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| 1 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 4 | Competition between radiation damping and transverse relaxation effects on NMR signal intensities 显示文摘 | Mao X A Guo J X Ye C H | 1994 | Chem Phys Lett1994，218，： | 2 |
| 5 | Raman scattering spectra of coupled LO-phonon-plasmon modes in N-In codoped p-type ZnO thin films显示文摘 | KONG J F CHEN H YE H B | 2007 | Appl Phys Lett2007，90，04： | 1 |
| 6 | An energy efficient clustering scheme in wireless sensor networks显示文摘 | M Ye C F Li G H Chen J Wu | 2007 | International Journal of Ad Hoc & Sensor Wireless Networks2007，3，2： | 1 |
| 7 | Analysis of marker or complex chromosomal rearrangements present in pre-and post-natal karyotypes utilizing a combination of G-banding,spectral karyotyping and fluorescence in situ hybridization 显示文摘 | Heng H H Ye C J Yang F | 2003 | Clin Genet2003，63，5： | 1 |
| 8 | Induction of cysteine and serine proteases during xylogenesis in Zinnia elegans显示文摘 | Ye Z H Varner J E | 1996 | Plant Molecular Biology1996，30，： | 1 |
| 9 | Synthese and characterization of oligomers containing the α-aminoalkylphenone chromophore as oligomeric photoinitiator 显示文摘 | Ye G D Zhou H Z Yang J W | 2006 | J Appl Polym Sci2006，99，： | 1 |
| 10 | Flavonoids and volatiles in Chrysanthe-mum morifolium Ramat flower from Tongxiang county in China显示文摘 | SUN Q L HUA S YE J H | 2010 | AfricanJ Biotech2010，9，25： | 1 |
| 11 | Modeling of the solidification of gas-atomized alloy droples during spary forming显示文摘 | Liu D Zhao J Ye H | 2004 | Mater Sci and Eng A2004，372，12： | 1 |
| 12 | Wireless tracing and locating system for in-pipe robot 显示文摘 | QI H M YE J R ZHANG X H | 2010 | Sensors and Actuators A2010，159，： | 1 |
| 13 | Tumoral indoleamine 2,3-dioxygenase ex- pression predicts poor outcome in laryngeal squamous cell carcinoma 显示文摘 | Ye J Liu H Hu Y | 2013 | Virchows Arch2013，462，1： | 1 |
| 14 | Fault diagnosis of net- worked control systems 显示文摘 | FANG H J YE H ZHONG M Y | 2007 | Annual Reviews in Control2007，31，1： | 1 |
| 15 | Photocatalytic decomposition of organic contaminants by Bi2WO6 under visible light ir- radiation 显示文摘 | Tang J W Zou Z G Ye J H | 2004 | Catal Lett2004，92，12： | 1 |
| 16 | Development of an LCMS method for determination of three active constituents of shuanghuanglian injection in rat plasma and its application to the drug interaction study of Shuanghuanglian freezedried powder combined with levofloxacin injection显示文摘 | YE J SONG X W LIU Z H | 2012 | J Chromatogr B2012，898，12： | 1 |
| 17 | Ondansetron exhibits the properties of a local anesthetic显示文摘 | YE J H MUI W C REN J | 1997 | Anesth Analg1997，85，5： | 1 |
| 18 | Plasmonic nanoclus- ters : near field properties of the Fano resonance interroga-ted with sers显示文摘 | YE J WEN F SOBHANI H | 2012 | Nano Letters2012，12，： | 1 |
| 19 | Low voltage power line carrier channel modeling and testing applications 显示文摘 | Sun H L Ye J | 2014 | WIT Transactions on Modeling and Simulation2014，60，： | 1 |
| 20 | Bulk heterojunction solar cell s:morphology and performance relationships显示文摘 | Ye H Kramer E J Heeger A J | 2014 | Chemical Reviews2014，114，14： | 1 |
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