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| 1 | Long acting octreotide in the treatment of advanced hepatocellular cancer and overexpression of somatostatin receptors: Randomized placebo-controlled trial显示文摘AIM: To estimate if and to what extent long acting octreotide (LAR) improves survival and quality of life in patients with advanced hepatocellular carcinoma (HCC). METHODS: A total of 127 cirrhotics, stages A-B, due to chronic viral infections and with advanced HCC, were enrolled in the study. Scintigraphy with 111Indium labeled octreotide was performed in all cases. The patients with increased accumulation of radionuclear compound were randomized to receive either oral placebo only or octreotide/octreotide LAR only as follows: octreotide 0.5mg s.c. every 8 h for 6 wk, at the end of wk 4-8 octreotide LAR 20 mg i.m. and at the end of wk 12 and every 4 wk octreotide LAR 30mg i.m.. Follow-up was worked out monthly as well as the estimation of quality of life (QLQ-C30 questionnaire). Patients with negative somatostatin receptors (SSTR) detection were followed up in the same manner. RESULTS: Scintigraphy demonstrated SSTR in 61 patients. Thirty were randomized to receive only placebo and 31 only octreotide. A significantly higher survival time was observed for the octreotide group (49 ± 6 wk) as compared to the control group (28 ± 1 wk) and to the SSTR negative group (28 ± 2 wk), LR = 20.39, df = 2, P < 0.01. The octreotide group presented 68.5% lower hazard ratio [95% CI (47.4%-81.2%)]. During the f irst year, a 22%, 39% and 43% decrease in the QLQ-C30 score was observed in each group respectively.CONCLUSION: The proposed therapeutic approach has shown to improve the survival and quality of life in SSTR positive patients with advanced HCC. | D Dimitroulopoulos D Xinopoulos K Tsamakidis A Zisimopoulos E Andriotis D Panagiotakos A Fotopoulou C Chrysohoou A Bazinis D Daskalopoulou E Paraskevas | 2007 | World Journal of Gastroenterology2007，13，23： | 18 |
| 2 | Pancreatic duct guidewire placement for biliary cannulation in a single-session therapeutic ERCP显示文摘AIM: To investigate the technical success and clinical complication rate of a cannulated pancreatic duct with guidewire for biliary access. METHODS: During a five-year study period, a total of 2843 patients were included in this retrospective analysis. Initial biliary cannulation method consisted of single-guidewire technique (SGT) for up to 5 attempts, followed by double-guidewire technique (DGT) when repeated unintentional pancreatic duct cannulation had taken place. Pre-cut papillotomy technique was reserved for when DGT had failed or no pancreatic duct cannulation had been previously achieved. Main outcome measurements were defined as biliary cannu-lation success and post-endoscopic retrograde cholangiopancreatography (ERCP) complication rate. RESULTS: SGT (92.3% success rate) was characterized by statistically significant enhanced patient outcome compared to either the DGT (43.8%, P < 0.001), pre-cut failed DGT (73%, P < 0.001) or pre-cut as first step method (80.6%, P = 0.002). Pre-cut as first step method offered a statistically significantly more favorable outcome compared to the DGT (P < 0.001). The incidence of post-ERCP pancreatitis did not differ in a statistically significant manner between either method (SGT: 5.3%, DGT: 6.1%, Pre-cut failed DGT: 7.9%, Pre-cut as first step: 7.5%) or with patients' gender. CONCLUSION: Although DGT success rate proved not to be superior to SGT or pre-cut papillotomy, it is considered highly satisfactory in terms of safety in order to avoid the risk of a pre-cut when biliary therapy is necessary in difficult-to-cannulate cases. | Dimitrios Xinopoulos Stefanos P Bassioukas Dimitrios Kypreos Dimitrios Korkolis Andreas Scorilas Konstantinos Mavridis Dimitrios Dimitroulopoulos Emmanouil Paraskevas | 2011 | World Journal of Gastroenterology2011，17，15： | 8 |
| 3 | Solitary fibrous tumor of the liver expressing CD34 and vimentin:A case report显示文摘A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported.An 82-year-old female presented with left upper abdominal discomfort,a firm mass on palpation,and imaging studies revealed a large tumor,15 cm in diameter,arising from the left lobe of the liver.A formal left hepatectomy was performed.Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 and positive vimentin,supporting the diagnosis of a benign SFT.The patient remained well 21 months after surgery.SFT of the liver is a very rare neoplasm of mesenchymal origin.In most cases it is a benign lesion,although some may have malignant histological features and recur locally or metastasize.With less than 30 reported cases in the literature,little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy.Complete surgical resection remains the cornerstone of its treatment. | Dimitris P Korkolis Katerina Apostolaki Chrysanthi Aggeli George Plataniotis Emmanuel Gontikakis Dimitra Volanaki Maria Sebastiadou Dimitris Dimitroulopoulos Dimitris Xinopoulos George N Zografos Perikles P Vassilopoulos | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 4 | Immunohistochemical localization of glutathione S-transferase-pi in human colorectal polyps显示文摘AIM:To investigate the distribution of the placental form of glutathione-S-transferase (GST) in colon polyps in order to evaluate the role of GST-pi in these tissues. METHODS: Sixteen polyp tissues removed at colonoscopy were examined. Tissues were investigated histologically and ultrastructurally. GST-pi expression was also analysed immunohistochemically, using peroxidase anti-peroxidase (PAP) method and immunogold labelling method, for light and electron microscope respectively. RESULTS: All polyp tissues examined were adenoma of low, mild and high-grade dysplasia as shown in the histopathological reports. Nevertheless, the examination of the above specimens with electron microscope revealed that 3 of 9 adenoma of mild dysplasia had ultrastuctural features similar to high-grade dysplasia adenoma. GST-pi was variably expressed in adenoma, with the lowest relative levels occurring in low-gradeadenoma and the highest levels found in high-grade adenoma. GST-pi was located mainly in undifferentiated epithelial cells. GST-pi positive particles were found in the cytoplasm and especially in the nucleus adjacent to the nuclear membrane of these cells. CONCLUSION:The overexpression of GST-pi in mildgrade adenomas with significant subcellular changes and in the majority of high-grade dysplasia adenoma suggests that this might be related to the carcinogenetic proceeding. Immunohistochemical localization of GST-pi in combination with ultrastructural changes indicate that GST-pi might be a sensitive agent for the detection of preneoplastic transformations in adenoma. | Eleni Gaitanarou Eleni Seretis Dimitrios Xinopoulos Emmanuel Paraskevas Niki Arnoyiannaki Irene Voloudakis-Baltatzis | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
| 5 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer显示文摘 | Dimitroulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepato-gastroenterology2002，49，47： | 1 |
| 6 | Treatment of malignant colonic obstructions with metal stents and laser显示文摘 | Xinopoulos D Dimitroulopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，44： | 1 |
| 7 | Palliative treatment of advanced esophageal cancer with metal-covered expandable stents:a cost-effectiveness and quality of life study显示文摘 | Xinopoulos D Dimitroulopoulos D Tsamakidis K | 2005 | J BUON2005，10，4： | 1 |
| 8 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer显示文摘 | Dimitroulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，47： | 1 |
| 9 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer显示文摘 | Dimitroulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，47： | 1 |
| 10 | Successful en bloc resection of primary hepatocellular carcinoma directly invading the stomach and pancreas显示文摘Multivisceral surgical resection for cure was successfully performed in a 70-year-old man suffering from a primary hepatocellular carcinoma(HCC)associated with direct invasion to the stomach and pancreas.The patient presented with gastric outlet obstruction,upper abdominal pain and a history of chronic liver disease due to hepatitis B virus(HBV)infection.Upper gastro-intestinal(GI)endoscopy revealed an infiltrating tumor protruding through the gastric wall and obliterating the lumen.Computer tomograghy(CT)and magnetic resonance imaging(MRI)scan demonstrated a 15-cm tumor in the left lateral segment of the liver with invasion to the stomach and pancreas.Alpha-foetoprotein (AFP)levels and liver function tests were normal.The patient underwent an en bloc left hepatectomy,total gastrectomy,distal pancreatectomy with splenectomy and radical lymphadenectomy.Pathology revealed a poorly differentiated,giant cell HCC involving the stom-ach and pancreas.Disease-free margins of resection were achieved.The patient's postoperative course was uneventful.Sixteen months after surgery,he has norecurrence or distal metastasis.Direct invasion of HCC into the GI tract is rarely encountered.Complete surgical resection should be considered in selected patients with an appropriate hepatic functional reserve. | Dimitris P Korkolis Chrysanthi Aggeli George D Plataniotis Emmanuel Gontikakis Helen Zerbinis Nikitas Papantoniou Dimitris Xinopoulos Nikiforos Apostolikas Perikles P Vassilopoulos | 2009 | World Journal of Gastroenterology2009，15，9： | 1 |
| 11 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer显示文摘 | Dimitroulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，47： | 1 |
| 12 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer显示文摘 | Dimitroulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，： | 1 |
| 13 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer 显示文摘 | Dimitmulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，47： | 1 |
| 14 | Palliative treatment of advanced esophageal cancer with metal-covered expandable stents:A cost-effectiveness and quality of life study显示文摘 | Xinopoulos D Dimitroulopoulos D Tsamakidis K | | 0，，04： | 1 |
| 15 | Do Papillary Manipulations with a Guidewire Increase the Incidence of Post-ERCP Pancreatitis? Lessons Learned from 1858 Consecutive Therapeutic Endoscopic Retrograde Cholangiopancreatographies (ERCPs) from a Single Institution显示文摘 | Dimitrios Xinopoulos Stefanos P. Bassioukas Dimitrios Kypreos Dimitrios Dimitroulopoulos Dimitris P. Korkolis Klisthenis Tsamakidis Stamatia Patsavela Emmanuil Paraskevas | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 16 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer显示文摘 | Dimitroulopoulos D Xinopoulos D Tsamakidis K et 81 | 2002 | Hepatogastmentemlogy2002，49，： | 1 |
| 17 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer 显示文摘 | Dimitroulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，： | 1 |
| 18 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer 显示文摘 | Dimit roulopoulos D Xinopoulos D Tsamakidis K | 2002 | Hepatogastroenterology2002，49，47： | 1 |
| 19 | The role of sandostatin LAR in treating patients with advanced hepatocellular cancer显示文摘 | Dimitrios Dimitroulopoulos Dimitrios Xinopoulos Klisthenis Tsamakidis | 2002 | Hepato-gastroenterology2002，49，： | 1 |
| 20 | The role of sandostatin LAR in treating patients with advanced hepatoccellular cancer 显示文摘 | DIMITROULOPOULOS D XINOPOULOS D TSAMAKIDIS K | 2002 | Hepatogastroenterology2002，49，47： | 1 |
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