|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 2 | Concurrent Design for Process Quality, Statistical Tolerance, and SPC 显示文摘 | ZHANG Yu YANG Musheng ZHANG Yanxin | 2006 | Communications in Statistics - Theory and Methods2006，35，10： | 1 |
| 3 | A Coordinate SPC Model for Assuring Designated Fit Quality Via Quality -oriented Statistical Tolerancing显示文摘 | ZHANG Yu YANG Musheng | 2009 | Computers and Industrial Engineering2009，57，1： | 1 |
| 4 | A Coordinate SPC Model for Assuring Designated Fit Quality via Quality-oriented Statistical Tolerancing显示文摘 | Zhang Yu Yang Musheng | | 0，，01： | 1 |
| 5 | Concurrent design for process quality, statistical tolerance, and SPC 显示文摘 | Zhang Yu Yang Musheng Zhang Yanxin | 2006 | Communications in Statistics-Theory and Methods2006，35，10： | 1 |
| 6 | Concurrent design for process quality,statistical tolerance,and SPC显示文摘 | Zhang Yu Yang Musheng Zhang Yanxin | 2006 | Communications in Statistics-Theory and Methods2006，35，10： | 1 |
| 7 | The Technique of Building a Networked Manufacturing Process Monitoring System显示文摘This paper introduces the constitute,structure and the software model of a set of networked manufacturing process monitoring system,using JAVA network technique to realize a set of three layer distributed manufacturing process monitoring sys- tem which is comprised with remote manage center,manufacturing process supervision center and the units of measure and control layer such as displacement sensor,the device of temperature measure and alarm etc.The network integration of the production management layer,the process control layer and the hard ware control layer is realized via using this approach.The design using object-oriented technique based on JAVA can easily transport to different operation systems with high performance of the expansibili- ty. | XIE Yong ZHANG Yu YANG Musheng (College of Mechanical Engineering,Shandong University of Technology,Zibo 255049,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 8 | The Remote Product Check and Acceptance Technology Based on Web显示文摘This paper analyzes the feasibility of the remote check and acceptance of product and presents an architecture through which the remote product check and acceptance system can be realized. This paper also illuminates the work process of this system and discusses the technological details of the quality inspection as well as the key technologies. | YANG Musheng 1,2 ,ZHANG Yu1 (1.School of Mechanical Engineering,Shandong University of Technology,Zibo 255000,China 2.School of Mechanical Engineering,Nanjing University of Science and Technology, Nanjing 210094,China) | 2006 | 武汉理工大学学报2006，28，S1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员