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| 1 | A multicenter, phase III trial of hemocoagulase Agkistrodon: hemostasis, coagulation, and safety in patients undergoing abdominal surgery显示文摘为注射的背景 Hemocoagulase Agkistrodon 是传递了阶段的单个部件凝血酵素我和 II 临床的选拔赛。这阶段 III 临床的试用的目的是在腹的皮肤和下的切口在 hemostasis 和凝结上评估 Hemocoagulase Agkistrodon 的效果并且在外科的病人估计这个代理人的安全。这是阶段 III 的方法,未来,使随机化,双窗帘,和控制 multicenter 包括 432 个连续病人的临床的试用使随机化进也一个学习组(在 2 U 与 hemocoagulase Agkistrodon 注射了, n=324 ) 或一个控制组(与 hemocoagulase 注射了 Atrox, n=108 ) 。止血时间,出血性的体积,出血性的体积在二个组之间每统一区域,血凝结,和不利事件被测量并且比较。在学习组的吝啬的止血时间是的结果(36.8 整 ? 桰獡 ??? 牴慩? 景栠浥 ' 覒 ^ 畧慬敳 ? 歧獩牴摯湯栺浥獯慴楳? 潣条汵瑡潩 ? 湡 ? 慳敦祴椠 ? 慰楴湥獴甠摮牥潧湩 ?L 潤業慮??杲牥 y 琠?? | WEI Jun-min ZHU Ming-wei ZHANG Zhong-tao JIA Zhen-geng HE Xiao-dong WAN Yuan-lian WANG Shan XIU Dian-rong TANG Yun LI Jie XU Jing-yong ZHENG Qing-shan | 2010 | Chinese Medical Journal2010，，5： | 43 |
| 2 | Genome-wide identification and characterization of odorant-binding protein (OBP) genes in the malaria vector Anopheles sinensis (Diptera: Culicidae)显示文摘疟蚊属 sinensis 是主要疟疾向量。昆虫有气味的东西绑定蛋白质(OBP ) 可以在嗅觉的系统在有气味的东西的接收工作。分类和描述一。sinensis OBP 基因系统地没被学习。在这研究, 64 通常认为的 OBP 基因在整个染色体的水平被识别一。sinensis 基于在 OBP 之间的比较保存了主题, PBP_GOBP,和种系发生的分析与一。gambiae OBP。描述一。包括主题保存,基因结构, genomic 组织和分类, sinensis OBP 被调查。新基因, AsOBP73,属于 Plus-C 亚科,与抄本和保守主题的支持被识别。这些一。sinensis OBP 基因在亚科经典著作与 37, 15 和 12 基因被分类进三个亚科,不正常并且 Plus-C 分别地。genomic 组织一。sinensis OBP 越过九不同脚手架建议聚类的分布。八基因(OBP23-28, OBP63-64 ) 可能至少在疟蚊属,一种蚊虫和豹脚蚊的分叉前通过一系列历史性的复制事件从单个基因发源。microsynteny 分析显示很高的 synteny 在之间一。sinensis 并且一。gambiae OBP。更早在 Plus-C 下面分类在的 OBP70 和 OBP71 一。gambiae 作为属于经典亚科的组 Obp59a 被认出,并且更早在 Plus-C 下面分类的 OBP69 在这研究被移动了到不正常的亚科。学习在昆虫以及在为 OBP 基因的进一步的学习建立了一个基本信息框架一。sinensis。 | Xiu He Zheng-Bo He Yu-Juan Zhang Yong Zhou Peng-Jie Xian Liang Qiao Bin Chen | 2016 | Insect Science2016，23，3： | 16 |
| 3 | Icariin prevents bone loss by inhibiting bone resorption and stabilizing bone biological apatite in a hindlimb suspension rodent model显示文摘microgravity 导致的骨头损失是对在长期的 spaceflight 的人的一个实质的障碍。最近的研究表明了 icariin (集成通信适配器) 能在绝经后的女人和 ovariectomized 老鼠稀释骨质疏松症。然而,集成通信适配器是否能免于导致 microgravity 的骨头损失,仍然保持未知。在这研究,一个 hindlimb 暂停啮齿类动物模型上的集成通信适配器的效果被调查。Two-month-old 女 Wistar 老鼠是与集成通信适配器推迟并且对待的 hindlimb (25mg ??? ?? ?? ??? ??????? 牆 ?? 搠 ? 渠癯 ? 氠灩杯湥獥獩吗?? | Jin-peng He Xiu Feng Ju-fang Wang Wen-gui Shi He Li Sergei Danilchenko Aleksei Kalinkevich Mykhailo Zhovner | 2018 | Acta Pharmacologica Sinica2018，39，11： | 11 |
| 4 | Optimal allocation of multi-sensor passive localization显示文摘To improve multi-sensor passive localization precision,the optimal allocation form of multi-sensor bearing-only localization is analyzed from the perspective of the geometric dilution of precision(GDOP) of the least squares(LS) algorithm.This paper indicates that whether the target lies inside the closed region formed by the sensors or not,the optimal allocation is when each adjacent cut angle between a sensor pair is identical,and all sensors are located on the border of the circle that has the target(which is also the origin of the coordinate system) as its center.When there is no restriction on the adjacent cut angle in the above allocation,the optimal estimate of the LS algorithm in the sense of minimum variance can be acquired.When the LS algorithm achieves the optimal estimate and the sensors present the optimal allocation,the respective consistencies are analyzed.Simulation results verify the analysis of the optimal allocation form above,which can be used in multi-sensor passive localization algorithms based on sensor management. | WANG BenCai HE You WANG GuoHong XIU JianJuan | 2010 | Science China(Information Sciences)2010，53，12： | 11 |
| 5 | Study on Wireless Power Transmission for Gastrointestinal Microsystems Based on Inductive Coupling显示文摘Wireless power transmission based on inductive coupling for remotely implanted micro devices has been considered in this paper. The receiving coil, integrated in microsystems and the external transmitting coil compose a loosely coupled transformer. The coupling coefficient was calculated and measured on spacing misalignments. The geometric size of transmitting coil was analyzed for the target of remotely delivering power. The received power was maximized by choosing appropriate value of frequency, tuning capacitance and the load resistance. A conventional full bridge rectifier circuit was employed to convert ac to dc voltage. The received dc power was up to 160 mW with a transmitting voltage of 5 Vrms when the receiving coil was placed at the center of the transmitting coil. This may meet the requirement of some microsystems for high power over a long time. | MA Guan-ying YAN Guo-zheng HE Xiu | 2007 | Chinese Journal of Biomedical Engineering(English Edition)2007，16，2： | 7 |
| 6 | Surgical resection for hepatoportal bile duct cancer显示文摘METHODSAretrospectiveanalysiswasmadefor52casesofhepatoportalbileductcancertreatedfromJanuary1991toDecember1996.Althecaseswere... | HE Xiao Shun, HUANG Jie Fu, LIANG Li Jian, LU Ming De and CAO Xiu Hu | 1999 | World Journal of Gastroenterology1999，5，2： | 7 |
| 7 | Regional Characteristics and Causes of Haze Events in Northeast China显示文摘Northeast China experiences severe atmospheric pollution, with an increasing occurrence of heavy haze episodes. However, the underlying forces driving haze formation during different seasons are poorly understood. In this study, we explored the spatio-temporal characteristics and causes of haze events in Northeast China by combining a range of data sources(i.e., ground monitoring, satellite-based products, and meteorological products). It was found that the ‘Shenyang-Changchun-Harbin(SCH)'city belt was the most polluted area in the region on an annual scale. The spatial distribution of air quality index(AQI) values had a clear seasonality, with the worst pollution occurring in winter, an approximately oval-shaped polluted area around western Jilin Province in spring, and the best air quality occurring in summer and most of the autumn. The three periods that typically experienced intense haze events were Period I from mid-October to mid-November(i.e., late autumn and early winter), Period II from late-December to February(i.e., the coldest time in winter), and Period III from April to mid-May(i.e., spring). During Period I, strong PM_(2.5) emissions from seasonal crop residue burning and coal burning for winter heating were the dominant reasons for the occurrence of extreme haze events(AQI > 300). Period II had frequent heavy haze events(200 < AQI < 300) in the coldest months of January and February, which were due to high PM_(2.5) emissions from coal burning and vehicle fuel consumption, a lower atmospheric boundary layer, and stagnant atmospheric conditions. Haze events in Period III, with high PM_(10) concentrations, were primarily caused by the regional transportation of windblown dust from degraded grassland in central Inner Mongolia and bare soil in western Jilin Province. Local agricultural tilling could also release PM_(10) and enhance the levels of windblown dust from tilled soil. Better control of coal burning, fuel consumption, and crop residue burning in winter and autumn is urgently needed to address the haze problem in Northeast China. | CHEN Weiwei ZHANG Shichun TONG Quansong ZHANG Xuelei ZHAO Hongmei MA Siqi XIU Aijun HE Yuexin | 2018 | Chinese Geographical Science2018，28，5： | 7 |
| 8 | Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth显示文摘AIM:To determine the expression characteristics of connective tissue growth factor(CTGF/CCN2) in human hepatocellular carcinoma(HCC) in histology and to elucidate the roles of CCN2 on hepatoma cell cycle progression and metastasis in vitro.METHODS:Liver samples from 36 patients(who underwent hepatic resection for the first HCC between 2006 and 2011) and 6 normal individuals were examined for transforming growth factor β1(TGF-β1) or CCN2 mRNA by in situ hybridization.Computer image analysis was performed to measure integrated optimal density of CCN2 mRNA-positive cells in carcinoma foci and the surrounding stroma.Fibroblast-specific protein-1(FSP-1) and E-cadherin were examined to evaluate the process of epithelial to mesenchymal transition,α-smooth muscle actin and FSP-1 were detected to identify hepatic stellate cells,and CD34 was measured to evaluate the extent of vascularization in liver tissues by immunohistochemical staining.CCN2 was assessed for its stimulation of HepG2 cell migration and invasion using commercial kits while flow cytometry was used to determine CCN2 effects on HepG2 cell-cycle.RESULTS:In situ hybridization analysis showed that TGF-β1 mRNA was mainly detected in connective tissues and vasculature around carcinoma foci.In comparison to normal controls,CCN2 mRNA was enhanced 1.9-fold in carcinoma foci(12.36 ± 6.08 vs 6.42 ± 2.35) or 9.4-fold in the surrounding stroma(60.27 ± 28.71 vs 6.42 ± 2.35),with concomitant expression of CCN2 and TGF-β1 mRNA in those areas.Epithelial-mesenchymal transition phenotype related with CCN2 was detected in 12/36(33.3%) of HCC liver samples at the edges between carcinoma foci and vasculature.Incubation of HepG2 cells with CCN2(100 ng/mL) resulted in more of the cells transitioning into S phase(23.85 ± 2.35 vs 10.94 ± 0.23),and induced a significant migratory(4.0-fold) and invasive(5.7-fold) effect.TGF-β1-induced cell invasion was abrogated by a neutralizing CCN2 antibody showing that CCN2 is a downstream mediator of TGF-β1-induced hepatoma cell invasion.CONCLUSION:These data support a role for CCN2 in the growth and metastasis of HCC and highlight CCN2 as a potential novel therapeutic target. | Ming Xiu Ya-Hui Liu David R Brigstock Fang-Hui He Rui-Juan Zhang Run-Ping Gao | 2012 | World Journal of Gastroenterology2012，18，47： | 7 |
| 9 | Effect of β3-adrenergic agonists on alveolar fluid clearance in hypoxic rat lungs显示文摘背景最近的研究建议 _2 肾上腺素能的收缩筋在生理、病理学的条件下面增加牙槽的液体清理(声频抗流圈) 。_3 肾上腺素能的收缩筋是否也在病理学的条件下面增加声频抗流圈,是未知的。这研究的目的是调查 _3 的效果肾上腺素能的声频抗流圈后面的 hypoxic 肺损害和机制 involved.Methods Hypoxic 老鼠上的收缩筋暴露于 10% 氧。BRL-37344 (_3 肾上腺素能的收缩筋) 或 CGP-12177 (选择 _3 肾上腺素能的收缩筋) 与受体对手,钠隧道 blockers,或 Na^+/K^+-ATPase blockers 独自一个或联合被酒直到暴露于 10% 氧 48 个小时的老鼠的牙槽的空间。全部的肺水内容(TLW ) 和声频抗流圈是声频抗流圈没改变开始的 24 个小时了,但是然后在 48 小时的暴露以后减少到 10% 氧的 measured.Results。BRL-37344 或 CGP-12177 的灌注显著地在正常和 hypoxic 老鼠增加了声频抗流圈。CGP-12177 的刺激声频抗流圈的效果被 37% 和 49% 分别地与 amiloride (Na^+ 隧道 blocker ) 和 ouabain (一个 Na^+/K^+-ATPase 禁止者) 降低。用番红花作原料而制成的植物盐基显著地禁止了 CGP-12177.Conclusions 的效果这些调查结果建议那(3-adrenergic 收缩筋能在老鼠在 hypoxic 肺损害期间增加声频抗流圈并且加速肺的浮肿的改善。 | LI Nai-jing LI Wei HE Ping GU Xiu LI Sheng-qi | 2010 | Chinese Medical Journal2010，，8： | 6 |
| 10 | A Pair of New Geometrically Isomeric Triterpenoid Saponins fromthe Seeds of Aesculus chinensis显示文摘Two new triterpenoid saponins were isolated from the seeds of Aesculus chinensis bypreparative HPLC. On the basis of chemical evidence and spectral data, their structures wereestablished as 21β-tigloyl-28-acetylprotoaescig 36-O-[β-D-xylopyranosyl (1→2)] [β-D-glucopyranosyl (1→4)-β-D-glucopyranosiduronic acid (isoescin IIa, 1) and 21β-tigloyl-28-acetylprotoaescigenin 30-O-[β-D-xylopyranosyl (1-2)] [β-D-glucopyranosyl (1→4)]-β-D-glucopyranosiduronic acid (isoescin IIb, 2), which are a pair of geometrical isomers. | Xiu Wei YANG Jing ZHAO Yu Xin CUI Li He ZHANG(National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University.Beijing 100083) | 1999 | Chinese Chemical Letters1999，10，11： | 6 |
| 11 | Effect of cytokines on liver necrosis显示文摘EfectofcytokinesonlivernecrosisYUYanYan1,SIChongWen1,TIANXiuLan1,HEQun2andXUEHaiPeng2Subjectheadingshepatitis;livernecro... | YU YanYan1, SI ChongWen1, TIAN XiuLan1, HE Qun2 and XUE HaiPeng2Keywords hepatitis liver necrosis tumor necrosis factor interleukins interferon | 1998 | World Journal of Gastroenterology1998，4，4： | 6 |
| 12 | A New Triterpenoid Oligoglycoside Escin IVe from the Seeds ofAesculus Chinensis显示文摘A new triterpenoid saponin named escin IVr was isolated from the seeds ofAesculus chinensis its structure was established as 28-tigloylprotoaescigenin-3β-O-[β-D-glucopyranosyl (1-2 )][β-D-glucopyranosyl (1-4)] -β-D-glucopyranosiduronic acid. | Jing ZHAO Xiu Wei YANGI Yu Xin CUl Xue Hut LIU Shun He OUYANGZ(National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University.Beijing 100083Yantai Luye Pharmaceutical Co. Ltd.. 43 Yingbin Road. Yantai. Shandong 264001) | 1999 | Chinese Chemical Letters1999，10，6： | 5 |
| 13 | Anatomical characteristics of patients with symptomatic severe aortic stenosis in China显示文摘With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated. | Tian-Yuan Xiong Yi-Ming Li Yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei Fang Jun Jin Guo-Sheng Fu Yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen Yi Li Yi-Bing Shao Yi Zhang Bo-Sen Yang Yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He Fa-Xin Ren Jian-Cheng Xiu Xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen | 2021 | Chinese Medical Journal2021，，22： | 5 |
| 14 | Effect of Electric Potentials on Microstructure, Corrosion and Wear Characteristic of the Nitrided Layer Prepared on 2Cr13 Stainless Steel by Plasma Nitriding显示文摘Plasma nitriding is a widely used technology to enhance the surface performance and extend the service life of alloy parts.The current research mainly focuses on the influences of time,temperature,gas type and pressure parameters on nitriding behavior,while fewer studies have been conducted on the electric potential.This paper mainly reports the effect of the electric potential on nitriding behavior.Test conditions were set using cathodic,anodic and floating potentials in a plasma nitriding furnace.2Cr13 stainless steel was nitrided at 450°C for 5h in an NH3 atmosphere.The experimental results show that the nitriding treatment can be well performed under the different electric potentials,but differences exist in microstructures,morphologies and performance results of the modified layers.The thickness and hardness values of the nitrided layer are ranked as follows:cathodic[anodic[floating potential.The anodic nitrided surface has an obvious particle deposition layer composed of nitrides and oxides.Electrochemical and tribological experiments show that the corrosion resistance and wear resistance were significantly improved after a nitriding treatment using the three electric potentials.Moreover,the floating nitriding treatment resulted in the best tribological performance and corrosion resistance. | Yang Li Shang-Zhou Zhang Jian-Xun Qiu Yong-Yong He Jun-Jie Xiu Qian-Wen Ye Zhong-Li Liu | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，6： | 5 |
| 15 | Bone Loss Induced by Simulated Microgravity,Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats显示文摘Objective To better understand the pathological causes of bone loss in a space environment, including microgravity, ionizing radiation, and ultradian rhythms. Methods Sprague Dawley(SD) rats were randomly divided into a baseline group, a control group, a hindlimb suspension group, a radiation group, a ultradian rhythms group and a combined-three-factor group. After four weeks of hindlimb suspension followed by X-ray exposure and/or ultradian rhythms, biomechanical properties, bone mineral density, histological analysis, microstructure parameters, and bone turnover markers were detected to evaluate bone loss in hindlimbs of rats. Results Simulated microgravity or combined-three factors treatment led to a significant decrease in the biomechanical properties of bones, reduction in bone mineral density, and deterioration of trabecular parameters. Ionizing radiation exposure also showed adverse impact while ultradian rhythms had no significant effect on these outcomes. Decrease in the concentration of the turnover markers bone alkaline phosphatase(b ALP), osteocalcin(OCN), and tartrate-resistant acid phosphatase-5 b(TRAP-5 b) in serum was in line with the changes in trabecular parameters. Conclusion Simulated microgravity is the main contributor of bone loss. Radiation also results in deleterious effects but ultradian rhythms has no significant effect. Combined-three factors treatment do not exacerbate bone loss when compared to simulated microgravity treatment alone. | ZHANG Ya Nan SHI Wen Gui LI He HUA Jun Rui FENG Xiu WEI Wen Jun WANG Ju Fang HE Jin Peng LEI Su Wen | 2018 | Biomedical and Environmental Sciences2018，31，2： | 4 |
| 16 | Dependence of Mixed Aerosol Light Scattering Extinction on Relative Humidity in Beijing and Hong Kong显示文摘The hygroscopic properties of mixed aerosol particles are crucial for the application of remote sensing products of aerosol optical parameters in the study of air quality and climate at multiple scales. In this study, the authors investigated aerosol optical properties as a function of relative humidity (RH) for two representative metropolises: Beijing and Hong Kong. In addition to the RH data, mass concentrations of PM 10 (particulate matter up to 10 μm in diameter) and aerosol scattering extinction coefficient (σ ext ) data were used. The relationship between the mass scattering extinction efficiency (MEE, defined as σ ext /PM 10 ) and RH can be expressed by regression functions as f = 1.52x + 0.29 (r2 = 0.77), f = 1.42x + 1.53 (r2 = 0.58), f = 1.19x + 0.65 (r2 = 0.59), and f = 1.58x + 1.30 (r2 = 0.61) for spring, summer, autumn, and winter, respectively, in Beijing. Here, f represents MEE, x represents 1/(1 RH), and the coefficients of determination are pre- sented in parentheses. Conversely, in Hong Kong, the corresponding functions are f = 1.98x 1.40 (r2 = 0.55), f = 1.32x 0.36 (r2 = 0.26), f = 1.87x 0.65 (r2 = 0.64), and f = 2.39x 1.47 (r2 = 0.72), respectively. The MEE values for Hong Kong at high RHs (RH > 70%) are higher than those for Beijing, except in summer; this suggests that aerosols in Hong Kong are more hygroscopic than those in Beijing for the other three seasons, but the aerosol hygroscopicity is similarly high in summer over both cities. This study describes the effects of moisture on aerosol scattering extinction coefficients and provides a potential method of studying atmospheric visibility and groundlevel air quality using some of the optical remote sensing products of satellites. | LI Cheng-Cai HE Xiu DENG Zhao-Ze Alexis Kai-Hon LAU LI Ying | 2013 | Atmospheric and Oceanic Science Letters2013，6，2： | 4 |
| 17 | An infrastructure with user-centered presentation data model for integrated management of materials data and services显示文摘With scientific research in materials science becoming more data intensive and collaborative after the announcement of the Materials Genome Initiative,the need for modern data infrastructures that facilitate the sharing of materials data and analysis tools is compelling in the materials community.In this paper,we describe the challenges of developing such infrastructure and introduce an emerging architecture with high usability.We call this architecture the Materials Genome Engineering Databases(MGED).MGED provides cloud-hosted services with features to simplify the process of collecting datasets from diverse data providers,unify data representation forms with user-centered presentation data model,and accelerate data discovery with advanced search capabilities.MGED also provides a standard service management framework to enable finding and sharing of tools for analyzing and processing data.We describe MGED’s design,current status,and how MGED supports integrated management of shared data and services. | Shilong Liu Yanjing Su Haiqing Yin Dawei Zhang Jie He Haiyou Huang Xue Jiang Xuan Wang Haiyan Gong Zhuang Li Hao Xiu Jiawang Wan Xiaotong Zhang | 2021 | npj Computational Materials2021，，1： | 4 |
| 18 | Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients显示文摘Background The Global Leadership Initiative on Malnutrition(GLIM)recently developed a new set of diagnostic criteria for identifying patients with malnutrition.Because the GLIM criteria were only introduced a little over 3 years ago,additional validation and reliability testing are needed in a variety of populations.Methods We performed an observational,multicenter cohort study.From July 2013 to October 2018,lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project.Previously-established cut-off values for the calf circumference(CC,male<30 cm,female<29.5 cm)were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis.Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.Results A total of 1219 patients with lung cancer were studied as subjects.Their age was 58.81±9.92 years old,and 820 were male and 399 were female.According to the GLIM diagnostic criteria using the CC as a muscle mass measurement,303 patients(24.9%)were categorized as malnourished,142 patients(23.1%)in the adult group(18≤age<60)and 161 patients(26.7%)in the older group(age≥60 years).The patients with malnutrition had a higher incidence of anemia than the nourished patients(P=0.012).The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group(all P<0.001).The median survival of the malnutrition group was 42(95%CI:34-50)months,which was much shorter than the 62(95%CI:57-66)months in the nourished group(P<0.001).In the adult group,the median survival decreased from 65(95%CI:55-72)months in nourished group to 34(95%CI:25-48)months in the patients with malnutrition(P<0.001).In the older group,it decreased from 61(95%CI:55-67)months to 48(95%CI:39-59)months(P=0.001).A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group(HR=1.670,95%CI:1.29-2.16),older group(HR=1.332,95%CI:1.05-1.69)and overall(HR=1.453,95%CI:1.22-1.72).Conclusion All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients,independent of age. | Fei Fei Chong Liang Yu Yin Jie Liu Na Li Jing Guo Yang Fan Meng Yuan Zhang Ling Zhang Xiu Mei He Hong Mei Zhang Mu Li Shi Wei Li Hong Xia Xu | 2022 | Journal of Nutritional Oncology2022，7，1： | 4 |
| 19 | The potential value of microRNA-4463 in the prognosis evaluation in hepatocellular carcinoma显示文摘The purpose of this study is to measure the expression of microRNA-4463 and microRNA-6087 between normal persons and patients with hepatocellular carcinoma(HCC),and to clarify the meaning of them in the prognosis evaluation in HCC.Forty-five samples from healthy people and patients,who had been diagnosed with hepatocellular carcinoma before any treatment,were collected to study respectively.Real-time PCR was used to detect the expression of miRNA-4463 and miRNA-6087 in the serum of control group and hepatocellular carcinoma patients.The expression of miR-4463 in the serum of HCC patients was significantly higher than that in control group(P<0.05),and the expression level was independent of gender,tumor size,cell types,stages,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and HBsAg status(P>0.05).But there was a significant difference of different level of AFP in HCC(P<0.05),and the difference between the group of AFP lower than 400 ug/l and the control group is statistically significant(P<0.05).Besides,the survival time had showed a significant difference at the high and low expression levels(P<0.05).But the expression level of miRNA-6087 was no difference in HCC and control group.The disorder of miRNA-4463 occurred in HCC,even the AFP level doesn’t rises.What’s more,patients who get the high level of miRNA-4463 seem to have a shorter survival time.And it contributes great to the prognostic evaluation.This is the first study to illustrate the potential significance of miRNA-4463 in the prognosis in HCC. | Tian Hu Jincheng Li Chuhong Zhang Xiu lv Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo | 2017 | Genes & Diseases2017，4，2： | 3 |
| 20 | Kaposiform Hemangioendothelioma: Case Report and Literature Review显示文摘Kaposiform hemangioendothelioma (KHE) is a rare locally ag- gressive vascular tumor that mainly occurs in children and early adolescents. It is often associated with the | Gang Zhou Shuhua Yang Xiu Nie Jingyuan Du Jin Li Jianxiang Liu Renhao Ze Yu He | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 3 |
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