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| 1 | The Change of the Inlet Geometry of a Centrifugal Compressor Stage and its Influence on the Compressor Performance显示文摘The impact on the compressor performance is important for designing the inlet pipe of the centrifugal compressor of a vehicle turbocharger with different inlet pipes. First, an experiment was performed to determine the compressor performance from three cases: a straight inlet pipe, a long bent inlet pipe and a short bent inlet pipe. Next, dynamic sensors were installed in key positions to collect the sign of the unsteady pressure of the centrifugal compressor. Combined with the results of numerical simulations, the total pressure distortion in the pipes, the pressure distributions on the blades and the pressure variability in the diffuser are studied in detail. The results can be summarized as follows: a bent pipe results in an inlet distortion to the compressor, which leads to performance degradation, and the effect is more apparent as the mass flow rate increases. The distortion induced by the bent inlet is not only influenced by the distance between the outlet of the bent section and the leading edge of the impeller but also by the impeller rotation. The flow fields in the centrifugal impeller and the diffuser are influenced by a coupling effect produced by the upstream inlet distortion and the downstream blocking effect from the volute tongue. If the inlet geometry is changed, the distributions and the fluctuation intensities of the static pressure on the main blade surface of the centrifugal impeller and in the diffuser are changed accordingly. | WANG Leilei YANG Ce ZHAO Ben LAO Dazhong MA Chaochen LI Du | 2013 | Journal of Thermal Science2013，22，3： | 13 |
| 2 | Forced Responses on a Radial Turbine with Nozzle Guide Vanes显示文摘Radial turbines with nozzle guide vanes are widely used in various size turbochargers.However,due to the interferences with guide vanes,the blades of impellers are exposed to intense unsteady aerodynamic excitations,which cause blade vibrations and lead to high cycle failures(HCF).Moreover,the harmonic resonance in some frequency regions are unavoidable due to the wide operation conditions.Aiming to achieve a detail insight into vibration characteristics of radial flow turbine,a numerical method based on fluid structure interaction(FSI) is presented.Firstly,the unsteady aerodynamic loads are determined by computational fluid dynamics(CFD).And the fluctuating pressures are transformed from time domain to frequency domain by fast Fourier-transform(FFT).Then,the entire rotor model is adopted to analyze frequencies and mode shapes considering mistuning in finite element(FE) method.Meanwhile,harmonic analyses,applying the pressure fluctuation from CFD,are conducted to investigate the impeller vibration behavior and blade forced response in frequency domain.The prediction of the vibration dynamic stress shows acceptable agreement to the blade actual damage in consistent tendency. | LIU Yixiong YANG Ce MA Chaochen LAO DaZhong | 2014 | Journal of Thermal Science2014，23，2： | 3 |
| 3 | Epidemiologic psychiatric studies on post‐disaster impact among Chi‐Chi earthquake survivors in Yu‐Chi, Taiwan显示文摘 | FRANK HUANG‐CHIHCHOU HUNG‐CHIWU PESUSCHOU CHAO‐YUEHSU KUAN‐YITSAI SHIN‐SHINCHAO MING‐CHAOCHEN TOM TUNG‐PINGSU WEN‐JUNGSUN WEN‐CHENOU‐YANG | 2007 | Psychiatry and Clinical Neurosciences2007，，4： | 1 |
| 4 | A (t,n)multi-secret sharing scheme显示文摘 | Yang Chaochen Chang Tingyi Min-Shiang Hwang | 2004 | Applied Mathematics and Computation2004，151，： | 1 |
| 5 | Recent advances in program verification through computer algebra显示文摘 | Lu Yang Chaochen Zhou Naijun Zhan Bican Xia | 2010 | Frontiers of Computer Science in China2010，，1： | 1 |
| 6 | Hsa‐let‐7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c‐Myc and upregulation of p16<sup>INK4A</sup>显示文摘 | Fei‐FeiLan HuaWang Yang‐ChaoChen Chu‐YanChan Samuel S.Ng KuiLi DanXie Ming‐LiangHe Marie C.Lin Hsiang‐FuKung | 2010 | Int J Cancer2010，，2： | 1 |
| 7 | Recent advances in program verification through computer algebra 显示文摘 | Yang Lu Zhou Chaochen Zhan Naijun | 2010 | Front Computer Science2010，4，1： | 1 |
| 8 | A New Privacy and Authentication Protocol for End-to-end Mobile Users显示文摘 | Lee C C Yang Chaochen Hwang M S | 2003 | International Journal of Commmunication Systems2003，16，9： | 1 |
| 9 | Novel Epoxy Nanocomposite of Low Dk Introduced Fluorine Containing POSS Structure显示文摘 | YenZen Wang WenYi Chen ChaoChen Yang | 2007 | Journal of Polymer SciencePart B :Polymer Physics2007，45，4： | 1 |
| 10 | New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway显示文摘Objective:To clarify the anti-depressive potential mechanisms of Kaixin Powder(KP),a drug that helps to prevent and treat depression and other mentaldiseases,from genome-wide transcriptome profiling.Methods:Transcriptome and KEGG pathway analysis were conducted on the hippocampus of depressed rats,then the differentially expressed genes were validated and serum concentration of lipid parameters were identified by enzymatic assays.Furthermore,high-fat diets induced depression-like behaviors in Syrian golden hamsters were conducted to verify the predicted molecular mechanisms acquired from the transcriptome analysis.Results:Transcriptome results revealed that the 24 differentially expressed genes(DEGs)in chronic mild stress(CMS)rats could be reversed after two weeks of KP treatment.The mechanisms of KP in treating depression firstly involved the regulation of several pathology modules,including lipid metabolism,synapse function and inflammation.KP could regulate imbalances of lipid homeostasis in high-fat diet induced depressive symptoms.Furthermore,it was validated that cholesterol metabolism dysfunction can be ameliorated by KP,which was correlated with upregulation of the AdipoR1-BDNF(brainderived neurotrophic factor)co-regulatory pathway.Conclusion:Taken together,our results demonstrated that KP not only alleviates depression via traditional mental illness targets,but it may also simulates the cholesterol metabolism and adiponectin signaling with multi-target characteristics. | Wenshan Yang Hong Yin Yichen Wang Yuanbo Wang Xia Li Chaochen Wang Ping Liu Yuan Hu | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 11 | Metabolic profiles and morphological characteristics of leaf tips among different sweet potato(Ipomoea batatas Lam.)varieties显示文摘Sweet potato leaf tips have high nutritional value,and exploring the differences in the metabolic profiles of leaf tips among different sweet potato varieties can provide information to improve their qualities.In this study,a UPLC-Q-Exactive Orbitrap/MS-based untargeted metabolomics method was used to evaluate the metabolites in leaf tips of 32 sweet potato varieties.Three varieties with distinct overall metabolic profiles(A01,A02,and A03),two varieties with distinct profiles of phenolic acids(A20 and A18),and three varieties with distinct profiles of flavonoids(A05,A12,and A16)were identified.In addition,a total of 163 and 29 differentially expressed metabolites correlated with the color and leaf shape of sweet potato leaf tips,respectively,were identified through morphological characterization.Group comparison analysis of the phenotypic traits and a metabolite-phenotypic trait correlation analysis indicated that the color differences of sweet potato leaf tips were markedly associated with flavonoids.Also,the level of polyphenols was correlated with the leaf shape of sweet potato leaf tips,with lobed leaf types having higher levels of polyphenols than the entire leaf types.The findings on the metabolic profiles and differentially expressed metabolites associated with the morphology of sweet potato leaf tips can provide useful information for breeding sweet potato varieties with higher nutritional value. | Wenqing Tan Xinbo Guo Zhangying Wang Rong Zhang Chaochen Tang Bingzhi Jiang Ruixue Jia Yuanyuan Deng Shaohai Yang Jingyi Chen | 2024 | Journal of Integrative Agriculture2024，23，2： | 0 |
| 12 | Regulatory Effect of JAK2/STAT3 on the Immune Function of Endotoxin-tolerant Dendritic Cells and its Involvement in Acute Liver Failure显示文摘Background and Aims:Acute liver failure(ALF)is a potentially fatal clinical syndrome with no effective treatment.This study aimed to explore the role of Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)pathway in modulating the phenotype and immune function of endotoxin-tolerant dendritic cells(ETDCs).In addition,we explored the use of EDTCs in an experimental model of ALF and investigated the associated mechanisms.Methods:In the in vitro experiment,ETDCs were transfected with adenovirus to induce SOCS1^(+/+)ETDCs and SOCS1^(−/−)ETDCs.Thereafter,costimulatory molecules and mixed lymphocyte reaction were assessed.Experimental mice were randomly divided into normal control,ALF,ALF+mock-ETDCs,ALF+SOCS1^(+/+)ETDCs,ALF+AG490,and ALF+AG490+SOCS1^(+/+)ETDCs groups.We examined the therapeutic effect of adoptive cellular immunotherapy by tail-vein injection of target ETDCs 12 h before ALF modeling.AG490,a JAK2/STAT3 inhibitor,was used in the in vivo experiment to further explore the protective mechanism of SOCS1^(+/+)ETDCs.Results:Compared with control ETDCs,SOCS1^(+/+)ETDCs had lower expression of costimulatory molecules,weaker allostimulatory ability,lower levels of IL-6 and TNF-αexpression and higher IL-10 secretion.SOCS1^(−/−)ETDCs showed the opposite results.In the in vivo experiments,the ALF+SOCS1^(+/+)ETDCs and ALF+AG490+SOCS1^(+/+)ETDCs groups showed less pathological damage and suppressed activation of JAK2/STAT3 pathway.The changes were more pronounced in the ALF+AG490+SOCS1^(+/+)ETDCs group.Infusion of SOCS1^(+/+)ETDCs had a protective effect against ALF possibly via inhibition of JAK2 and STAT3 phosphorylation.Conclusions:The SOCS1 gene had an important role in induction of endotoxin tolerance.SOCS1^(+/+)ETDCs alleviated lipopolysaccharide/D-galactosamine-induced ALF by downregulating the JAK2/STAT3 signaling pathway. | Yukai Chen Chaochen Hou Naibin Yang Yanyan Yang Youran Chen Deyong Kong Yuchun Jiang Minghao Lin Sijie Zheng Shanshan Li Mingqin Lu | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 0 |
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