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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | Albuminuria and risk ofcardiovascular events,death,and heart failure in diabetic andnondiabetic individuals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，4： | 1 |
| 3 | kln-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer 显示文摘 | YI JF LI YM LIU T | 2010 | World J Gastroenterol2010，16，37： | 1 |
| 4 | Albuminuria and risk of cardio- vascular events,death,and heart failure in diabetic and nondiabetic individuals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，4： | 1 |
| 5 | Albuminuria and riskof cardiorascular events, death, and heart fuilure in dia-betic and nondiabetic indiriduals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，4： | 1 |
| 6 | Albuminuria and risk of cardiovascular events, death ,and heart failure in diabetic and nondiabetic individuals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，： | 1 |
| 7 | Diagnosis of simple endobronchial tuberculosis by fiberohronchoscopy显示文摘 | MENG YW ZHANG D YI JF | 2005 | J First Mil Med Univ2005，25，5： | 1 |
| 8 | Evolution of management forBudd-Chiari syndrome : a team's view from 2564 patients 显示文摘 | Wang ZG Zhang JF Yi MQ | 2005 | ANZ J Surg2005，75，12： | 1 |
| 9 | Albuminuria and risk of cardi ovascular events,death?and heart failure in diabetic and nondiabe- fic individuals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAM A2001，286，4： | 1 |
| 10 | Albuminuria and risk of cardiovascular events ,death,and heart failure in dia- betic and nondiabetic individuals 显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，4： | 1 |
| 11 | Vascularised greater trochanter bone graft, combined free iliac flap and impaction bone grafting for osteo- necrosis of the femoral head显示文摘 | Yi RZ Sheng He Wen JF | 2013 | Int Orthop (SICOT)2013，37，： | 1 |
| 12 | Albuminuria and risk of cardio- vascular events, death, and heart failure in diabetic and nondiabetic individuals 显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，4： | 1 |
| 13 | Albuminuria and risk of cardiovascular events,death,and heart failure in diabetic and nondiabetic individuals显示文摘 | GERSTEIN HC MANN JF YI Q | 2001 | JAMA-Journal of the Americaan Medical Association2001，286，4： | 1 |
| 14 | Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiahetic individuals显示文摘 | Gertein HC Mann JF Yi Q et at | 2001 | JAMA2001，286，4： | 1 |
| 15 | Albuminuria and risk of cardiovascular events,death,and heart failure in diabetes and non diabetes individuals 显示文摘 | Gerstein HC Mann JF Yi O | 2001 | JAMA2001，286，4： | 1 |
| 16 | Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAM A2001，286，4： | 1 |
| 17 | Albuminuria and risk of cardiovascular events, death,and heart failure in diabetic and non-diabetic individuals显示文摘 | Gerstein HC Mann JF Yi Q | 2001 | JAMA2001，286，4： | 1 |
| 18 | IgG purification using affinity filtration with sulfamethazine-affinity carriers 显示文摘 | Yi Y Zhu L Mei JF | 2012 | Prepar Biochem Biotech2012，42，6： | 1 |
| 19 | Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor显示文摘 | Frank SJ Yi W Zhao Y Goldsmith JF Gilliland G Jiang J Sakai I Kraft AS | | 0，，： | 1 |
| 20 | Ameloblastoma with varied sites of metastasis: report of two cases and literature review 显示文摘 | Lin Yi He JF Li ZY | 2013 | J Craniomaxillofac Surg2013，42，5： | 1 |
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