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| 1 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 2 | Pancreatic cancer incidence and mortality patterns in China, 2011显示文摘Objective: The National Central Cancer Registry(NCCR) collected population-based cancer registration data in 2011 from all cancer registries in China. The incidence and mortality rates for pancreatic cancer were compiled and pancreatic cancer incident new cases and deaths were estimated.Methods: A total of 234 cancer registries submitted cancer data to NCCR. Data from 177 cancer registries were qualified and compiled for cancer statistics in 2011. Pancreatic cancer cases were extracted and analyzed from the national database. The pooled data were stratified by area(urban/rural), gender and age group(0, 1-4, 5-9, 10-14…85+). Pancreatic cancer incident cases and deaths were estimated using age-specific rates and national population in 2010. The national census in 2000 and Segi's population were used for agestandardized rates.Results: All 177 cancer registries(77 in urban and 100 in rural areas) covered 175,310,169 populations(98,341,507 in urban and 76,968,662 in rural areas). The morphology verified pancreatic cancer cases(MV%) accounting for 40.52% and 4.33% of pancreatic cancer incident cases were identified through death certifications only(DCO%) with mortality to incidence ratio(M/I) of 0.91. The estimated number of newly diagnosed pancreatic cancer cases and deaths were 80,344 and 72,723 in 2011, respectively. The crude incidence rate was 5.96/100,000(males 6.57/100,000, females 5.32/100,000). The age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 4.27/100,000 and 4.23/100,000 respectively, ranking 10 th among all cancers. Pancreatic cancer incidence rate and ASIRC were 7.03/100,000 and 4.94/100,000 in urban areas whereas they were 4.84/100,000 and 3.56/100,000 in rural areas. The incidence rate of pancreatic cancer of 33 cancer registries increased from 3.24/100,000 in 2003 to 3.59/100,000 in 2011 with an annual percentage change(APC) of 1.44. The pancreatic cancer mortality rate was 5.40/100,000(males 5.88/100,000, females 4.89/100,000), ranking 6th among all cancers. The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 3.81/100 000 and 3.79/100 000. The pancreatic cancer mortality and ASMRC were 6.47/100,000 and 4.48/100,000 in urban areas, and 4.27/100,000 and 3.08/100,000 in rural areas, respectively. The mortality rates of pancreatic cancer showed an approximately 1.14-fold increase, from 2.85/100,000 in 2003 to 3.26/100,000 in 2011, with an APC of 1.68.Conclusions: The burden of pancreatic cancer is increasing in China. Identification of high-risk population and adequate treatment and prevention are important. | Yutong He Rongshou Zheng Daojuan Li Hongmei Zeng Siwei Zhang Wanqing Chen | 2015 | Chinese Journal of Cancer Research2015，27，1： | 24 |
| 3 | Incidence and mortality of esophagus cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of esophagus cancer in China from 2008 to 2012.Methods: Incident and mortality cases of esophagus cancer were retrieved from the National Central Cancer Registry(NCCR) database collecting from 135 cancer registries in China during 2008-2012. The incidence and mortality rates of esophagus cancer were calculated by area(urban/rural), region(eastern, middle, western), gender and age group(0, 1-4, 5-84 by 5 years and 85+ years). China census in 2000 and Segi’s world population were applied for age-standardized rates. Joinpoint model was used for time-trend analysis.Results: The crude incidence rate of esophagus cancer was 22.57/100,000. The age-standardized incidence rates by China standard population(ASIRC) and by world standard population(ASIRW) were 14.58/100,000 and14.80/100,000, respectively. The crude mortality rate of esophagus cancer was 17.19/100,000. The agestandardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 10.80/100,000 and 10.86/100,000 respectively. Incidence and mortality rates of esophagus cancer were higher in males than in females and higher in rural areas than in urban areas. The crude incidence rate in middle areas was the highest among all areas, followed by western areas and eastern areas. The age-specific incidence rate of esophagus cancer was relatively low in age groups before 40 years old and then increased after 45 years old. It peaked in the age group of 80-84 years. The patterns of age-specific mortality rates of esophagus cancer were close to those of age-specific incidence rates. The ASIRC of esophagus cancer decreased dramatically by 29.87% between 2003 and 2012, from 14.33/100,000 to 10.05/100,000. The esophagus cancer incidence rate decreased by 3.76% per year(P>0.05). The mortality rate of esophagus cancer decreased annually over the decades from 2003 to 2012 in China(P>0.05). In females, the annual percentage change(APC) of mortality rate was-5.43%[95% confidence intervals(95% CI):-6.50%,-4.30%](P<0.05) and the mortality rate of esophagus cancer in rural females was statistically significant(APC:-3.20%, 95% CI:-4.20%,-2.20%)(P<0.05).Conclusions: The focus of prevention and treatment for esophagus cancer is strengthening primary prevention of esophageal cancer, and promoting esophagus cancer secondary prevention to reduce incidence and mortality rates of esophagus cancer, prolong survival rate of patients and decline the burden of esophagus cancer in China. | Yutong He Daojuan Li Baoen Shan Di Liang Jin Shi Wanqing Chen Jie He | 2019 | Chinese Journal of Cancer Research2019，31，3： | 24 |
| 4 | Mineral chemistry and isotope geochemistry of pyrite from the Heilangou gold deposit, Jiaodong Peninsula, Eastern China显示文摘The Heilangou gold deposit is located in the northern QixiaePenglai gold belt, which is one amongst the three large gold belts in the eastern Shandong Province(Jiaodong Peninsula). The ore body has formed within the Guojialing granite. In this study, we report the mineral chemistry of pyrite, as well as the S, Pb,and HeO isotope data of the Heilangou gold deposit. The chemical composition of pyrite in the Heilangou gold deposit indicates that the associated gold deposit is a typical magmatic hydrothermal one. The geochemical signatures and crystal structure of pyrite show that the ore-forming materials have been derived from the crust. The S isotope data of the pyrites from Heilangou show an overall range from 5.5 to7.8& and an average of 6.7&. The S isotope data in this deposit are similar to those from the deposits in the Jiaodong gold belt. The Pb and S isotope variations are small in the Heilangou gold deposit. The206Pb/204Pb,207Pb/204Pb and208Pb/204Pb ratios are 17.4653-17.5958, 15.5105-15.5746 and 38.0749-38.4361, respectively. These data plot between the lower crust and the orogenic belt. The Pb isotope data in the Heilangou gold deposit are similar to those in the Linglong gold deposit. From the Qixia gold area(the Liukou and Majiayao gold deposits) to the MupingeRushan gold belt(Rushan gold deposit) to the ZhaoeYe gold belt(the Linglong, Sanshandao and Jiaojia gold deposits), the206Pb/204Pb ratios progressively increase. The DeO isotope data obtained from quartz separates suggest that the ore-forming fluid was similar to a mixture of magmatic and meteoric waters. These results suggest that the ore-forming elements were primarily from source fluids derived from the lower crust. | Yutong Yan Na Zhang Shengrong Li Yongsheng Li | 2014 | Geoscience Frontiers2014，5，2： | 22 |
| 5 | Incidence and mortality rate of esophageal cancer has decreased during past 40 years in Hebei Province,China显示文摘Background:Hebei province is located in North of China with of approximately 6% of whole national population.It is known as a high-risk area for esophageal cancer in China and worldwide.The aim of our study was to estimate the esophageal cancer burden and trend in Hebei Province.Methods:Eight cancer registries in Hebei Province submitted cancer registry data to the Hebei Provincial Cancer Registry Center.All data were qualified and compiled for cancer statistics in 2011.The pooled data were stratified by gender and age group(0,1-4,5-9,10-14…80+).Incidence and mortality rates were age-standardized to World Segi's population standard and expressed per 100,000 persons.In addition,proportions and cumulative incidence/mortality rates for esophageal cancer were calculated.Esophageal cancer mortality data during the periods 1973-1975,1990-1992,and 2004-2005 were extracted from the national death surveys.Mortality and incidence rate data from Cixian and Shexian were obtained from population-based cancer registries in each county.Results:The estimated number of newly diagnosed esophageal cancer cases and deaths in 2011 in Hebei Province was 24,318 and 18,226,respectively.The crude incidence rate of esophageal cancer was 33.37/100,000(males,42.18/100,000 and females,24.31/100,000).The age-standardized rate by world standard population(ASRW) was 28.09/100,000,ranking third among all cancers.The esophageal cancer mortality rate was 25.01/100,000(males,31.40/100,000 and females,18.45/100,000),ranking third in deaths among all cancers.The mortality rates of esophageal cancer displayed a significant decreasing trend in Hebei Province from 1973-1975(ASRW =48.69/100,000) to 2004-2005(ASRW =28.02/100,000),with a decreased rate of 42.45%.In Cixian,the incidence of esophageal cancer decreased from 250.76/100,000 to 106.74/100,000 in males and from 153.86/100,000 to 75.41/100,000 in females,with annual percentage changes(APC) of 2.13 and 2.16,while the mortality rates declined with an APC of 2.46 for males and 3.10 for females from 1988 to 2011.In Shexian,the incidence rate decreased from 116.90/100,000 to 74.12/100,000 in males and from 46.98/100,000 to 40.64/100,000 in females,while the mortality rates declined,with an APC of 4.89 in males from 2003 to 2011.Conclusions:Although the incidence and mortality rates of esophageal cancer remain high,an obvious decreasing trend has been observed in Hebei Province,as well as in high-risk regions,such as Cixian and Shexian,over the past 40 years. | Yutong He Yan Wu Guohui Song Yongwei Li Di Liang Jing Jin Denggui Wen Baoen Shan | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 6 | Hybrid hierarchy storage system in MilkyWay-2 supercomputer显示文摘 | Weixia XU Yutong LU Qiong LI Enqiang ZHOU Zhenlong SONG Yong DONG Wei ZHANG Dengping WEI Xiaoming ZHANG Haitao CHEN Jianying XING Yuan YUAN | 2014 | Frontiers of Computer Science2014，8，3： | 11 |
| 7 | Investigation of dielectric barrier discharge plasma flow control显示文摘Effects of plasma flow control are researched on the basis of plasma exciting flow experiments and numerical simulations. Turbulent model is more effective than laminar model in plasma numerical simulation as results showed. Both plasma exciting effects of acceleration and flow separation suppression are investigated through experiments carried on the flat plate and the compressor cascades. The results demonstrate that boundary layer characteristic is modified by plasma exciting. Distributions of total pressure and velocity in the wake are improved notably for 20 m/s coming velocity and the effect of plasma can still be observed while velocity is increased to 50 m/s. For low velocity flow, plasma exciting is effective in flow separation suppression. | NIE ChaoQun LI Gang ZHU JunQiang ZHANG Yi LI YuTong | 2008 | Science China(Technological Sciences)2008，51，7： | 9 |
| 8 | Estimated cancer incidence and mortality in Hebei province,2012显示文摘Objective: This study estimates the numbers of new cancer cases and cancer deaths in Hebei province using incidence and mortality data from 9 population-based cancer registries in 2012.Methods: The data of new diagnosed cancer cases and cancer deaths in 2012 were collected from 9 population-based cancer registries of Hebei province in 2015. All the data met the National Central Cancer Registry of China(NCCR) criteria of data quality. The pooled data analysis was stratified by areas(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+) and cancer type. New cancer cases and deaths in Hebei province were estimated using age-specific rates and corresponding provincial population in 2012. The 10 most common cancers in different groups and the cumulative rates were calculated. Chinese population census in 2000 and Segi's population were used for age-standardized incidence/mortality rates. Results: All cancer registries covered 4,986,847 populations, 6.84% of Hebei provincial population(2,098,547 in urban and 2,888,300 in rural areas). The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 76.40% and 4.72%, respectively. The mortality to incidence rate ratio(M/I) was 0.64. In 2012, it is estimated that there were about 187,900 new diagnosed cancer cases and 119,800 cancer deaths in Hebei province. The incidence rate of cancer was 258.12/100,000(275.75/100,000 in males, 239.78/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 210.65/100,000 and 208.50/100,000, with the cumulative incidence rates(0-74 years old) of 24.46%. The cancer incidence and ASIRC were 256.99/100,000 and 211.32/100,000 in urban areas and 258.94/100,000 and 209.99/100,000 in rural areas, respectively. The cancer mortality rate was 164.63/100,000(201.85/100,000 in males, 125.92/100,000 in females). Agestandardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 137.30/100,000 and 137.39/100,000 with the cumulative mortality rate(0-74 years old) of 14.58%, respectively. The cancer mortality rate in rural areas(167.16/100,000) was higher than that in urban areas(161.16/100,000). The most common cancers were lung cancer, stomach cancer, breast cancer, esophageal cancer, liver cancer and colorectal cancer, which accounted for 72.31% of all cancer cases. Lung cancer, stomach cancer, liver cancer, esophageal cancer and colorectal cancer were the major causes of cancer death in Hebei province, which accounted for 75.24% of all cancer deaths. The cancer spectrum differs between urban and rural, males and females in both incidence and mortality rates.Conclusions: The most common cancers were lung cancer, stomach cancer, esophageal cancer, breast cancer, liver cancer and colorectal cancer in Hebei province. | Yutong He Di Liang Daojuan Li Jingbo Zhai Junqing Zhu Jing Jin Denggui Wen Baoen Shan | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 9 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 10 | Generation and manipulation of chiral terahertz waves in the three-dimensional topological insulator Bi2Te3显示文摘Arbitrary manipulation of broadband terahertz waves with flexible polarization shaping at the source has great potential in expanding numerous applications,such as imaging,information encryption,and all-optical coherent control of terahertz nonlinear phenomena.Topological insulators featuring unique spinmomentum-locked surface state have already exhibited very promising prospects in terahertz emission,detection,and modulation,which may lay a foundation for future on-chip topological insulator-based terahertz systems.However,polarization-shaped terahertz emitters based on topological insulators with an arbitrarily manipulated temporal evolution of the amplitude and the electric-field vector direction have not yet been explored.We systematically investigated the terahertz radiation from topological insulator Bi2Te3 nanofilms driven by femtosecond laser pulses and successfully realized the generation of efficient chiral terahertz waves with controllable chirality,ellipticity,and principal axis.The convenient engineering of the chiral terahertz waves was interpreted by a photogalvanic effect(PGE)-induced photocurrent,while the linearly polarized terahertz waves originated from linear PGE-induced shift currents.Our work not only provides further understanding of femtosecond coherent control of ultrafast spin currents but also describes an effective way to generate spin-polarized terahertz waves at the source. | Haihui Zhao Xinhou Chen Chen Ouyang Hangtian Wang Deyin Kong Peidi Yang Baolong Zhang Chun Wang Gaoshuai Wei Tianxiao Nie Weisheng Zhao Jungang Miao Yutong Li Li Wang Xiaojun Wu | 2020 | Advanced Photonics2020，2，6： | 6 |
| 11 | Hierarchical-structure anatase TiO2 with conductive network for high-rate and high-loading lithium-ion battery显示文摘Titanium dioxides have been extensively investigated as promising anodes for Lithium ion batteries(LIBs)because of the high–rate capacity and cyclability,as well as the improved safety over graphite anode(1,2)However,as a typical insertion–type anode,anatase TiO2 exhibits low conductivity(10–12S cm-1 for electron conductivity[3]and 10–17–10–10 cm2 s1 for Li+ion diffusion coefficient[4])and poor specific capacity(only accommodate<0.5 Li per bulk TiO2 unit[5]),severely limiting its practical applications. | Xinghua Liu Lijiang Zhao Shitong Wang Meng Chao Yutong Li Jin Leng Junying Zhang Zilong Tang | 2019 | Science Bulletin2019，64，16： | 6 |
| 12 | Computer-based Creativity Enhanced Conceptual Design Model for Non-routine Design of Mechanical Systems显示文摘Computer-based conceptual design for routine design has made great strides, yet non-routine design has not been given due attention, and it is still poorly automated. Considering that the function-behavior-structure(FBS) model is widely used for modeling the conceptual design process, a computer-based creativity enhanced conceptual design model(CECD) for non-routine design of mechanical systems is presented. In the model, the leaf functions in the FBS model are decomposed into and represented with fine-grain basic operation actions(BOA), and the corresponding BOA set in the function domain is then constructed. Choosing building blocks from the database, and expressing their multiple functions with BOAs, the BOA set in the structure domain is formed. Through rule-based dynamic partition of the BOA set in the function domain, many variants of regenerated functional schemes are generated. For enhancing the capability to introduce new design variables into the conceptual design process, and dig out more innovative physical structure schemes, the indirect function-structure matching strategy based on reconstructing the combined structure schemes is adopted. By adjusting the tightness of the partition rules and the granularity of the divided BOA subsets, and making full use of the main function and secondary functions of each basic structure in the process of reconstructing of the physical structures, new design variables and variants are introduced into the physical structure scheme reconstructing process, and a great number of simpler physical structure schemes to accomplish the overall function organically are figured out. The creativity enhanced conceptual design model presented has a dominant capability in introducing new deign variables in function domain and digging out simpler physical structures to accomplish the overall function, therefore it can be utilized to solve non-routine conceptual design problem. | LI Yutong WANG Yuxin DUFFY Alex H B | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 5 |
| 13 | Dynamic and static performance optimization of dual active bridge DC-DC converters显示文摘High efficiency and fast dynamic response are two main control objectives for dual active bridge(DAB)DC-DC converters. Traditional extended phase shift(EPS)control can significantly enhance the conversion efficiency of DAB DC-DC converters by reducing current stress;however, it cannot fulfill fast dynamic response requirements. In this paper, a novel hybrid control scheme consisting of EPS control and direct power control(DPC),named as EPS-DPC, is proposed. EPS-DPC control has salient features in both efficiency and dynamic performance. In order to verify the outstanding performance of the proposed EPS-DPC scheme, an experimental comparison was carried out on a scale-down DAB DC-DC converter among several control strategies, including single phase shift control with traditional voltage-loop(SPS-TVL), EPS control with traditional voltage-loop(EPSVTL), and EPS-DPC. Experimental results have been high consistent with theoretical analysis, and verified these advantages of the proposed EPS-DPC scheme. | Nie HOU Wensheng SONG Yutong ZHU Xiao SUN Wei LI | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 5 |
| 14 | Integrated Inspection of QoM, QoP, and QoS for AOI Industries in Metaverses显示文摘With the rapid development of information technologies such as digital twin, extended reality, and blockchain,the hype around 'metaverse' is increasing at astronomical speed. However, much attention has been paid to its entertainment and social functions. Considering the openness and interoperability of metaverses, the market of quality inspection promises explosive growth. In this paper, taking advantage of metaverses, we first propose the concept of Automated Quality Inspection(Auto QI), which performs integrated inspection covering the entire manufacturing process, including Quality of Materials, Quality of Manufacturing(Qo M), Quality of Products, Quality of Processes(Qo P), Quality of Systems, and Quality of Services(Qo S). Based on the scenarios engineering theory, we discuss how to perform interactions between metaverses and the physical world for virtual design instruction and physical validation feedback. Then we introduce a bottomup inspection device development workflow with productivity tools offered by metaverses, making development more effective and efficient than ever. As the core of quality inspection,we propose Quality Transformers to complete detection task,while federated learning is integrated to regulate data sharing.In summary, we point out the development directions of quality inspection under metaverse tide. | Yutong Wang Yonglin Tian Jiangong Wang Yansong Cao Shixing Li Bin Tian | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，12： | 5 |
| 15 | Protein adsorption onto diethylaminoethyl dextran modified anion exchanger:Effect of ionic strength and column behavior显示文摘Our previous studies on bovine serum albumin(BSA) adsorption to diethylaminoethyl dextran(DEAE dextran,DexD, grafting-ligand) and DEAE(D, surface-ligand) modified Sepharose FF resins found that all the grafted resins(FF-DexD and FF-D-DexD) exhibited extremely fast uptake rate(effective diffusivity, D_e, D_e/D_O> 1.4),which was six times greater than the ungrafted resins(D_e/D_O < 0.3). In this work, the influence of ionic strength(IS) on 6 typical DEAE dextran-grafted resins was investigated. Bath adsorption equilibria and kinetics, breakthrough, and linear gradient elution experiments were conducted. Commercial DEAE Sepharose FF was used for comparison. It is found that protein adsorption capacities on DEAE dextran-FF resins and the commercial resin decreased with increasing IS, but DEAE dextran-FF resins exhibited much higher capacity sensitivity to salt concentration. Besides, steeper decrease of adsorption capacities could be obtained at higher graftingligand or surface-ligand density. It is worth noting that the facilitating role of surface-ligand to the 'chain delivery' effect was weakened after adding salt, leading to the less improvement in uptake rate by increasing surface-ligand density at higher IS. Although the uptake rates of the DEAE dextran-FF resins increased first and then decreased with increasing IS, they kept the extremely high level of De values(D_e/D_O > 1.1) at the their working/binding IS range. Moreover, the DEAE dextran-FF resin displayed much higher adsorption capacities and De values than commercial ungrafted resin in their working condition. Furthermore, the column results of DEAE dextran-FF resins presented higher dynamic binding capacities than and similar elution ISs with DEAE Sepharose FF to achieve similar(or even higher) recoveries suggest the excellent chromatographic column performance of the DEAE dextran-FF resins. Finally, both high recovery and purity of BSA and γ-globulin could be easily achieved using the typical DEAE dextran-FF column, FF-D60-DexD160, to separate their binary mixtures,by step gradient elution. The research has provided new insights into the practical application of the series of DEAE-dextran grafted resins in protein chromatography and proved their superiority. | Shu Bai Lingli Gong Detao Han Yutong Li Linling Yu Yan Sun | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 5 |
| 16 | Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediatedMAPK signaling显示文摘Background:Colorectal cancer(CRC)is one of the most malignant tumorswith high incidence,yet its molecular mechanism is not fully understood,hindering the development of targeted therapy.Metabolic abnormalities are a hallmark of cancer.Targeting dysregulated metabolic features has become an important direction for modern anticancer therapy.In this study,we aimed to identify a new metabolic enzyme that promotes proliferation of CRC and to examine the related molecular mechanisms.Methods:We performed RNA sequencing and tissue microarray analyses of human CRC samples to identify new genes involved in CRC.Squalene epoxidase(SQLE)was identified to be highly upregulated in CRC patients.The regulatory function of SQLE in CRC progression and the therapeutic effect of SQLE inhibitors were determined by measuring CRC cell viability,colony and organoid formation,intracellular cholesterol concentration and xenograft tumor growth.Themolecularmechanism of SQLE functionwas explored by combining transcriptome and untargeted metabolomics analysis.Western blotting and realtime PCR were used to assess MAPK signaling activation by SQLE.Results:SQLE-related control of cholesterol biosynthesis was highly upregulated in CRC patients and associated with poor prognosis.SQLE promoted CRC growth in vitro and in vivo.Inhibition of SQLE reduced the levels of calcitriol(active form of vitamin D3)and CYP24A1,followed by an increase in intracellular Ca2+concentration.Subsequently,MAPK signaling was suppressed,resulting in the inhibition of CRC cell growth.Consistently,terbinafine,an SQLE inhibitor,suppressed CRC cell proliferation and organoid and xenograft tumor growth.Conclusions:Our findings demonstrate that SQLE promotes CRC through the accumulation of calcitriol and stimulation of CYP24A1-mediated MAPK signaling,highlighting SQLE as a potential therapeutic target for CRC treatment. | Luwei He Huaguang Li Chenyu Pan Yutong Hua Jiayin Peng Zhaocai Zhou Yun Zhao Moubin Lin | 2021 | Cancer Communications2021，41，8： | 4 |
| 17 | Cloud model-based analysis of regional sustainable water resource utilization schemes显示文摘Given the adverse effects of current water shortages,low utilization and imbalance between the supply and demand,and other status quo problems relating to social economic development,the construction industry and agriculture,a cloud model was applied to a water resource system using five sustainable water resource utilization schemes for Kiamusze,Heilongjiang Province,as an example.This research changes the qualitative description of the concept language into a quantitative analysis of an evaluation indicator.A cloud model-based analytical method for regional sustainable water resource utilization schemes was proposed,and the sustainable grades of the water resources were calculated.The research results showed that,in addition to the natural continuation of such schemes,the development trends of four new schemes achieved the sustainable utilization of water resources,and thus,the sustainable water resource utilization was optimized.However,when the open-source,throttle,comprehensive and coordination schemes were subjected to the optimum applicability analysis,based on the limiting factors in different periods,resource availability and long-term development,decision-making regarding the best solution in different periods better ensures sustainable development in Kiamusze.The research results provide a significant theoretical basis for the formulation of scientific and reasonable sustainable water resource utilization strategies in Kiamusze. | Fu Qiang Meng Fanxiang Li Tianxiao Liu Dong Gong Fanli Amgad Osman Li Yutong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 4 |
| 18 | Nonlinear distortion and spatial dispersion of intense terahertz generation in lithium niobate via the tilted pulse front technique显示文摘We systematically investigate the influences of the input infrared spectrum, chirp, and polarization on the emitted intense terahertz spectrum and spatial dispersion in lithium niobate via optical rectification. The terahertz yield and emission spectrum depend on both the chirp and spectrum of the input pump laser pulses. We also observe slight non-uniform spatial dispersion using a knife-edge measurement, which agrees well with the original predictions. The possible mechanism is the nonlinear distortion effect caused by high-energy laser pumping.Our study is very important and useful for developing intense terahertz systems with applications in extreme terahertz sciences and nonlinear phenomena. | BAOLONG ZHANG SHANGQING LI SHUSU CHAI XIAOJUN Wu JINGLONG MA LIMING CHEN YUTONG LI | 2018 | Photonics Research2018，6，10： | 4 |
| 19 | The ChatGPT After: Building Knowledge Factories for Knowledge Workers with Knowledge Automation显示文摘Briefing: This perspective introduces the concept and framework of knowledge factories with knowledge machines for knowledge workers to achieve knowledge automation for Industry 5.0 and intelligent industries.Introduction The big hit of Chat GPT makes it imperative to contemplate the practical applications of big or foundation models [1]-[5]. However, as compared to conventional models, there is now an increasingly urgent need for foundation intelligence of foundation models for real-world industrial applications. | Yutong Wang Xiao Wang Xingxia Wang Jing Yang Oliver Kwan Lingxi Li Fei-Yue Wang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，11： | 4 |
| 20 | A Predictive 6G Network with Environment Sensing Enhancement:From Radio Wave Propagation Perspective显示文摘In order to support the future digital society,sixth generation(6G)network faces the challenge to work efficiently and flexibly in a wider range of scenarios.The traditional way of system design is to sequentially get the electromagnetic wave propagation model of typical scenarios firstly and then do the network design by simulation offline,which obviously leads to a 6G network lacking of adaptation to dynamic environments.Recently,with the aid of sensing enhancement,more environment information can be obtained.Based on this,from radio wave propagation perspective,we propose a predictive 6G network with environment sensing enhancement,the electromagnetic wave propagation characteristics prediction enabled network(EWave Net),to further release the potential of 6G.To this end,a prediction plane is created to sense,predict and utilize the physical environment information in EWave Net to realize the electromagnetic wave propagation characteristics prediction timely.A two-level closed feedback workflow is also designed to enhance the sensing and prediction ability for EWave Net.Several promising application cases of EWave Net are analyzed and the open issues to achieve this goal are addressed finally. | Gaofeng Nie Jianhua Zhang Yuxiang Zhang Li Yu Zhen Zhang Yutong Sun Lei Tian Qixing Wang Liang Xia | 2022 | China Communications2022，19，6： | 4 |
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