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| 1 | Overexpression of β3/γ2 chains of laminin-5 and MMP7 in biliary cancer显示文摘AIM:To clarify the clinicopathological significance of laminin-5 γ2 (LNγ2) and β3 (LNβ3) chains and MMP7 expression in biliary tract cancer.METHODS: We analyzed the association between immunohistochemically detected LNγ2, LNβ3, and MMP7 expression in biliary tract cancer and clinicopathological characteristics. Activity of MMP7 was analyzed by casein zymography. An in vitro invasion assay after treatment with MMP7-specific siRNA was performed.RESULTS: LNγ2 expression was predominantly observed in carcinoma cells at the invasive front. LNγ2 expression was seen in 57% of patients with biliary tract cancer, and was associated with depth of invasion, histologic type, and advanced stage. The expression pattern of LNβ3 was classified into two types: invasive front dominant type (38%) and diffuse type (28%).The invasive front dominant type was associated with histologic type and advanced stage. MMP7 positivity was correlated with LNγ2 or LNβ3 expression but not with clinicopathological characteristics. Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage. Downregulation of MMP7 expression by siRNA resulted in a significant decrease in biliary tract cancer cell invasion in vitro.CONCLUSION: Our results suggest that LNγ2 and LNβ3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer. | Toshikuni Oka Hiroyuki Yamamoto Shigeru Sasaki Masanori Ii Keiichi Hizaki Hiroaki Taniguchi Yasushi Adachi Kohzoh Imai Yasuhisa Shinomura | 2009 | World Journal of Gastroenterology2009，15，31： | 2 |
| 2 | Role of matrix metalloproteinase-7 (matrilysin) in human eaneer invasion, apoptosis, growth, and angiogenesis显示文摘 | Ii M Yamamoto H Adaehi Y | 2006 | Exp Biol Med2006，231，1： | 1 |
| 3 | Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med2006，231，1： | 1 |
| 4 | Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers显示文摘 | Yu Wang Yasushi Adachi Arisa Imsumran Hiroyuki Yamamoto Wenhua Piao Hua Li Masanori Ii Yoshiaki Arimura Mi Young Park Dalrae Kim Choon-Taek Lee David P. Carbone Kohzoh Imai Yasuhisa Shinomura | 2010 | Journal of Gastroenterology2010，，2： | 1 |
| 5 | Role of matrix metallo- proteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis 显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med (Mayzvood)2006，231，1： | 1 |
| 6 | Role of matrix metalloproteinase-7 (matrilysin) in human eancer invasion, apoptosis, growth, and angiogenesis 显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med (Maywood)2006，231，1： | 1 |
| 7 | Loss of heterozyosity and microsatellite alteration in p53 and RB genes in adenoid cystic carcinoma of the salivary glands显示文摘 | Yamamoto Y Virmanni AK Wistuba II | 1996 | Hum Pathol1996，27，： | 1 |
| 8 | DNA analysis at p53 Locus in Carcinomas Arising from Pleomorphic Adenomas of Salivary Glands: Comparison of Molceular Study and p53 Immunostaining显示文摘 | Yamamoto Y Kishimoto Y Wistuba II | 1998 | Pathol-Int1998，48，4： | 1 |
| 9 | The efficacy of IGF-Ⅰ receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status显示文摘 | Ii M Li H Adachi Y Yamamoto H Ohashi H Taniguchi H | 2011 | Clin Cancer Res2011，17，： | 1 |
| 10 | Role of matrix metalloproteinase - 7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis 显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med2006，231，1： | 1 |
| 11 | Role of matrix metalloproteinase - 7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis显示文摘 | Ii M Yamamoto H Adaehi Y | 2006 | Exp Biol Meal2006，231，1： | 1 |
| 12 | Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion,apoptosis,growth,and angiogenesis显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med (Maywood)2006，231，1： | 1 |
| 13 | Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic car- cinoma of the salivary glands显示文摘 | Yamamoto Y Virmani AK Wistuha II | 1996 | Hum Pathol1996，27，11： | 1 |
| 14 | Role of matrix metalloproteinase-7 in human cancer invasion, apoptosis, growth, and angiogenesis 显示文摘 | Ii M Yamamoto H Adachi Y Mamyama Y | 2006 | Exp Biol Med2006，231，1： | 1 |
| 15 | Mild postischemic hypothermia limits cerebral injry following transient focal ischemia in rat neocortex显示文摘 | YAMAMOTO II HONG SC SOLEAU S | 1996 | Brain Res1996，718，： | 1 |
| 16 | Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion,apoptosis,growth,and angiogenesis显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med (Maywood)2006，231，1： | 1 |
| 17 | Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers显示文摘 | Yu Wang Yasushi Adachi Arisa Imsumran Hiroyuki Yamamoto Wenhua Piao Hua Li Masanori Ii Yoshiaki Arimura Mi Young Park Dalrae Kim Choon-Taek Lee David P. Carbone Kohzoh Imai Yasuhisa Shinomura | 2010 | Journal of Gastroenterology2010，，2： | 1 |
| 18 | Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion,apoptosis,growth,and angiogenesis显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med2006，231，1： | 1 |
| 19 | Role of matrix metallopro- teinase 7 (matrilysin) in human cancer invasion, apoptosis, growth and angiogenesis显示文摘 | Ii M Yamamoto H Adachi Y | 2006 | Exp Biol Med2006，231，： | 1 |
| 20 | Role of Matrix metalloproteinase-7(Matrilysin) in Human Cancer Invasion,Apoptosis, Growth, and Angiogenesis 显示文摘 | MASANORI II HIROYUKI YAMAMOTO | 2006 | Exp Biol Med2006，231，： | 1 |
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