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| 1 | Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma显示文摘Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na?ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid)(PEG-PLGA) nanoparticles. Neutrophil membranecoated nanoparticles(NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma. | Xi Cao Ying Hu Shi Luo Yuejing Wang Tao Gong Xun Sun Yao Fun Zhirong Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 9 |
| 2 | Effect of doped strontium on catalytic properties of La_(1-x)SrxMnO_(3) for rhodamine B degradation显示文摘A series of La_(1-x)Sr_(x)MnO_(3) samples were prepared by sol-gel method and used to degrade rhodamine B(RhB) in water.All samples were characterized by X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),N_(2) adsorption-desorption,temperature-programmed reduction of H_(2)(H_(2)-TPR) and temperature-programmed desorption of O_(2)(O_(2)-TPD).The results show that the degradation of RhB is highly dependent on the initial pH value of solution.Sr doping enhances the degradation ability of LaMnO_(3) for RhB in the time range of 0-40 min under a strong acidic environment,but all samples exhibit similar degradation rate from 40 to 60 min.In La_(0.7)Sr_(0.3)MnO_(3)-RhB reaction system,there are two different degradation pathways,including N-de-ethylation,chromophore cleavage,ring-opening and mineralization.La_(1-x)Sr_(x)MnO_(3)(x ≤0.3) has the perovskite structure of La-Mn oxides,while La_(0.6)Sr_(0.4)MnO_(3) exhibits a Sr_(0.4)MnLa_(0.6)O_(2).98 perovskite phase.Sr doping leads to distortion of rhombohedral crystal structure and increases the relative content of Mn^(4+).The perovskite structure is stable in strong acidic environment during RhB degradation,but the relative content of Mn^(4+)and Mn^(3+) on the material surface changes.Sr doped LaMnO_(3) achieves specific surface area of 58.8 m^(2)/g and total pore volume of 0.152 cm^(3)/g.Furthermore,Sr^(2+)doping improves redox properties of La-Mn oxides,and the presence of defects makes oxygen diffusion easier compared with the undoped samples. | Jiaxiu Guo YueJing Ting Shen Hongdi Luo Juan Liang Shandong Yuan | 2021 | Journal of Rare Earths2021，39，11： | 2 |
| 3 | Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation显示文摘AMP-activated protein kinase(AMPK)is a conserved energy sensor that plays roles in diverse biological processes via phosphorylating various substrates.Emerging studies have demonstrated the regulatory roles of AMPK in DNA repair,but the underlying mechanisms remain to be fully understood.Herein,using mass spectrometry-based proteomic technologies,we systematically investigate the regulatory network of AMPK in DNA damage response(DDR).Our system-wide phosphoproteome study uncovers a variety of newly-identified potential substrates involved in diverse biological processes,whereas our system-wide histone modification analysis reveals a link between AMPK and histone acetylation.Together with these findings,we discover that AMPK promotes apoptosis by phosphorylating apoptosis-stimulating of p53 protein 2(ASPP2)in an irradiation(IR)-dependent manner and regulates histone acetylation by phosphorylating histone deacetylase 9(HDAC9)in an IR-independent manner.Besides,we reveal that disrupting the histone acetylation by the bromodomain BRD4 inhibitor JQ-1 enhances the sensitivity of AMPKdeficient cells to IR.Therefore,our study has provided a resource to investigate the interplay between phosphorylation and histone acetylation underlying the regulatory network of AMPK,which could be beneficial to understand the exact role of AMPK in DDR. | Yuejing Jiang Xiaoji Cong Shangwen Jiang Ying Dong Lei Zhao Yi Zang Minjia Tan Jia Li | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 4 | Advanced paternal age increases the risk of schizophrenia and obsessive - compulsive disorder in a Chinese Man population 显示文摘 | WU Yuejing LIU Xiang LUO Hongrong | 2012 | Psychiatry Res2012，198，3： | 1 |
| 5 | The treatment of unstable thoracic spine fractures with transpedicular screw instru- mentation: a 3 - year consecutive series EJ3显示文摘 | Yuej J Sossan A SELGRATH C | 2002 | Spine2002，27，24： | 1 |
| 6 | Progress in characteristics of cytochromeP-450 CYP2E1 in protein structure and regulation mecha-nisms[J]显示文摘 | LiuCH YueJ | | 中国药理学与毒理学杂志0，，： | 1 |
| 7 | Miero RNA smaberrantly ex?pressed in hypertrophic heart: do they play a role in cardiac hy?pertrophy显示文摘 | CHENG Y JI R YUEJ | 2007 | AmJ Pathol2007，170，6： | 1 |
| 8 | Breeding newseedless grapes using in ovulo embryo rescue and marker-assist?ed selection显示文摘 | LI Zhiqian LI Tiemei WANG Yuejing XU Yan | 2015 | In vitro Cellular&Development Biology-Plant2015，51，3： | 1 |
| 9 | MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation显示文摘 | Ji R Cheng Y YueJ | 2007 | Circ Res2007，100，11： | 1 |
| 10 | Synthesis and characterization of hyperbranched aromatic poly(ether imide)s显示文摘 | Li Xiuru Li Yuesheng Tong Yuejing | 2003 | Macromolecules2003，36，15： | 1 |
| 11 | Application of catalytic wet oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | ZHU Wangpeng BIN Yuejing LI Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 12 | Application of catalytic wet oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | Zhu Wangpeng Bin Yuejing Li Zhonghe | 2002 | Wat Res2002，36，8： | 1 |
| 13 | Application of catalytic wet air oxidation for the treatment of H-acid manufacturing process wastewater 显示文摘 | ZHU Wanpeng BIN Yuejing LI Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 14 | Coordination of cooperative adverting in a two-level supply chain when manufacturer offers discount 显示文摘 | YueJ Austin J Wang M | 2006 | European Journal of Operational Research2006，168，1： | 1 |
| 15 | Thermal behavior, microstruc- ture and protein quality of squid fillets dried by far-infrared assis-ted heat pump drying 显示文摘 | Deng Y Wang Y G YueJ | 2014 | Food Control2014，26，1： | 1 |
| 16 | Application of Catalytic Wet Air Oxidation for the Treatment of H-Acid Manufacturing Process Wastewater显示文摘 | Zhu Wanpeng Bin Yuejing Li Zhonghe | | 0，，8： | 1 |
| 17 | Application of catalytic wet air oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | Zhu Wanpeng Bin Yuejing Li Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 18 | Streptomyces vulcanius sp. nov., a novel actinomycete isolated from volcanic sediment显示文摘 | Feiyu Jia Chongxi Liu Junwei Zhao Yuejing Zhang Lianjie Li Shuyu Zhou Yue Shen Xiangjing Wang Wensheng Xiang | 2015 | Antonie van Leeuwenhoek2015，，1： | 1 |
| 19 | Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmtl in HOX gene silencing显示文摘 | Wu X Gong Y YueJ | 2008 | Nucleic Acids Res2008，36，11： | 1 |
| 20 | Application of catalytic wet air oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | ZHU Wanpeng BIN Yuejing LI Zhonghe | 2002 | Water Research2002，36，8： | 1 |
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