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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Ultrastructure of neuronal-like cells differentiated from adult adipose-derived stromal cells显示文摘β-mercaptoethanol induces in vitro adult adipose-derived stromal cells(ADSCs) to differentiate into neurons.However,the ultrastructural features of the differentiated neuronal-like cells remain unknown.In the present study,inverted phase contrast microscopy was utilized to observe β-mercaptoethanol-induced differentiation of neuronal-like cells from human ADSCs,and immunocytochemistry and real-time polymerase chain reaction were employed to detect expression of a neural stem cells marker(nestin),a neuronal marker(neuron-specific enolase),and a glial marker(glial fibrillary acidic protein).In addition,ultrastructure of neuronal-like cells was observed by transmission election microscopy.Results revealed highest expression rate of nestin and neuron-specific enolase at 3 and 5 hours following induced differentiation;cells in the 5-hour induction group exhibited a neuronal-specific structure,i.e.,Nissl bodies.However,when induction solution was replaced by complete culture medium after 8-hour induction,the differentiated cells reverted to the fibroblast-like morphology from day 1.These results demonstrate that β-mercaptoethanol-induced ADSCs induced differentiation into neural stem cells,followed by morphology of neuronal-like cells.However,this differentiation state was not stable. | Changqing Ye Xiaodong Yuan Hui Liu Yanan Cai | 2010 | Neural Regeneration Research2010，5，19： | 16 |
| 3 | Nat Microbiol:已结首次构建出小鼠肠道微生物组数据库显示文摘小鼠模型通常被广泛用于药理学和医学研究。我们都知道小鼠肠道中的微生物群落通常会对研究结果产生明显的影响,然而目前研究者们并没有获取到关于小鼠肠道中栖息细菌群落的详细信息。近日刊登在国际杂志Nature Microbiology上的一篇研究报告中。德国慕尼黑理工大学的研究者通过研究首次收集到了小鼠肠道中的多种细菌群落。同时研究者还对其进行了分裂、特性分析。最后得到了100种细菌,其中还包括15种迄今为止未知的细菌群落。 | Lu, Qiulun Yao, Yufeng Hu, Zhenkun Hu, Changqing Song, Qixue Ye, Jian Xu, Chengqi Wang, Annabel Z. Chen, Qiuyun Wang, Qing Kenneth | 2016 | 现代生物医学进展2016，16，32： | 13 |
| 4 | Spatial and temporal variation of runoff of Red River Basin in Yunnan显示文摘这篇论文学习红河盆的流量的变化并且讨论“走廊障碍”的影响由基于每月的降水使用 GIS 和统计方法的流量的变化上的山谷和山的功能。 | LI Yungang HE Daming YE Changqing | 2008 | Journal of Geographical Sciences2008，18，3： | 12 |
| 5 | SHRIMP Zircon U-Pb and Molybdenite Re-Os Datings of the Superlarge Donggou Porphyry Molybdenum Deposit in the East Qinling,China,and Its Geological Implications显示文摘摘要:在东方 Qinling 铝带的东方部分定位了, Donggou 存款是在最近的年里发现的 superlarge 斑岩铝存款。作者执行了在 Donggou 铝存款的使矿物化的斑岩和矿石的高度精确的标明日期。Donggou 铝土的 A 类型花岗石斑岩标明日期的虾 U-Pb 锆石给了 112 楬瑡摥 ? 的形成岩石的年龄 ??????? | YE Huishou MAO Jingwen LI Yongfeng GUO Baojian ZHANG Changqing LIU Jun YAN Quanren LIU Guoyin | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 6 |
| 6 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 7 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 8 | Drinking water treatment using a submerged internal-circulation membrane coagulation reactor coupled with permanganate oxidation显示文摘A submerged internal circulating membrane coagulation reactor(MCR) was used to treat surface water to produce drinking water. Polyaluminum chloride(PACl) was used as coagulant,and a hydrophilic polyvinylidene fluoride(PVDF) submerged hollow fiber microfiltration membrane was employed. The influences of trans-membrane pressure(TMP), zeta potential(ZP) of the suspended particles in raw water, and KMnO_4 dosing on water flux and the removal of turbidity and organic matter were systematically investigated. Continuous bench-scale experiments showed that the permeate quality of the MCR satisfied the requirement for a centralized water supply, according to the Standards for Drinking Water Quality of China(GB 5749-2006), as evaluated by turbidity(<1 NTU) and total organic carbon(TOC)(<5 mg/L)measurements. Besides water flux, the removal of turbidity, TOC and dissolved organic carbon(DOC) in the raw water also increased with increasing TMP in the range of 0.01–0.05 MPa. High ZP induced by PACl, such as 5–9 mV, led to an increase in the number of fine and total particles in the MCR, and consequently caused serious membrane fouling and high permeate turbidity.However, the removal of TOC and DOC increased with increasing ZP. A slightly positive ZP, such as 1–2 mV, corresponding to charge neutralization coagulation, was favorable for membrane fouling control. Moreover, dosing with KMnO_4 could further improve the removal of turbidity and DOC, thereby mitigating membrane fouling. The results are helpful for the application of the MCR in producing drinking water and also beneficial to the research and application of other coagulation and membrane separation hybrid processes. | Zhongguo Zhang Dan Liu Yu Qian Yue Wu Peiran He Shuang Liang Xiaozheng Fu Jiding Li Changqing Ye | 2017 | Journal of Environmental Sciences2017，29，6： | 3 |
| 9 | Relationship between the parent charge transfer gap and maximum transition temperature in cuprates显示文摘One of the biggest puzzles concerning the cuprate high temperature superconductors is what determines the maximum transition temperature(Tc,max), which varies from less than 30 to above 130 K in different compounds.Despite this dramatic variation, a robust trend is that within each family, the double-layer compound always has higher Tc,maxthan the single-layer counterpart. Here we use scanning tunneling microscopy to investigate the electronic structure of four cuprate parent compounds belonging to two different families. We find that within each family, the double layer compound has a much smaller charge transfer gap size(DCT), indicating a clear anticorrelation between DCTand Tc,max. These results suggest that the charge transfer gap plays a key role in the superconducting physics of cuprates, which shed important new light on the high Tc mechanism from doped Mott insulator perspective. | Wei Ruan Cheng Hu Jianfa Zhao Peng Cai Yingying Peng Cun Ye Runze Yu Xintong Li Zhenqi Hao Changqing Jin Xingjiang Zhou Zheng-Yu Weng Yayu Wang | 2016 | Science Bulletin2016，61，23： | 3 |
| 10 | Room temperature ferromagnetism of Ni, (Ni, Li), (Ni, N)-doped ZnO thin films显示文摘Ni-doped ZnO thin films (Ni concentration up to 10 mol%) were generated on Si (100) substrates by a sol-gel technique. The films showed wurtzite structure and no other phase was found. The chemical state of Ni was found to be bivalent by X-ray photoelectron spectroscopy. The results of magnetic measurements at room temperature indicated that the films were ferromagnetic, and magnetic moment decreased with rise of Ni concentration. The magnetization of Ni (10 mol%)-doped ZnO film annealed in nitrogen was lower than that annealed in argon, suggesting that the density of defects had an effect on ferromagnetism. | YE XiaoJuan SONG HaiAn ZHONG Wei QI XiaoSi XU MeiHua JIN ChangQing YANG ZaiXin AU ChakTong DU YouWei | 2010 | 中国科学:技术科学2010，40，2： | 2 |
| 11 | Exploring detailed urban-rural development under intersecting population growth and food production scenarios: Trajectories for China’s most populous agricultural province to 2030显示文摘Henan,China,is likely the most populous agricultural province worldwide.It is China’s major grain-producing area,with a continuously increasing population(96 million),which is greater than 93%of countries worldwide.However,this province has been experiencing unprecedented urbanization recently due to national policies and measures,such as a plan to build the capital city of Henan into a national center,resulting in severe conflicts in land use that endanger food security regionally and globally.To facilitate decision-making on this problem,we explored the detailed urban-rural development of Henan by modeling these land-use conflicts.Conventional modeling of a region’s urban-rural development is to navigate trade-offs(a)solely between different land-use types(b)by assuming that each type provides a single service(e.g.,croplands produce all the food),and(c)under a polynomial regression-based projection of population.In contrast,we considered both land-use type and intensity,resulting in a detailed land system for Henan.By introducing the concept of land system services(e.g.,food production),we established a many-to-many relationship between land system classes and services.These allowed us to carry out the most comprehensive modeling of Henan’s urban-rural development under eighteen combined scenarios of population growth and land-use policies on food production.The modeling results of these scenarios provide a solid basis for making decisions regarding Henan’s urban-rural development.We also revealed the influence mechanism of population growth,land-use policies,and their combinations,highlighting the benefits of securing food production by agricultural intensification rather than merely expanding the area of cropland. | GAO Peichao XIE Yiru SONG Changqing CHENG Changxiu YE Sijing | 2023 | Journal of Geographical Sciences2023，33，2： | 2 |
| 12 | Cross-national Perspectives on Using Sustainable Development Goals(SDGs) Indicators for Monitoring Sustainable Development: A Database and Analysis显示文摘Sustainable development is the theme of the 21st century. To monitor the progress of sustainable development, the United Nations launched Sustainable Development Goals(SDGs) in 2015. Subsequently, nations of the world have drawn up a list of localized indicators regarding the United Nations SDGs as a paradigm. We established a database including SDGs indicator systems of 11 economies by collecting and determining a large number of materials. Based on this database, we analyzed SDGs indicators by designing a conceptual framework of comparative analysis that included three views. We found that the SDGs indicator systems of 11 economies are different between the number of indicators, the proportion of different categories, and the connotation of indicators. Although the SDGs indicator systems among economies regarded the United Nations SDGs as a framework and included the major social problems related to sustainability, the inconsistency between SDGs indicator systems is large. It is a major reason why scholars lack the systematic method for developing indicators. There are challenges faced in data accessibility. The framework for comparative analysis could be applied to different economies. | WANG Xiangyu SONG Changqing CHENG Changxiu YE Sijing SHEN Shi | 2021 | Chinese Geographical Science2021，31，4： | 2 |
| 13 | k-value-based ferron assay and its application显示文摘 | Ye Changqing Wang Dongsheng Wu Xiaohong | 2009 | J Colloid Interface Sci2009，335，1： | 1 |
| 14 | Formation of AI from aqueous polyaluminum chloride under high tem- perature : Role of Alt3 aggregates 显示文摘 | Ye Changqing Bi Zhe Wang Dongsheng | 2013 | Colloids and Surfaces A : Physicochem Eng Aspects2013，436，123： | 1 |
| 15 | Expression of Human Peroxisome Proliferator-Activated Receptors Ligand Binding Domain- Maltose Binding Protein Fusion Protein in Escherichia coli:A Convenient and Reliable Method for Preparing Receptor for Screening Ligands显示文摘 | LI Changqing TIAN Mi YUAN Ye | 2008 | ASSAY and Drug Development Technologies2008，6，6： | 1 |
| 16 | Alkalinity effect of coagulation with poly aluminum chlorides: role of electrostatic patch 显示文摘 | Ye Changqing Dongsheng Wang Baoyou Shi et ol | 2007 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2007，294，13： | 1 |
| 17 | Graphenemodified carbon fiber microelectrode for the detection of dopamine in mice hippocampus tissue显示文摘 | ZHU Mingfang ZENG Changqing YE Jianshan | 2011 | Electroanalysis2011，23，4： | 1 |
| 18 | Chitooligosaccharides and N-acetyl-D-glucosamine stimulate peripheralblood mononuclear cell-mediated antitumor immune responses显示文摘 | Wenhua Xu Changqing Jiang Xiaoying Kong Ye Liang Mi Rong Wanshun Liu | 2012 | Molecular Medicine Reports2012，，： | 1 |
| 19 | Developments of Green Building Standards in China显示文摘 | Ling Ye Zhijun Cheng Qingqin Wang Haiyan Lin Changqing Lin Bin Liu | 2014 | Renewable Energy2014，，： | 1 |
| 20 | Linking the past and present to predict the distribution of Asian crested ibis(Nipponia nippon)under global changes显示文摘Understanding how species’ecological niches adapt to environmental changes through time is critical for predicting the effect of future global change on endangered species.Yet few studies have incorporated knowledge of past niche shifting into the assessment of species’future fate in a changing world.In this study,we integrated the ecological niche dynamics into the species distribution modeling of the Asian crested ibis(Nipponia nippon)in East Asia.Specifically,we compared historical and present ecological niches of crested ibis in four-dimensional environmental space based on species occurrence and environmental data.We then employed a multi-temporal ecological niche model to estimate the potential geographical distribution of crested ibis under future climate and land-use changes.Our results show that crested ibis retained similar though not identical ecological niches over time.Compared to the historical baseline range,the current suitable habitat for crested ibis has been reduced by 39.6%.The effects of human activity outweigh those of climate change regarding the distribution of crested ibis.We conclude that the ecological niche of crested ibis was tended to be conservative,and future potentially suitable habitat may encounter northeastward and northwestward shift,and possibly expand by 18.7%referred to the historical range.Thefindings of our study are of clear importance for the conservation and successful reintroduction of crested ibis in East Asia. | Fangyuan YU Yiwen SUN Tiejun WANG Andrew KSKIDMORE Changqing DING Xinping YE | 2022 | Integrative Zoology2022，17，6： | 1 |
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