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| 1 | Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue显示文摘AIM: To investigate whether NF-κB is activated in human gastric carcinoma tissues and, if so, to study whether there is any correlation between NF-κB activity and heparanase expression in gastric carcinoma.METHODS: NF-κB activation was assayed by immunohistochemical staining in formalin-fixed, paraffin-embedded specimens from 45 gastric carcinoma patients. Electrophoretic mobility shift assay (EMSA) method was used for nuclear protein from these fresh tissue specimens. Heparanase gene expression was quantified using quantitative RT-PCR.RESULTS: The nuclear translocation of RelA (marker of NF-κB activation) was significantly higher in tumor cells compared to adjacent and normal epithelial cells [(41.3±3.52)% vs (0.38±0.22) %, t= 10.993, P= 0.000<0.05; (41.3±3.52)%vs (0±0.31)%, t = 11.484, P = 0.000<0.05]. NF-κB activation was correlated with tumor invasion-related clinicopathological features such as lymphatic invasion,pathological stage, and depth of invasion (Z = 2.148,P= 0.032<0.05; χ2 = 8.758, P= 0.033<0.05; χ2 = 18.531,P = 0.006<0.05). NF-κB activation was significantly correlated with expression of heparanase gene (r= 0.194,P= 0.046<0.05).CONCLUSION: NF-κB RelA (p65) activation was related with increased heparanase gene expression and correlated with poor clinicopathological characteristics in gastric cancers. This suggests NF-κB as a major controller of the metastatic phenotype through its reciprocal regulation of some metastasis-related genes. | Hou-JunCao YongFang XingZhang Wen-JunChen Wen-PengZhou HongWang Lin-BoWang Jin-MinWu | 2005 | World Journal of Gastroenterology2005，11，6： | 18 |
| 2 | Research and control of well water pollution in high esophageal cancer areas显示文摘AIM: In order to detect risk factors for esophageal cancer,a national research program was carried out during the Eighth Five-Year Plan (from 1991 to 1995).
METHODS: Cixian County and Chichen County in Hebei Province were selected as the index and the control for the study fields with higher or lower incidence of esophagus cancer in China, respectively. In these areas, we investigated the pollution of three nitrogenous compounds in well water for drinking and the use of nitrogen fertilizer in farming.
RESULTS: In well water, nitrate nitrogen, nitrite nitrogen and ammonia nitrogen were 8.77 mg/L, 0.014 mg/L and 0.009 mg/L in Cixian County in 1993, respectively. They were significantly higher than their levels (3.84 mg/L, 0.004 mg/L and 0.004 mg/L) in Chichen County (P<0.01, t=6.281,t=3.784,t=3.775). There was a trend that the nitrogenous compounds in well water increased from 1993 to 1996.The amount of nitrogen fertilizer used in farming was 787.6 kg per hectare land in Cixian County in 1991, significantly higher than 186 kg per hectare in Chichen County (t=9.603,P<0.001).
CONCLUSION: These investigations indicate that the poilution of nitrogenous compounds in well water for drinking is closely related to the use of nitrogen fertlizer in farming, and there is a significantly positive correlation between the level of three nitrogenous compounds in well water and the mortality ofesophageal cancer (correlation coefficient =0.5992). We suggest that improvement of well system for drinking water quality should be an effective measure for esophageal cancer prevention and control in rural areas. | Xiu-LanZhang BingZhang XingZhang Zhi-FengChen Jun-ZhenZhang Shuo-YuangLiang Fan-ShuMen Shu-LiangZheng Xiang-PingLi Xiu-LanBai | 2003 | World Journal of Gastroenterology2003，9，6： | 7 |
| 3 | Susceptibility assessment of debris flows using the analytic hierarchy process method——A case study in Subao river valley, China显示文摘Many debris flows have occurred in the areas surrounding the epicenter of the Wenchuan earthquake.Susceptibility assessment of debris flows in this area is especially important for disaster prevention and mitigation. This paper studies one of the worst hit areas, the Subao river valley, and the susceptibility assessment of debris flows is performed based on field surveys and remote sensing interpretation. By investigating the formation conditions of debris flows in the valley, the following assessment factors are selected: mixture density of landslides and rock avalanches, distance to the seismogenic fault, stratum lithology, ground roughness, and hillside angle. The weights of the assessment factors are determined by the analytic hierarchy process(AHP) method. Each of the assessment factors is further divided into five grades. Then, the assessment model is built using the multifactor superposition method to assess the debris flow susceptibility. Based on the assessment results, the Subao river valley is divided into three areas: high susceptibility areas, medium susceptibility areas, and low susceptibility areas. The high susceptibility areas are concentrated in the middle of the valley, accounting for 17.6% of the valley area.The medium susceptibility areas are in the middle and lower reaches, most of which are located on both sides of the high susceptibility areas and account for 45.3% of the valley area. The remainders are classified as low susceptibility areas. The results of the model are in accordance with the actual debris flow events that occurred after the earthquake in the valley, confirming that the proposed model is capable of assessing the debris flow susceptibility. The results can also provide guidance for reconstruction planning and debris flow prevention in the Subao river valley. | Xingzhang Chen Hui Chen Yong You Jinfeng Liu | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，4： | 5 |
| 4 | Migration of Some Elements and Radionuclides across aGranite-Granite Contact Zone: A Natural Analoguefor Safe Disposal of High-Level Radwastes显示文摘Elements and natural radionuclides in the contact zone of two granites with different ages would migrate from one to the other because of the difference in their chemical contents and later water-rock interactions. This migration could serve as an analogue for the near-field process of radwastes in a high-level radwaste deep geological disposal repository.In the contact between the Indosinian granite (whole-rock Rb-Sr isochron age at 214@3 Ma) and Hercynian granite (zircon U-Pb isochron age at 296@31 Ma) located in Ziyuan County, Guangxi, the O and Pb isotope characteristics and the activity ratios of 234U/238U, 230Th/238U, 230Th/234U and 226Ra/230Th show that, based on the whole-rock chemical contents, both of the two granites have maintained a relatively open chemical system in their evolution processes. However, as there is no obvious open fault, the migration of major elements, trace elements and natural U-series nu-clides takes place within only 1-2 m in the contact zone, and water-rock | LUO Xingzhang MIN Maozhong ZHANG Guanghui LI Xianguo YANG Zhe ZHAI Liying Zhu Deling | 1999 | Acta Geologica Sinica(English Edition)1999，73，4： | 4 |
| 5 | Adsorption of p -nitroaniline from aqueous solutions onto activated carbon fiber prepared from cotton stalk显示文摘 | Kunquan Li Zheng Zheng Jingwei Feng Jibiao Zhang Xingzhang Luo Guohua Zhao Xingfa Huang | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 6 | Spillover on a Platinum Electrode Modified by MWNTs显示文摘The spillover phenomenon is observed on the platinum (Pt) disk electrode modified by multi-wall carbon nanotubes (MWNTs). The rate of the spillover of oxygen-containing species produced on Pt surface to and from MWNTs is fast. However for hydrogen-adatoms, the spillover is very weak. The selective spillover on the Pt/MWNTs electrode may provide a novel way to design catalysts. | XiaoFengWANG DongPingZHAN YunYiFU RuHUANG XingZHANG YuanHuaSHAO | 2004 | Chinese Chemical Letters2004，15，12： | 1 |
| 7 | Cohort Studies on Cancer Mortality Among Workers Exposed Only to Chrysotile Asbestos: a Meta-analysis显示文摘Objective To determine whether there was excessive risk of cancer among workers exposed to chrysotile fiber alone by applying a meta-analysis technique. Methods All data meeting the criteria of cohort studies on cancer mortality among workers exposed only to chrysotile were incorporated into meta-analysis. Pooled standardized mortality ratios (SMRs) and their corresponding 95% confidence intervals (CIs) for main cancer sites were calculated using two approaches of unweighted ratio and random effect model. The heterogeneity and its sources of the results were examined with a Q-statistic and Z-score test. The dose-response effect as reflected in the percentage of all deaths due to mesothelioma served as a proxy measure of chrysotile exposure. Results A cohort of twenty six workers exposed to chrysotile alone was summarized. The significantly elevated meta-SMRs for all deaths (1.27), all cancers (1.28), cancers of respiratory organs (2.51), cancers of lung (2.35) and cancers of stomach (1.24) were observed. The significantly elevated meta-SMRs for lung cancer within occupational strata were observed among textile workers (3.55), asbestos product manufacturers (3.30), miners and millers (2.24), cement product workers (1.22), and for stomach cancer among asbestos product manufacturers (1.49). Meta-SMRs for cancers at other sites were not significant. Meta-SMR for lung cancer showed an increasing trend with an elevated percentage of all deaths from mesothelioma, but no such trend for stomach cancer. Conclusion There are excessive risks of lung cancer and mesothelioma among workers exposed to chrysotile fiber alone, and likely no convincing indication of an etiological association between chrysotile exposure and cancers at other sites. | LuLI TONG-DASUN XINGZHANG RUI-NANLAI XIU-YANGLI XUE-JINFAN KENJIMORINAGA | 2004 | Biomedical and Environmental Sciences2004，17，4： | 1 |
| 8 | Nitrogen‐Doped Porous Carbon Nanofiber Webs as Anodes for Lithium Ion Batteries with a Superhigh Capacity and Rate Capability显示文摘 | LongQie Wei‐MinChen Zhao‐HuiWang Qing‐GuoShao XiangLi Li‐XiaYuan Xian‐LuoHu Wu‐XingZhang Yun‐HuiHuang | 2012 | Adv Mater2012，，15： | 1 |
| 9 | Enhancement of rural domestic sewage treatment performance, and assessment of microbial community diversity and structure using tower vermifiltration显示文摘 | Longmian Wang Feihong Guo Zheng Zheng Xingzhang Luo Jibiao Zhang | 2011 | Bioresource Technology2011，，20： | 1 |
| 10 | Performance and mechanisms of a microbial-earthworm ecofilter for removing organic matter and nitrogen from synthetic domestic wastewater显示文摘 | Longmian Wang Zheng Zheng Xingzhang Luo Jibiao Zhang | 2011 | Journal of Hazardous Materials2011，，： | 1 |
| 11 | Preliminary mapping of high-resolution rural population distribution based on imagery from Google Earth: A case study in the Lake Tai basin, eastern China显示文摘 | Xiaoying Yang Geng-Ming Jiang Xingzhang Luo Zheng Zheng | 2011 | Applied Geography2011，，2： | 1 |
| 12 | Adsorption of p -nitroaniline from aqueous solutions onto activated carbon fiber prepared from cotton stalk显示文摘 | Kunquan Li Zheng Zheng Jingwei Feng Jibiao Zhang Xingzhang Luo Guohua Zhao Xingfa Huang | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 13 | Debris flow formation conditions and optimal characteristics of drainage canal following Wenchuan earthquake显示文摘 | Yong You Jinfeng Liu Xingzhang Chen | 2012 | Environmental Earth Sciences2012，65，4： | 1 |
| 14 | Bmi‐1 expression predicts prognosis for patients with gastric carcinoma显示文摘 | Jian‐HuaLiu Li‐BingSong XingZhang Bao‐HongGuo YanFeng Xue‐XianLi Wen‐TingLiao Mu‐ShengZeng Kai‐HongHuang | 2008 | J Surg Oncol2008，，3： | 1 |
| 15 | Effects of various LED light wavelengths and intensities on the performance of purifying synthetic domestic sewage by microalgae at different influent C/N ratios显示文摘 | Yan Cheng Zhang Li Luo Xingzhang | 2013 | Ecological Engineering2013，51，： | 1 |
| 16 | The current pollution status and control technology of the Taihu Lake Basin, Jiangsu Province, China显示文摘 | WANG Longmian ZHENG Zheng LUO Xingzhang | 2010 | International Journal of Environmental Studies2010，67，2： | 1 |
| 17 | Spatial Economic Hubs and State Power显示文摘The paper seeks to analyze the rise of state power in the light of spatial economic shifts and examines the historical context of China's rise and challenges facing it.In world history,only countries that were spatial economic hubs have been able to enjoy prosperity over centuries.China is not yet such a country,despite its persistent efforts.Nor is China likely to become an economic hub in the foreseeable future.China is under mounting pressure from new economic demands posed by shifts in the geo-economic status of the U.S..The fact that the global economy thrives along coastlines also causes problems for China,a country with a long coastline and a vast hinterland,creating riffs between northern and southern China,central and local governments,and different provinces. All these factors might well hinder China's development in the future. | Xuan Xingzhang | 2008 | Contemporary International Relations2008，18，5： | 0 |
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