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| 1 | Effect of catheter radiofrequency ablation on C-reactive protein, brain natriuretic peptide and echocardiograph in patients with persistent and permanent atrial fibrillation显示文摘 | Huang Q QiuCG Yuan YQ Zhao Y J Mao YL Wang RM Wang Q | 2014 | Chinese Medical Journal2014，，4： | 7 |
| 2 | Expression of co-stimulator 4-1BB molecule in hepatocellular carcinoma and adjacent non-tumor liver tissue,and its possible role in tumor immunity显示文摘AIM:To investigate the expression of 4-1BB molecule in hepatocellular carcinoma (HCC) and its adjacent tissues.METHODS:Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the gene expression of 4-1BB in hepatocarcinoma and its adjacent tissues,and peripheral blood mononuclear cells (PBMCs) from both HCC and health control groups.Flow cytometry was used to analyse the phenotypes of T cell subsets from the blood of HCC patients and healthy volunteers,and further to determine whether 4-1BB molecules were also expressed on the surface of CD4+ and CD8+ T cells. The localization of 4-1BB proteins on tumor infiltrating T cells was determined by direct immunofluorescence cytochemical staining and detected by confocal microscopy.RESULTS:4-1BB mRNA, which was not detectable in normal liver,was found in 19 liver tissues adjacent to tumor edge(<1.0cm).Low expression of 4-1BB mRNA was shown in 8 tumor tissues and 6 liver tissues located within 1 to 5cm away from tumor edge. In PBMCs, 4-1BB mRNA was almost not detected. Percentage of CD4^+, CD8^+ and CD3^+/CD25^+ T cells, as well as ratio of CD4 to CD8 revealed no difference between groups (P>0.05,respectively),while a significant lower percentage of CD3^+ T cell was found in HCC group as compared to healthy control group (P<0.05).However, 4-1BB molecules were almost not found on the surface of CD4+ and CD8+ T cells in HCC and healthy control group.Double-staining of 4-1BB^+/CD4^+ and 4-1BB^+/CD8^+ immunofluorescence on tumor infiltrating T cells was detected in 13 liver tissues adjacent to tumor edge (<1.0cm) by confocal microscopy.CONCLUSION: Although HCC may escape from immune attack by weak immunogenicity or downregulated expression of MHC-1 molecules on the tumor cell surface,tumor infiltrating T cells can be activated via other costimulatory signal pathways to exert a limited antitumor effect on local microenvironment. The present study also implicates that modulating 4-1BB/4-1BBL costimulatory pathway may be an effective immunotherapy strategy to augment the host response. | Wan, YL Zheng, SS Zhao, ZC Li, MW Jia, CK Zhang, H | 2004 | World Journal of Gastroenterology2004，10，2： | 6 |
| 3 | Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome p450 1A2 in rats显示文摘 | Nadai, M Kato, M Yasui, K Kimura, M Zhao, YL Ueyama, J Tsunekawa, Y Yoshizumi, H Hasegawa, T | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 4 | Induction of cytotoxic T-lymphocytes by electroporation-enhanced needle-free skin immunization显示文摘 | Zhao YL Murthy SN Manjili MH | 2006 | Vaccine2006，24，9： | 1 |
| 5 | Mechanism of transcriptional regulation of LRP16 gene expression by 1713 estradid in MCF-7 human breast cancer ceUs显示文摘 | ZHAO YL HAN WD LI Q | 2005 | J Mol Endocrinol2005，34，1： | 1 |
| 6 | Toxic effects of over-load copper chloride on primary cultured rat asrocytes显示文摘 | Hu HL Wang XP Zhao YL | 2012 | Parkinsonism Relat Disord2012，18，： | 1 |
| 7 | Pifithrin-alpha enhances the surviv- al of transplanted neural stem cells in stroke rats by inhibiting p53 nuclear translocation 显示文摘 | Lei XH Zhao D Li YL | 2013 | CNS Neurosci Ther2013，19，： | 1 |
| 8 | Brief communication : body massindex, body adiposity index, and percent body fat in asians显示文摘 | Zhao DP Li YL Zheng LB | 2013 | AmJ Physical Anthropol2013，152，2： | 1 |
| 9 | A single-center study of hemorrhag- ic stroke caused by cerebrovascular disease during pregnancy and pu- erperium in China显示文摘 | Liu XJ Wang S Zhao YL | 2011 | Int J Gynaecol Obstet2011，113，1： | 1 |
| 10 | 显示文摘 | Shenoy SK Han S Zhao YL | 2012 | Oncogene2012，31，3： | 1 |
| 11 | BigH3 pro- ein expression as a marker for breast cancer显示文摘 | 2alaf GM Echiburu-Chau C Zhao YL | 2008 | Int J Viol Med2008，21，5： | 1 |
| 12 | MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the robol receptor显示文摘 | Tie J Pan YL Zhao LN | 2010 | PLoS Genet2010，6，10： | 1 |
| 13 | Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction显示文摘 | Tang YL Zhao Q Qin XY | | 0，，： | 1 |
| 14 | Snail promotes epithelial mesenchymal transition and invasiveness in human ovarian cancer cells 显示文摘 | Wang YL Zhao XM Shuai ZF | 2015 | Int J Clin Exp Med2015，1538，5： | 1 |
| 15 | Mechanism of transcriptional regulation of LRP16 gene expression by 17-β estradiol in MCF-7 human breast cancer cells显示文摘 | Zhao YL Han WD Li Q | 2005 | J Mol Endocrinol2005，34，1： | 1 |
| 16 | Interleukin-10 gene promoter polymorphisms and their protein production in pleural fluid in patients with tuberculosis显示文摘 | Liang L Zhao YL Yue J | | 0，，01： | 1 |
| 17 | In silico prediction of binding of promiscuous peptides to multiple MHC class-II molecules i-dentifies the Thl cell epitopes from secreted and transmembrane proteins of Schistosoma japonicum in BALB/c mice显示文摘 | Zhao BP Chen L Zhang YL | 2011 | Micro In-fec/Inst Past2011，13，70： | 1 |
| 18 | Enzyme-histochemicl staining differentiation of lymphatics from blood vessels 显示文摘 | Li YL Xu YD | 1993 | Chinese J Histochem Cytochem1993，2，2： | 1 |
| 19 | Preparation of analogues of Territrem B, a potent AChE inhibitor显示文摘 | Zhao Y Ku YL Hao XJ | 2000 | Tetrahedron2000，56，： | 1 |
| 20 | Comparison of outcomes for laparoseopically assisted and open radical distal gastrectomy with lymphadenectomy for advanced gastric cancer 显示文摘 | Zhao YL Yu PW Hao YX | 2011 | Surg Endosc2011，25，9： | 1 |
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