|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | Coarsening behavior of γ' and γ'' phases in GH4169 superalloy by electric field treatment显示文摘The coarsening behaviors of γ' and γ'' phases in GH4169 alloy aged at 1023 and 1073 K with electric feld treatment(EFT) were investigated by transmission electron microscopy(TEM) and positron annihilation lifetime spectroscopy(PALS).It is demonstrated that precipitation coarsening occurs,and the growth activation energies of γ' and γ'' phases can be decreased to 115.6 and 198.1 kJ·mol-1,respectively,by applying the electric feld.The formation of a large number of vacancies in the matrix is induced by EFT.Due to the occurrence of vacancy migration,the difusion coefcients of Al and Nb atoms are increased to be 1.6-5.0 times larger than those without EFT at 1023 or 1073 K.Furthermore,the formation of vacancy clusters is promoted by EFT,and the increase in strain energy for the coarsening of γ' and γ'' phases can be counterbalanced by the formation of vacancy clusters. | Lei Wang Yao Wang Yang Liu Xiu Song Xu-dong Lü Bei-jiang Zhang | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，9： | 5 |
| 3 | Combustion synthesis and photoluminescence of perovskite PbTiOs nanopowders 显示文摘 | Liu S W Xiu Z L Liu J | 2007 | Journal of Alloys and Compounds2007，441，12： | 1 |
| 4 | Influence of processing conditions on the luminescence of YVO4: Eu3 + nanoparticles 显示文摘 | ZHANG H P LU M K XIU Z L | 2006 | Mater Sci Eng: B2006，130，： | 1 |
| 5 | Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3- butanediol显示文摘 | Xiu Z L Zeng A P | 2008 | Applied Microbiology and Biotechnology2008，78，6： | 1 |
| 6 | Effects of nano-scale zero- valent iron particles on a mixed culture dechlorinating trichloroeth- ylene 显示文摘 | Xiu Z M Jin Z H Li T L | 2010 | Bioresource Technology2010，101，4： | 1 |
| 7 | Application of da- ta mining techniques in customer relationship man- agement : A literature review and classification 显示文摘 | Ngai E W T Xiu L Chau D C K | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 8 | Molecular characterization of two pheromone binding proteins and quantitative analysis of their expression in the beet armyworm, Spodoptera exigua Hubner显示文摘 | Xiu W M Dong S L | 2007 | J Chem Ecol2007，33，： | 1 |
| 9 | Controlled synthesis of high-quality PbS star-shaped dendrites,multipods,truncated nanocubes,and nanocubes and their shape evolution process显示文摘 | Zhou G J Lu M K Xiu Z L | 2006 | J Phys Chem B2006，110，13： | 1 |
| 10 | Combustion synthesis and photo-luminescence ofDy3+-doped YPO4 nanocrystals,submitted to mater显示文摘 | XIU Z L YANG Z S LU M K | 2006 | Opt Mater2006，29，4： | 1 |
| 11 | A Comprehensive Study of the Friction and Dynamic Motion of the Piston Assembly显示文摘 | K Liu Y B Xiu C L Gui | 1998 | IMechE Journal of Engineering Tribology1998，212，3： | 1 |
| 12 | Optimality condition of the nonlinear impulsive system in fed-batch fer- mentation 显示文摘 | WANG H Y FENG E M XIU Z L | 2008 | Nonlinear Analysis2008，68，： | 1 |
| 13 | Spodoptera litura PBP 1 and Spodoptera litura PBP2 Molecular Characterization and Expression Pattern of Two Pheromone-Binding Pro- teins from Spodoptera litura (Fabrieius) 显示文摘 | Xiu W M Zhou Y Z Dong S L | 2008 | J Chem Ecol2008，34，： | 1 |
| 14 | Decitabine reduces transfusion dependence in older patients with acute myeloid leukemia:results from a post hoc analysis of a randomized phase DI study显示文摘 | He J Xiu L De Porre P | 2014 | Leuk Lymphoma2014，56，4： | 1 |
| 15 | Optimization of dissimilation of glycerol to 1,3-propanediol by Klebsiella pneu-moniae in one-and two-stage anaerobic culture显示文摘 | Xiu z L Song B H Wang Z T | 2004 | Biochem Eng J2004，19，： | 1 |
| 16 | The influence of tempering temperature on the reversed austenite formation and tensile properties in Fe-13% Cr-4% Ni-Mo low carbon martensite stainless steels 显示文摘 | Yuan Y S Xiu Y L Li J R Yi Li | 2011 | Materials Science and Engineering A2011，528，： | 1 |
| 17 | The Pollen cones of Ginkgo from the early cretaceous of China,and their bearing on the evolutionary significance显示文摘 | Xiu Q L Cheng S L Wang Y F | 2006 | Botanical Journal of the Linnean Society2006，152，： | 1 |
| 18 | Synthsis of nanocrystallineyttria powder and fabrication of transparent YAG ce-ramics显示文摘 | Wen L Sun X D Xiu Z M | 2004 | J Eur Ceram Soc2004，90，24： | 1 |
| 19 | Stoichiometric analysis and experimental investigation of glycerol-glucose co- fermentation in Klebsiella pneumoniae under microaero- bic conditions显示文摘 | Xiu Z L Chen X Sun Y Q | 2007 | Biochemical Engineering Journal2007，33，1： | 1 |
| 20 | Negligible par- ticle-specific antibacterial activity of silver nanoparticles 显示文摘 | Xiu Z M Zhang Q 'B Puppala H L | 2012 | Nano Letters2012，12，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员