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| 1 | Danggui Buxue decoction ameliorates lipid metabolic defects involved in the initiation of diabetic atherosclerosis;identification of active compounds显示文摘OBJECTIVE: To determine the constituent compounds of Danggui buxue decoction(DBD) involved and the potential mechanisms mediating its effects, with specific reference to lipids playing a role in the initiation of diabetic atherosclerosis.METHODS: Liquid chromatography-tandem mass spectrometry was used to identify and quantify the absorbed bioactive compounds(ABCs) present in DBD. Goto-Kakizaki(GK) rats were randomly allocated to a diabetes atherosclerosis(DA) group, a DBD group, and an ABC group(10 per group), which were all high-fat diet-fed. The treated rats were administered DBD(4 g/kg) or ABCs(in amounts equal to those present in DBD) once daily for 28 d, and a control group of Wistar rats were administered vehicle. Body mass gain, fasting blood glucose, and homeostasis assessment of insulin resistance(HOMAIR) were measured. Serum triglyceride(TG), cholesterol(CHOL), high density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDLC) and tumor necrosis factor-α(TNF-α) concentrations were determined. Hematoxylin and eosin staining and microscopy were used to characterize the abdominal aorta and the expression of lipogenic genes was quantified in this vessel.RESULTS: Seven ABCs were identified in rat serum:ferulic acid, formononetin, calycosin, astragaloside,caffeic acid, ligustilide, and butyphthalide. DBD significantly reduced HOMA-IR, the serum concentrations of TG, CHOL, and LDL-C, and the expression of the lipogenic genes monocyte chemotactic protein1, Fas, intercellular adhesion molecule 1, and Cd36 in aorta;and significantly increased the mRNA expression of Scd1 in aorta.CONCLUSION: DBD affects lipid metabolism in the early stage of atherosclerosis in diabetic GK rats,with the mechanism likely involving the regulation of lipid metabolic genes in vessels. The contribution of ABCs to the effect of DBD on lipid metabolism was 24%-101%. | Xue Mei Bian Yong Liu Yalin Zhou Junjie Xu Jianjun Zhang Liang Huang Xi | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 13 |
| 2 | Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson's disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells显示文摘85 kDa (CIN85 ) 的最新发现的交往 Cbl 蛋白质在大脑涉及许多细胞的过程,而是它的功能,在 neurodegenerative,疾病仍然保持不清楚。在这篇论文,我们用蛋白质印迹分析和免疫组织化学在成年老鼠大脑的不同区域调查了 CIN85 蛋白质的分发,并且发现 CIN85 无所不在地在老鼠大脑被表示。在条纹弦音器和 substantia nigra,二个区域最深深地在 Parkinson 的疾病影响了, CIN85 蛋白质的水平相对高。在 Parkinson 的疾病的 MPTP 鼠标模型,在条纹弦音器和 substantia nigra 的 CIN85 的表达式是复杂的。但是在 1-methyl-4-phenyl-pyridinium 对待离子的人的 dopaminergic SH-SY5Y 房间, CIN85 的表示戏剧性地增加了。由短发卡 RNA CIN85 击倒减少了 SH-SY5Y 房间死亡。因此, CIN85 可能在神经毒素挑战下面在 dopaminergic 房间线并且在老鼠大脑的 nigrostriatum 起不同作用。 | Minjuan Bian Mei Yu Shanzheng Yang Hui Gao Yalin Huang Chunguang Deng Yanqin Gao Fengyan Sun Fang Huang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 3 |
| 3 | Author correction to'Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TL R4 signaling’[Acta Pharmaceutica Sinica B 12(2022)1198-1212]显示文摘The authors regret that there were some errors or inexact de-scriptions in author afiliation,the section of materials and methods,and the figure caption of Fig.2A owing to the negligence of authors when writing the manuscript,and there was a picture error in Fig.10 and graphical abstract figure owing to the inappropriate selection for the picture of Radix Ophiopogon japonicus.In author afiliation,'Department of Pharmacology of Chinese Material Medica'should be corrected to'Department of Pharmacology of Chinese Materia Medica'.In 2.4. | Yunhao Wu Xiu Yu Yuwei Wang Yalin Huang Jiahui Tang Shuaishuai Gong Siyu Jiang Yuanli Xia Fang Li Boyang Yu Yuanyuan Zhang Junping Kou | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 3 |
| 4 | In-situ growth of flexible 3D hollow tubular Cu_(2)S nanorods on Cu foam for high electrochemical performance supercapacitor显示文摘For pursing high-performance supercapacitors,both of the design strategy and structural characteristic of electrode materials are crucial.Herein,we report the in-situ growth of flexible self-assembled 3D hollow tubular Cu_(2)S nanorods on Cu foam substrate(Cu_(2)S@Cu).The Cu substrate is simultaneously acted as a copper source and a collector,which reduces the contact resistance.Moreover,the highly ordered 3D unique structure increases the redox reactive sites and enhances the ion transmission effectively,resulting in greatly improved electrochemical performance.Based on the Cu_(2)S@Cu electrode,the supercapacitor exhibits high areal capacitance of 1000 mF cm^(-2) at a current density of 2 mA cm^(-2),and great cycle stability,maintaining 96.9% capacitance after 10,000 cycles.Furthermore,the supercapacitor also shows an excellent flexibility with no significant decrease in the twisting or bending state.The capacity retention rates are 99.8% and 86.1%,respectively,and finally recover to 99.3%,confirming its great potential in practical application for portable electronic devices. | Xinrui He Yalin Hu Hanqing Tian Zhipeng Li Pei Huang Jing Jiang Chao Wang | 2020 | Journal of Materiomics2020，6，1： | 2 |
| 5 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 6 | Internal Loads and Bioavailability of Phosphorus and Nitrogen in Dianchi Lake,China显示文摘Sediments have a significant influence on the cycling of nutrient elements in lake environments. In order to assess the distribution characteristics and estimate the bioavailability of phosphorus and nitrogen in Dianchi Lake, organic and inorganic phosphorus and nitrogen forms were analysed. The 210 Pb radiometric dating method was employed to study temporal changes in the phosphorus and nitrogen pools in Dianchi Lake. The result show that the total phosphorus(TP) and total nitrogen(TN) were both at high concentrations, ranging from 697.5–3210.0 mg/kg and 1263.7–7155.2 mg/kg, respectively. Inorganic phosphorus(IP) and total organic nitrogen(TON) were the main constituents, at percentages of 59%–78% and 74%–95%, respectively, in the sediments. Spatially, there was a decreasing trend in phosphorus and nitrogen contents from the south and north to the lake centre, which is related to the distribution pattern of local economic production. The burial rates of the various phosphorus and nitrogen forms increased in same spatially and over time. Particularly in the past two decades, the burial rates doubled, with that TN reached to 1.287 mg/(cm^2·yr) in 2014. As the most reactive forms, nitrate nitrogen(NO_3-N) and ammonia nitrogen(NH_4-N) were buried more rapidly in the south region, implying that the potential for releasing sedimentary nitrogen increased from north to south. Based on their concentrations and burial rates, the internal loads of phosphorus and nitrogen were analysed for the last century. A TP pool of 71597.6 t and a TN pool of 81191.7 t were estimated for Dianchi Lake. Bioavailable phosphorus and nitrogen pools were also estimated at 44468.0 t and 5429.7 t, respectively, for the last century. | WU Yalin HUANG Tao HUANG Changchun SHEN Yinyin LUO Yang YANG Hao YU Yanhong LI Ruixiao GAO Yan ZHANG Mingli | 2018 | Chinese Geographical Science2018，28，5： | 2 |
| 7 | Changes of NF-κB, Bax and Caspase 3 in Apoptosis Induced by Ligustrazine Combined with Cis-dichlorodiamine Platinum in Human Gastric Carcinoma SGC-7901 Cell Lines显示文摘[Objective] This study aimed to investigate the mechanism of apoptosis induced by ligustrazine(TMP) and cis-dichlorodiamine platinum(DDP) in SGC-7901 cell lines in vitro. [Methods] SGC-7901 cell lines were treated with ligustrazine and DDP alone or combined for 48 h for Western blot analysis, respectively. Western blot analysis was used to determine the expression of proteins involved in apoptosis including NF-κB p65, bax and caspase-3. [Results] The viability of SGC-7901 cells was inhibited after treated with ligustrazine and/or combined with DDP. The expression of NF-κB P65 protein decreased after treated with drugs, in which the protein decreased significantly in 1.2 mg/ml of TMP combined with 2 μg/ml of DDP group.Meanwhile, we investigated the protein expression of bax and caspase-3. The results showed that the expression of the two proteins increased following with the increasing concentration of TMP. [Conclusion] All the results indicated that ligustrazine combined with DDP could induce the apoptosis of SGC-7901 cell lines, and NF-κB maybe the possible way to induce the cell apoptosis. | Tao HUANG Liyan LI Xiaona GUO Zhigang GUO Yalin Zhang | 2015 | Agricultural Science & Technology2015，16，7： | 1 |
| 8 | Ferromagnetic and ferroelectric properties of Aurivillius phase Bi_9Fe_(4.7)Me_(0.3)Ti_3O_(27)(Me 5 Fe, Co, Ni, Mn)显示文摘New Aurivillius phase Bi9Fe4.7Me0.3Ti3O27(Me = Fe, Co, Ni, Mn) oxides have been prepared using a citrate combustion method. X-ray diffraction on powders and high-resolution transmission electron microscopy investigation confirmed that the Bi9Fe4.7Me0.3Ti3O27 samples are with an eight-layer structure. Both ferromagnetic and ferroelectric investigations suggested that Co or Ni substitution could enhance their multiferroic properties,while Mn substitution depressed them. Among all the samples, Bi9Fe4.7Co0.3Ti3O27 sample exhibits the largest remnant polarization of Pr*3.8 l C/cm2, and the largest remnant magnetization of Mr*0.06 lB/f.u. with a Curie temperature about 764 K, while the Bi9Fe4.7Ni0.3Ti3O27 sample has the largest spontaneous magnetization(0.26 lB/f.u.). The improved ferromagnetic properties ofboth Bi9Fe4.7Co0.3Ti3O27 and Bi9Fe4.7Ni0.3Ti3O27 can be ascribed to the spin canting of magnetic ion-based sublattices via the Dzyaloshinskii–Moriya interaction and also the magnetic ions exchanging interactions(Fe3–O–Co3or Fe3–O–Ni3). | Guopeng Wang Shujie Sun Yan Huang Jianlin Wang Ranran Peng Zhengping Fu Yalin Lu | 2014 | Chinese Science Bulletin2014，59，36： | 1 |
| 9 | Preparation andcharacterization of a novel microcapsule-type latent curing agentfor epoxy resin显示文摘 | Xing Suli Yang Jinshui Huang Yalin | 2015 | Mater Design2015，85，： | 1 |
| 10 | Transformer-Based Deep Learning Network for Tooth Segmentation on Panoramic Radiographs显示文摘Panoramic radiographs can assist dentist to quickly evaluate patients’overall oral health status.The accurate detection and localization of tooth tissue on panoramic radiographs is the first step to identify pathology,and also plays a key role in an automatic diagnosis system.However,the evaluation of panoramic radiographs depends on the clinical experience and knowledge of dentist,while the interpretation of panoramic radiographs might lead misdiagnosis.Therefore,it is of great significance to use artificial intelligence to segment teeth on panoramic radiographs.In this study,SWin-Unet,the transformer-based Ushaped encoder-decoder architecture with skip-connections,is introduced to perform panoramic radiograph segmentation.To well evaluate the tooth segmentation performance of SWin-Unet,the PLAGH-BH dataset is introduced for the research purpose.The performance is evaluated by F1 score,mean intersection and Union(IoU)and Acc,Compared with U-Net,Link-Net and FPN baselines,SWin-Unet performs much better in PLAGH-BH tooth segmentation dataset.These results indicate that SWin-Unet is more feasible on panoramic radiograph segmentation,and is valuable for the potential clinical application. | SHENG Chen WANG Lin HUANG Zhenhuan WANG Tian GUO Yalin HOU Wenjie XU Laiqing WANG Jiazhu YAN Xue | 2023 | Journal of Systems Science & Complexity2023，36，1： | 1 |
| 11 | Magnetic logic inverter from crossed structures of defect-free graphene with large unsaturated room temperature negative magnetoresistance显示文摘Introducing defects into graphene has been widely utilized to realize the negative magnetoresistanee(MR)effect in graphene.However,the reported graphene negative MR exhibits only^10%under 10 T at room temperature to date,which extremely limits the resolution of future spintronics devices.Moreover,intentional defect introduction can also cause unintentional degradation in graphene's intrinsic properties.In this paper,we report a magnetic logic inverter based on a crossed structure of defect-free graphene,resulting in a substantial gain of 4.81 mV/T while exhibiting room temperature operation.This crossed structure of graphene shows large unsaturated room temperature negative MR with an enhancement of up to 1,000%at 9 T.A transition behavior between negative and positive MR is observed in this crossed structure and the transition temperature can be tuned by a ratio of the conductivity between in-plane and out-of-plane transport.Our results open an intriguing path for future two-dimensional spintronics device applications. | Chao Feng Junxiang Xiang Ping Liu Xiangqi Wang Jianlin Wang Guojing Hu Meng Huang Zhi Wang Zengming Zhang Yuan Liu Yalin Lu Bin Xiang | 2019 | Nano Research2019，12，10： | 1 |
| 12 | Dielectric AlN/epoxy and SiC/epoxy composites with enhanced thermal and dynamic mechanical properties at low temperatures显示文摘In a superconducting magnet,the thermal properties of the insulating material at low temperatures is an important technical index to ensure the normal operation of a superconducting coil.Herein,a low-temperature thermal conductivity testing device with a tiny uncertainty was developed to measure the composites.Furthermore,SiC/epoxy and AlN/epoxy composites were prepared and their properties were tested at low temperatures.The results showed that the composites have a better thermal conductivity at low temperatures than pure epoxy.In addition,the AlN/epoxy and SiC/epoxy composites have excellent dynamic mechanical properties and low coefficient of thermal expansion.Due to the fair thermal and dynamic mechanical properties,the composites will have potential application in the superconducting magnet. | Zhengrong Zhou Rongjin Huang Huiming Liu Yalin Zhao Zhicong Miao Zhixiong Wu Wanyin Zhao Chuanjun Huang Laifeng Li | 2022 | Progress in Natural Science:Materials International2022，32，3： | 1 |
| 13 | Decomposition of Mongolian pine litter in the presence of understory species in semi-arid northeast China显示文摘The effects of understory plant litter on dominant tree litter decomposition are not well documented especially in semi-arid forests. In this study, we used a microcosm experiment to examine the effects of two understory species(Artemisia scoparia and Setaria viridis)litter on the mass loss and N release of Mongolian pine(Pinus sylvestris var. mongolica) litter in Keerqin Sandy Lands, northeast China, and identified the influencing mechanism from the chemical quality of decomposing litter. Four litter combinations were set up: one monoculture of Mongolian pine and three mixtures of Mongolian pine and one or two understory species in equal mass proportions of each species. Total C, total N, lignin, cellulose and polyphenol concentrations, and mass loss of pine litter were analyzed at days 84 and 182 of incubation.The chemistry of pine litter not only changed with the stages of decomposition, but was also strongly influenced by the presence of understory species during decomposition. Both understory species promoted mass loss of pine litter at 84 days, while only the simultaneous presence of two understory species promoted mass loss of pine litter at182 days. Mass loss of pine litter was negatively correlated with initial ratios of C/N, lignin/N and polyphenol/N of litter combinations during the entire incubation period; at 182 days it was negatively correlated with polyphenol concentration and ratios of C/N and polyphenol/N of litter combinations at84 days of incubation. Nitrogen release of pine litter was promoted in the presence of understory species. Nitrogen release at 84 days was negatively correlated with initial N concentration; at 182 days it was negatively correlated with initial polyphenol concentration of litter combinations and positively correlated with lignin concentration of litter combinations at 84 days of incubation. Our results suggest that the presence of understory species causes substantial changes in chemical components of pine litter that can exert strong influences on subsequent decomposition of pine litter. | Bing Mao Rong Mao Yalin Hu Yue Huang Dehui Zeng | 2016 | Journal of Forestry Research2016，27，2： | 1 |
| 14 | A fluorometric assay for acetylcholinesterase activity and inhibitor detection based on DNA-templated copper/silver nanoclusters显示文摘 | Wenhua Li Wang Li Yufang Hu Yalin Xia Qinpeng Shen Zhou Nie Yan Huang Shouzhuo Yao | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
| 15 | Agonist-induced Formation of Opioid Receptor-G Protein-coupled Receptor K inase (GRK)-Gβγ Complex onMembrane Is Required for GRK2 Function in Vivo显示文摘 | Jiali Li Bin Xiang Wenjuan Su Xiaoqing Zhang Yalin Huang Lan Ma | 2005 | 中国生物学文摘2005，19，8： | 0 |
| 16 | Preparation of Peanut Shell Cellulose Double-Network Hydrogel and Its Adsorption Capacity for Methylene Blue显示文摘To achieve optimal recovery and value-added utilisation of cellulose in peanut shells,the cellulose in peanut shells was first extracted using the sodium hydroxide-sodium chlorite method.Then,cellulose hydrogel was prepared by graft copolymerisation using N,N’-methylenebisacrylamide as the cross-linking agent,sodium persulfate as the initiator,and acrylic acid as the monomer.Orthogonal optimisation experiments were designed to obtain optimal process parameters for hydrogel preparation with the cellulose dosage of 0.40 g,initiator dosage of 0.20 g,polymerisation temperature of 70°C,cross-linking agent of 0.25 g,and monomer dosage of 3.0 mL.The effect of initiator dosage on hydrogel synthesis was the most significant,followed by monomer dosage and reaction temperature.Characterisation using X-ray diffraction analysis and scanning electron microscopy revealed that the hydrogel was amorphous and exhibited a distinct three-dimensional double network structure.Hydrogel swelling kinetic analysis showed that the hydrogel swelling process was divided into three stages,and fitted the Schott secondary swelling kinetic model.The prepared hydrogel had a good adsorption effect on methylene blue;the adsorption of methylene blue by the hydrogel was 1.259 mg/g at 25°C when the initial concentration of methylene blue was 5 mg/L.The adsorption kinetics of the hydrogel fit the pseudo-first-order kinetic model,pseudo-secondorder kinetic model,Eovich model and particle diffusion model.The best fitting effect was obtained with the pseudo-second-order kinetic model.The adsorption isotherm analysis of methylene blue on hydrogel showed that the adsorption process was consistent with Langmuir and Freundlich models.The correlation coefficient of the Freundlich isotherm model was higher,indicating that the adsorption of methylene blue on hydrogel was mainly chemisorption. | Yalin Li Lei Liu Wenbao Huang Junpu Xie Zhaoxia Song Shuna Guo Enci Wang | 2023 | Journal of Renewable Materials2023，11，7： | 0 |
| 17 | Clomipramine inhibits microglial NLRP3 inflammasome in the hippocampus of depressive rats显示文摘Neuroinflammation is implicated in the pathophysiology of depression. The reduction of hippocampal volume indepression remains controversial because of interindividual variability in clinical studies. Herein, we studied theeffects of clomipramine, a tricyclic antidepressant (TCA) that modulates serotonin and norepinephrine uptake, onchronic mild unpredictable stress (CMS) induced depressive-like behaviors, hippocampal neuroinflammation, and hippocampal volume. Using a rat model of CMS induced depression, we administered clomipramine every day for4 weeks, starting 8 weeks after the beginning of the CMS procedure. Behavioral changes were measured by forcedswim test, open field test, and elevated plus maze. Neuroinflammation in the hippocampus was assessed byimmunohistochemistry, Western blot analysis, and quantitative polymerase chain reaction. Hippocampal volumeswere dynamically measured using T2- weighted imaging with 7T structural magnetic resonance imaging. | Wang Yalin Zhang Shanshan Yue Na Liu Guixue Huang Huijie Han Qiuqin Gong Wenqing Chen Xiaorong Zhang Yaodong Yu Jin Xiao Honglei Qin Song Li Wensheng Liu Qiong | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 18 | Time -Sharing Power Supply Optimal Decision forElectrolytic Deposition Process of Zinc Based onSimulated Annealing Algorithm显示文摘According to time-sharing valuation principle (TSVP) of power supply, the relationships of current density and current efficiency at different acidities are obtained based on the processed data of electrolytic deposition process of zinc (EDPZ) with the least square method (LSM). Thus an optimal model of time-sharing power supply system for EDPZ is established, which has been optimized by use of an improved efficient simulated annealing algorithm (SAA). Practical results show that industrial and mining enterprises can obtain enormous economic benefits every year. | Huang Taisong Gui Weihua Wang Yalin Yang Chunhua | 2000 | Journal of Systems Engineering and Electronics2000，11，4： | 0 |
| 19 | Clomipramine inhibits microglial NLRP3 inflammasome in the hippocampus of depressive rats显示文摘Neuroinflammation is implicated in the pathophysiology of depression.The reduction of hippocampal volume in depression remains controversial because of interindividual variability in clinical studies.Herein,we studied the effects of clomipramine,a tricyclic antidepressant(TCA)that modulates serotonin and norepinephrine uptake,on chronic mild unpredictable stress(CMS)-induced depressive-like behaviors,hippocampal neuroinflammation,and hippocampal volume. | Wang Yalin Zhang Shanshan Yue Na Liu Guixue Huang Huijie Han Qiuqin Gong Wenqing Chen Xiaorong Zhang Yaodong Yu Jin Xiao Honglei Qin Song Li Wensheng Liu Qiong | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 20 | Planar-symmetry-breaking induced antisymmetric magnetoresistance in van der Waals ferromagnet Fe_(3)GeTe_(2)显示文摘Recently discovered magnetic van der Waals(vdW)materials provide an ideal platform to explore low-dimensional magnetism and spin transport.Its vdW interaction nature opens up unprecedented opportunities to build vertically stacked heterostructures with novel properties and functionalities.By engineering the planar structure as an alternative degree of freedom,herein we demonstrate an antisymmetric magnetoresistance(MR)in a vdW Fe_(3)GeTe_(2)flake with a step terrace that breaks the planar symmetry.This antisymmetric MR originates from a sign change of the anomalous Hall effect and the continuity of the current transport near the boundary of magnetic domains at the step edge.A repeatable domain wall due to the unsynchronized magnetization switching is responsible for this sign change.Such interpretation is supported by the observation of field-dependent domain switching,and the step thickness,temperature,and magnetic field orientation dependent MR.This work opens up new opportunities to encode magnetic information by controlling the planar domain structures in vdW magnets. | Ping Liu Caixing Liu Zhi Wang Meng Huang Guojing Hu Junxiang Xiang Chao Feng Chen Chen Zongwei Ma Xudong Cui Hualing Zeng Zhigao Sheng Yalin Lu Gen Yin Gong Chen Kai Liu Bin Xiang | 2022 | Nano Research2022，15，3： | 0 |
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