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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 5 |
| 3 | Spatial-temporal evolution of injection-induced earthquakes in the Weiyuan Area determined by machine-learning phase picker and waveform cross-correlation显示文摘Anthropogenic induced seismicity has been widely reported and investigated in many regions,including the shale gas fields in the Sichuan basin,where the frequency of earthquakes has increased substantially since the commencement of fracking in late 2014.However,the details of how earthquakes are induced remain poorly understood,partly due to lack of high-resolution spatial-temporal data documenting the evolution of such seismic events.Most previous studies have been based on a diffusive earthquake catalog constructed by routine methods.Here,however,we have constructed a high resolution catalog using a machine learning detector and waveform cross-correlation.Despite limited data,this new approach has detected one-third more earthquakes and improves the magnitude completeness of the catalog,illuminating the comprehensive spatial-temporal migration of the emerging seismicity in the target area.One of the clusters clearly delineates a potential unmapped fault trace that may have led to the Mw 5.2 in September 2019,by far the largest earthquake recorded in the region.The migration of the seismicity also demonstrates a pore-pressure diffusion front,suggesting additional constraints on the inducing mechanism of the region.The patterns of the highly clustered seismicity reconcile the causal link between the emerging seismicity and the activity of hydraulic fracturing in the region,facilitating continued investigation of the mechanisms of seismic induction and their associated risks. | Wing Ching Jeremy Wong JinPing Zi HongFeng Yang JinRong Su | 2021 | Earth and Planetary Physics2021，5，6： | 5 |
| 4 | Near‑Instantaneously Self‑Healing Coating toward Stable and Durable Electromagnetic Interference Shielding显示文摘Durable electromagnetic interference(EMI)shielding is highly desired,as electromagnetic pollution is a great concern for electronics’stable performance and human health.Although a superhydrophobic surface can extend the service lifespan of EMI shielding materials,degradation of its protection capability and insufficient self-healing are troublesome issues due to unavoidable physical/chemical damages under long-term application conditions.Here,we report,for the first time,an instantaneously self-healing approach via microwave heating to achieve durable shielding performance.First,a hydrophobic 1H,1H,2H,2H-perfluorooctyltriethoxysilane(POTS)layer was coated on a polypyrrole(PPy)-modified fabric(PPy@POTS),enabling protection against the invasion of water,salt solution,and corrosive acidic and basic solutions.Moreover,after being damaged,the POTS layer can,for the first time,be instantaneously self-healed via microwave heating for a very short time,i.e.,4 s,benefiting from the intense thermal energy generated by PPy under electromagnetic wave radiation.This self-healing ability is also repeatable even after intentionally severe plasma etching,which highlights the great potential to achieve robust and durable EMI shielding applications.Significantly,this approach can be extended to other EMI shielding materials where heat is a triggering stimulus for healing thin protection layers.We envision that this work could provide insights into fabricating EMI shielding materials with durable performance for portable and wearable devices,as well as for human health care. | Lihua Zou Chuntao Lan Songlin Zhang Xianhong Zheng Zhenzhen Xu Changlong Li Li Yang Fangtao Ruan Swee Ching Tan | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 5 | Finite element simulation of food transport through the esophageal body显示文摘The peristaltic transport of swallowed material in the esophagus is a neuro-muscular function involving the nerve control, bolus-structure interaction, and structure-mechanics relationship of the tissue. In this study, a finite element model (FEM) was developed to simulate food transport through the esophagus. The FEM consists of three components, i.e., tissue, food bolus and peristaltic wave, as well as the interactions between them. The transport process was simulated as three stages, i.e., the filling of fluid, contraction of circular muscle and traveling of peristaltic wave. It was found that the maximal passive intraluminal pressure due to bolus expansion was in the range of 0.8-10 kPa and it increased with bolus volume and fluid viscosity. It was found that the highest normal and shear stresses were at the inner surface of muscle layer. In addition, the peak pressure required for the fluid flow was predicted to be 1-15 kPa at the bolus tail. The diseases of systemic sclerosis or osteogenesis imperfecta, with the remodeled microstructures and mechanical properties, might induce the malfunction of esophageal transport. In conclusion, the current simulation was demonstrated to be able to capture the main characteristics in the intraluminal pressure and bolus geometry as measured experimentally. Therefore, the finite element model established in this study could be used to further explore the mechanism of esophageal transport in various clinical applications. | Wei Yang Tat Ching Fung Kerm Sire Chian Chuh Khiun Chong | 2007 | World Journal of Gastroenterology2007，13，9： | 3 |
| 6 | The Beneficial Effect of Regular Endurance Exercise Training on Blood Pressure and Quality of Life in Patients with Hypertension显示文摘 | Jen‐Chen Tsai Hung‐Yu Yang Wei‐Hsin Wang Ming‐Hsiung Hsieh Pei‐Ti Chen Ching‐Chiu Kao Pai‐Feng Kao Chia‐Hui Wang Paul Chan | 2004 | Clinical and Experimental Hypertension2004，，3： | 2 |
| 7 | Assessing Number Sense of Student in Australia, Sweden, and the United States 显示文摘 | Robert Rey Barbara Rey Der Ching Yang | 1999 | School Science and Mathematics1999，99，2： | 2 |
| 8 | Teaching and Learning Number Sense 显示文摘 | Der Ching Yang | 2002 | School Science and Mathematics2002，102，4： | 2 |
| 9 | Applications of bio-derived/bio-inspired materials in the field of interfacial solar steam generation显示文摘Interfacial solar steam generation(ISSG)system has attracted extensive attention as a sustainable desalination technology because of its cost efficiency and zero fossil-energy consumption.Aiming at optimizing the desalination properties,materials and system design have been the current research focus.Recently,many novel bio-derived/bio-inspired design strategies were proposed owing to their highly efficient structures inherited from nature,which were fine-tuned over eons of evolution,as well as their low cost and ease of treatment.In this review,we are going to systematically report recent progress of various bio-derived/bio-inspired strategies in terms of optical design,wetting,thermal management,and overall system design,presenting an overview of the current challenges of bio-inspired materials in ISSG system and other application fields.This article is intended to provide a comprehensive review of recent developments about bio-derived/bio-inspired materials in ISSG system and conclude with suggestions regarding further research directions for performance enhancement through design of bio-derived/bio-inspired materials. | Yang Geng Kai Jiao Xu Liu Peijin Ying Omololu Odunmbaku Yaoxin Zhang Swee Ching Tan Ling Li Wei Zhang Meng Li | 2022 | Nano Research2022，15，4： | 2 |
| 10 | Characterization of deep ground geothermal field in Jiahe Coal Mine显示文摘Research into the characteristics of geothermal fields is important for the control of heat damage in mines. Based on measured geothermal data of boreholes from 200 m to 1200 m in a Jiahe Coal Mine, we demonstrate non-linear but increasing relations of both geo-temperatures and geothermal gradients with increases depth. Numerically, we fitted the relationship between geo-temperatures and depth, a first-order exponential decay curve, formulated as: T(h) = 4.975 + 23.08 exp(h/1736.1). | Zhang Yi Guo Dongming He Manchao Jiang Yaodong Yang Ching | 2011 | Mining Science and Technology2011，21，3： | 2 |
| 11 | Assessing Number Sense of Student in Australia, Sweden, and the United States 显示文摘 | Robert Rey Barbara Rey Der Ching Yang | 1999 | School Science and Mathematics1999，99，2： | 1 |
| 12 | An evaluation of the in- vestment environment in international logistics zones: A Taiwanese manufacturer' s perspective 显示文摘 | CHIN - SHAN LU CHING - CHIAO YANG | 2007 | Production Economics2007，，107： | 1 |
| 13 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 1 |
| 14 | Salvinal, a Novel Mierotubule Inhibitor Isolated from Salvia miltiorrhizae Bunge (Danshen), with Antimitotie Activity in Multidrug- Sensitive and -Resistant Human Tumor Cells显示文摘 | JANG -YANG CHANG CHI YEN CHANG CHING -CHUAN KUO | 2004 | Mol Pharmaeol2004，65，： | 1 |
| 15 | E-critical/Thematic Doing History Project: Integrating the Critical Thinking Approach with Computer -Mediated History Learning显示文摘 | Shu Ching Yang | 2007 | Computers in Human Behavior2007，5，： | 1 |
| 16 | Spectrum of toxic hepatitis following intentional paraquat ingestion: analysis of 187 cases显示文摘 | Chin‐Jung Yang Ja‐Liang Lin Dan‐Tzu Lin‐Tan Cheng‐Hao Weng Ching‐Wei Hsu Shen‐Yang Lee Shwu‐Hua Lee Chia‐Ming Chang Wey‐Ran Lin Tzung‐Hai Yen | 2012 | Liver Int2012，，9： | 1 |
| 17 | The cell surface marker CD36 selectively identifies matured, mitochondria-rich hPSC-cardiomyocytes显示文摘Dear Editor,Human pluripotent stem cell(hPSC)-derived cardiomyocytes(CMs)are of significant translational value to in vitro studies of human cardiac development,drug and cardiotoxicity testing and cardiac disease modelling.Differentiation of hPSCs to CMs,however,yields mixed cultures of atrial-,ventricular-,and pacemaker-like cells as well as non-CMs in variable proportions.1 Strategies to enrich CMs from non-CMs and to generate ventricular versus atrial cells have been successful;however,enriched hPSC-CMs are developmentally immature and fail to recapitulate key functional traits that are fundamental to the(patho)physiology of adult CMs.1,2 Moreover,these strategies do not adequately address experimental variabilities caused by differences in the genomes and differentiation capabilities of diverse hPSC lines.One validated approach that overcomes issues of cell heterogeneity and experimental variability is immunophenotyping;however,accessible markers suitable for defining mature,live CMs are lacking.Although cell surface markers such as SIRPA(CD172a)and VCAM1(CD106)3,4 have been used to sort for hPSC-CMs,they do not distinguish between maturation states.Here,we report the identification of CD36 as a cell surface marker of maturation,which can be used to reduce experimental variability and improve drug screens. | Ellen Ngar-Yun Poon Xiao-ling Luo Sarah EWebb Bin Yan Rui Zhao Stanley Chun Ming Wu Yong Yang Peng Zhang Huajun Bai Jiaofang Shao Ching Man Chan Godfrey Chi-Fung Chan Suk Ying Tsang Rebekah LGundry Huang-Tian Yang Kenneth RBoheler | 2020 | Cell Research2020，30，7： | 1 |
| 18 | Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postir radiation in mice显示文摘 | Hsue-Yin Hsu Jenq-Jer Yang Chun Ching Lin | 1997 | Cancer Letters1997，111，： | 1 |
| 19 | The prognostic role of microsatellite instability, codon‐specific KRAS , and BRAF mutations in colon cancer显示文摘 | Chun‐Chi Lin Jen‐Kou Lin Tzu‐Chen Lin Wei‐Shone Chen Shung‐Haur Yang Huann‐Sheng Wang Yuan‐Tzu Lan Jeng‐Kai Jiang Muh‐Hwa Yang Shih‐Ching Chang | 2014 | J. Surg. Oncol2014，，4： | 1 |
| 20 | Sequence selective binding of peptides by artificial receptors in aqueous solution显示文摘 | Breslow R Yang Z Ching R | 1998 | J Am Chem Soc1998，120，14： | 1 |
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