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| 1 | circStrn3 is involved in bone cancer pain regulation in a rat model显示文摘Bone cancer pain(BCP)is a common chronic pain that is caused by a primary or metastatic bone tumor,More detailed molecular mechanisms of BCP are warranted.In this study,we established a BCP rat model.The von Frey hair test,body weight,and hematoxylin and eosin staining were employed.We screened differentilly expressed circRNAs(DECs)between the BCP group and sham group.The results revealed that 850 DECs were significantly up-regulated and 644 DECs were significantly down-regulated in the BCP group.Furthermore,we identified 1177 diffrentially expressed genes(DEGs)significantly up-regulated and 565 DEGs significantly down-regulated in the BCP group.Gene Ontology annotation of all 1742 DEGs revealed that biological regulation of metabolic processes,cellular processes,and binding were the top enriched terrms.For Kyoto Ency-clopedia of Genes and Genomes analysis,phagosome,HTLV-I infection,proteoglycans in cancer,and herpes simplex infection were significantly enriched in this study.In addition,we identified four selected circRNAs,chr6:72418120|72430205.chr20:756105717573740,chr18:69943105|69944476,and chr5:167516581|167558250,by quantitative real time PCR.chr6:72418120|72430205(circStrn3)was selected for further study based on expression level and the circRNA--miRNA--mRNA network table.Western blot analysis suggested that knockdown of circStrn3 could effectively induce Walker 256 cell apoptosis.In summary,our study provided a more in-depth understanding of the molecular mechanisms of BCP. | Yiwen Zhang Xiaoxia Zhang Zumin Xing Shuyi Tang Hanwen Chen Zhongqi Zhang Jiyuan Li Yalan Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 2 | Structure-design and theoretical-calculation for ultrasmall Co_(3)O_(4) anchored into ionic liquid modified graphene as anode of flexible lithium-ion batteries显示文摘Cobalt oxide(Co_(3)O_(4))is currently suitable in energy storage applications because of its high capacity based on the conversion reaction mechanism.However,unmodified Co_(3)O_(4)suffers from distinctly inferior rate capability and poor cycling stability.On the basis of the aforementioned considerations and density functional theory(DFT)simulations,the three-dimensional hierarchical porous structure(HPS)ultrasmall Co_(3)O_(4)anchored into ionic liquid(IL)modified graphene oxide(GO)has been successfully prepared(ultrasmall/Co_(3)O_(4)-GA-IL).The ultrasmall/Co_(3)O_(4)-GA-IL consists of Co_(3)O_(4)co-assembled with IL modified GO to generate the HPS which can facilitate ion transfer channels through reduction of the electron and ion transportation path and transmission impedance.In addition,N-doping graphene can enhance the inherent electrical conductivity of Co_(3)O_(4),which is proved by the DFT calculations.By virtue of the novel superstructure,the ultrasmall/Co_(3)O_(4)-GA-IL electrode demonstrates a high reversible capacity of 1,304 mAh·g^(−1),an enhanced high-rate capability(715 mAh·g^(−1)at 5 C),and a capacity retention of 98.4%even after 500 cycles at 5 C rate,which corresponds to 0.0003%capacity loss per cycle.Pouch cells based on the cathode are further fabricated and demonstrate excellent mechanical and electrochemical properties under bent and folded state,highlighting the practical application of our deliberately designed electrode in wearable electronics. | Longda Cong Shichao Zhang Hengyao Zhu Weixin Chen Xueyan Huang Yalan Xing Jun Xia Puheng Yang Xia Lu | 2022 | Nano Research2022，15，3： | 1 |
| 3 | Fabrication and Dealloying Behavior of Monolithic Nanoporous Copper Ribbons with Bimodal Channel Size Distributions显示文摘Monolithic nanoporous copper (NPC) ribbons with bimodal channel size distributions can be fabricated through chemical dealloying of Mg-32 Cu alloy in an acidic solution at room temperature. The microstructure of the asdealloyed samples was characterized by X-ray diffraction, scanning electron microscopy, and energy dispersive X-ray analysis. These NPC ribbons are composed of interconnected large-sized channels (hundreds of nm) with highly porous channel walls (tens of nm). Both large-and small-sized channels are open, bicontinuous, and interpenetrating. Additionally, it is the first time to find that the evolution process of porous structure along the thickness direction of samples during the dealloying is from the interior to exterior, which is just contrary to the coarsening process along the thickness direction during the post-dealloying. Meanwhile, the corresponding mechanism is discussed in detail. | Wenbo Liu Shichao Zhang Ning Li Jiwei Zheng Yalan Xing | 2012 | Journal of Materials Science & Technology2012，28，8： | 1 |
| 4 | C(sp^3)–H bond functionalization of non-cyclic ethers by decarboxylative oxidative coupling with α,β-unsaturated carboxylic acids显示文摘A copper-catalyzed decarboxylative oxidative coupling of α,β-unsaturated carboxylic acids with non-cyclic ethers is developed.This method provides a new approach for C(sp^3)–H bond functionalization of non-cyclic ethers. Mechanism study shows the reaction involves a radical process. | Tong Zhang Xing-Wang Lan Yu-Qiang Zhou Nai-Xing Wang Yue-Hua Wu Yalan Xing Jia-Long Wen | 2018 | Science China Chemistry2018，61，2： | 1 |
| 5 | Electrolyte induced synergistic construction of cathode electrolyte interphase and capture of reactive free radicals for safer high energy density lithium-ion battery显示文摘As the energy density of battery increases rapidly,lithium-ion batteries(LIBs)are facing serious safety issue with thermal runaway,which largely limits the large-scale applications of high-energy-density LIBs.It is generally agreed that the chemical crosstalk between the cathode and anode leads to thermal runaway of LIBs.Herein,a multifunctional high safety electrolyte is designed with synergistic construction of cathode electrolyte interphase and capture of reactive free radicals to limit the intrinsic pathway of thermal runaway.The cathode electrolyte interphase not only resists the gas attack from the anode but suppresses the parasitic side reactions induced by electrolyte.And the function of free radical capture has the ability of reducing heat release from thermal runaway of battery.The dual strategy improves the intrinsic safety of battery prominently that the triggering temperature of thermal runaway is increased by 24.4℃and the maximum temperature is reduced by 177.7℃.Simultaneously,the thermal runaway propagation in module can be self-quenched.Moreover,the electrolyte design balances the trade-off of electrochemical and safety performance of high-energy batteries.The capacity retention of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)|graphite pouch cell has been significantly increased from 53.85%to 97.05%with higher coulombic efficiency of 99.94%at operating voltage extended up to 4.5 V for 200 cycles.Therefore,this work suggests a feasible strategy to mitigate the safety risk of high-energy-density LIBs without sacrificing electrochemical performances. | Mengfei Ding Xuning Feng Yong Peng Jing Jing Tong Bowen Hou Yalan Xing Weifeng Zhang Li Wang Yu Wu Jiabin Lv Chunyan Luo Dejun Xiong Shichao Zhang Minggao Ouyang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 6 | Intrinsic lithiophilic carbon host derived from bacterial cellulose nanofiber for dendrite-free and long-life lithium metal anode显示文摘Although lithium metal is considered a promising anode for advanced Li-S and Li-air batteries,the uncontrolled dendrite growth and infinite volume change impede its practical application.Herein,we report an ideal framework composed of carbonized bacterial cellulose(CBC)nanofibers,which shows intrinsic lithiophilicity to molten lithium without any lithiophilic surface modification.The wetting behavior of molten lithium can be significantly improved because its surface functional groups provide thermodynamical driving force,and the high surface roughness derived from nanocracks leads to rapid infusion in kinetics.The hybrid anode exhibits long cycle life up to 2000 h and excellent deep stripping-platting capacity up to 20 mAh·cm^(-2).When the anode is assembled with LiFePO_(4) cathode,the full cell delivers a good cycling stability up to 700 cycles.This is attributed to the intrinsic lithiophilic scaffold,which can not only lower the nucleation barrier of Li and provide uniform nucleation sites for stable Li stripping/plating,but also offer interspace to accommodate volume fluctuation of lithium during long cycling.This work provides a new manner to achieve a series of intrinsic lithiophilic carbon skeletons based on the large family of biomass materials and organic materials. | Gangyi Xiong Jiayu Yu Yalan Xing Puheng Yang Shichao Zhang | 2024 | Nano Research2024，17，5： | 0 |
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