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| 1 | The flexural property and its synergistic mechanism of multibody molded beetle elytron plates显示文摘To improve the applications of beetle elytron plates(BEPs,which are biomimetic sandwich plates inspired by beetle elytra),the flexural performance and its synergistic mechanism of multibody molded BEPs were investigated via cantilever testing and finite element method(FEM).The results are summarized as follows.(1)Although debonding damage causes failure of the multibody molded BEPs and honeycomb plate and the reasonable range of trabecular size for BEPs is narrow,both the optimal loading capacity per mass and failure deformation of the BEPs are over two times those of the honeycomb plate.(2)A flexural synergistic mechanism is revealed in the trabecular-honeycomb core structure of BEPs;this mechanism causes the maximum deformation of core structure to gradually transfer from the honeycomb wall to the trabeculae with the increase inη(the ratio of the trabecular radius to the distance between the center points of two trabeculae),which means the different stretching behaviors in these core structures.(3)Unlike the compressive mechanism of BEPs,by controlling and balancing the deformation degrees of the trabeculae and honeycomb walls,the flexural mechanism achieves a minimum core deformation and an optimal flexural performance.These results suggest a qualitative relationship between the deformation behavior of trabecular-honeycomb core structure and bending performance of the whole BEP,and provide a solid foundation for subsequent research and the considerable application potential of this biomimetic sandwich structure in many fields. | YU XinDi ZHANG XiaoMing CHEN JinXiang ZHAO CaiQi ZHAO TiDong FU YaQin | 2020 | Science China(Technological Sciences)2020，63，5： | 2 |
| 2 | Coloration strategies in peacock feathers显示文摘 | Zi Jian Yu Xindi Li Yizhou | 2003 | PNAS2003，100，12： | 1 |
| 3 | Vibration properties and transverse shear characteristics of multibody molded beetle elytron plates显示文摘This study utilized cantilever experiments to investigate the vibration properties of multibody molded beetle elytron plates(BEPs),which is a type of biomimetic sandwich plate inspired by beetle elytra;the corresponding shear characteristics were further revealed by a finite element method(FEM). The following results were obtained:(1) Experimental results suggest that the maximum displacement response of the BEPs was about 25% less than that of a honeycomb plate with almost the same first natural frequency,which indicates that a BEP with reasonable structural parameters has the potential to replace a honeycomb plate to achieve better vibration performance;(2) The trabecular structure not only enhanced the shear stiffness of the core layer in column areas but also the skins in the honeycomb wall areas,thus changing the distribution of the shear force in the different components and improving the mechanical performances of the BEP;and(3) Although this enhancement effect from trabeculae was not uniform,the average shear force proportion of the skins(or core structure) in the entire BEP structure was very close to that of the honeycomb plate. Therefore,the shear calculation assumption used for honeycomb plates is still applicable in the BEP.The results provide an experimental basis for the design and application of BEPs and inspiration for the development of related products in vibrational environments. | ZHANG XiaoMing YU XinDi CHEN JinXiang PAN LongCheng HU LiPing FU YaQin | 2020 | Science China(Technological Sciences)2020，63，12： | 1 |
| 4 | Recent Advances in Organic-inorganic Hybrid Photoresists显示文摘Photoresists are radiation-sensitive materials used for forming patterns to build up IC devices.To date,most photoresists have been based on organic polymers,which have been dominating the semiconductor industries over the past few decades.It is obvious that extreme ultraviolet(EUV)lithography has become the next-generation lithography technology.The development of comprehensive performance EUV resist is one of the most critical issues.However,organic polymeric photoresists are difficult to meet the harsh requirements of EUV lithography.Pure inorganic photoresists such as metal salts,hydrogen silsesquioxane(HSQ)are expected for EUV lithography due to their high resistance and high resolution.But the low sensitivity makes them not suitable for high volume manufacturing(HVM).Organic-inorganic hybrid photoresists,containing both organic and inorganic components,are regarded as one of the most promising EUV resists.They combine both merits of organic and inorganic materials and have significant advantages in machinability,etching resistance,EUV absorption,and chemical/thermal stability.Organic-inorganic hybrid photoresists are considered as ideal materials for realizing industrialgrade patterns below 10 nm.This review mainly focuses on the development of organic-inorganic hybrid photoresists over the past decade. | Zhihao Wang Xindi Yao Huiwen An Yake Wang Jinping Chen Shuangqing Wang Xudong Guo Tianjun Yu Yi Zeng Guoqiang Yang Yi Li | 2021 | Journal of Microelectronic Manufacturing2021，4，1： | 0 |
| 5 | Influence Mechanism of the Trabecular and Chamfer Radii on the Three-point Bending Properties of Trabecular Beetle Elytron Plates显示文摘To improve the mechanical properties of Trabecular Beetle Elytron Plates(TBEPs,a type of biomimetic sandwich structure inspired by the beetle elytron)under transverse loads,three-point bending tests are performed to investigate the influence of the trabecular and chamfer radii of the core structure on the mechanical performance of TBEPs manufactured by 3D printing technology.The results show that the three-point bending performance of TBEPs can be improved by setting reasonable trabecular and chamfer radii;however,excessive increases in these radii can cause a decline in the mechanical performance.For the reason,these two structural parameters can enhance the deformation stiffness of the whole structure and the connection property between the core and skin,which is also the mechanical reason why Prosopocoilus inclinatus beetle elytra have thick,short trabeculae with a large chamfer radius.However,when these radii increase to a certain extent,the cracks are ultimately controlled between two adjacent trabeculae,and the failure of the plate is determined by the skin rather than the core structure.Therefore,this study suggests a reasonable range for trabecular and chamfer radii,and indicates that TBEPs are better suited for engineering applications that have high compression requirements and general bending requirements. | Xiaoming Zhang Xindi Yu Jinxiang Chen Caiqi Zhao Sujun Guan Yaqin Fu | 2021 | Journal of Bionic Engineering2021，18，2： | 0 |
| 6 | Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies显示文摘Background:Chimeric antigen receptor T(CAR-T)therapy has substantially revolutionized the clinical outcomes of patients with hematologic malignan-cies,but the cancer-intrinsic mechanisms underlying resistance to CAR-T cells remain yet to be fully understood.This study aims to explore the molecular deter-minants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical efficacy.Methods:The human whole-genome CRISPR/Cas9-based knockout screening was conducted to identify key genes that enable cancer cells to evade CD19 CAR-T-cell-mediated killing.The in vitro cytotoxicity assays and evaluation of tumor tissue and bone marrow specimens were further conducted to confirm the role of the key genes in cancer cell susceptibility to CAR-T cells.In addition,the specific mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular models.Results:The CRISPR/Cas9-based knockout screening showed that the enrich-ment of autophagy-related genes(ATG3,BECN1,and RB1CC1)provided protec-tion of cancer cells from CD19 CAR-T cell-mediated cytotoxicity.These findings were further validated by in vitro cytotoxicity assays in cells with genetic and pharmacological inhibition of autophagy.Notably,higher expression of the three autophagy-related proteins in tumor samples was correlated with poorer respon-siveness and worse survival in patients with relapsed/refractory B-cell lymphoma after CD19 CAR-T therapy.Bulk RNA sequencing analysis of bone marrow samples from B-cell leukemia patients also suggested the clinical relevance of autophagy to the therapeutic response and relapse after CD19 CAR-T cell ther-apy.Pharmacological inhibition of autophagy and knockout of RB1CC1 could dramatically sensitize tumor cells to CD19 CAR-T cell-mediated killing in mouse models of both B-cell leukemia and lymphoma.Moreover,our study revealed that cancer-intrinsic autophagy mediates evasion of CAR-T cells via the TNF-α-TNFR1 axis-mediated apoptosis and STAT1/IRF1-induced chemokine signaling activation.Conclusions:These findings confirm that autophagy signaling in B-cell malig-nancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy. | Lu Tang Huan Zhang Fen Zhou Qiuzhe Wei Mengyi Du Jianghua Wu Chenggong Li Wenjing Luo Jie Zhou Xindi Wang Zhaozhao Chen Yinqiang Zhang Zhongpei Huang Zhuolin Wu Yuxi Wen Huiwen Jiang Danying Liao Haiming Kou Wei Xiong Heng Mei Yu Hu | 2024 | Cancer Communications2024，44，3： | 0 |
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