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| 1 | Regulation of innate immune responses by rabies virus显示文摘Rabies virus(RABV)is an infectious and neurotropic pathogen that causes rabies and infects humans and almost all warm-blooded animals,posing a great threat to people and public safety.It is well known that innate immunity is the critical first line of host defense against viral infection.It monitors the invading pathogens by recognizing the pathogen-associated molecular patterns and danger-associated molecular patterns through pattern-recognition receptors,leading to the production of type I interferons(IFNα/β),inflammatory cytokines,and chemokines,or the activation of autophagy or apoptosis to inhibit virus replication.In the case of RABV,the innate immune response is usually triggered when the skin or muscle is bitten or scratched.However,RABV has evolved many ways to escape or even hijack innate immune response to complete its own replication and eventually invades the central nervous system(CNS).Once RABV reaches the CNS,it cannot be wiped out by the immune system or any drugs.Therefore,a better understanding of the interplay between RABV and innate immu-nity is necessary to develop effective strategies to combat its infection.Here,we review the innate immune responses induced by RABV and illustrate the antagonism mechanisms of RABV to provide new insights for the control of rabies. | Haili Zhang Jingbo Huang Yumeng Song Xingqi Liu Meichen Qian Pei Huang Yuanyuan Li Ling Zhao Hualei Wang | 2022 | Animal Models and Experimental Medicine2022，5，5： | 2 |
| 2 | Intricacies of TGF-βsignaling in Treg and Th17 cell biology显示文摘Balanced immunity is pivotal for health and homeostasis.CD4+helper T(Th)cells are central to the balance between immune tolerance and immune rejection.Th cells adopt distinct functions to maintain tolerance and clear pathogens.Dysregulation of Th cell function often leads to maladies,including autoimmunity,inflammatory disease,cancer,and infection.Regulatory T(Treg)and Th17 cells are critical Th cell types involved in immune tolerance,homeostasis,pathogenicity,and pathogen clearance.It is therefore critical to understand how Treg and Th17 cells are regulated in health and disease.Cytokines are instrumental in directing Treg and Th17 cell function.The evolutionarily conserved TGF-β(transforming growth factor-β)cytokine superfamily is of particular interest because it is central to the biology of both Treg cells that are predominantly immunosuppressive and Th17 cells that can be proinflammatory,pathogenic,and immune regulatory.How TGF-βsuperfamily members and their intricate signaling pathways regulate Treg and Th17 cell function is a question that has been intensely investigated for two decades.Here,we introduce the fundamental biology of TGF-βsuperfamily signaling,Treg cells,and Th17 cells and discuss in detail how the TGF-βsuperfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks. | Junying Wang Xingqi Zhao Yisong Y.Wan | 2023 | Cellular & Molecular Immunology2023，20，9： | 2 |
| 3 | Synthesis of Bis Triethylenediamine Bromide Sur- factants and Their Oilfield Application Investigation显示文摘 | Ming Zhou Jinzhou Zhao Xingqi Hu | 2012 | Jour- nal of Surfactants and Detergents2012，15，： | 1 |
| 4 | MALE STERILITY 3 encodes a plant homeodomain-finger protein for male fertility in soybean显示文摘Male-sterile plants are used in hybrid breeding to improve yield in soybean(Glycine max(L.)Merr.).Developing the capability to alter fertility under different environmental conditions could broaden germplasm resources and simplify hybrid production.However,molecular mechanisms potentially underlying such a system in soybean were unclear.Here,using positional cloning,we identified a gene,MALE STERILITY 3(MS3),which encodes a nuclear-localized protein containing a plant homeodomain(PHD)-finger domain.A spontaneous mutation in ms3 causing premature termination of MS3 translation and partial loss of the PHD-finger.Transgenetic analysis indicated that MS3 knockout resulted in nonfunctional pollen and no selfpollinated pods,and RNA-seq analysis revealed that MS3 affects the expression of genes associated with carbohydrate metabolism.Strikingly,the fertility of mutant ms3 can restore under longd conditions.The mutant could thus be used to create a new,more stable photoperiod-sensitive genic male sterility line for two-line hybrid seed production,with significant impact on hybrid breeding and production. | Jingjing Hou Weiwei Fan Ruirui Ma Bing Li Zhihui Yuan Wenxuan Huang Yueying Wu Quan Hu Chunjing Lin Xingqi Zhao Bao Peng Limei Zhao Chunbao Zhang Lianjun Sun | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
| 5 | Synthesis of Bis IN, N- (alkylamideethyl) ethyl] triethylenediamine bromide surfactants and their oilfield application investigation 显示文摘 | ZHOU MING ZHAO JINZHOU HU XINGQI | 2012 | J Surfact Deterg2012，15，3： | 1 |
| 6 | Engineering the morphology/porosity of oxygen-doped carbon for sulfur host as lithium-sulfur batteries显示文摘Despite the intriguing merits of lithium-sulfur(Li-S) systems, they still suffer from the notorious‘‘shuttling-effect' of polysulfides. Herein, carbon materials with rational tailoring of morphology and pores were designed for strong loading/adsorption with the controlling of energy-storage ability.Through rational tailoring, it is strongly verified that such engineering of evolutions result in variational of sulfur immobilization in the obtained carbon. As expected, the targeted sample delivers a stable capacity of 925 m Ah g^(-1) after 100 loops. Supporting by the 'cutting-off' manners, it is disclosed that mesopores in carbon possess more fascinated traits than micro/macropores in improving the utilization of sulfur and restraining Li_(2)S_x(4≤x≤8). Moreover, the long-chain polysulfide could be further consolidated by auto-doping oxygen groups. Supported by in-depth kinetic analysis, it is confirmed that the kinetics of ion/e-transfer during charging and discharging could be accelerated by mesopores, especially in stages of the formation of solid S_(8) and Li_(2)S, further improving the capacity of ion-storage in Li-S battery. Given this, the elaborate study provide significant insights into the effect of pore structure on kinetic performance about Li-storage behaviors in Li-S battery, and give guidance for improving sulfur immobilization. | Limin Zhang Wenqing Zhao Shaohui Yuan Feng Jiang Xingqi Chen Yue Yang Peng Ge Wei Sun Xiaobo Ji | 2021 | Journal of Energy Chemistry2021，30，9： | 1 |
| 7 | Analysis and application of carbon-bearing rate of reservoirs in the Puguang gas field,northeastern Sichuan Basin显示文摘With wells Puguang 2 and 6 in the Puguang gas field as the research objects by choosing organic carbon as characterization reservoir carbon(indirectly reflecting the bitumen contents),this paper discusses the relationship between bitumen contents and lithologic characteristics,reservoir characteristics,and calculates the volume of paleo-oil and oil cracked gas.The study shows that the organic carbon contents of the reservoirs are related to lithologic characteristics.Due to variations in the particle size or structure of rocks,the porosity of the reservoirs varies,furthermore,it will influence the contents of organic carbon.And the relationship between these two parameters is positive.Based on the analysis,the relationship between total organic carbon(TOC)and the contents of reservoir bitumen also appears to be positive.The volume of paleo-oil and cracked gas of the Changxing-Feixian’guan Formation are respectively 495 million tons and 360.4 billion m3 through the calculation of reservoir’s organic carbon.Therefore,the relationship between carbon-bearing rate and characteristics of the reservoirs can be used to indirectly evaluate reservoir types.Besides,the carbon-bearing rate of the reservoirs also reflects the contents of reservoir bitumen,paleo-oil as well as natural gas.It makes a new approach for the study of the types of reservoirs and the amounts of paleo-oil and oil cracked gas in northeastern Sichuan Basin. | ZHAO Xingqi CHEN Jianfa GUO Wang LIU Gaozhi LIU Fenfen XU Liheng | 2013 | Chinese Journal Of Geochemistry2013，32，4： | 0 |
| 8 | PoWRKY71 is involved in Paeonia ostii resistance to drought stress by directly regulating light-harvesting chlorophyll a/b-binding 151 gene显示文摘Although the functions of WRKY transcription factors in drought resistance are well known,their regulatory mechanisms in response to drought by stabilising photosynthesis remain unclear.Here,a differentially expressed PoWRKY71 gene that was highly expressed in drought-treated Paeonia ostii leaves was identified through transcriptome analysis.PoWRKY71 positively responded to drought stress with significantly enhanced expression patterns and overexpressing PoWRKY71 in tobacco greatly improved plant tolerance to drought stress,whereas silencing PoWRKY71 in P.ostii resulted in a drought-intolerant phenotype.Furthermore,lower chlorophyll contents,photosynthesis,and inhibited expression of photosynthesis-related light-harvesting chlorophyll a/b-binding 151(CAB151)gene were found in PoWRKY71-silenced P.ostii.Meanwhile,a homologous system indicated that drought treatment increased PoCAB151 promoter activity.Interactive assays revealed that PoWRKY71 directly bound on the W-box element of PoCAB151 promoter and activated its transcription.In addition,PoCAB151 overexpressing plants demonstrated increased drought tolerance,together with significantly higher chlorophyll contents and photosynthesis,whereas these indices were dramatically lower in PoCAB151-silenced P.ostii.The above results indicated that PoWRKY71 activated the expression of PoCAB151,thus stabilising photosynthesis via regulating chloroplast homeostasis and chlorophyll content in P.ostii under drought stress.This study reveals a novel drought-resistancemechanism in plants and provides a feasible strategy for improving plant drought resistance via stabilising photosynthesis. | Yuting Luan Zijie Chen Ziwen Fang Xingqi Huang Daqiu Zhao Jun Tao | 2023 | Horticulture Research2023，10，11： | 0 |
| 9 | Mannonic Acid and Bio-Ethanol Production from Konjac Using a Two-Step Bioprocess with Candida Shehatae and Gluconobacter Oxydans显示文摘Amorphophallus konjac is rich in glucomannan,which can be hydrolyzed into glucose and mannose,thereby acting as an economic raw material for the acquisition of glucose and mannose.The total sugar yield was 91.2%when konjac powder was treated with 0.75%hydrochloric acid at 121℃for 1 h.Thus,dilute acid hydrolysates of konjac powder were used as a carbon source for obtaining value-added products.Here we showed that the microbial production of ethanol and mannonic acid was obtained by employing Candida shehatae(C.shehatae)and Gluconobacter oxydans(G.oxydans).Through a step-by-step bioprocess,glucose is the first selectively converted to ethanol by C.shehatae,which enables G.oxydans-mediated biocatalysis of mannose to mannonic acid.Finally,approximately 100 g ethanol and 340 g mannonic acid were produced starting from 1 kg refined konjac powder.The results demonstrated the feasibility of this bioconversion method for producing mannonic acid starting from crude hydrolysates of konjac powder. | Jianglin Zhao Xiaotong Zhang Weiwei Lei Xingqi Ji Xin Zhou Yong Xu | 2020 | Journal of Renewable Materials2020，8，1： | 0 |
| 10 | Selective precipitation and non-isothermal crystallization kinetics of britholite from low grade REE-bearing slag显示文摘In order to improve the recovery rate of rare earth,the effect of P_(2)O_(5) and cooling rate on the selective precipitation of CaO-SiO_(2)-TiO_(2)-P_(2)O_(5)-Nb_(2)O_(5)-CeO_(2)-CaF_(2) slag system was explored using X-ray powder diffraction,a scanning electron microscope,an electron probe micro-analyzer and a confocal laser scanning microscope.The apatite(Ca_(2.02)Ce_(7.98)Si_(6.00)O_(26.00))is tiny and difficult to be separated from the slag without P_(2)O_(5).When the addition of P_(2)O_(5) is 6 wt%-10 wt%,the cerium and phosphorus are found to be enriched in britholite(Ca_(5-x)Ce_(x)[(SiO_(4))_(x)(PO_(4))_(3-x)]F)phase while x is negatively correlated with P_(2)O_(5) content in the slag.The influence of P_(2)O_(5) and cooling rate on the non-isothermal crystallization kinetics was also investigated.For the cooling rate between 5 and 40℃/min,continuous cooling transformation diagram of britholite was constructed when the P205 content is between 6 wt%-10 wt%.The modified Avrami model was applied to determine the crystallization mode of slag with 10 wt%P_(2)O_(5).It is shown that the crystallization mode is diffusion-controlled with constant nucleation rate and one-dimensional growth.In consideration of quantity and volume of crystals,the reasonable cooling rate is between 10and 30℃/min. | Zhuang Ma Zengwu Zhao Xingqi Guo Wentao Guo | 2023 | Journal of Rare Earths2023，41，11： | 0 |
| 11 | Numerical simulation on centrifugal pump compressible flow field with different gas volume fractions显示文摘In order to study the influence of gas-liquid two-phase flow on the performance and internal flow field of a centrifugal pump,the steady three-dimensional flow with different gas volume fractions was simulated by applying the Reynolds-average N-S equation and mixture gas-liquid two-phase flow model,and the compressibility of gas was taken into consideration in the simulation. Then the centrifugal pump characteristic and the gas distribution law in different gas volume fractions were analyzed. The computational results show that gas volume fraction has a certain influence on the performance of the centrifugal pump,and the efficiency and head of the pump are on the decline with the increase of it.Static pressure in the impeller increases in the radial direction,but the pressure gradient in the flow direction is different under the different gas volume fractions. The gas volume is distributed mainly in the ipsilateral direction of impeller back shroud in the flow channel of the volute. On the suction side of the blade inlet there is an obvious low-pressure area,which causes bubbles agglutination and higher gas volume fraction. With the gas entering passage flow,gas volume fraction in the suction decreases and the pressure surface rises gradually. Higher gas volume fraction causes air blocking phenomenon in the flow passage and the discharge capacity reduces. The increase of gas volume makes the turbulent motion within the impeller more and more intense,which leads to more and more energy loss. | WANG Like LIAO Weili LU Jinling LUO Xingqi RUAN Hui ZHAO Yaping WANG Jing | 2019 | 排灌机械工程学报2019，37，2： | 0 |
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