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| 1 | Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation显示文摘Spinal cord injury is linked to the interruption of neural pathways,which results in irreversible neural dysfunction.Neural repair and neuroregeneration are critical goals and issues for rehabilitation in spinal cord injury,which require neural stem cell repair and multimodal neuromodulation techniques involving personalized rehabilitation strategies.Besides the involvement of endogenous stem cells in neurogenesis and neural repair,exogenous neural stem cell transplantation is an emerging effective method for repairing and replacing damaged tissues in central nervous system diseases.However,to ensure that endogenous or exogenous neural stem cells truly participate in neural repair following spinal cord injury,appropriate interventional measures(e.g.,neuromodulation)should be adopted.Neuromodulation techniques,such as noninvasive magnetic stimulation and electrical stimulation,have been safely applied in many neuropsychiatric diseases.There is increasing evidence to suggest that neuromagnetic/electrical modulation promotes neuroregeneration and neural repair by affecting signaling in the nervous system;namely,by exciting,inhibiting,or regulating neuronal and neural network activities to improve motor function and motor learning following spinal cord injury.Several studies have indicated that fine motor skill rehabilitation training makes use of residual nerve fibers for collateral growth,encourages the formation of new synaptic connections to promote neural plasticity,and improves motor function recovery in patients with spinal cord injury.With the development of biomaterial technology and biomechanical engineering,several emerging treatments have been developed,such as robots,brain-computer interfaces,and nanomaterials.These treatments have the potential to help millions of patients suffering from motor dysfunction caused by spinal cord injury.However,large-scale clinical trials need to be conducted to validate their efficacy.This review evaluated the efficacy of neural stem cells and magnetic or electrical stimulation combined with rehabilitation training and intelligent therapies for spinal cord injury according to existing evidence,to build up a multimodal treatment strategy of spinal cord injury to enhance nerve repair and regeneration. | Ya Zheng Ye-Ran Mao Ti-Fei Yuan Dong-Sheng Xu Li-Ming Cheng | 2020 | Neural Regeneration Research2020，15，8： | 29 |
| 2 | Pollution characteristics of organic and elemental carbon in PM_(2.5) in Xiamen,China显示文摘Xiamen,located on the southeastern coastal line of China,is undergoing rapid urbanization and industrialization,so its air quality has a trend of degradation.However,studies on level,temporal and spatial changes of fine particles (PM 2.5) and their carbonaceous fractions are scarce.In this article,abundance,sources,seasonal and spatial variations,distribution of organic carbon (OC) and elemental carbon (EC) in PM 2.5,were studied at suburban,urban and industrial sites in Xiamen during four season-representative months in 2009-2010.PM 2.5 samples were collected with middle volume sampler and were analyzed for OC and EC with thermal optical transmittance (TOT) method.Results showed that the annual average PM 2.5 concentrations were 63.88-74.80 μg/m 3 at three sites.While OC and EC concentrations were in the range of 15.81-19.73 μg/m 3 and 2.74-3.49 μg/m 3,respectively,and clearly presented the summerminima and winter maxima in this study.The carbonaceous aerosol accounted for 42.8%-47.3% of the mass of PM 2.5.The annual average of secondary organic carbon (SOC) concentrations in Xiamen were 9.23-11.36 μg/m 3,accounting for approximately 56% of OC.Strong correlations between OC and EC was found in spring (R 2=0.50) and autumn (R 2=0.73),suggesting that there were similar emission and transport processes for carbonaceous aerosols in these two seasons,while weak correlations were found in summer (R 2=0.33) and winter (R 2=0.41).The OC/EC ratios in PM 2.5 varied from 2.1 to 8.7 with an annual average of 5.7,indicating that vehicle exhaust,coal smoke and biomass burning were main source apportionments of carbonaceous fractions in Xiamen. | Fuwang Zhang Jinping Zhao Jinsheng Chen Ya Xu Lingling Xu | 2011 | Journal of Environmental Sciences2011，23，8： | 27 |
| 3 | Second harmonic generation in a high-Q lithium niobate microresonator fabricated by femtosecond laser micromachining显示文摘We report on second harmonic generation(SHG) in on-chip high-Q(>105) lithium niobate(Li Nb O3, LN) microresonators fabricated by femtosecond laser micromachining. We examine the efficiency of SHG with either a continuous-wave(CW) or an ultrashort pulsed pump laser. The normalized conversion efficiencies of SHG obtained with the CW and pulsed pump lasers are measured to be 1.35×10?5 m W?1 and 2.30×10?6 m W?1, respectively. | LIN JinTian XU YingXin FANG ZhiWei WANG Min WANG NengWen QIAO LingLing FANG Wei CHENG Ya | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，11： | 25 |
| 4 | Advances in on-chip photonic devices based on lithium niobate on insulator显示文摘Crystalline lithium niobate(LN)is an important optical material because of its broad transmission window that spans from ultraviolet to mid-infrared and its large nonlinear and electro-optic coefficients.Furthermore,the recent development and commercialization of LN-on-insulator(LNOI)technology has opened an avenue for the realization of integrated on-chip photonic devices with unprecedented performances in terms of propagation loss,optical nonlinearity,and electro-optic tunability.This review begins with a brief introduction of the history and current status of LNOI photonics.We then discuss the fabrication techniques of LNOI-based photonic structures and devices.The recent revolution in the LN photonic industry has been sparked and is still being powered by innovations of the nanofabrication technology of LNOI,which enables the production of building block structures,such as optical microresonators and waveguides of unprecedented optical qualities.The following sections present various on-chip LNOI devices categorized into nonlinear photonic and electro-optic tunable devices and photonic-integrated circuits.Some conclusions and future perspectives are provided. | JINTIAN LIN FANG BO YA CHENG JINGJUN XU | 2020 | Photonics Research2020，8，12： | 26 |
| 5 | Crustal P-wave velocity structure of the Longmenshan region and its tectonic implications for the 2008 Wenchuan earthquake显示文摘The P-wave velocity structure of the crust in the Longmenshan region has been imaged by seismic travel time tomography us ing local and regional first P-wave arrivals recorded from 2000 to 2008. The tomographic model provides a way to analyze the deep tectonics of the Longmenshan fault belt and the tectonic implications for the 2008 Ms8.0 Wenchuan earthquake. The P-wave velocity images indicate that the initial rupture site and focal depth of the Wenchuan earthquake, together with the di rection of rupture propagation, closely relate to the crustal structure of the Longmenshan region. The Pengguan massif to the west of the Longmenshan fault belt is characterized by high velocity anomalies, suggesting that the crust has a strong strain strength that can accumulate large stresses over a long period. The Ms8.0 Wenchuan earthquake is located at the southwestern end of the Pengguan massif and the western edge of the Sichuan Basin. The collision between the Pengguan massif and the Sichuan Basin becomes the primary reason for the occurrence of the Ms8.0 Wenchuan earthquake. To the north of Wenchuan, the occurrence and propagation of rupture benefit from low velocity anomalies along the Longmenshan fault belt; whereas to the south of Wenchuan, the brittle rupture can occur with more difficulty in relatively weak crust with low velocities. This may be one of the reasons for the absence of aftershocks to the south of Wenchuan, and the rupture induced by the Ms8.0 Wenchuan earthquake propagating from the north to the south along the Longmenshan fault belt. The deep geodynamics of the Ms8.0 Wenchuan earthquake may occur due to the discrepancy of crustal structures on the two sides of the Longmenshan fault belt. Ductile deformation and crustal flow can easily occur in the weak middle-lower crust beneath the Songpan-Garze orogenic belt. The eastward movement of the Tibetan Plateau is obstructed by the rigid lithosphere of the Sichuan Basin, and then the thick ening of the middle-lower crust and vertical deformation occur in the crust of the Longmenshan fault belt. In addition, the down-warping of the Moho and the basement thrusting onto the range front induced crustal deformation and strain accumula tion, which provided the potential energy to trigger the occurrence of the Ms8.0 Wenchuan earthquake. | LI ZhaWei XU Yi HUANG RunQiu HAO TianYao XU Ya LIU JingSong LIU JianHua | 2011 | Science China Earth Sciences2011，54，9： | 23 |
| 6 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 7 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 8 | Uppermost mantle structure of the North China Craton: Constraints from interstation Pn travel time difference tomography显示文摘The uppermost mantle is the key area for exchange of heat flux and material convection between the crust and lithospheric mantle. Spatial variations of lithospheric thinning and dynamic processes in the North China Craton could inevitably induce the velocity heterogeneity in the uppermost mantle.In this study,we used Pn arrivals from permanent seismic stations in North China and surrounding regions to construct a tomographic image of the North China Craton.The tomographic method with Pn travel time difference data were used to study the velocity variations in the uppermost mantle.Pn velocities in the uppermost mantle varied significantly in the Eastern,Central and Western blocks of the North China Craton.This suggests that the lithosphere beneath different blocks of the North China Craton have experienced distinct tectonic evolutions and dynamic processes since the Paleo- zoic.The current uppermost mantle has been imprinted by these tectonic and dynamic processes.Fast Pn velocities are prominent beneath the Bohai Bay Basin in the Eastern Block of the North China Craton,suggesting residuals of the Archean lithospheric mantle.Beneath the Tanlu Fault Zone and Bohai Sea,slow Pn velocities are present in the uppermost mantle,which can be attributed to significant lithospheric thinning and asthenospheric upwelling.The newly formed lithospheric mantle beneath Yanshan Mountain may be the dominant reason for the existence of slow Pn velocities in this region.Conversely,the ancient lower crust and lithospheric mantle already have been delaminated.In the Central Block,significant slow Pn velocities are present in Taihangshan Mountain,which also extends northward to the Yinchuan-Hetao Rift on the northern margin of the Ordos Block and Yinshan Orogen.This characteristic probably is a result of hot asthenospheric upwelling along the active tectonic boundary on the margin of the Western Block.The protracted thermal erosion and underplating of hot asthenospheric upwelling may induce lithospheric thinning and significant slow velocities in the uppermost mantle.Fast velocities beneath the Western Block suggest that the thick,cold and refractory Archean lithospheric keel of craton still is retained without apparent destruction. | LI ZhiWei HAO TianYao XU Ya | 2011 | Chinese Science Bulletin2011，56，16： | 16 |
| 9 | Prospects for intelligent rehabilitation techniques to treat motor dysfunction显示文摘More than half of stroke patients live with different levels of motor dysfunction after receiving routine rehabilitation treatments.Therefore,new rehabilitation technologies are urgently needed as auxiliary treatments for motor rehabilitation.Based on routine rehabilitation treatments,a new intelligent rehabilitation platform has been developed for accurate evaluation of function and rehabilitation training.The emerging intelligent rehabilitation techniques can promote the development of motor function rehabilitation in terms of informatization,standardization,and intelligence.Traditional assessment methods are mostly subjective,depending on the experience and expertise of clinicians,and lack standardization and precision.It is therefore difficult to track functional changes during the rehabilitation process.Emerging intelligent rehabilitation techniques provide objective and accurate functional assessment for stroke patients that can promote improvement of clinical guidance for treatment.Artificial intelligence and neural networks play a critical role in intelligent rehabilitation.Multiple novel techniques,such as braincomputer interfaces,virtual reality,neural circuit-magnetic stimulation,and robot-assisted therapy,have been widely used in the clinic.This review summarizes the emerging intelligent rehabilitation techniques for the evaluation and treatment of motor dysfunction caused by nervous system diseases. | Cong-Cong Huo Ya Zheng Wei-Wei Lu Teng-Yu Zhang Dai-Fa Wang Dong-Sheng Xu Zeng-Yong Li | 2021 | Neural Regeneration Research2021，16，2： | 12 |
| 10 | Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population显示文摘The effects of genetic factors on the noise-induced hearing loss(NIHL)are still unclear.In the present study,eight single-nucleotide polymorphisms(SNPs)included rs1227049 and rs3802711(CDH23),rs1695(GSTP1),rs137852540(GJB2),rs2289274(PMCA2),rs4880(SOD2),rs7943316,and rs769214 within CAT that might associated with NIHL were further validated | WANG Sheng Li YU Lu Gang LIU Ren Ping ZHU Wan Zhan GAO Wei Min XUE Li Ping JIANG Xu ZHANG Ya Han YI Ding CHEN Dong ZHANG Yong Hong | 2014 | Biomedical and Environmental Sciences2014，27，12： | 12 |
| 11 | Esophageal cancer:Epidemiology,risk factors and screening显示文摘More than 600,000 people are diagnosed with esophageal cancer(EC)every year globally,and the five-year survival rate of EC is less than 20%.Two common histological subtypes of EC,esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC),have great geographical variations in incidence rates.About half of the world’s EC was diagnosed in China and a majority of which belong to ESCC.Globally,the overall incidence rate of EC is decreasing.In some high-risk Asian regions,such as China,the incidence rate of ESCC has generally declined,potentially due to economic growth and improvement of diet habits.In some European high-income countries and the United States,the decline is mainly attributed to the decrease in smoking and drinking.The risk factors of EC are not well understood,and the importance of environmental and genetic factors in the pathogenesis is also unclear.The incidence and mortality of advanced EC can be reduced through early diagnosis and screening.White light endoscopy is still the gold standard in the current screening technology.This article reviews the epidemiology,risk factors,and screening strategies of EC in recent years to help researchers determine the most effective management strategies to reduce the risk of EC. | Jiang Li Jianguo Xu Yadi Zheng Ya Gao Siyi He He Li Kaiyong Zou Ni Li Jinhui Tian Wanqing Chen Jie He | 2021 | Chinese Journal of Cancer Research2021，33，5： | 12 |
| 12 | Evaluating the suitability of TRMM satellite rainfall data for hydrological simulation using a distributed hydrological model in the Weihe River catchment in China显示文摘这研究的目的到份量上评估热带降雨测量有雨计量器数据并且进一步的使命(TRMM ) 数据到使用驱使一个分布式的时间变体获得模型(DTVGM ) 在中国在半潮湿的 Weihe 河集水执行水文学模拟的这个 TRMM 数据。在模拟前,比较与一 10 年(20012010 ) 设置的每日的雨计量器数据表明在每日的时间步, TRMM 降雨数据擅长比降雨极端捕获雨出现和吝啬的值。在每月的时间规模上,在 TRMM 和雨计量器降雨数据之间的好线性关系被发现,与决心系数 R < 啜 class= “ a-plus-plus ” > 为个人在 0.78 和 0.89 之间变化的 2 驻扎。每日的水文学过程上的数据的七年( 20012007 )的随后的模拟结果证实 DTVGM 什么时候由雨计量器数据校准了,比什么时候由 TRMM 数据校准更好表现,但是 TRMM 数据驾驶的模拟的性能比在每月的时间规模上由计量器数据开车的好。结果因此建议 TRMM 降雨数据对在学习的每月的流速及流水量模拟更合适区域,和那当为水平衡部件的刻度和结果的效果也被考虑时, TRMM 3B42-V7 产品有潜力表现很好在类似的盆。 | ZHAO Haigen | 2015 | Journal of Geographical Sciences2015，25，2： | 12 |
| 13 | Joint land-sea seismic survey and research on the deep structures of the Bohai Sea areas显示文摘This paper presents the survey and research work of two land-sea profiles in the Bohai Sea,China,carried out in 2010–2011,including the seismic sources on land and in the sea,the ocean bottom seismographs(OBS)and their recovery,the coupling of OBS and the environment noise in sea area,the data quality of OBSs,and the result of data analysis.We focused on the investigation of crustal structures revealed by the two NE\EW-trending joint land-sea profiles.In combination with the Pn-velocity distribution and gravitymagnetic inversion results in the North China Craton,we propose that the undulation of the Moho interface in the Bohai and surrounding areas is not strong,and the lithospheric thinning is mainly caused by the thinning of its mantle part.The research result indicates that obvious lateral variations of Moho depth and seismic velocity appear nearby all the large-scale faults in Bohai Sea,and there is evidence of underplating and reforming of the lower crust by mantle material in the Bohai area.However,geophysical evidence does not appear to support the'mantle plume'or'delamination'model for the North China Craton destruction.The crustal structure of the Bohai Sea revealed'a relatively normal crust and obviously thinned mantle lid',local velocity anomalies and instability phenomena in the crust.These features may represent a combined effect of North China-Yangtze collision at an early stage and the remote action of Pacific plate subduction at a late stage. | HAO Tianyao YOU Qingyu LIU Lihua LV Chuanchuan XU Ya LI Zhiwei ZHAO Chunlei ZHENG Yanpeng LIU Chenguang HAN Guozhong | 2013 | Acta Oceanologica Sinica2013，32，12： | 11 |
| 14 | Response of sediment yield to vegetation restoration at a large spatial scale in the Loess Plateau显示文摘The impact of vegetation coverage on erosion and sediment yield in the Loess Plateau has been extensively studied,but the research has been primarily based on observations from slope runoff plots or secondary forest regions;the scaling method remains unresolved when it is applied at a large spatial scale,and it is difficult to apply to regions with severe soil and water loss given the predominance of herbs and shrubs.To date,there is little data on the quantitative impact of changes to vegetation on sediment concentration at a large spatial scale.This paper is based on vegetation information from remote sensing images,measured rainfall and sediment data over nearly 60 years,and results from previous runoff and sediment variation research on the Yellow River.We introduce the concepts of a sediment yield coefficient and the percentage of effective vegetation and erodible area,analyze the impact of different vegetation conditions on the flood sediment concentration and sediment yield,and evaluate the effect of rainfall intensity on sediment yield under different vegetation conditions at the watershed scale.We propose models to evaluate the impact of vegetation on sediment yield in the loess gully hilly region,which are based on remote sensing data and support an application at a large spatial scale.The models can be used to assess sediment reduction that results from the current significant improvement of vegetation in the Loess Plateau. | LIU XiaoYan YANG ShengTian DANG SuZhen LUO Ya LI XiaoYu ZHOU Xu | 2014 | Science China(Technological Sciences)2014，57，8： | 11 |
| 15 | Memristors with organic-inorganic halide perovskites显示文摘Organic-inorganic halide perovskites(OHPs)have been intensively studied for application in solar cells with high conversion efficiency exceeding 22%.The unique electrical and optical properties of OHPs have led to their use in optoelectronic device applications beyond photovoltaics,such as light-emitting diodes,photodetectors,transistors.New information storage technologies and computing architectures are being researched extensively with the aim of addressing the growing challenge of approaching end of Moore's law and von Neumann bottleneck.As the fourth basic circuit element,memristor is a leading candidate with powerful capabilities in information storage and neuromorphic computing applications.Recently,OHPs have received growing attention as promising materials for memristors.In particular,their mixed ionic-electronic conduction ability paired with light sensitivity provide OHPs with the opportunity to display novel functions such as optical-erase memory,optogenetics-inspired synaptic functions,and lightaccelerated learning capability.This review covers recent advances in OHP-based memristors development including memristive mechanism and analytical models,universal memristive characteristics for memory and neuromorphic computing applications,and novel multi-functionalization.Challenges and future prospects of OHP-based memristors are also discussed. | Xiaoning Zhao Haiyang Xu Zhongqiang Wang Ya Lin Yichun Liu | 2019 | InfoMat2019，1，2： | 10 |
| 16 | Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain显示文摘The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A(BoNT/A)on depression-like behaviors in mice and to explore the potential mechanisms.These results revealed that a single facial injection of BoNT/A induced a rapid and prolonged improvement of depression-like behaviors in naive and space-restriction-stressed(SRS)mice,reflected by a decreased duration of immobility in behavioral despair tests.BoNT/A significantly increased the 5-hydroxytryptamine(5-HT)levels in several brain regions,including the hippocampus and hypothalamus,in SRS mice.BoNT/A increased the expression of the N-methyl-Daspartate receptor subunits NR1 and NR2 B in the hippocampus,which were significantly decreased in SRS mice.Furthermore,BoNT/A significantly increased the expression of brain-derived neurotrophic factor(BDNF)in the hippocampus,hypothalamus,prefrontal cortex,and amygdala,which were decreased in SRS mice.Finally,BoNT/A transiently increased the levels of phosphorylated extracellular signal-regulated kinase(p-ERK)and cAMPresponse element binding protein(p-CREB),which were suppressed in the hippocampus of SRS mice.Collectively,these results demonstrated that BoNT/A treatment has antidepressant-like activity in mice,and this is associated with increased 5-HT levels and the activation of BDNF/ERK/CREB pathways in the hippocampus,supporting further investigation of BoNT/A therapy in depression. | Yang Li Jing Liu Xu Liu Cun-Jin Su Qi-Lin Zhang Zhi-Hong Wang Lei-Fang Cao Xue-Yan Guo Ya Huang Weifeng Luo Tong Liu | 2019 | Neuroscience Bulletin2019，35，4： | 10 |
| 17 | BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules显示文摘Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V nodules.Methods: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound examination.Results: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules. | Ya Wu Ting Xu Xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang Xiao Li Qing Yao Xinhua Ye Meiping Shen Xiaohong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 9 |
| 18 | Intravenous tirofiban therapy for patients with capsular warning syndrome显示文摘Background Capsular warning syndrome(CWS)is defined as recurrent episodes of transient ischaemic attacks≥3 times during a short time frame.There is no effective therapy to stop these attacks.We,herein,report our experience of using intravenous tirofiban to treat CWS.Methods All patients with CWS in our hospital from January 2013 to September 2017 were reviewed.Patients in tirofiban group(T-group)were treated by intravenous tirofiban at 0.4μg/kg/min for 30 min followed by 0.1-0.15μg/kg/min infusion.Other treatments(non-T-group)included thrombolytic,oral antiplatelet agents and anticoagulant.Intracerebral haemorrhage(ICH),systematic bleeding,new attacks after treatment,National Institutes of Health Stroke Scale(NIHSS)scores at 24 hours and modified Rankin Scales(mRSs)at 3 months were recorded.Descriptive statistics were used for analysis.results Of 23 patients qualified(15 in T-group,8 in non-T-group),the duration of symptoms ranged from 2 to 100 min before treatments.After treatment,in T-group,four patients(26.7%)had recurrent attacks,and NIHSS scores were 0 in 11 patients(73.3%)at 24 hours.All patients reached a favourable outcome(mRS≤2) at 3 months.In non-T-group,five patients(62.5%)had new attacks.NIHSS scores were 0 in two patients(25%)at 24 hours.At 3 months,seven patients(87.5%)reached a favourable outcome.Neither ICH nor systematic bleeding or thrombocytopaenia occurred in both groups of patients.Conclusions Intravenous tirofiban can be a potentially effective and safe therapy to stop early symptomatic fluctuations and shorten the duration of functional deficits in patients with CWS. | Wei Li Ya Wu Xiao-Shu Li Cheng-Chun Liu Shu-Han Huang Chun-Rong Liang Huan Wang Li-Li Zhang Zhi-Qiang Xu Yan-Jiang Wang Meng Zhang | 2019 | Stroke & Vascular Neurology2019，4，1： | 9 |
| 19 | Characterization of polycyclic aromatic hydrocarbons and gas/particle partitioning in a coastal city, Xiamen, Southeast China显示文摘An intensive sampling program had been undertaken in autumn (October, 2008) and winter (December, 2008 and January, 2009) at urban (Xiamen University and Xianyue residential area), suburban (Institute of Urban Environment), industrial area (Lulian Hotel) and background (Tingxi Reservoir) in Xiamen, Fujian Province, to characterize the atmospheric concentration and gas-particle phase partitioning of PAHs. The average concentration of total PAHs in winter was almost 1.7 times higher than those in autumn. The log scale plot of Kp versus sub-cooled liquid vapor pressure (P0L) for all the data of autumn and winter season samples gave significantly different slopes. The slope for the winter samples (-0.72) was steeper than that for the autumn samples (-0.58). The partitioning results indicated that slope values varied depending on characteristics of specific site, source region and meteorological conditions which play important roles in the partitioning of PAHs. In addition, local emission sources had a stronger effect on partitioning results than long-transported polluted plume. The sources of PAHs in five sampling sites in Xiamen also have been discussed initially. Diagnostic ratios showed that the primary source of PAHs in urban, suburban and industrial area was from vehicle exhausts. While emission from petrochemical factory and power plant was another main contributor to industrial area. | Jinping Zhao Fuwang Zhang Jinsheng Chen Ya Xu | 2010 | Journal of Environmental Sciences2010，22，7： | 9 |
| 20 | Study of Static Adsorption Capacity of ACF for Xenon at 201 K显示文摘The static adsorption performances of a series of active carbon fiber(ACF)for xenon at 201 K were measured with a model ASAP2010M specific surface area and aperture distribution instrument by changing the working gas of instrument from N 2 to Xenon. Compared with grain active carbon(GAC): (1) the adsorption performance of Viscose based ACF(VACF) adsorbents is better than that of GAC; (2) owing to the difference of aperture distribution, the adsorption performance of ACF with different radicales is different under the same experiment conditions though the specific surface area is similar; (3) there is no definite relationship between adsorption performance and specific surface area; (4) the VACF A2 is the superior xenon adsorbent at the experimental temperature. | WANG Ya long ** , ZHANG Hai tao, WANG Xu hui, ZHANG Li xing, CHEN Li yun, XIE Jin chuan (Northwest Institute of Nuclear Technology, Xian 710024, P. R. China) | 2002 | Chemical Research in Chinese Universities2002，18，2： | 9 |
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