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| 1 | 广泛耐药革兰阴性菌感染的实验诊断、抗菌治疗及医院感染控制:中国专家共识显示文摘广泛耐药革兰阴性杆菌(XDR-GNB),是指除1~2类抗菌药物(主要指多黏菌素和替加环素)外,几乎对所有类别抗菌药物均不敏感的革兰阴性杆菌。XDR-GNB常见于肠杆菌科细菌、鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌等。近年来,中国XDR-GNB的发生率呈不断上升趋势,由于缺乏有效的治疗药物,XDR-GNB感染成为公共卫生安全的一大威胁。我国有关感染的临床、微生物学及临床药理学专家们就XDR-GNB感染的实验室诊断、临床诊疗和医院感染控制等问题深入讨论,形成此共识。其中细菌药敏试验的抗菌药物品种及结果判定标准遵循美国临床和实验室标准化协会(CLSI)、欧洲抗菌药物敏感性试验委员会(EUCAST)或美国食品与药物监督管理局(FDA)的指南。研究提示长疗程使用广谱抗菌药物是引发XDR-GNB感染最重要的危险因素。根据现有的临床研究和实验室数据,共识提供治疗各种XDRGNB感染的联合用药推荐方案,其中常用的抗菌药物有替加环素、多黏菌素、碳青霉烯类、氨基糖苷类和磷霉素等。同时建议实行严格的感染控制措施,包括手卫生、接触隔离、主动筛查、环境消毒、去定植和抗菌药物应用管理等遏制XDRGNB感染的传播。 | 王明贵 X.Guan L.He B.Hu J.Hu X.Huang G.Lai Y.Li Y.Liu Y.Ni H.Qiu Z.Shao Y.Shi M.Wang R.Wang D.Wu C.Xie Y.Xu F.Yang K.Yu Y.Yu J.Zhang C.Zhuo | 2017 | 中国感染与化疗杂志2017，17，1： | 269 |
| 2 | Layer and broiler chicks exhibit similar hypothalamic expression of orexigenic neuropeptides but distinct expression of genes related to energy homeostasis and obesity显示文摘 | Yuan L Y.Ni S.Barth Y.Wang R.Grossmann and R.Zhao | | 0，，： | 1 |
| 3 | Motion of the moonlet in the binary system 243 Ida显示文摘The motion of the moonlet Dactyl in the binary system 243 Ida is investigated in this paper. First, periodic orbits in the vicinity of the primary are calculated, including the orbits around the equilibrium points and large-scale orbits. The Floquet multipliers' topological cases of periodic orbits are calculated to study the orbits' stabilities. During the continuation of the retrograde near-circular orbits near the equatorial plane, two period-doubling bifurcations and one Neimark–Sacker bifurcation occur one by one, leading to two stable regions and two unstable regions. Bifurcations occur at the boundaries of these regions. Periodic orbits in the stable regions are all stable, but in the unstable regions are all unstable. Moreover, many quasi-periodic orbits exist near the equatorial plane. Long-term integration indicates that a particle in a quasi-periodic orbit runs in a space like a tire. Quasi-periodic orbits in different regions have different styles of motion indicated by the Poincare sections. There is the possibility that moonlet Dactyl is in a quasi-periodic orbit near the stable region I, which is enlightening for the stability of the binary system. | L.Lan Y.Ni Y.Jiang J.Li | 2018 | Acta Mechanica Sinica2018，34，1： | 0 |
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