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| 1 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 2 | Can the rat donor liver tolerate prolonged warm ischemia?显示文摘INTRODUCTIONThe last two decades of the twentieth century havewitnessed increasingly successful rates of livertransplantation.The number of liver transplantations hasincreased steadily while the number of organ donors | Yan JQ Li HW Cai WY Zhang MJ Yang WP | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | Protein thermal aggre- gation involves distinct regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin显示文摘 | Yan YB Wang Q He HW | 2004 | Biophys J2004，86，3： | 1 |
| 4 | Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth显示文摘 | Yan F Cao HW Cover TL | 2007 | Gastroenterology2007，132，2： | 1 |
| 5 | Analysis of serum from type 11 diabetes mellitus and diabetic complication using surface-en- hanced Raman spectra显示文摘 | Han HW Yan XL Dong RX | 2009 | Appl Phys2009，94，4： | 1 |
| 6 | Resveratrol induces human K562 cells apoptosis,erythroid differentiation,and autophagy显示文摘 | Yan HW Hu WX Zhang JY | 2014 | Tumor Biol2014，35，： | 1 |
| 7 | Characteristics of a supersonic swirling dehydration system of natural gas 显示文摘 | Liu HW Liu ZL Feng YX Gu KY Yan TM | 2005 | Chinese Journal of Chemical Engineering2005，13，： | 1 |
| 8 | Incomplete digestion preserves chondrocytes from dedifferentiating in long-termed culture on plastic substrate 显示文摘 | Liu K Wang KZ Yan HW | 2009 | Tissue Cell2009，41，1： | 1 |
| 9 | Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of beta-amyloid peptide 1-42 in mice显示文摘 | Kim HS Cho JY Kim DH Yan JJ Lee HK Suh HW | 2004 | Biol Pharm Bull2004，27，1： | 1 |
| 10 | Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracere-broventricular injection of beta-amyloid peptide(1-42) in mice 显示文摘 | Cho JY Kim HS Kim DH Yan JJ Suh HW Song DK | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，6： | 1 |
| 11 | Cytotoxic and antibacterial triterpenoids derivatives from Clematis ganpiniana显示文摘 | Ding Q Yang LX Yan HW | | 0，，10： | 1 |
| 12 | Radioactive iodine labe- ling of monoclonal antibody against Hsp90a and its use in diag- nostic imaging in prostate cancer xenograft model显示文摘 | SUN HW WAN( - RF YAN P | 2015 | Eur Rev Med Pharmacol Sci2015，19，5： | 1 |
| 13 | Jixing Feisunshang Xiaoshu NF- kB Biaoda Yiyi 显示文摘 | Li HZ Qi HW Huang WJ Cheng BF Yan PS | 2001 | Di-si Junyi Daxue Xuebao (J Fourth Mili Med Univ)2001，21，2： | 1 |
| 14 | Effects of DIMBOA on impulse discharges of maxillary lateral sensillum styloconicum of armyworm larvae显示文摘THE DIMBOA (2, 4-dihydroxy-7-methoxy-1, 4-benzoxazin-3-one), a secondary product present in corn plants, plays an important role in protecting the plant against the pest attack. DIMBOA is rich in seedlings of cereal crops, especially in maize. Many investigators demonstrated a linear relationship between the DIMBOA content in plant and the resistance of the plant to pest. Feng et al. (1992) summarized that the toxicity of DIMBOA is associated | Yang, DM Luo, L Yan, FM Cheng, HW Zhou, PA | 1997 | Chinese Science Bulletin1997，42，1： | 1 |
| 15 | Direct Characterization of Bulk Sam- pies by Internal Extractive Electrospray Ionization Mass Spectrometry 显示文摘 | Zhang H Gu HW Yan FY | 2013 | Sci Rep2013，3，5： | 1 |
| 16 | Leptin ' s effect on accelerated fracturehealing after traumatic brain injury 显示文摘 | Yan H Zhang HW Fu P | 2013 | Neurol Res2013，35，5： | 1 |
| 17 | Abnormal enlargement of pituitary Gland during pregnancy remitted spontaneously after delivery 显示文摘 | Chen HW SuDH Chen HW Yan CH | 2007 | Chang gung medical journal2007，30，1： | 1 |
| 18 | Lead cytotoxicity in primary cultured rat astrocytes and Schwann cells显示文摘 | Yan HL Hu XH | 1996 | J Appl Toxicol1996，16，3： | 1 |
| 19 | Feasibility study on using an infrared thermometer for evaluation and administration of cryosurgery显示文摘 | Yan JF Wang HW Liu J | 2007 | Minim Invasive Ther Allied Technol2007，16，3： | 1 |
| 20 | Arandomized study of a new landmark - guided vs traditional para - carotid approach in internal jugular venous cannulation in infants 显示文摘 | Xiao WJ Yan FX Ji HW | 2009 | Pediatr A nesth2009，19，5： | 1 |
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