower,compared with those ofcontrol animals at the 48th h postburn.TheGMBF and EC were also significantly reducedafter severe burns,consistent with the trend ofgastric acid production changes.CONCLUSION Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some respects.Therefore,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 3 | Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats显示文摘 | Zhao,ZM Li,HJ Liu,HY Lu,SH Yang,RC Zhang,QJ Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 4 | Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages显示文摘 | Liu,YJ Lu,SH Xu,B Yang,RC Ren,Q Liu,B Lu,M Yan,FY Han,ZB Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 5 | Pathogenesis and management of chronic idiopathic thrombocytopenic purpura: An update 显示文摘 | Yang R Han ZC | 2000 | Intern J Hematol2000，71，1： | 1 |
| 6 | Proteome analysis of muhidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR 显示文摘 | Yang YX Xiao ZQ Chen ZC | 2006 | Proteomics2006，6，6： | 1 |
| 7 | Proteome analysis of mul- tidrug resistance in vincristine- resistance human gastric cancer cell line SCK37901/VCR显示文摘 | Yang YX Xiao ZQ Chen ZC | 2006 | Proteomics2006，6，6： | 1 |
| 8 | HER-2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tu- morigenesis显示文摘 | Hartman ZC Yang XY Glass O | 2011 | Cancer Res2011，71，13： | 1 |
| 9 | Dynamic Model and Numerical Simulation for Synchronal Rotary Compressor 显示文摘 | Zhou H Qu ZC Yang H | 2009 | Joumal of Fluids Engineering-Transactions of the ASME2009，131，04： | 1 |
| 10 | The significance of changes in serum tumor necrosis factor (TNF) activity in severely burned patients显示文摘 | Liu XS Lou ZH Yang ZC | 1994 | Burns1994，20，1： | 1 |
| 11 | Comparison between radioim- munotherapy and external beam radiation therapy for patients with hepatoceUular carcinoma显示文摘 | ZENG ZC TANG ZY YANG BH | 2002 | Eur J Nuel Med2002，29，： | 1 |
| 12 | Pathogenesis of early cardiac myocyte damage after severe burns显示文摘 | Yang ZC Yan BG | 1999 | J Trauma1999，46，3： | 1 |
| 13 | Pathogenesis of early cardiac myocyte damage after severe burns 显示文摘 | Hwang YS Yang ZC Yan BG | 1999 | Trauma1999，46，3： | 1 |
| 14 | Pathogenesis and management of chronic idiopathic thrombocytopenic purpura : an update 显示文摘 | Yang R Han ZC | 2000 | Int J Hematol2000，71，1： | 1 |
| 15 | Mechanistic insights into diabetes mellitus and oxidative stress显示文摘 | Kenneth M Zhao ZC Yang CS | 2007 | Curr Med Chem2007，14，16： | 1 |
| 16 | Prediction of soil organic matter in peak-cluster depression region using kriging and terrain indices显示文摘 | Yang QY Jiang ZC Li WJ Li H | 2014 | Soil and Tillage Research2014，144，： | 1 |
| 17 | Roles of some inflammatory mediatots in the pathogenesis of early pulmonary edema in steam respiratory bums 显示文摘 | Li Ao Jiang KY Yang ZC | 1987 | Chin ned J (Engl)1987，100，2： | 1 |
| 18 | Comparison between radioimmunotherapy and external beam radiation therapy for patients with hepatocellular carcinoma 显示文摘 | Zeng ZC Tang ZY Yang BH | 2002 | Eur J Nucl Med2002，29，： | 1 |
| 19 | A highly selective charge lransfer fluoroionophore for Cu^2- 显示文摘 | Wen ZC Yang R He H | 2006 | Chem Commun2006，，： | 1 |
| 20 | Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome in severe burns显示文摘 | Huang YS Yang ZC Liu XS | 1998 | Burns1998，84，： | 1 |
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