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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | Sulfur-containing amino acid methionine as the precursor of volatile organic sulfur compounds in algea-induced black bloom显示文摘After the application of methionine, a progressive and significant increase occurred in five volatile organic sulfur compounds (VOSCs): methanethiol (MeSH), dimethyl sulfide (DMS), dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS) and dimethyl tetrasulfide (DMTeS). Even in the untreated control without a methionine addition, methionine and its catabolites (VOSCs, mainly DMDS) were found in considerable amounts that were high enough to account for the water's offensive odor. However, blackening only occurred in two methionine-amended treatments. The VOSCs production was observed to precede black color development, and the reaching of a peak value for total VOSCs was often followed by water blackening. The presence of glucose stimulated the degradation of methionine while postponing the occurrence of the black color and inhibiting the production of VOSCs. In addition, DMDS was found to be the most abundant species produced after the addition of methionine alone, and DMTeS appeared to be the most important compound produced after the addition of methionine+glucose. These results suggest that methionine acted as an important precursor of the VOSCs in lakes suffering from algea-induced black bloom. The existence of glucose may change the transformation pathway of methionine into VOSCs to form larger molecular weight compounds, such as DMTS and DMTeS. | Xin Lu Chengxin Fan Wei He Jiancai Deng Hongbin Yin | 2013 | Journal of Environmental Sciences2013，25，1： | 27 |
| 3 | A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity显示文摘由调整 transcriptional 激活剂 Yorkie (Yki ) 的活动的河马(Hpo ) 小径控制织物生长和机关尺寸,它在原子核与抄写因素 Scalloped (Sd ) 联系下游地支持指向基因表示。这里,我们识别新奇蛋白质 Sd-Binding-Protein (SdBP )/Tgi,它直接通过它的 TDU 域为绑定与 Yki 竞争到 Sd 并且禁止 Sd-Yki transcriptional 活动。我们也发现 SdBP 经由它的 PPXY 主题与 Yki WW 领域通过协会在原子核保留 Yki。一起,我们作为 Hpo 小径的一个新奇部件识别 SdBP,否定地调整 Sd-Yki 的 transcriptional 活动限制织物生长。 | Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang | 2013 | Cell Research2013，23，10： | 13 |
| 4 | Green fluorescent protein (GFP) transgenic pig produced by somatic cell nuclear transfer显示文摘Transgenic somatic cell nuclear transfer is a very promising route for producing transgenic farm ani-mals. Research on GFP transgenic pigs can provide useful information for breeding transgenic pigs, human disease models and human organ xenotransplantation. In this study, a liposomal transfection system was screened and transgenic embryos were reconstructed by nuclear transfer of GFP positive cells into enucleated in vitro matured oocytes. The development of reconstructed embryos both in vitro and in vivo was observed, and GFP expression was determined. The results showed that porcine fe-tal-derived fibroblast cells cultured with 4.0 μL/mL liposome and 1.6 μg/mL plasmid DNA for 6 h re-sulted in the highest transfection rate (3.6%). The percentage of GFP reconstructed embryos that de-veloped in vitro to the blastocyst stage was 10%. Of those the GFP positive percentage was 48%. Re-constructed transgenic embryos were transferred to 10 recipients. 5 of them were pregnant, and 3 de-livered 6 cloned piglets in which 4 piglets were transgenic for the GFP as verified by both GFP protein expression and GFP DNA sequence analysis. The percentage of reconstructed embryos that resulted in cloned piglets was 1.0%; while the percentage of piglets that were transgenic was 0.7%. This is the first group of transgenic cloned pigs born in China, marking a great progress in Chinese transgenic cloned pig research. | LIU ZhongHua SONG Jun WANG ZhenKun TIAN JiangTian KONG QingRan ZHENG Zhong YIN Zhi GAO Li MA HaiKun SUN Shuang LI YuTian WANG HongBin R S PRATHER | 2008 | Chinese Science Bulletin2008，53，7： | 8 |
| 5 | Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR显示文摘Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)therapy.Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity.Using flow cytometry-based assay,we identify tubeimoside-1(TBM-1)as a promising antitumor immune modulator that negatively regulates PD-L1 level.TBM-1 disrupts PD-1/PD-L1 interaction and enhances the cytotoxicity of T cells toward cancer cells through decreasing the abundance of PD-L1.Furthermore,TBM-1 exerts its antitumor effect in mice bearing Lewis lung carcinoma(LLC)and B16 melanoma tumor xenograft via activating tumor-infiltrating T-cell immunity.Mechanistically,TBM-1 triggers PD-L1 lysosomal degradation in a TFEB-dependent,autophagy-independent pathway.TBM-1 selectively binds to the mammalian target of rapamycin(m TOR)kinase and suppresses the activation of m TORC1,leading to the nuclear translocation of TFEB and lysosome biogenesis.Moreover,the combination of TBM-1 and anti-CTLA-4 effectively enhances antitumor T-cell immunity and reduces immunosuppressive infiltration of myeloid-derived suppressor cells(MDSCs)and regulatory T(Treg)cells.Our findings reveal a previously unrecognized antitumor mechanism of TBM-1 and represent an alternative ICB therapeutic strategy to enhance the efficacy of cancer immunotherapy. | Xiaojia Liu Mingxiao Yin Jingwen Dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu Na Zhang Hongbin Deng | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 6 | Finding Deceptive Opinion Spam by Correcting the Mislabeled Instances显示文摘Assessing the trustworthiness of reviews is a key in natural language processing and computational linguistics. Previous work mainly focuses on some heuristic strategies or simple supervised learning methods, which limit the performance of this task. This paper presents a new approach, from the viewpoint of correcting the mislabeled instances, to find deceptive opinion spam. Partition a dataset into several subsets, construct a classifier set for each subset and select the best one to evaluate the whole dataset. Error variables are defined to compute the probability that the instances have been mislabeled. The mislabeled instances are corrected based on two threshold schemes, ma jority and non-objection. The results display significant improvements in our method in contrast to the existing baselines. | REN Yafeng JI Donghong YIN Lan ZHANG Hongbin | 2015 | Chinese Journal of Electronics2015，24，1： | 2 |
| 7 | 高铝相变诱发塑性钢用硅钙和铝钙结晶器保护渣的开发评估显示文摘连铸生产高强钢时,如高铝相变诱发塑性钢(简称TRIP钢),传统的硅钙保护渣由于SiO2的急剧减少而表现出了固有的不稳定性。保护渣中二氧化硅的减少导致氧化铝增加约30%,这种变化的程度和不稳定性会影响到保护渣的物理性能,从而影响结晶器散热、保护渣的消耗量及保护渣在结晶器内的行为。以上因素综合作用,导致铸坯表面产生横向和纵向凹陷及裂纹。由于这种铝钙保护渣在连铸生产高铝TRIP钢时,不易发生反应而备受人们的关注。在安赛乐米塔尔美国公司(AM-USA)的两家研发中心—东芝加哥中心和施托尔贝格进行了这两种保护渣的生产试验,研究相对于传统的硅钙保护渣,新保护渣对生产高铝TRIP钢的影响。利用光学显微镜、阴极发光显微镜和扫描电子显微镜来检查结晶器中的渣膜层,以此来确定渣层中沉淀物的性质和分布。铝钙保护渣的使用使钢/渣间的化学反应有了明显的变化,改善了铸坯的表面质量。 | Kenneth Blazek Hongbin Yin George Skoczylas Marc McClymonds Mike Frazee 毛天成(译) 刘金学(译) 杜锋(校) | 2013 | 世界钢铁2013，，3： | 2 |
| 8 | Incidence, risk factors for amputation among patients with diabetic foot ulcer in a Chinese tertiary hospital显示文摘 | Xiang Li Ting Xiao Yuzhen Wang Hongbin Gu Zhiguo Liu Yufeng Jiang Yanjun Liu Zuqian Lu Xiaopin Yang Yin Lan Zhangrong Xu | 2011 | Diabetes Research and Clinical Practice2011，，1： | 2 |
| 9 | Phosphorus removal from sediments by Potamogeton crispus:New high-resolution in-situ evidence for rhizosphere assimilation and oxidization-induced retention显示文摘Macrophytes are usually chosen for phytoremediation tools to remove P in eutrophic aquatic ecosystems,but the lack of test methods hinders the understanding of removal mechanism and application.In this study,we used the novel technologies combined of Diffusive gradients in thin films(DGT),Planar optode(PO),and Non-invasive micro-test technology(NMT)to explore P dynamics in water-sediment continuum and rhizosphere of Potamogeton crispus over time.Results of the high-resolution in situ measurement showed that labile P(LPDGT)fluxes at the surficial sediment significantly decreased from approximate 120,140,and 200 pg/(cm^(2)·sec)via 30 days incubation period to 17,40,and 56 pg/(cm2•sec)via that of 15 days.Obvious synchronous increase of LPDGT was not detected in overlying water,suggesting the intense assimilation of dissolve reactive P via root over time.PO measurement indicated that O_(2)concentration around the rhizosphere remarkably increased and radially diffused into deeper sediment until 100%saturation along with the root stretch downwards.NMT detection of roots showed the obvious O_(2)inflow into root tissue with the uppermost flux of 30 pmol/(cm2•sec)from surroundings via aerenchyma on different treatment conditions.Different from previous reports,gradually saturating O_(2)concentrations around the rhizosphere was principally driven by O_(2)penetration through interspace attributing to root stretch downward rather than root O_(2)leakage.Increased O_(2)concentrations in deep sediment over time finally induced the oxidization of labile Fe(II)into Fe(III)bound P and local P immobilization. | Hezhong Yuan Yiwei Cai Zhen Yang Qiang Li Enfeng Liu Hongbin Yin | 2021 | Journal of Environmental Sciences2021，33，11： | 2 |
| 10 | Urban traffic flow prediction using a fuzzy- neural approach显示文摘 | Yin Hongbin Wong S C Jianmin Xu and Wong C K | 2002 | Transportation Research Part C: Emerging Technologies2002，10，2： | 1 |
| 11 | Urban traffic flow prediction using a fuzzy-neural approach显示文摘 | Wong S C Xu Jianmin | 2002 | Transportation Research Part C2002，，10： | 1 |
| 12 | Urban Traffic Flow Prediction Using a Fuzzy-neural Approach显示文摘 | Yin Hongbin Wong S C Xu Jianmin | 2002 | Transportation Research Part C2002，，： | 1 |
| 13 | Distribution characteristics and toxicity assessment of heavy metals in the sediments of Lake Chaohu, China 显示文摘 | YIN Hongbin DENG Jiancai SHAO Shiguang | 2011 | Environmental Monitoring and Assessment2011，179，1234： | 1 |
| 14 | Effects of the lyotropic series salts on the gelation of konjac glucomannan in aqueous solutions显示文摘 | Yin Wanchun Zhang Hongbin Huang Long | 2008 | Carbohydrate Polymers2008，74，1： | 1 |
| 15 | Characteristics of Agglomeration of Various Inclusion Particles on Molten SteelSurface显示文摘 | Hongbin YIN Hiroyuki SHIBATA Toshihiko EMI | 1997 | ISIJ Int1997，37，10： | 1 |
| 16 | 'In-situ' Observation of Collision, Agglomeration and Cluster Formation of Alumina Inclusion Particles on Steel Melts显示文摘 | Hongbin YIN Hiroyuki SHIBATA Toshihiko EMI | 1997 | ISIJ Int1997，37，10： | 1 |
| 17 | Urban traffic flow prediction using a fuzzy-neural approach显示文摘 | Yin Hongbin Wang S C Xu Jianmin | 2002 | Transportation Research Part C: Emerging Technologies2002，10，2： | 1 |
| 18 | Red uction of sediment internal P- loading from eutrophic lakes using thermally modified calcium-rich attapulgite-based thin-layer cap 显示文摘 | YIN Hongbin KONG Ming | 2015 | Journal of Environmental Management2015，151，1： | 1 |
| 19 | In-situ observation of engulfment and pushing of nonmetallic inclusions in steel melt by advancing melt/Solid interface显示文摘 | Hiroyuki Shibata Yin Hongbin | 1998 | ISIJ Int1998，38，2： | 1 |
| 20 | Comparison of curdlanand its carboxymethylated derivative by means of rheology,DSC,andAFM显示文摘 | JIN Yang ZHANG Hongbin YIN Yimei | 2006 | Carbohydrate Research2006，341，1： | 1 |
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