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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | WAVELET METHOD FOR CALCULATING THE DEFECT STATES OF TWO-DIMENSIONAL PHONONIC CRYSTALS显示文摘Based on the variational theory,a wavelet-based numerical method is developed to calculate the defect states of acoustic waves in two-dimensional phononic crystals with point and line defects.The supercell technique is applied.By expanding the displacement field and the material constants (mass density and elastic stiffness) in periodic wavelets,the explicit formula- tions of an eigenvalue problem for the plane harmonic bulk waves in such a phononic structure are derived.The point and line defect states in solid-liquid and solid-solid systems are calcu- lated.Comparisons of the present results with those measured experimentally or those from the plane wave expansion method show that the present method can yield accurate results with faster convergence and less computing time. | Zhizhong Yah Yuesheng Wang Chuanzeng Zhang | 2008 | Acta Mechanica Solida Sinica2008，21，2： | 16 |
| 3 | Curculigoside isolated from Curculigo orchioides prevents hydrogen peroxide-induced dysfunction and oxidative damage in calvarial osteoblasts显示文摘反应的氧种类(ROS ) 包括 H2O2,在骨质疏松症的 pathophysiology 起一个关键作用。因此,能禁止 ROS 生产的代理人或抗氧化剂在骨质疏松症的治疗有高临床的价值。Curculigoside (杂种狗) ,酉分的混合物从 Curculigo orchioides Gaertn 的根茎孤立的主要 bioactive 之一,被报导有有势力抗氧化剂和 anti-osteoporotic 性质。然而,没有直接证据与观察 anti-osteoporotic 效果连接杂种狗的抗氧化剂能力,并且相关分子的机制仍然保持不清楚。因此,我们在 calvarial 造骨细胞对氧化应力调查了杂种狗的保护的效果并且讨论了相关机制。造骨细胞生存能力在 48-h 暴露以后显著地减少了到 H2O2 的 400 M,这被发现,与对待车辆的房间相比,并且 H2O2 的细胞毒素的效果显著地被颠倒什么时候有杂种狗的 0.110 M 的 pretreated (P < 0.05 ) 。有杂种狗的 0.110 M 的预告的处理减少了 ROS 生产和类脂化合物 peroxidation,并且增加了抗氧化剂酶的活动,例如 superoxide,在造骨细胞的 dismutase 和谷胱甘肽 peroxidase 由 H2O2 导致了。另外,象碱的磷酸酶,钙免职,和 Runx2 水平那样的区别标记的导致 H2O2 的减小显著地面对杂种狗被恢复。杂种狗也颠倒了细胞外的调整信号的 kinase 1/2,并且原子 factor-B 发信号和 p38 的抑制的导致 H2O2 的刺激激活 mitogen 的蛋白质 kinase 激活。这些结果通过减少 ROS 的生产提供新卓见进杂种狗的造骨细胞保护的机制,建议那条杂种狗可以作为为骨质疏松症和另外的骨头相关的人的疾病的预防和处理的一个对简历安全的代理人被开发。 | Ying Wang Lu Zhao Yin Wang Jinlong Xu Yah Nie Yuanhui Guo Yongtao Tong Luping Qin Qiaoyan Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 15 |
| 4 | 功能的限制的积极选择而非松驰在鸡驯服期间驾驶视觉的进化显示文摘是由达尔文,注意了鸡有所有鸟,而是国内鸡和他们的野祖先之间的有趣的进化差别的最大的 phenotypic 差异,红 Junglefowl,是他们的比较地更弱的视觉。存在理论建议在国内鸡之中的减少的视觉英勇反映功能的限制的松驰在识别负责的内在的基因机制的视觉,而是证据上驾驶的变化因为这个变化决定性地没被描绘。这里,国内鸡的染色体宽的分析和红 Junglefowl 染色体为涉及视觉的发展的断然选择的基因显示出重要丰富。关于为在视网膜的这些基因的 mRNA 表示的水平国内鸡和他们的野祖先之间有重要差别。涉及视觉的发展的众多的另外的基因也在在国内鸡和他们的野祖先之间的 mRNA 表示显示出重要差别,特别地为与 phototransduction 和光敏电阻器开发联系的基因,例如 RHO (视紫红质) , GUCA1A, PDE6B 和 NR2E3。最后,我们在视觉描绘了 VIT 基因的潜在的角色,它在村庄鸡的视网膜经历了积极选择和 downregulated 表示。总的来说,我们的结果建议净化选择的那种积极选择,而非松驰,在国内鸡贡献了视觉的进化。怀有更弱的视觉的国内鸡的祖先可能显示出减少的害怕回答和警戒,使他们更安逸无意识地被选择或驯养。 | Ming-Shan Wang Rong-wei Zhang Ling-Yan Su Yah Li Min-Sheng Peng He-Qun Liu Lin Zeng David M Irwin Jiu-Lin Du Yong-Gang Yao Dong-Dong Wu Ya-Ping Zhang | 2016 | Cell Research2016，26，5： | 15 |
| 5 | Reconstruction of Ore-controlling Structures Resulting from Magmatic Intrusion into the Tongling Ore Cluster Area during the Yanshanian Epoch显示文摘摘要:Tongling 矿石簇区域经历了集中的压缩并且联系了在 Indosinian-Yanshanian 时代期间砍,它形成了一个箱子在 caprock 的控制矿石的褶层和差错系统。在 Yanshanian 时代的 magmatic 侵入导致了多相的液体的多级式的 unmixing,导致多层、宽范围、多种形式的式样描绘的矿化作用。在 Tongling 区域的 magmatic 侵入不仅供应了必要形成矿石的材料,而且重建控制矿石的结构根据下列五条阶层边界的趋势表面模拟:志留纪泥盆纪,泥盆纪含碳,含碳二叠,中间二叠上面二叠、二叠三叠纪。这模拟的结果证明那在那里存在在上面的部分和那些在的阶层之间的重要差别更低。而上面的趋势表面是 synform,更低的趋势表面是 antiform。另外,趋势迭加邻近的床边界出现(例如,志留纪泥盆纪边界在泥盆纪含碳的边界之上迭加) 证明更低的趋势表面总是上面穿透那。而且,不同迭加的趋势表面的穿透的部分的位置和取向是类似的并且根据地区性的 E-W-trending magmatic-metallogenic 带的分发显示出 E-W-trending 带的分发。基于阶层,结构的变丑机制,和地现象的机械性质的全面分析,看起来, stratal 趋势表面的特殊特征由于 magmatic 侵入源于 jacking 进一个 E-W-trending 地下室差错以前控制的 caprock。因此,主要控制矿石的结构,在地区性的水平压缩期间形成了,被形成矿石的岩浆的垂直 jacking 功能在 Yanshanian 时代期间重建,这被推出。在形成矿石的过程期间,岩浆的本地垂直 jacking,结合了地区性的水平压缩,在液体水管网络优化了广泛的环境并且加速了多相的液体的 unmixing 后面的 magmatic 炮兵阵地。Jacking 也加强了垂直、侧面的指导液体的结构,供应为多层的炮兵阵地和多相的液体的广阔运输的更合适的物理条件。 | DENG Jun WANG Qingfei YANG Liqiang GAO Bangfei HUANG Dinghua LIU Yah XU Hao JIANG Shaoqing | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 13 |
| 6 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 7 | Female Fertility: Is it Safe to Freeze.显示文摘 | Lu Zhang Li-Ying Yan Xu Zhi Jie Yah Jie Qiao | 2015 | Chinese Medical Journal2015，，3： | 11 |
| 8 | Evaluation of the efficacy and safety of tiotropium bromide (5 μg) inhaled via Respimat in Chinese patients with chronic obstructive pulmonary disease显示文摘 | TANG Yah Dan Massey ZHONG Nan-shan | 2013 | Chinese Medical Journal2013，，19： | 11 |
| 9 | Hydrogen peroxide primes heart regeneration with a derepression mechanism显示文摘当成年的人的心很限制了再生潜力时,成年 zebrafish 心能充分在 20% 室的切除术以后再生。尽管以前的报告建议象 FGF 和 PDGF 那样的发展发信号小径在成年的心新生被再使用,内在的细胞内部的机制仍然保持大部分未知。这里,我们显示出那 H 2 O 2 充当新奇 epicardial 和心肌的信号在成年 zebrafish 为新生告知心。未经触动的心的实时成像揭示了高度局部性的 H 2 O 2(~ 30 μ M ) 在在切除术地点的心外膜和邻近的紧缩的心肌层的生产。减少的 H 2有 Duox 禁止者 diphenyleneiodonium (点每英寸)或 apocynin 的 O 2形成,或清除 H 2当时,由过氧化氢酶 overexpression 的 O 2显著地损害了心脏的新生外长的 H 2 O 2在心脏的新生上救了点每英寸的禁止的效果,显示那 H 2 O 2是在这个过程的一个必要、足够的信号。机械学地,提高了 H 2 O 2 使动摇氧化还原作用敏感的磷酸酶 Dusp6 并且因此增加了 Erk1/2 的 phosphorylation。当 dusp6 的转基因的 overexpression 损害了心脏的新生时, Dusp6 禁止者 BCI 完成了类似的支持 regenerative 效果。H 2 O 2 在招募起一个双作用通过二条相对独立的小径的有免疫力的房间和支持的心新生。我们结束那 H 2 潜在地从 Duox/Nox2 产生的 O 2 由解开通过包含 Dusp6 的 derepression 机制发信号的地图 kinase 在 zebrafish 支持心新生。 | Peidong Han Xiao-Hai Zhou Nannan Chang Cheng-Lu Xiao Shouyu Yah He Ren Xin-Zhuang Yang Mei-Ling Zhang Qing Wu Boyang Tang Ju-Peng Diao Xiaojun Zhu Chuanmao Zhang Chuan-Yun Li Heping Cheng Jing-Wei Xiong | 2014 | Cell Research2014，24，9： | 10 |
| 10 | Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia显示文摘 | Li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang Bin Zhang Tao Wang Chun-Feng Liu Hui Lu Xiao-Ping Dong Zhi-Ying Wu Jie-Wen Zhang Ji-Hui Zhang Zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier Jian-Ping Jia Yu-Ping Wang | 2018 | Chinese Medical Journal2018，，13： | 10 |
| 11 | The Total Embedding Distributions of Cacti and Necklaces显示文摘全部的嵌入分布以仅仅图的一些班著名。在这份报纸,仙人掌和项链的全部的嵌入分布被获得。而且,我们获得与 1 由使用这的方法糊的最大的类嵌入所有图的分布的总数。关键词重叠矩阵 - 全部的嵌入分发 - 仙人掌,项链先生(2000 ) 题目分类 05C10 支持了由由不到资助号码 60373030 的 NNSFC 并且在资助号码 2004SM054 下面北京交通 Univeristy | Yi Chao CHEN Yah Pei LIU Tao WANG | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 9 |
| 12 | The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells显示文摘AIM:Toinvestigate the effects of vitamin E succinate(VES)on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.METHODS:After SGC-7901cells were treated with VESat different doses(5,10,20mg·L^-1)at different time,reverse transcription-PCR technique was used to detect the level of c-jun mRNA;Western Blot was applied to measure the expression of c-jun protein.RESULTS:After the cells were theated with VESat 20mg·L^-1for 3h,the expression rapidly reached its maximun that was3.5times of UT control(P<0.01).The level of c-jun mRNA was also increased following treatment of VESfor 6h.However the expression after treatment of VES at 5mg·L^-1for24h was 1.6tmes compared with UTcontrol(P<0.01),Western blot analysis showed that the level of c-jun protein was obviusly elevated in VES-treated SGC-7901cells at 20mg·L^-1for3h,The expression of c-jun protein was gradually increased after treatment of VES at 20mg·L^-1for3,6,12and24h,respectively,with an evident time-effect relationship.CONCONCLUSION:The levels of c-jun mRNA and protein in VES-treated SGC-7901cells were increased in a dose-and time-dependent manner;the expression of c-jun was prolonged by VES,indicating that c-jun is involvedin VES-induced apoptosis in SGC-7901 cells. | Yah Zhao Kun Wu Wei Xia Yu-Juan Shan Li-Jie Wu Department of Nutrition and Food Hygiene,Public Health School,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Wei-Ping Yu Genetics Institute,Texas University of USA,Austin,USA | 2002 | World Journal of Gastroenterology2002，8，5： | 8 |
| 13 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 14 | Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I显示文摘 | Joon Ha Park Ok kyu Park Yah Bingchun Ji Hyeon Ahn In Hye Kim Jae-Chul Lee Seung-Hae Kwon Ki-Yeon Yoo Choong Hyun Lee In Koo Hwang Jung Hoon Choi Moo-Ho Won Jong-Dai Kim | 2014 | Chinese Medical Journal2014，，19： | 8 |
| 15 | A Modified Hestenes-Stiefel Conjugate Gradient Method and Its Convergence显示文摘It is well-known that the direction generated by Hestenes-Stiefel (HS) conjugate gradient method may not be a descent direction for the objective function. In this paper, we take a little modification to the HS method, then the generated direction always satisfies the sufficient descent condition. An advantage of the modified Hestenes-Stiefel (MHS) method is that the scalar βkH Sffikeeps nonnegative under the weak Wolfe-Powell line search. The global convergence result of the MHS method is established under some mild conditions. Preliminary numerical results show that the MHS method is a little more efficient than PRP and HS methods. | Zeng Xin WEI Hai Dong HUANG Yah Rong TAO | 2010 | Journal of Mathematical Research and Exposition2010，30，2： | 8 |
| 16 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 17 | Genome evolution trend of common carp (Cyprinus carpio L.) as revealed by the analysis of microsatellite loci in a gynogentic family显示文摘Genome evolution arises from two main ways of duplication and reduction. Fish specific genome duplication (FSGD) may have occurred before the radiation of the teleosts. Common carp (Cyprinus carpio L.) has been considered to be a tetraploid species, because of its chromosome numbers (2n=100) and its high DNA content. Using 69 microsatellite primer pairs, the variations were studied to better understand the genome evolution (genome duplication and diploidization) of common carp from a gynogenetic family. About 48% of primer pairs were estimated to amplify duplicates based on the number of PCR amplification per individual. Segregation patterns in the family suggested a partially duplicated genome structure and disomic inheritance. This indicates that the common carp is tetraploid and polyploidy occurred by allotetraploidy. Two primer pairs (HLJ021 and HLJ332) were estimated to amplify reduction based on the number of PCR amplification per individual. One allele in HLJ002 locus and HLJ332 locus was clearly lost in the gynogenetic family and the same as in six wild populations. Segregation patterns in the family suggested a partially diplodization genome structure. A hypothesis transition (dynamic) and equilibrium (static) were proposed to explain the common carp genome evolution between genome duplication and diploidization. | Yah Zhang Liqun Liang Peng Jiang Dayu Li Cuiyun Lu Xiaowen Sun | 2008 | Journal of Genetics and Genomics2008，35，2： | 7 |
| 18 | Concurrent Blind Channel Equalization in Impulsive Noise Environments显示文摘 | LI Sen WANG Yah LIN Bin | 2013 | Chinese Journal of Electronics2013，22，4： | 6 |
| 19 | Relationship between age and prostate size显示文摘在基于社区的研究,在年龄和人的前列腺尺寸之间的关系在在 40 和 70 年的年龄之间的人的一张人口被调查决定正常前列腺增加曲线方程。1000 个男志愿者随机从上海被招募社区,和长度,宽度,高度,转变地区(TZ ) 的体积和整个前列腺被 transrectal 超声(TRUS ) 测量。每个志愿者被国际前列腺症状分数(IPSS ) 评估。在完成了考试的那些之中,吝啬的前列腺参数都断然与增加的年龄被联系。每个年龄组之间有统计上重要的差别(P< 0.05 ) 。吝啬的转变地区体积(TZV ) 让更高的增加比吝啬的全部的前列腺体积(TPV ) 与年龄评价,显示 TZ 的增大贡献了到 TPV 的增加的大多数。当所有前列腺参数断然与 IPSS 被相关时,最强壮的关联与 TZ 长度(TZL ) 和 TZV 被联系。为前列腺宽度,高度和长度的生长曲线方程断然也与增加年龄被联系。 | Shi-Jun Zhang Hai-Ning Qian Yah Zhaos Kai Sun Hui-Qing Wang Guo-Qing Liang Feng-Hua Li Zheng Li | 2013 | Asian Journal of Andrology2013，15，1： | 6 |
| 20 | Preoperative Evaluation and Midterm Outcomes after the Surgical Correction of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery in 50 Infants and Children显示文摘 | Hui-Li Zhang Shou-Jun Li Xu Wang Jun Yah Zhong-Dong Hua | 2017 | Chinese Medical Journal2017，，23： | 6 |
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