|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Atmospheric Circulation and Dynamic Mechanism for Persistent Haze Events in the Beijing–Tianjin–Hebei Region显示文摘In this study, regional persistent haze events(RPHEs) in the Beijing–Tianjin–Hebei(BTH) region were identified based on the Objective Identification Technique for Regional Extreme Events for the period 1980–2013. The formation mechanisms of the severe RPHEs were investigated with focus on the atmospheric circulation and dynamic mechanisms. Results indicated that:(1) 49 RPHEs occurred during the past 34 years.(2) The severe RPHEs could be categorized into two types according to the large-scale circulation, i.e. the zonal westerly airflow(ZWA) type and the high-pressure ridge(HPR) type. When the ZWA-type RPHEs occurred, the BTH region was controlled by near zonal westerly airflow in the mid–upper troposphere.Southwesterly winds prevailed in the lower troposphere, and near-surface wind speeds were only 1–2 ms^(-1). Warm and humid air originating from the northwestern Pacific was transported into the region, where the relative humidity was 70% to 80%, creating favorable moisture conditions. When the HPR-type RPHEs appeared, northwesterly airflow in the mid–upper troposphere controlled the region. Westerly winds prevailed in the lower troposphere and the moisture conditions were relatively weak.(3) Descending motion in the mid-lower troposphere caused by the above two circulation types provided a crucial dynamic mechanism for the formation of the two types of RPHEs. The descending motion contributed to a reduction in the height of the planetary boundary layer(PBL), which generated an inversion in the lower troposphere. This inversion trapped the abundant pollution and moisture in the lower PBL, leading to high concentrations of pollutants. | Ping WU Yihui DING Yanju LIU | 2017 | Advances in Atmospheric Sciences2017，34，4： | 58 |
| 2 | Comparisons in subcellular and biochemical behaviors of cadmium between Iow-Cd and high-Cd accumulation cultivars of pakchoi (Brassica chinensis L.)显示文摘 | Meng XUE Yihui ZHOU Zhongyi YANG Biyun LIN Jiangang YUAN Shanshan WU | 2014 | Frontiers of Environmental Science & Engineering2014，8，2： | 14 |
| 3 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 4 | Environmental and Dynamic Conditions for the Occurrence ofPersistent Haze Events in North China显示文摘This paper presents a concise summary of recent studies on the long-term variations of haze in NorthChina and on the environmental and dynamic conditions for severe persistent haze events. Resultsindicate that haze days have an obviously rising trend over the past 50 years in North China. Theoccurrence frequency of persistent haze events has a similar rising trend due to the continuous riseof winter temperatures, decrease of surface wind speeds, and aggravation of atmospheric stability. InNorth China, when severe persistent haze events occur, anomalous southwesterly winds prevail in thelower troposphere, providing sufficient moisture for the formation of haze. Moreover, North China ismainly controlled by a deep downdraft in the mid-lower troposphere, which contributes to reducing thethickness of the planetary boundary layer, obviously reducing the atmospheric capacity for pollutants.This atmospheric circulation and sinking motion provide favorable conditions for the formation andmaintenance of haze in North China. | Yihui Ding Ping Wu Yanju Liu Yafang Song | 2017 | Engineering2017，3，2： | 13 |
| 5 | SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless显示文摘果蝇无翼(Wg ) 在开发期间充当 morphogen。Wg 分泌物被七通行证的 transmembrane 货物 Wntless (Wls ) 控制。我们最近作为涉及 Wls trafficking 的一个关键管理者识别了 retromer。因为排序的 nexin (SNX ) 分子是 retromer 建筑群的必要部件,我们假设了那特定的 SNX 为调停 retromer 的 Wnt 被要求分泌物。这里,我们八个 snx 成员为所有产生了果蝇异种,并且作为为 Wg 分泌物要求的一个必要分子识别了果蝇 SNX3 (DSNX3 ) 。我们证明那 Wg 分泌物和它的发信号的活动在在翅膀磁盘的 Dsnx3 变异的克隆是有缺点的。在弄空 Dsnx3 的 S2 房间的文化媒介的 Wg 层次显著地也被减少。重要地, Wls 层次惊人地在 Dsnx3 变异的房间被减少,并且 Wls 的 overexpression 能救在 Dsnx3 变异的房间观察的 Wg 分泌物缺点。而且, DSNX3 能与 retromer 部件 Vps35 交往,并且在早内涵体与 Vps35 共同本地化。这些数据显示 DSNX3 经由再循环的 retromer 依赖的 Wls 调整 Wg 分泌物。相反,我们发现那 Wg 分泌物不在为果蝇 snx1 和 snx6 变异的房间是有缺点的,古典 retromer 建筑群的二个部件。DSNX1 或 DSNX6 的宫外的表示没能在 Dsnx3 变异的翅膀磁盘并且在 Dsnx3 对待 dsRNA 的 S2 房间救 Wg 分泌物缺点。这些数据在再循环的 Wls 表明 DSNX3-retromer 建筑群的特性。一起,我们的调查结果建议 DSNX3 充当 retromer 的一个货物特定的部件,它为 Wls 和 Wg/Wnt 分泌物再循环的 endocytic 被要求。 | Peng Zhang Yihui Wu Tatyana Y Belenkaya Xinhua Lin | 2011 | Cell Research2011，21，12： | 11 |
| 6 | Editorial显示文摘As we will soon celebrate the 90th anniversary of the founding of the Chinese Meteorological Society(CMS),Acta Meteorologica Sinica(AMS),which was originally named as Bulletin of the Chinese Meteorological Society,has gone through 89 years of development and excitement since her first issue in July 1925.According to archived documents(CMS Editorial Committee,1925),AMS was founded to report the research findings of Chinese meteorologists,record their recommendations for improving meteorological services,and share | DING Yihui WU Guoxiong Da-Lin ZHANG ZHANG Renhe | 2014 | Journal of Meteorological Research2014，28，5： | 9 |
| 7 | How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis?显示文摘Wistar rats were intragastrically perfused with Chinese medicines used for tonifying the kidney.These included 0.180 g/mL of Herba Epimedii(Epimedium), Semen Cuscutae(Dodder Seed), or Herba Cistanches(Desertliving Cistanche), 0.04 mg/mL monoamine oxidase-B inhibitor selegiline,or distilled water for 14 consecutive days to prepare drug-containing serum or blank serum.MES23.5 cells in the logarithmic phase were cultured in media supplemented with 15%drug-containing serum for 24 hours, followed by incubation in culture solution containing 100 μmol/L H2O2for 3 hours. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) and flow cytometry results showed that all drug-containing serums improved the survival rate of H2O2-injured MES23.5 cells, inhibited pro-apoptotic FasL and caspase-3 expression, promoted anti-apoptotic Bcl-2 expression. However, drug-containing serums had little influence on Fas expression in H2O2-injured MES23.5 cells. Enzyme-linked immunosorbent assay results showed that serum containing Herba Cistanches or Herba Epimedii increased the expression of nerve growth factor,brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in injured MES23.5cells; serum containing Semen Cuscutae only increased brain-derived neurotrophic factor expression; while expression of the above neurotrophic factors remained the same in cells treated with serum containing selegiline. These findings indicate that Chinese medicines used to tonify the kidney can protect nerve cells by regulating the expression of apoptosis-related factors and neurotrophic factors in MES23.5 cells. | Shaogang Lin Shuifen Ye Jinmu Huang Yun Tian Yihui Xu Mengqi Wu Jingxia Wang Songying Wu Jing Cai | 2013 | Neural Regeneration Research2013，8，30： | 9 |
| 8 | Role of ENSO in the interannual relationship between Tibetan Plateau winter snow cover and Northwest Pacific tropical cyclone genesis frequency显示文摘Previous studies have revealed a significantly negative correlation between prior winter snow cover over the Tibetan Plateau(TPSC) and tropical cyclone genesis frequency(TCF) over the western North Pacific(WNP) in the following typhoon season. This study revisited this relationship based on long-term observational data. The results showed that the interannual correlation between TCF over the WNP and TPSC experienced a shift in the early 1990 s. This correlation is significant during only 1993–2012 and is considerably weak during 1976–1992. The possible reasons causing the shift were examined further, and the results demonstrated that the central Pacific(CP) El Ni?o-Southern Oscillation(ENSO) has played a vital role in intensifying the interannual relationship between TCF over the WNP and TPSC since the early 1990 s. During 1993–2012, TPSC was negatively related to CP ENSO. When TPSC was higher than(lower than) normal, CP ENSO was often in its cold(warm) phase. Such a combination remarkably enhances the relationship of TPSC with the zonal land-sea thermal difference and thus with the summer monsoon over the WNP. Additionally, it enhances the modulation of TPSC on the dynamical environments controlling TCF. As a result, the linkage between TPSC and TCF was significantly strengthened in this period. In sharp contrast, due to the weak relationship between TPSC and ENSO followed by the weak modulation of TPSC on the summer monsoon over the WNP and the dynamical environment during 1976–1992, the linkage between TPSC and TCF was weak during this time period. The results from additional dynamical diagnostic analyses further showed that during 1993–2012 CP ENSO modulated the barotropic energy conversion of zonal winds over the WNP, contributing to the intensified relationship between TPSC and TCF. These results will improve seasonal forecasting of tropical cyclone activity over the WNP. | ZHAN RuiFen DING YiHui WU LiGuang LEI XiaoTu | 2016 | Science China Earth Sciences2016，59，10： | 6 |
| 9 | Electroacupuncture at Tianshu (ST 25) for diarrhea-predominant irritable bowel syndrome using positron emission tomography Changes in visceral sensation center显示文摘Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome (IBS). We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions: resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range: bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu (ST 25) manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain. | Huirong Liu Li Qi Xiaolong Wang Yihui Guan Chuantao Zuo Linying Tan Lingsong Yuan Xiaopeng Ma Xiaomei Wang Enhua Zhou Huangan Wu | 2010 | Neural Regeneration Research2010，5，16： | 6 |
| 10 | The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation显示文摘The immune checkpoint blockade(ICB)targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers.However,the low response rate and frequently observed severe side effects limit its broad benefits.It is partially due to less understanding of the biological regulation of PD-L1.Here,we systematically and comprehensively summarized the regulation of PD-L1 from nuclear chromatin reorganization to extracellular presentation.In PD-L1 and PD-L2 highly expressed cancer cells,a new TAD(topologically associating domain)(chr9:5,400,000-5,600,000)around CD274 and CD273 was discovered,which includes a reported super-enhancer to drive synchronous transcription of PD-L1 and PD-L2.The re-shaped TAD allows transcription factors such as STAT3 and IRF1 recruit to PD-L1 locus in order to guide the expression of PD-L1.After transcription,the PD-L1 is tightly regulated by mi RNAs and RNA-binding proteins via the long 3’UTR.At translational level,PD-L1 protein and its membrane presentation are tightly regulated by post-translational modification such as glycosylation and ubiquitination.In addition,PD-L1 can be secreted via exosome to systematically inhibit immune response.Therefore,fully dissecting the regulation of PD-L1/PD-L2 and thoroughly detecting PD-L1/PD-L2 as well as their regulatory networks will bring more insights in ICB and ICB-based combinational therapy. | Zhiwei Fan Changyue Wu Miaomiao Chen Yongying Jiang Yuanyuan Wu Renfang Mao Yihui Fan | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 11 | Nanocrystals of halide perovskite:Synthesis,properties,and applications显示文摘Recently, halide perovskite materials have become an exciting topic of research mainly due to their outstanding photovoltaic performance with the highest efficiency up to 22.1% at present. The nanocrystals(NCs) of these perovskites show quantum size effect, tunable bandgap, and excellent photoluminescence quantum yield(PLQY) in specific cases. Perovskite NCs have hence displayed great potentials in a broad range of applications, such as solar cells, light-emitting devices(LEDs), photodetectors, and lasers. In this review, we summarized the recent progress on the synthesis, optoelectronic properties and applications of the nanostructures of these halide perovskite materials, including hybrid organic–inorganic perovskites,pure inorganic perovskite, and perovskite-derived NCs. We have also provided a critical outlook into the challenges ahead. | Chi Yang Yihui Wu Qingshan Ma Wen-Hua Zhang | 2018 | Journal of Energy Chemistry2018，27，3： | 4 |
| 12 | Distribution of bacterial communities across plateau freshwater lake and upslope soils显示文摘Microorganisms are involved in a variety of biogeochemical processes in natural environments.The differences between bacterial communities in freshwaters and upslope soils remain unclear. The present study investigated the bacterial distribution in a plateau freshwater lake,Erhai Lake(southwestern China), and its upslope soils. Illumina MiS eq sequencing illustrated high bacterial diversity in lake sediments and soils. Sediment and soil bacterial communities were mainly composed of Proteobacteria, Acidobacteria, Actinobacteria,Bacteroidetes, Chloroflexi and Planctomycetes. However, a distinctive difference in bacterial community structure was found between soil and sediment ecosystems. Water content, nitrogen and p H affected the distribution of the bacterial community across Erhai Lake and its upslope soils. Moreover, the soil bacterial community might also be shaped by plant types. This work could provide some new insights into plateau aquatic and terrestrial microbial ecology. | Yihui Chen Yu Dai Yilin Wang Zhen Wu Shuguang Xie Yong Liu | 2016 | Journal of Environmental Sciences2016，28，5： | 4 |
| 13 | An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients显示文摘Objective:The frontal lobe may be involved in circuits associated with depression,apathy,aggression,and other psychiatric symptoms.Although white matter changes(WMC)are related to the severity of behavioral and psychological symptoms of dementia(BPSD)in patients with Alzheimer’s disease(AD),it is unclear which part of the WMC may play the most important role in BPSD.This study was designed to investigate the relationship between the location of WMC and the severity of BPSD in AD patients.Methods:Among patients diagnosed with Alzheimer’s disease between 2009 and2014,387 patients were retrospectively reviewed after those with pre‐existing organic brain syndrome,psychiatric diseases,or toxic‐metabolic encephalopathy were excluded.Patients’demographic and laboratory data,WMC measured with brain computed tomography and scored using the age‐related white matter changes(ARWMC)scale,and neuropsychological tests,including the cognitive abilities screening instrument(CASI),the Mini‐Mental State Examination(MMSE),the clinical dementia rating scale with sum‐box(CDR‐SB),and the neuropsychiatric inventory(NPI)were analyzed.Results:There was no significant difference in the NPI between patients with and without a history of stroke,hypertension,and diabetes.No significant difference in the NPI was identified between different sexes or different Apolipoprotein E(APOE)alleles.The NPI score was significantly correlated with the duration of education(r=–0.4515,P=0.0172),CASI(r=–0.2915,P<0.0001),MMSE(r=–0.8476,P<0.0001),and CDR‐SB(r=2.2839,P<0.0001).WMC in the right frontal lobe showed a significant difference in NPI in comparison to those without WMC(P=0.0255).After adjusting for age,duration of education,and CASI,WMC in the right frontal lobe remained significantly associated with the NPI score(β=3.8934,P=0.042).Conclusions:WMC involving the right frontal lobe may play an important role in the BPSD in AD patients during their dementia diagnosis.Further studies are necessary to confirm whether controlling the risk factors of WMC can slow the progression of BPSD. | Tzuchou Lin Yihui Lin Linli Kao Yihui Kao Yuanhan Yang Pingsong Chou Mengni Wu | 2016 | Translational Neuroscience and Clinics2016，2，1： | 3 |
| 14 | A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors显示文摘The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2(SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screening protocol that combined the fluorescence-based enzyme assay and the conformation-dependent thermal shift assay for the discovery of SHP2 inhibitors. The established method can effectively exclude the false positive SHP2 inhibitors with fluorescence interference and was also successfully employed to identify new protein tyrosine phosphatase domain of SHP2(SHP2-PTP) and allosteric inhibitors. Of note, this protocol showed potential for identifying SHP2 inhibitors against cancer-associated SHP2 mutation SHP2-E76 A. After initial screening of our in-house compound library(w2300 compounds), we identified 4 new SHP2-PTP inhibitors(0.17%hit rate) and 28 novel allosteric SHP2 inhibitors(1.22% hit rate), of which SYK-85 and WS-635 effectively inhibited SHP2-PTP(SYK-85: IC_(50) Z 0.32 mmol/L;WS-635: IC_(50) Z 4.13 mmol/L) and thus represent novel scaffolds for designing new SHP2-PTP inhibitors. TK-147, an allosteric inhibitor, inhibited SHP2 potently(IC_(50) Z 0.25 mmol/L). In structure, TK-147 could be regarded as a bioisostere of the well characterized SHP2 inhibitor SHP-099, highlighting the essential structural elements for allosteric inhibition of SHP2. The principle underlying the cross-validation protocol is potentially feasible to identify allosteric inhibitors or those inactivating mutants of other proteins. | Yihui Song Min Zhao Yahong Wu Bin Yu Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 2 |
| 15 | How to Measure the Strength of the East Asian Summer Monsoon显示文摘 | Wang Bin Wu Zhiwei Li Jianping Liu Jian Chang Chih-Pei Ding Yihui Wu Guoxiong | 2008 | Journal of Climate2008，，17： | 2 |
| 16 | High performance perovskite solar cells using TiO2 nanospindles as ultrathin mesoporous layer显示文摘Single crystal anatase TiO_2 nanospindles(NSs) with highly exposed {101} facets were synthesized and employed as electron transport materials(ETMs) in perovskite solar cells(PSCs). Time-resolved photoluminescence(TRPL) spectra revealed that the TiO_2 NSs are more effective than TiO_2 nanoparticles in accepting electrons from perovskite. Moreover, the TiO_2 nanospindles further endowed the PSCs with good reproducibility and suppressed hysteresis. The best device with TiO_2 NSs as ETMs yielded power conversion efficiency(PCE) of 19.6%, demonstrating that the home-made TiO_2 NSs is a good ETM for PSCs. | Yinhua Lv Bing Cai Yihui Wu Shubo Wang Qike Jiang Qingshan Ma Jingyue(Jimmy)Liu Wen-Hua Zhang | 2018 | Journal of Energy Chemistry2018，27，4： | 2 |
| 17 | Zhuifeng tougu capsules (追风透骨胶囊) improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway显示文摘OBJECTIVE: To investigate the efficacy of Zhuifeng tougu capsules(追风透骨胶囊, ZFTG) in the treatment of rheumatoid arthritis(RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B(TLR2/4-NF-κB) signaling pathway.METHODS: TypeⅡ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-,and low-dose ZFTG groups. The methotrexate(MTX) control group was treated with the corresponding drug intervention for 28 d. The joint temperature, pain threshold, joint swelling degree, and arthritis index(AI) score were measured. The production of C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), and rheumatoid factors(RFs) in the blood was detected by enzyme-linked immunosorbent assay. The protein expression of TLR2, TLR4, and NF-κB in synovial tissues was detected by Western blotting, and the m RNA expression of TLR2, TLR4, and NF-κB was detected by real-time polymerase chain reaction.RESULTS: Compared with the model group, the joint temperature in each treatment group, the MTX control group, and MTX group recovered, the degree of foot swelling, pain threshold, AI score decreased, serum CRP, ESR, RF level and the levels of TLR2, TLR4, and NF-κB in synovial tissue were decreased(P < 0.05). Among them, the curative effect in the medium-dose and MTX groups was more evident(P < 0.01).CONCLUSION: ZFTG has a significant effect on RA in rats, and its mechanism may involve regulating CRP levels, the ESR, and RFs via the TLR2/4-NF-κB signaling pathway. | GONG Hui KUANG Gaoyan WU Yongrong LU Fangguo DENG Yihui HE Yanlin WANG Hengxin | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 2 |
| 18 | Coercivity enhancement mechanism of grain boundary diffused Nd-Fe-B sintered magnets by magnetic domain evolution observation显示文摘The grain boundary diffusion(GBD) technology was used to prepare high performance Nd-Fe-B sintered magnets by NdH3 and TbH3 nanoparticle diffusion.The factors affecting the coercivity of GBD magnets include distribution of rare earth rich grain boundary phase and substitution of the heavy rare earth.In order to distinguish the influence of various factors on the coercivity,the microstructure and magnetic domain evolution of the original,reference,Nd-diffused,and Tb-diffused magnets were analyzed.The core-shell structure formed by heavy rare earth substitution is the main factor of coercivity enhancement,and it can transform the magnetic domain reversal mode from easy-nucleation(EN) to difficultnucleation(DN).With increasing the diffusion depth,the shell of the core-shell structure gradually becomes thinner,DN grains gradually decrease while the EN grains gradually increase,indicating that the magnetic domain reversal mode is directly related to the core-shell structure. | Weiqiang Liu Yi Li Dan Wu Ming Yue Zhanjia Wang Shanshun Zha Youhao Liu Xiaofei Yi Yihui Du | 2021 | Journal of Rare Earths2021，39，6： | 2 |
| 19 | Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum 显示文摘 | Kaiwei Li Guigen Liu Yihui Wu | 2014 | Talanta2014，120，： | 1 |
| 20 | Uniformity study of nickel thin-film microstructure deposited by electroplating显示文摘 | Li Jiadong Zhang Ping Wu Yihui | 2009 | Microsyst Technol2009，15，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员