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| 1 | Trends of foodborne diseases in China: lessons from laboratory- based surveillance since 2011显示文摘Foodborne 疾病是世界范围的最重要的公共健康问题之一。中国在食物链的所有方面面对各种各样、崭新的挑战。从从 2013 ~ 2016 的基于实验室的 foodborne 疾病监视系统的数据,以及不同区域和年龄,能在与多样的特征检测的病原体的模式与差别一起被发现。Vibrio parahaemolyticus 是在中国的传染腹泻的领先的原因,特别在在沿海的区域的成年人之中。沙门氏菌是为实质的社会经济的负担负责的严肃、广泛地分布式的病原体。Shigella 主要在 5 年下面在孩子之中与开发更少的区域在西北中国和内陆省(河南省) 被识别。从从 2011 ~ 2016 报导系统的 foodborne 疾病爆发的数据证明有毒的动物和为大多数死亡负责的植物因素在在西南区域的遥远的区域是有毒的蘑菇(54.7%) 。引起了报导的大多数案例(42.3%) 的生物危险被归因于 V。parahaemolyticus, foodborne 爆发的领先的原因。在这评论,我们在中国总结最近的监视途径到 foodborne 疾病并且在发达国家把结果与那些作比较。 | Jikai Liu Li Bai Weiwei Li Haihong Han Ping Fu Xiaochen Ma Zhenwang Bi Xiaorong Yang Xiuli Zhang Shiqi Zhen Xiaoling Deng Xiumei Liu Yunchang Guo | 2018 | Frontiers of Medicine2018，12，1： | 55 |
| 2 | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy显示文摘The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism.Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases. | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 18 |
| 3 | Advanced fabrication for electrospun three-dimensional nanofiber aerogels and scaffolds显示文摘Electrospinning is a versatile strategy for creating nanofiber materials with various structures,which has broad application for a myriad of areas ranging from tissue engineering,energy harvesting,filtration and has become one of the most important academic and technical activities in the field of material science in recent years.In addition to playing a significant role in the construction of two-dimensional(2D)nanomaterials,electrospinning holds great promise as a robust method for producing three-dimensional(3D)aerogels and scaffolds.This article reviews and summarizes the recent advanced methods for fabricating electrospun three-dimensional nanofiber aerogels and scaffolds,including gas foaming,direct electrospinning of 3D nanofibrous scaffold,short nanofibers assembling into 3D aerogels/scaffolds,3D printing,electrospray,origami and cell sheet engineering,centrifugal electrospinning,and other methods.Besides,intriguing formation process,crosslinking pathway,properties,and applications of 3D aerogels and scaffolds are also introduced.Taken together,these aerogels and scaffolds with various excellent features present tremendous potential in various fields. | Yujie Chen Muhammad Shafiq Mingyue Liu Yosry Morsi Xiumei Mo | 2020 | Bioactive Materials2020，5，4： | 12 |
| 4 | Current status and future of acid rain in China显示文摘As a part of the national key project of acid rain research, chemical element analysis of rainwater has been carried out based on observation of acid rain network in Chinese MeteorologicalAdministration over the years of 1992 and 1993. Samples of precipitation collected from eachacid rain station were taken according to the standard established by Chinese MeteorologicalAdministration. pH value was measured with pH meter (accuracy of 0. 01) made in | DING Guo’an, XU Xiaobing, FANG Xiumei, JIN Shaping, XU Xia, Tang Jie, LIU Qijun, WANG Shufeng and WANG Wenxing1. Chinese Academy of Meteorological Sciences, Beijing 100081, China 2. Chinese Academy of Environment Sciences, Beijing 100012, China | 1997 | Chinese Science Bulletin1997，42，24： | 8 |
| 5 | An update on the function and regulation of methylerythritol phosphate and mevalonate pathways and their evolutionary dynamics显示文摘Isoprenoids are among the largest and most chemically diverse classes of organic compounds in nature and are involved in the processes of photosynthesis, respiration, growth, development,and plant responses to stress. The basic building block units for isoprenoid synthesis-isopentenyl diphosphate and its isomer dimethylallyl diphosphate-are generated by the mevalonate (MVA) and methylerythritol phosphate(MEP) pathways. Here, we summarize recent advances on the roles of the MEP and MVA pathways in plant growth, development and stress responses, and attempt to define the underlying gene networks that orchestrate the MEP and MVA pathways in response to developmental or environmental cues.Through phylogenomic analysis, we also provide a new perspective on the evolution of the plant isoprenoid pathway. We conclude that the presence of the MVA pathway in plants may be associated with the transition from aquatic to subaerial and terrestrial environments, as lineages for its core components are absent in green algae. The emergence of the MVA pathway has acted as a key evolutionary event in plants that facilitated land colonization and subsequent embryo development, as well as adaptation to new and varied environments. | Xiaojun Pu Xiumei Dong Qing Li Zexi Chen Li Liu | 2021 | Journal of Integrative Plant Biology2021，63，7： | 8 |
| 6 | Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release显示文摘Sequential administration and controlled release of different drugs are of vital importance for regulating cellular behaviors and tissue regeneration,which usually demands appropriate carriers like microspheres(MS)to control drugs releases.Electrospray has been proven an effective technique to prepare MS with uniform particle size and high drug-loading rate.In this study,we applied electrospray to simply and hierarchically fabricate sphere-in-sphere composite microspheres,with smaller poly(lactic-co-glycolic acid)MS(~8-10 lm in diameter)embedded in a larger chitosan MS(~250-300 lm in diameter).The scanning electron microscopy images revealed highly uniform MS that can be accurately controlled by adjusting the nozzle diameter or voltage.Two kinds of model drugs,bovine serum albumin and chlorhexidine acetate,were encapsulated in the microspheres.The fluorescence-labeled rhodamine-fluoresceine isothiocyanate(Rho-FITC)and ultraviolet(UV)spectrophotometry results suggested that loaded drugs got excellent distribution in microspheres,as well as sustained,slow release in vitro.In addition,far-UV circular dichroism and matrixassisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS)results indicated original secondary structure and molecular weight of drugs after electrospraying.Generally speaking,our research proposed a modified hierarchically electrospraying technique to prepare sphere-in-sphere composite MS with two different drugs loaded,which could be applied in sequential,multi-modality therapy. | Zhu Liu Weilong Ye Jingchuan Zheng Qindong Wang Guowu Ma Huiying Liu Xiumei Wang | 2020 | Regenerative Biomaterials2020，7，4： | 5 |
| 7 | Drug-nanoencapsulated PLGA microspheres prepared by emulsion electrospray with controlled release behavior显示文摘The development of modern therapeutics has raised the requirement for controlled drug delivery system which is able to efficiently encapsulate bioactive agents and achieve their release at a desired rate satisfying the need of the practical system.In this study,two kind of aqueous model drugs with different molecule weight,Congo red and albumin from bovine serum(BSA)were nanoencapsulated in poly(DL-lactic-co-glycolic acid)(PLGA)microspheres by emulsion electrospray.In the preparation process,the aqueous phase of drugs was added into the PLGA chloroform solution to form the emulsion solution.The emulsion was then electrosprayed to fabricate drugnanoencapsulated PLGA microspheres.The morphology of the PLGA microspheres was affected by the volume ratio of aqueous drug phase and organic PLGA phase(V_(w)/V_(o))and the molecule weight of model drugs.Confocal laser scanning microcopy showed the nanodroplets of drug phase were scattered in the PLGA microspheres homogenously with different distribution patterns related to V_(w)/V_(o).With the increase of the volume ratio of aqueous drug phase,the number of nanodroplets increased forming continuous phase gradually that could accelerate drug release rate.Moreover,BSA showed a slower release rate from PLGA microspheres comparing to Congo red,which indicated the drug release rate could be affected by not only V_(w)/V_(o)but also the molecule weight of model drug.In brief,the PLGA microspheres prepared using emulsion electrospray provided an efficient and simple systemto achieve controlled drug release at a desired rate satisfying the need of the practices. | Shenglian Yao Huiying Liu Shukui Yu Yuanyuan Li Xiumei Wang Luning Wang | 2016 | Regenerative Biomaterials2016，3，5： | 5 |
| 8 | A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocelluar carcinoma显示文摘 | Xiaozhou Yu Hua Zhao Liang Liu Shui Cao Baozhu Ren Naining Zhang Xiumei An Jinpu Yu Hui Li Xiubao Ren | 2014 | Journal of Clinical Immunology2014，，2： | 5 |
| 9 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 10 | “Polymer-in-ceramic” based poly(ε-caprolactone)/ceramic composite electrolyte for all-solid-state batteries显示文摘Inspired by the concept of 'polymer-in-ceramic',a composite poly(ε-caprolactone)(PCL)/ceramic containing LiTFSI is prepared and investigated as a solid electrolyte for all-solid-state batteries.The composite with the optimum concentration of 45 wt% LiTFSI and 75 wt% Li1.5Al0.5Ge1.5(PO4)3(LAGP,NASICON-type structure) exhibits a high ionic conductivity(σi=0.17 mS cm-1) at 30℃,a transference number of 0.30,and is stable up to 5.0 V.The composite electrolyte is a flexible and self-standing membrane.Solid-state LiFePO4//Li batteries with this composite electrolyte demonstrate excellent cycling stability with high discharge capacity of 157 mA h g-1,high capacity retention of 96% and coulombic efficiency of 98.5% after 130 cycles at 30℃ and 0.1 C rate.These electrochemical properties are better than other PCL-based allsolid-lithium batteries,and validate the concept of 'polymer-in-ceramic' by avoiding the drawback of lower conductivity in prior 'polymer-in-ceramic' electrolyte at high concentration of the ceramic. | Bohao Zhang Yulong Liu Jia Liu Liqun Sun Lina Cong Fang Fu Alain Mauger Christian M.Julien Haiming Xie Xiumei Pan | 2021 | Journal of Energy Chemistry2021，30，1： | 4 |
| 11 | Electrical and Raman properties of p-type and n-type modified graphene by inorganic quantum dot and organic molecule modification显示文摘We obtained n-type and p-type modified graphene by mixing quantum dots and depositing electron-acceptor molecules on the surface of graphene, respectively. The electrical and optical properties of these two types of samples were measured. For n-type modified graphene, the electrons were transferred from quantum dots to graphene. The resistance of these quantum dots in modified n-type graphene is significantly smaller than that of pristine graphene. For p-type graphene, modified by electron-acceptor organic molecules of tetracyanoethylene (TCNE), electrons were transferred from graphene to TCNE molecules. The resistance of this molecular modified p-type graphene is about 10% larger than that of pristine graphene. The charge transfer effect on the optical properties of graphene was investigated with Raman spectra. | HOU YanXue GENG XiuMei LI YuanZuo DONG Bin LIU LiWei SUN MengTao | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 4 |
| 12 | Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis显示文摘 | Jinqing Hu Huaiyuan Wang Jinfa Gu Xinyuan Liu Xiumei Zhou | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 3 |
| 13 | A silica-immobilized Pt^(2+) catalyst for the selective,aerobic oxidation of methane via an electron-transfer chain显示文摘磅 2+, benzoquinone 和 NaNO 2 的联合形成电子转移链,它在 CF 32 导致甲烷的氧化 > COOH 水的答案。全面周转数字然而每在 120 ° C 的甲烷的小时(TOF ) 是 0.5 h −1, ,(23%) 仅仅大约四分之一在 CF 3 一种色情的扭摆舞 3 。到在有磅 2+ 种类的催化剂上的公司 2, 的甲烷的在氧化上在硅石底层上作为 ligand 经由 2,2 使 ′-bipyridyl 不能调动,清楚地被压抑。在一样的条件下面,到甲醇的变换统治,并且没有公司 2 被观察由于甲烷的在氧化上,是由同位素实验证实了。 | Zengjian An Xiulian Pan Xiumei Liu Xiuwen Han Xinhe Bao | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 3 |
| 14 | Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair显示文摘The repair of infective bone defects is a great challenge in clinical work.It is of vital importance to develop a kind of bone scaffold with good osteogenic properties and long-term antibacterial activity for local anti-infection and bone regeneration.A porous mineralized collagen(MC)scaffold containing poly(D,L-lactide-co-glycolic acid)(PLGA)microspheres loaded with two antibacterial synthetic peptides,Pac-525 or KSL-W was developed and characterized via scanning electron microscopy(SEM),porosity measurement,swelling and mechanical tests.The results showed that the MC scaffold embedded with smooth and compact PLGA microspheres had a positive effect on cell growth and also had antibacterial properties.Through toxicity analysis,cell morphology and proliferation analysis and alkaline phosphatase evaluation,the antibacterial scaffolds showed excellent biocompatibility and osteogenic activity.The antibacterial property evaluated with Staphylococcus aureus and Escherichia coli suggested that the sustained release of Pac-525 or KSL-W from the scaffolds could inhibit the bacterial growth aforementioned in the long term.Our results suggest that the antimicrobial peptides-loaded MC bone scaffold has good antibacterial and osteogenic activities,thus providing a great promise for the treatment of infective bone defects. | Yuzhu He Yahui Jin Xiaoxia Ying Qiong Wu Shenglian Yao Yuanyuan Li Huiying Liu Guowu Ma Xiumei Wang | 2020 | Regenerative Biomaterials2020，7，5： | 3 |
| 15 | Effects of human mesenchymal stem cell transplantation in the bilateral corpus striatum in a rat model of Tourette's syndrome显示文摘Tourette's syndrome is treated by behavioral or pharmacological therapy. However, patients with malignant Tourette's syndrome also exhibit life-threatening symptoms, which are unresponsive to conservative treatments or neurosurgical procedures, such as deep brain stimulation. In recent years, mesenchymal stem cells (MSCs) have shown therapeutic potential in many neurological diseases. Therefore, the present study proposed to use MSC transplantation as a novel therapy for Tourette's syndrome. Stereotypic behaviors in Tourette's syndrome rats decreased significantly at 21 days after human MSCs transplantation into the striatum. Immunohistochemistry analyses revealed survival of transplanted human MSCs and differentiation into neurons and astrocytes in the rat brain. Results suggest that intrastriatal transplantation of human MSCs could provide therapeutic potential for Tourette's syndrome. | Xiumei Liu Yuwei Wang Mingji Yi | 2010 | Neural Regeneration Research2010，5，17： | 3 |
| 16 | Laves phase hydrogen storage alloys for super-high-pressure metal hydride hydrogen compressors显示文摘Ti-Cr- and Ti-Mn-based alloys were prepared to be low- and high-pressure stage metals for a double-stage super-high-pressure metal hydride hydrogen compressor. Their crystallographic characteristics and hydrogen storage properties were investigated. The alloy pair Ti0.9Zr0.1Mn1.4- Cr0.35V0.2Fe0.05/TiCr1.55Mn0.2Fe0.2 was optimized based on the comprehensive performance of the studied alloys. The product hydrogen with a pressure of 100 MPa could be produced from 4 MPa feed gas when hot oil was used as a heat reservoir. | GUO Xiumei WANG Shumao LIU Xiaopeng LI Zhinian LU Fang MI Jing HAO Lei JIANG Lijun | 2011 | Rare Metals2011，30，3： | 3 |
| 17 | The minimization of non-equilibrium plasma source at high pressure显示文摘The density of plasma produced by atmospheric non-equilibrium plasma source is the function of en-ergy dissipation rate in ionization electric field and gas particles momentum.The experiment shows that the plasma density highly rises with the increasing of energy dissipation rate and gas particles momentum.When the energy dissipation rate of activation field is 2.18 Wh/m3 and the average gas particles momentum is 109×10-22 g·m/s,the air throughput of plasma source whose volume is only 2.5 cm3 can be up to 12 m3/h and the density of plasma can be up to 1010 cm-3.The research can develop a method of producing minitype plasma source which is low energy consumption but high ion concen-tration used for chemical industry,environmental engineering and military. | BAI MinDi QIU XiuMei LIU Dong YANG Bo ZHOU JianGang XUE XiaoHong GU JianLong | 2008 | Chinese Science Bulletin2008，53，21： | 3 |
| 18 | Antioxidant and antihyperlipidemic activities of polysaccharides from sea cucumber Apostichopus japonicus显示文摘 | Xin Liu Zhenliang Sun Miansong Zhang Xiumei Meng Xuekui Xia Wenpeng Yuan Feng Xue Changheng Liu | 2012 | Carbohydrate Polymers2012，，4： | 3 |
| 19 | Progress on Li3VO4 as a Promising Anode Material for Li-ion Batteries显示文摘 | Jun Mo Xiumei Zhang Junjie Liu Jingang Yu Zhian Wang Zaichun Liu Xinhai Yuan Chunjiao Zhou Ruilian Li Xiongwei Wu Yuping Wu | 2017 | Chinese Journal of Chemistry2017，35，12： | 3 |
| 20 | Comparison of diagnostic value of PET using 18- fluoro-2-deoxyglucose, CT and MR1 in detecting skull base invasion of nasopharyngeal carcinomas显示文摘客观我们用 18-fluoro-2-deoxyglucose ( FDG )比较了正电子排放断层摄影术(宠物),提高的计算断层摄影术( CT )和在检测颅骨的磁性的回声成像( MRI )基于鼻咽的癌( NPC )的侵略并且基于鼻咽的癌的侵略在决定颅骨的存在评估这三个方法的价值。方法提高的 CT, MRI 和 PET-CT 扫描的图象,表现在间隔 ≤
到 2007 年 2 月的从 2004 年 7 月的 57 个 NPC 病人上的 20 天,被选择并且考察。比较的端点是敏感,特性,精确性,积极预兆的价值(PPV ) 和提高的 CT, MRI 和 PET-CT 的否定预兆的价值(NPV ) ,基于为至少 6 个月的组织病理学说的调查结果或临床的成像后续。检测 NPC,提高的 CT 的敏感, MRI 和 PET-CT 的颅骨底侵略的结果是 68.18% , 84.09% , 97.67% 分别地;特性是 76.92% , 69.23% , 57.14% 分别地;精确性是 70.18% , 80.7% , 87.72% 分别地;PPV 是 90.9% , 90.24% , 87.5% 分别地;NPV 是 41.67% , 56.25% , 88.89% 分别地。结论 PET-CT 比 CT 在敏感有明显的优点(P <
0.05 ) 并且 MRI,比在精确性和 NPV 的二个方法好并且可能为在检测 NPC 病人的颅骨底侵略的新病人更珍贵。 | Xiumei Ma Ming Ye Taifu Liu Li Li Liyan Dai | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，8： | 3 |
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